-
1
-
-
67649393351
-
Vaccination in the elderly: An immunolog-ical perspective
-
Chen WH, Kozlovsky BF, Effros RB, Grubeck-Loebenstein B, Edelman R, Sztein MB. Vaccination in the elderly: an immunolog-ical perspective. Trends Immunol 2009; 30: 351-9.
-
(2009)
Trends Immunol
, vol.30
, pp. 351-359
-
-
Chen, W.H.1
Kozlovsky, B.F.2
Effros, R.B.3
Grubeck-Loebenstein, B.4
Edelman, R.5
Sztein, M.B.6
-
2
-
-
35948988938
-
Cytomegalovirus infection: A driving force in human T cell immunosenescence
-
Koch S, Larbi A, Ozcelik D, et al. Cytomegalovirus infection: a driving force in human T cell immunosenescence. Ann N Y Acad Sci 2007; 1114:23-35.
-
(2007)
Ann N Y Acad Sci
, vol.1114
, pp. 23-35
-
-
Koch, S.1
Larbi, A.2
Ozcelik, D.3
-
3
-
-
0033911488
-
Inflamm-aging. An evolutionary perspective on immunosenescence
-
Franceschi C, Bonafe M, Valensin S, et al. Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 2000; 908:244-54.
-
(2000)
Ann N Y Acad Sci
, vol.908
, pp. 244-254
-
-
Franceschi, C.1
Bonafe, M.2
Valensin, S.3
-
4
-
-
34447319921
-
No Immune Risk Profile among individuals who reach 100 years of age: Findings from the Swedish NONA immune longitudinal study
-
Strindhall J, Nilsson BO, Lofgren S, et al. No Immune Risk Profile among individuals who reach 100 years of age: findings from the Swedish NONA immune longitudinal study. Exp Gerontol 2007; 42:753-61.
-
(2007)
Exp Gerontol
, vol.42
, pp. 753-761
-
-
Strindhall, J.1
Nilsson, B.O.2
Lofgren, S.3
-
5
-
-
33745451585
-
The immune risk phenotype is associated with IL-6 in the terminal decline stage: Findings from the Swedish NONA immune longitudinal study of very late life functioning
-
Wikby A, Nilsson BO, Forsey R, et al. The immune risk phenotype is associated with IL-6 in the terminal decline stage: findings from the Swedish NONA immune longitudinal study of very late life functioning. Mech Ageing Dev 2006; 127:695-704.
-
(2006)
Mech Ageing Dev
, vol.127
, pp. 695-704
-
-
Wikby, A.1
Nilsson, B.O.2
Forsey, R.3
-
6
-
-
67649397909
-
Human innate immunosenescence: Causes and consequences for immunity in old age
-
Panda A, Arjona A, Sapey E, et al. Human innate immunosenescence: causes and consequences for immunity in old age. Trends Immunol 2009; 30:325-33.
-
(2009)
Trends Immunol
, vol.30
, pp. 325-333
-
-
Panda, A.1
Arjona, A.2
Sapey, E.3
-
7
-
-
77953351071
-
Factors that may impact on immunosenescence: An appraisal
-
Ongradi J, Kovesdi V. Factors that may impact on immunosenescence: an appraisal. Immun Ageing 2010; 7:7.
-
(2010)
Immun Ageing
, vol.7
, pp. 7
-
-
Ongradi, J.1
Kovesdi, V.2
-
8
-
-
34247538298
-
In vivo kinetics of human natural killer cells: The effects of ageing and acute and chronic viral infection
-
Zhang Y, Wallace DL, de Lara CM, et al. In vivo kinetics of human natural killer cells: the effects of ageing and acute and chronic viral infection. Immunology 2007; 121:258-65.
-
(2007)
Immunology
, vol.121
, pp. 258-265
-
-
Zhang, Y.1
Wallace, D.L.2
de Lara, C.M.3
-
9
-
-
77954681312
-
The role of the thymus in immunosenescence: Lessons from the study of thymectomized indi-viduals
-
Appay V, Sauce D, Prelog M. The role of the thymus in immunosenescence: lessons from the study of thymectomized indi-viduals. Aging (Albany NY) 2010; 2:78-81.
-
(2010)
Aging (Albany NY)
, vol.2
, pp. 78-81
-
-
Appay, V.1
Sauce, D.2
Prelog, M.3
-
10
-
-
21044451726
-
The influence of age on T cell generation and TCR diversity
-
Naylor K, Li G, Vallejo AN, et al. The influence of age on T cell generation and TCR diversity. J Immunol 2005; 174:7446-52.
-
(2005)
J Immunol
, vol.174
, pp. 7446-7452
-
-
Naylor, K.1
Li, G.2
Vallejo, A.N.3
-
11
-
-
0034194058
-
Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging
-
Fagnoni FF, Vescovini R, Passeri G, et al. Shortage of circulating naive CD8(+) T cells provides new insights on immunodeficiency in aging. Blood 2000; 95:2860-8.
-
(2000)
Blood
, vol.95
, pp. 2860-2868
-
-
Fagnoni, F.F.1
Vescovini, R.2
Passeri, G.3
-
12
-
-
33847120921
-
Healthy aging and latent infection with CMV lead to distinct changes in CD8+ and CD4+ T-cell subsets in the elderly
-
Weinberger B, Lazuardi L, Weiskirchner I, et al. Healthy aging and latent infection with CMV lead to distinct changes in CD8+ and CD4+ T-cell subsets in the elderly. Hum Immunol 2007; 68:86-90.
-
(2007)
Hum Immunol
, vol.68
, pp. 86-90
-
-
Weinberger, B.1
Lazuardi, L.2
Weiskirchner, I.3
-
13
-
-
79959563324
-
Age-related deregulation of naive T cell homeostasis in elderly humans
-
Ferrando-Martinez S, Ruiz-Mateos E, Hernandez A, et al. Age-related deregulation of naive T cell homeostasis in elderly humans. Age (Dordr) 2011; 33(2): 197-207.
-
(2011)
Age (Dordr)
, vol.33
, Issue.2
, pp. 197-207
-
-
Ferrando-Martinez, S.1
Ruiz-Mateos, E.2
Hernandez, A.3
-
14
-
-
0031596522
-
CD8hi+CD57+ T lym-phocytes are enriched in antigen-specific T cells capable of down-modulating cytotoxic activity
-
Mollet L, Sadat-Sowti B, Duntze J, et al. CD8hi+CD57+ T lym-phocytes are enriched in antigen-specific T cells capable of down-modulating cytotoxic activity. Int Immunol 1998; 10:311-23.
-
(1998)
Int Immunol
, vol.10
, pp. 311-323
-
-
Mollet, L.1
Sadat-Sowti, B.2
Duntze, J.3
-
15
-
-
67649407892
-
CD28(-) T cells: Their role in the age-associated decline of immune function
-
Weng NP, Akbar AN, Goronzy J. CD28(-) T cells: their role in the age-associated decline of immune function. Trends Immunol 2009; 30:306-12.
-
(2009)
Trends Immunol
, vol.30
, pp. 306-312
-
-
Weng, N.P.1
Akbar, A.N.2
Goronzy, J.3
-
16
-
-
0027226014
-
Regulation of CD27 expression on subsets of mature T-lymphocytes
-
Hintzen RQ, de Jong R, Lens SM, Brouwer M, Baars P, van Lier RA. Regulation of CD27 expression on subsets of mature T-lymphocytes. J Immunol 1993; 151:2426-35.
-
(1993)
J Immunol
, vol.151
, pp. 2426-2435
-
-
Hintzen, R.Q.1
de Jong, R.2
Lens, S.M.3
Brouwer, M.4
Baars, P.5
van Lier, R.A.6
-
17
-
-
1642462973
-
Characteri-zation of naive, memory and effector CD8+ T cells: Effect of age
-
Gupta S, Bi R, Su K, Yel L, Chiplunkar S, Gollapudi S. Characteri-zation of naive, memory and effector CD8+ T cells: effect of age. Exp Gerontol 2004; 39:545-50.
-
(2004)
Exp Gerontol
, vol.39
, pp. 545-550
-
-
Gupta, S.1
Bi, R.2
Su, K.3
Yel, L.4
Chiplunkar, S.5
Gollapudi, S.6
-
18
-
-
10744223612
-
Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: A contribution to understand the relationship be-tween inflammation and immunosenescence
-
Zanni F, Vescovini R, Biasini C, et al. Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship be-tween inflammation and immunosenescence. Exp Gerontol 2003; 38:981-7.
-
(2003)
Exp Gerontol
, vol.38
, pp. 981-987
-
-
Zanni, F.1
Vescovini, R.2
Biasini, C.3
-
19
-
-
61849130012
-
Microarray analysis re-veals similarity between CD8+CD28- T cells from young and el-derly persons, but not of CD8+CD28+ T cells
-
Lazuardi L, Herndler-Brandstetter D, Brunner S, Laschober GT, Lepperdinger G, Grubeck-Loebenstein B. Microarray analysis re-veals similarity between CD8+CD28- T cells from young and el-derly persons, but not of CD8+CD28+ T cells. Biogerontology 2009; 10:191-202.
-
(2009)
Biogerontology
, vol.10
, pp. 191-202
-
-
Lazuardi, L.1
Herndler-Brandstetter, D.2
Brunner, S.3
Laschober, G.T.4
Lepperdinger, G.5
Grubeck-Loebenstein, B.6
-
20
-
-
0036867423
-
Divergent telomerase and CD28 ex-pression patterns in human CD4 and CD8 T cells following repeat-ed encounters with the same antigenic stimulus
-
Valenzuela HF, Effros RB. Divergent telomerase and CD28 ex-pression patterns in human CD4 and CD8 T cells following repeat-ed encounters with the same antigenic stimulus. Clin Immunol 2002; 105:117-25.
-
(2002)
Clin Immunol
, vol.105
, pp. 117-125
-
-
Valenzuela, H.F.1
Effros, R.B.2
-
21
-
-
34147222679
-
Telomerase induction in T cells: A cure for aging and disease?
-
Effros RB. Telomerase induction in T cells: a cure for aging and disease? Exp Gerontol 2007; 42:416-20.
-
(2007)
Exp Gerontol
, vol.42
, pp. 416-420
-
-
Effros, R.B.1
-
22
-
-
0037372304
-
Differential impairment of lytic and cytokine functions in senescent human immunodeficiency virus type 1-specific cytotoxic T lymphocytes
-
Dagarag M, Ng H, Lubong R, Effros RB, Yang OO. Differential impairment of lytic and cytokine functions in senescent human immunodeficiency virus type 1-specific cytotoxic T lymphocytes. J Virol 2003; 77:3077-83.
-
(2003)
J Virol
, vol.77
, pp. 3077-3083
-
-
Dagarag, M.1
Ng, H.2
Lubong, R.3
Effros, R.B.4
Yang, O.O.5
-
23
-
-
77951637832
-
Cytomegalovirus infection reduces telomere length of the circulating T cell pool
-
van de Berg PJ, Griffiths SJ, Yong SL, et al. Cytomegalovirus infection reduces telomere length of the circulating T cell pool. J Immunol 2010; 184:3417-33.
-
(2010)
J Immunol
, vol.184
, pp. 3417-3433
-
-
van de Berg, P.J.1
Griffiths, S.J.2
Yong, S.L.3
-
24
-
-
8444237735
-
Genetic manipulation of telomerase in HIV-specific CD8+ T cells: Enhanced antiviral functions accompany the increased proliferative potential and te-lomere length stabilization
-
Dagarag M, Evazyan T, Rao N, Effros RB. Genetic manipulation of telomerase in HIV-specific CD8+ T cells: enhanced antiviral functions accompany the increased proliferative potential and te-lomere length stabilization. J Immunol 2004; 173:6303-11.
-
(2004)
J Immunol
, vol.173
, pp. 6303-6311
-
-
Dagarag, M.1
Evazyan, T.2
Rao, N.3
Effros, R.B.4
-
25
-
-
78651272579
-
Sustained CD28 expression delays multiple features of replicative senescence in human CD8 T lym-phocytes
-
Parish ST, Wu JE, Effros RB. Sustained CD28 expression delays multiple features of replicative senescence in human CD8 T lym-phocytes. J Clin Immunol 2010; 30:798-805.
-
(2010)
J Clin Immunol
, vol.30
, pp. 798-805
-
-
Parish, S.T.1
Wu, J.E.2
Effros, R.B.3
-
26
-
-
42549163881
-
Biology of immune respons-es to vaccines in elderly persons
-
Weinberger B, Herndler-Brandstetter D, Schwanninger A, Weiskopf D, Grubeck-Loebenstein B. Biology of immune respons-es to vaccines in elderly persons. Clin Infect Dis 2008; 46:1078-84.
-
(2008)
Clin Infect Dis
, vol.46
, pp. 1078-1084
-
-
Weinberger, B.1
Herndler-Brandstetter, D.2
Schwanninger, A.3
Weiskopf, D.4
Grubeck-Loebenstein, B.5
-
27
-
-
33845215290
-
Role of T lymphocyte replicative senescence in vaccine efficacy
-
Effros RB. Role of T lymphocyte replicative senescence in vaccine efficacy. Vaccine 2007; 25:599-604.
-
(2007)
Vaccine
, vol.25
, pp. 599-604
-
-
Effros, R.B.1
-
28
-
-
0036604275
-
Lack of antibody production following immunization in old age: Association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines
-
Saurwein-Teissl M, Lung TL, Marx F, et al. Lack of antibody production following immunization in old age: association with CD8(+)CD28(-) T cell clonal expansions and an imbalance in the production of Th1 and Th2 cytokines. J Immunol 2002; 168:5893-9
-
(2002)
J Immunol
, vol.168
, pp. 5893-5899
-
-
Saurwein-Teissl, M.1
Lung, T.L.2
Marx, F.3
-
29
-
-
0242317690
-
Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vac-cination--an impact of immunosenescence
-
Trzonkowski P, Mysliwska J, Szmit E, et al. Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vac-cination--an impact of immunosenescence. Vaccine 2003; 21:3826-36.
-
(2003)
Vaccine
, vol.21
, pp. 3826-3836
-
-
Trzonkowski, P.1
Mysliwska, J.2
Szmit, E.3
-
31
-
-
0027265827
-
Increased cytokine produc-tion in mononuclear cells of healthy elderly people
-
Fagiolo U, Cossarizza A, Scala E, et al. Increased cytokine produc-tion in mononuclear cells of healthy elderly people. Eur J Immunol 1993; 23:2375-8.
-
(1993)
Eur J Immunol
, vol.23
, pp. 2375-2378
-
-
Fagiolo, U.1
Cossarizza, A.2
Scala, E.3
-
32
-
-
0028839467
-
Im-mune parameters in a longitudinal study of a very old population of Swedish people: A comparison between survivors and nonsurvivors
-
Ferguson FG, Wikby A, Maxson P, Olsson J, Johansson B. Im-mune parameters in a longitudinal study of a very old population of Swedish people: a comparison between survivors and nonsurvivors. J Gerontol A Biol Sci Med Sci 1995; 50:B378-82.
-
(1995)
J Gerontol a Biol Sci Med Sci
, vol.50
-
-
Ferguson, F.G.1
Wikby, A.2
Maxson, P.3
Olsson, J.4
Johansson, B.5
-
33
-
-
0032524932
-
Ferguson FG. Chang-es in CD8 and CD4 lymphocyte subsets, T cell proliferation re-sponses and non-survival in the very old: The Swedish longitudinal OCTO-immune study
-
Wikby A, Maxson P, Olsson J, Johansson B, Ferguson FG. Chang-es in CD8 and CD4 lymphocyte subsets, T cell proliferation re-sponses and non-survival in the very old: the Swedish longitudinal OCTO-immune study. Mech Ageing Dev 1998; 102:187-98.
-
(1998)
Mech Ageing Dev
, vol.102
, pp. 187-198
-
-
Wikby, A.1
Maxson, P.2
Olsson, J.3
Johansson, B.4
-
34
-
-
32044433093
-
Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage pre-dicting mortality and an increased number of dysfunctional cyto-megalovirus-specific T cells in the very elderly
-
Hadrup SR, Strindhall J, Kollgaard T, et al. Longitudinal studies of clonally expanded CD8 T cells reveal a repertoire shrinkage pre-dicting mortality and an increased number of dysfunctional cyto-megalovirus-specific T cells in the very elderly. J Immunol 2006; 176:2645-53.
-
(2006)
J Immunol
, vol.176
, pp. 2645-2653
-
-
Hadrup, S.R.1
Strindhall, J.2
Kollgaard, T.3
-
35
-
-
33745589746
-
Latency and reactivation of human cytomeg-alovirus
-
Sinclair J, Sissons P. Latency and reactivation of human cytomeg-alovirus. J Gen Virol 2006; 87:1763-79.
-
(2006)
J Gen Virol
, vol.87
, pp. 1763-1779
-
-
Sinclair, J.1
Sissons, P.2
-
36
-
-
0033873474
-
Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lym-phocytes in healthy seropositive donors
-
Gillespie GM, Wills MR, Appay V, et al. Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lym-phocytes in healthy seropositive donors. J Virol 2000; 74:8140-50.
-
(2000)
J Virol
, vol.74
, pp. 8140-8150
-
-
Gillespie, G.M.1
Wills, M.R.2
Appay, V.3
-
37
-
-
0036301613
-
High frequency of human cytomegalovirus (HCMV)-specific CD8+ T cells detected in a healthy CMV-seropositive donor
-
Lang KS, Moris A, Gouttefangeas C, et al. High frequency of human cytomegalovirus (HCMV)-specific CD8+ T cells detected in a healthy CMV-seropositive donor. Cell Mol Life Sci 2002; 59:1076-80.
-
(2002)
Cell Mol Life Sci
, vol.59
, pp. 1076-1080
-
-
Lang, K.S.1
Moris, A.2
Gouttefangeas, C.3
-
38
-
-
24344489044
-
Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects
-
Sylwester AW, Mitchell BL, Edgar JB, et al. Broadly targeted human cytomegalovirus-specific CD4+ and CD8+ T cells dominate the memory compartments of exposed subjects. J Exp Med 2005; 202:673-85.
-
(2005)
J Exp Med
, vol.202
, pp. 673-685
-
-
Sylwester, A.W.1
Mitchell, B.L.2
Edgar, J.B.3
-
39
-
-
0036109159
-
Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections
-
Appay V, Dunbar PR, Callan M, et al. Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections. Nat Med 2002; 8:379-85.
-
(2002)
Nat Med
, vol.8
, pp. 379-385
-
-
Appay, V.1
Dunbar, P.R.2
Callan, M.3
-
40
-
-
3543141247
-
Different contribution of EBV and CMV infections in very long-term carriers to age-related alterations of CD8+ T cells
-
Vescovini R, Telera A, Fagnoni FF, et al. Different contribution of EBV and CMV infections in very long-term carriers to age-related alterations of CD8+ T cells. Exp Gerontol 2004; 39:1233-43.
-
(2004)
Exp Gerontol
, vol.39
, pp. 1233-1243
-
-
Vescovini, R.1
Telera, A.2
Fagnoni, F.F.3
-
41
-
-
0033757875
-
Impact of age-related immune dysfunction on risk of infections
-
Castle SC. Impact of age-related immune dysfunction on risk of infections. Z Gerontol Geriatr 2000; 33:341-9.
-
(2000)
Z Gerontol Geriatr
, vol.33
, pp. 341-349
-
-
Castle, S.C.1
-
42
-
-
0032957642
-
Role of cytomegalovirus in the T cell changes seen in elderly individuals
-
Looney RJ, Falsey A, Campbell D, et al. Role of cytomegalovirus in the T cell changes seen in elderly individuals. Clin Immunol 1999; 90:213-9.
-
(1999)
Clin Immunol
, vol.90
, pp. 213-219
-
-
Looney, R.J.1
Falsey, A.2
Campbell, D.3
-
44
-
-
14744281718
-
Long-term cytomeg-alovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbal-ance in the cytokine production profile in elderly persons
-
Almanzar G, Schwaiger S, Jenewein B, et al. Long-term cytomeg-alovirus infection leads to significant changes in the composition of the CD8+ T-cell repertoire, which may be the basis for an imbal-ance in the cytokine production profile in elderly persons. J Virol 2005; 79:3675-83.
-
(2005)
J Virol
, vol.79
, pp. 3675-3683
-
-
Almanzar, G.1
Schwaiger, S.2
Jenewein, B.3
-
45
-
-
59249090000
-
Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals
-
Chidrawar S, Khan N, Wei W, et al. Cytomegalovirus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals. Clin Exp Immunol 2009; 155:423-32.
-
(2009)
Clin Exp Immunol
, vol.155
, pp. 423-432
-
-
Chidrawar, S.1
Khan, N.2
Wei, W.3
-
46
-
-
0037103256
-
Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals
-
Khan N, Shariff N, Cobbold M, et al. Cytomegalovirus seropositivity drives the CD8 T cell repertoire toward greater clonality in healthy elderly individuals. J Immunol 2002; 169:1984-92.
-
(2002)
J Immunol
, vol.169
, pp. 1984-1992
-
-
Khan, N.1
Shariff, N.2
Cobbold, M.3
-
47
-
-
0037825764
-
Large numbers of dys-functional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old
-
Ouyang Q, Wagner WM, Wikby A, et al. Large numbers of dys-functional CD8+ T lymphocytes bearing receptors for a single dominant CMV epitope in the very old. J Clin Immunol 2003; 23:247-57.
-
(2003)
J Clin Immunol
, vol.23
, pp. 247-257
-
-
Ouyang, Q.1
Wagner, W.M.2
Wikby, A.3
-
48
-
-
1642503829
-
Dysfunctional CMV-specific CD8(+) T cells accumu-late in the elderly
-
Ouyang Q, Wagner WM, Zheng W, Wikby A, Remarque EJ, Pawelec G. Dysfunctional CMV-specific CD8(+) T cells accumu-late in the elderly. Exp Gerontol 2004; 39:607-13.
-
(2004)
Exp Gerontol
, vol.39
, pp. 607-613
-
-
Ouyang, Q.1
Wagner, W.M.2
Zheng, W.3
Wikby, A.4
Remarque, E.J.5
Pawelec, G.6
-
49
-
-
77953169744
-
Cytomegalovirus infection- and age-dependent changes in human CD8+ T-cell cytokine expression patterns
-
Faist B, Fleischer B, Jacobsen M. Cytomegalovirus infection- and age-dependent changes in human CD8+ T-cell cytokine expression patterns. Clin Vaccine Immunol 2010; 17:986-92.
-
(2010)
Clin Vaccine Immunol
, vol.17
, pp. 986-992
-
-
Faist, B.1
Fleischer, B.2
Jacobsen, M.3
|