Diphenyl diselenide-modulation of macrophage activation: Down-regulation of classical and alternative activation markers

Innate Immunity

Volumn 18, Issue 4, 2012, Pages 627-637

  Rupil, Lucía L ^a,b   De Bem, Andreza F ^b   Roth, German A ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

^b FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Arginase; diphenyl diselenide; LPS; macrophages; nitric oxide

Indexed keywords

3 NITROTYROSINE; ARGINASE; CD86 ANTIGEN; DEXAMETHASONE; DIPHENYL DISELENIDE; INTERLEUKIN 10; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN METABOLITE;

ANIMAL CELL; ANTIGEN PRESENTATION; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; MACROPHAGE ACTIVATION; MAJOR HISTOCOMPATIBILITY COMPLEX; NONHUMAN; PERITONEUM CELL; PHENOTYPE; PROTEIN EXPRESSION; RAT;

ANIMALS; ANTIGEN PRESENTATION; BENZENE DERIVATIVES; CELL LINE; DEXAMETHASONE; DOWN-REGULATION; INTERLEUKIN-10; LECTINS, C-TYPE; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES, PERITONEAL; MANNOSE-BINDING LECTINS; MICE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; ORGANOSELENIUM COMPOUNDS; REACTIVE OXYGEN SPECIES; RECEPTORS, CELL SURFACE;

EID: 84863930243     PISSN: 17534259     EISSN: 17534267     Source Type: Journal    
DOI: 10.1177/1753425911431285     Document Type: Article

References (37)

1. Benoit M, Desnues B, Mege JL. Macrophage polarization in bacterial infections. J Immunol. 2008 ; 181: 3733-3739
2. Kigerl KA, Gensel JC, Ankeny DP, Alexander JK, Donnelly DJ, Popovich PG. Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J Neurosci. 2009 ; 29: 13435-13444
3. Benveniste EN. Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J Mol Med. 1997 ; 75: 165-173
4. Rival C, Theas MS, Suescun MO, Jacobo P, Guazzone V, van Rooijen N, et al. Functional and phenotypic characteristics of testicular macrophages in experimental autoimmune orchitis. J Pathol. 2008 ; 215: 108-117
5. Ma Y, Pope RM. The role of macrophages in rheumatoid arthritis. Curr Pharm Des. 2005 ; 11: 569-580
6. Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest. 2007 ; 117: 175-184
7. Khallou-Laschet J, Varthaman A, Fornasa G, Compain C, Gaston AT, Clement M, et al. Macrophage plasticity in experimental atherosclerosis. PLoS One. 2010 ; 5: e8852 - e8852
8. Rodero MP, Khosrotehrani K. Skin wound healing modulation by macrophages. Int J Clin Exp Pathol. 2010 ; 3: 643-653
9. Gustafsson C, Mjösberg J, Matussek A, Geffers R, Matthiesen L, Berg G, et al. Gene expression profiling of human decidual macrophages: evidence for immunosuppressive phenotype. PLoS One. 2008 ; 3: e2078 - e2078
10. Goerdt S, Orfanos CE. Other functions, other genes: alternative activation of antigen-presenting cells. Immunity. 1999 ; 10: 137-142
11. Martinez FO, Helming L, Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol. 2009 ; 27: 451-483
12. Bhatia S, Fei M, Yarlagadda M, Qi Z, Akira S, Saijo S, et al. Rapid host defense against Aspergillus fumigatus involves alveolar macrophages with a predominance of alternatively activated phenotype. PLoS One. 2011 ; 6: e15943 - e15943
13. Stempin CC, Dulgerian LR, Garrido VV, Cerbán FM. Arginase in parasitic infections: macrophage activation, immunosuppression, and intracellular signals. J Biomed Biotechnol. 2010 ; 2010: 683485-683485
14. Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol. 2008 ; 8: 958-969
15. Mantovani A, Sica A, Sozzani S, Allavena P, Vecchi A, Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004 ; 25: 677-686
16. Nogueira CW, Rocha JB. Toxicology and pharmacology of selenium: emphasis on synthetic organoselenium compounds. Arch Toxicol. 2011 ;:
17. de Freitas AS, de Souza Prestes A, Wagner C, Sudati JH, Alves D, Porciúncula LO, et al. Reduction of diphenyl diselenide and analogs by mammalian thioredoxin reductase is independent of their gluthathione peroxidase-like activity: A possible novel pathway for their antioxidant activity. Molecules. 2010 ; 15: 7699-7714
18. de Freitas AS, Rocha JBT. Diphenyl diselenide and analogs are substrates of cerebral rat thioredoxin reductase: A pathway for their neuroprotective effects. Neurosci Lett. 2011 ; 503: 1-5
19. Nogueira CW, Quinhones EB, Jung EA, Zeni G, Rocha JB. Anti-inflammatory and antinociceptive activity of diphenyl diselenide. Inflamm Res. 2003 ; 52: 56-63
20. Hort MA, Straliotto MR, Netto PM, da Rocha JB, de Bem AF, Ribeiro-do-Valle RM. Diphenyl diselenide effectively reduces atherosclerotic lesions in LDLr -/- mice by attenuation of oxidative stress and inflammation. J Cardiovasc Pharmacol. 2011 ; 58: 91-101
21. Shin KM, Shen L, Park SJ, Jeong JH, Lee KT. Bis-(3-hydroxyphenyl) diselenide inhibits LPS-stimulated iNOS and COX-2 expression in RAW 264.7 macrophage cells through the NF-kappaB inactivation. J Pharm Pharmacol. 2009 ; 61: 479-486
22. Haddad JJ. Antioxidant and prooxidant mechanisms in the regulation of redox(y)-sensitive transcription factors. Cell Signal. 2002 ; 14: 879-897
23. Straliotto MR, Mancini G, de Oliveira J, Nazari EM, Müller YM, Dafre A, et al. Acute exposure of rabbits to diphenyl diselenide: a toxicological evaluation. J Appl Toxicol. 2010 ; 30: 761-768
24. Scerbo MJ, Rupil LL, Bibolini MJ, Roth GA, Monferran CG. Protective effect of a synapsin peptide genetically fused to the B subunit of Escherichia coli heat-labile enterotoxin in rat autoimmune encephalomyelitis. J Neurosci Res. 2009 ; 87: 2273-2281
25. Dulgerian LR, Garrido VV, Stempin CC, Cerbán FM. Programmed death ligand 2 regulates arginase induction and modifies Trypanosoma cruzi survival in macrophages during murine experimental infection. Immunology. 2011 ; 133: 29-40
26. Woo CH, Lim JH, Kim JH. Lipopolysaccharide induces matrix metalloproteinase-9 expression via a mitochondrial reactive oxygen species-p38 kinase-activator protein-1 pathway in Raw 264.7 cells. J Immunol. 2004 ; 173: 6973-6980
27. Bisig CG, Purro SA, Contín MA, Barra HS, Arce CA. Incorporation of 3-nitrotyrosine into the C-terminus of alpha-tubulin is reversible and not detrimental to dividing cells. Eur J Biochem. 2009 ; 269: 5037-5045
28. Andersson A, Kokkola R, Wefer J, Erlandsson-Harris H, Harris RA. Differential macrophage expression of IL-12 and IL-23 upon innate immune activation defines rat autoimmune susceptibility. J Leukoc Biol. 2004 ; 76: 1118-1124
29. Radi R, Peluffo G, Alvarez MN, Naviliat M, Cayota A. Unraveling peroxynitrite formation in biological systems. Free Radic Biol Med. 2001 ; 30: 463-488
30. El Kasmi KC, Qualls JE, Pesce JT, Smith AM, Thompson RW, Henao-Tamayo M, et al. Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol. 2008 ; 9: 1399-1406
31. Ghisleni G, Porciúncula LO, Cimarosti H, Rocha JBT, Salbego CG, Souza DO. Diphenyl diselenide protects rat hippocampal slices submitted to oxygen-glucose deprivation and diminishes inducible nitric oxide synthase immunocontent. Brain Res. 2003 ; 986: 196-199
32. Matsue H, Edelbaum D, Shalhevet D, Mizumoto N, Yang C, Mummert ME, et al. Generation and function of reactive oxygen species in dendritic cells during antigen presentation. J Immunol. 2003 ; 171: 3010-3018
33. Zhao SJ, Sun FJ, Tian EJ, Chen ZP. The effects of iodine/selenium on the function of antigen presentation of peritoneal macrophages in rats. Zhonghua Yu Fang Yi Xue Za Zhi. 2008 ; 42: 485-488
34. Munder M. Arginase: an emerging key player in the mammalian immune system. Br J Pharmacol. 2009 ; 158: 638-651
35. Nelson SM, Lei X, Prabhu KS. Selenium levels affect the IL-4-induced expression of alternative activation markers in murine macrophages. J Nutr. 2011 ; 141: 1754-1761
36. Hrabák A, Bajor T, Csuka I. The effect of various inflammatory agents on the alternative metabolic pathways of arginine in mouse and rat macrophages. Inflamm Res. 2006 ; 55: 23-31
37. Rafferty TS, Walker C, Hunter JA, Beckett GJ, McKenzie RC. Inhibition of ultraviolet B radiation-induced interleukin 10 expression in murine keratinocytes by selenium compounds. Br J Dermatol. 2002 ; 146: 485-489