Protective effect of a synapsin peptide genetically fused to the B subunit of Escherichia coli heat-labile enterotoxin in rat autoimmune encephalomyelitis

Journal of Neuroscience Research

Volumn 87, Issue 10, 2009, Pages 2273-2281

  Scerbo, M Julia ^a   Rupil, Lucia L ^a   Bibolini, Mario J ^a   Roth, German A ^a   Monferran, Clara G ^a  

^a UNIVERSIDAD NACIONAL DE CÓRDOBA   (Argentina)

Author keywords

Autoimmunity; Experimental autoimmune encephalomy elitis; Multiple sclerosis; Myelin basic protein; Synapsin

Indexed keywords

ARGINASE; ESCHERICHIA COLI ENTEROTOXIN B SUBUNIT SYNAPSIN IA CONJUGATE; HYBRID PROTEIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2B; MYELIN BASIC PROTEIN; NITRIC OXIDE; UNCLASSIFIED DRUG; BACTERIAL TOXIN; ENTEROTOXIN; ESCHERICHIA COLI PROTEIN; HEAT LABILE ENTEROTOXIN, E COLI; HEAT-LABILE ENTEROTOXIN, E COLI; PEPTIDE; SYNAPSIN;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; FEMALE; IMMUNOLOGICAL TOLERANCE; IMMUNOMODULATION; INFLAMMATORY INFILTRATE; MACROPHAGE ACTIVATION; MALE; MULTIPLE SCLEROSIS; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; RAT; TH2 CELL; ANALYSIS OF VARIANCE; ANIMAL; BIOSYNTHESIS; CELL PROLIFERATION; DISEASE MODEL; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; GENETICS; IMMUNOLOGY; LYMPHOCYTE; MACROPHAGE; METHODOLOGY; PATHOLOGY; WISTAR RAT;

ANALYSIS OF VARIANCE; ANIMALS; BACTERIAL TOXINS; CELL PROLIFERATION; DISEASE MODELS, ANIMAL; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; ENTEROTOXINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; FEMALE; HYPERSENSITIVITY, DELAYED; LYMPHOCYTES; MACROPHAGES; MALE; MYELIN BASIC PROTEINS; PEPTIDES; RATS; RATS, WISTAR; RECOMBINANT FUSION PROTEINS; SYNAPSINS;

EID: 69249206886     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.22048     Document Type: Article

References (35)

1. Alpan O, Rudomen G, Matzinger P. 2001. The role of dendritic cells, B cells, and M cells in gut-oriented immune responses. J Immunol 166:4843-4852.
2. Andersson A, Kokkola R, Wefer J, Erlandsson-Harris H, Harris RA. 2004. Differential macrophage expression of IL-12 and IL-23 upon innate immune activation defines rat autoimmune susceptibility. J Leukocyte Biol 76:1118-1124.
3. + T cells. Immunology 118:311-320.
4. Cua DJ, Hinton DR, Kirkman L, Stohlman SA. 1995. Macrophages regulate induction of delayed-type hypersensitivity and experimental allergic encephalomyelitis in SJL mice. Eur J Immunol 25:2318-2324.
5. Dalton DK, Wittmer S. 2005. Nitric-oxide-dependent and independent mechanisms of protection from CNS inflammation during Th1-mediated autoimmunity: evidence from EAE in iNOS KO mice. J Neuroimmunol 160:110-121.
6. De Santis ML, Roth GA. 1996. Experimental allergic encephalomyelitis: characterization of T lymphocytes that bind myelin basic protein and synapsin. J Neurosci Res 43:50-54.
7. De Santis ML, Roth GA, Cumar FA. 1992. Cellular immune crossreactivity between myelin basic protein and synapsin in rats with experimental allergic encephalomyelitis. J Neurosci Res 31:46-51.
8. Degano AL, Roth GA. 2000. Passive transfer of experimental autoimmune encephalomyelitis in Wistar rats: dissociation of clinical symptoms and biochemical alterations. J Neurosci Res 59:283-290.
9. Degano AL, Bucher AE, Roth GA. 1998. Suppression of acute experimental allergic encephalomyelitis by intraperitoneal administration of synaptosomal antigens. J Neurosci Res 53:187-194.
10. Degano AL, Ditamo Y, Roth GA. 2004. Neuronal antigens modulate the immune response associated with experimental autoimmune encephalomyelitis. Immunol Cell Biol 82:17-23.
11. Ditamo Y, Degano AL, Maccio DR, Roth GA. 2005. Comparative development of acute experimental autoimmune encephalomyelitis in young and mature meddle-aged rats. Immunol Cell Biol 83:75-82
12. Faria AM, Weiner HL. 2005. Oral tolerance. Immunol Rev 206:232-259.
13. Goerdt S, Politz O, Schledzewski K, Birk R, Gratchev A, Guillot P, Hakiy N, Klemke CD, Dippel E, Kodelja V, Orfanos CE. 1999. Alternative versus classical activation of macrophages. Pathobiology 67:222-226.
14. 15N]nitrate in biological fluids. Anal Biochem 126:131-138.
15. Harrison LC, Hafler DA. 2000. Antigen-specific therapy for autoimmune disease. Curr Opin Immunol 12:704-711.
16. Hendriks JJA, Teunissen CE, de Vries HE, Dijkstra CD. 2005. Macrophages and neurodegeneration. Brain Res Rev 48:185-195.
17. Liguori M, Cittadella R, Manna I, Valentino P, La Russa A, Serra P, Trojano M, Messina D, Ruscica F, Andreoli V, Romeo N, Livrea P, Quattrone A. 2004. Association between synapsin III gene promoter polymorphisms and multiple sclerosis. J Neurol 251:165-170.
18. Ludwin SK. 2006. The pathogenesis of multiple sclerosis: relating human pathology to experimental studies. J Neuropathol Exp Neurol 65:205-318.
19. McFarland HF, Martin R. 2007. Multiple sclerosis: a complicated picture of autoimmunity. Nat Immunol 8:913-919.
20. Mestecky J, Russell MW, Elson CO. 2007. Perspectives on mucosal vaccines: is mucosal tolerance a barrier? J Immunol 179:5633-5638.
21. Mosmann TR, Sad S. 1996. The expanding universe of T-cells subsets: TH1, TH2 and more. Immunol Today 17:138-146.
22. Mosser DM. 2003. The many faces of macrophage activation. J Leukoc Biol 73:209-212.
23. Myers KJ, Sprent J, Dougherty JP, Ron Y. 1992. Synergy between encephalitogenic T cells and myelin basic protein-specific antibodies in the induction of experimental autoimmune encephalomyelitis. J Neuroimmunol 41:1-8.
24. Pedraza LT, Roth GA, Cumar FA. 1988. Identification as synapsin of a synaptosomal protein immunoreacting with anti-myelin basic protein antiserum. J Neurochem 51:413-420.
25. Peterson LK, Fujinami RS. 2007. Inflammation, demyelination, neurodegeneration and neuroprotection in the pathogenesis of multiple sclerosis. J Neuroimmunol 184:37-44.
26. Polak T, Schlaf G, Schöll U, Krome-Cesar C, Mäder M, Felgenhauer K, Weber F. 2001. Characterization of the human T cell response against the neuronal protein synapsin in patients with sclerosis multiple. J Neuroimmunol 115:176-181.
27. Rivero VE, Riera CM, Roth GA. 1999. Humoral response against myelin antigens in two strains of rats with different susceptibility to experimental allergic encephalomyelitis (EAE). Autoimmunity 29:129-137.
28. Roth GA, Obata K. 1991. Experimental allergic encephalomyelitis: Dissociation of immunochemical and clinico-pathological responses in two strains of rats. Neurochem Int 19:213-220.
29. Saoudi A, Kuhn J, Huygen K, de Kozak Y, Velu T, Goldman M, Druet P, Bellon B. 1993. Th2 activated cells prevent experimental autoimmune uveoretinitis, a Th1-dependent autoimmune disease. Eur J Immunol 23:3096-3103.
30. Scerbo MJ, Bibolini MJ, Barra JL, Roth GA, Monferran CG. 2008. Expression of a bioactive fusion protein of Escherichia coli heat-labile toxin B subunit to a synapsin peptide. Protein Expr Purif 59:320-326.
31. Slavin DA, Bucher AE, Degano AL, Soria NW, Roth GA. 1996. Time course of biochemical and immunohistological alterations during experimental allergic encephalomyelitis. Neurochem Int 29:597-605.
32. Stanford M, Whittall T, Bergmeier LA, Lindblad M, Lundin S, Shinnicks T, Mizushima Y, Holmgren J, Lehner T. 2004. Oral tolerization with peptide 336-351 linked to cholera toxin B subunit in preventing relapses of uveitis in Behcet's disease. Clin Exp Immunol 137:201-208.
33. + regulatory T cells. J Immunol 177:7634-7644.
34. Weiner HL. 2001. The mucosal milieu creates tolerogenic dendritic cells and T(R)1 and T(H)3 regulatory cells. Nat Immunol 2:671-672.
35. Zhu B, Luo L, Moore GRW, Paty DW, Cynader MS. 2003. Dendritic and synaptic pathology in experimental autoimmune encephalomyelitis. Am J Pathol 162:1639-1650.