메뉴 건너뛰기




Volumn 30, Issue 4, 2012, Pages 474-484

Involvement of endoplasmic reticulum stress in homocysteine-induced apoptosis of osteoblastic cells

Author keywords

Endoplasmic reticulum stress; Homocysteine; Osteoblast; Osteoporosis

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; BINDING PROTEIN; CASPASE 3; CASPASE 3 INHIBITOR; CCAAT ENHANCER BINDING PROTEIN; CYTOCHROME C; ENDONUCLEASE; GLUCOSE REGULATED PROTEIN 78; HOMOCYSTEINE; INOSITOL REQUIRING TRANSMEMBRANE KINASE AND ENDONUCLEASE 1ALPHA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN;

EID: 84863883139     PISSN: 09148779     EISSN: 14355604     Source Type: Journal    
DOI: 10.1007/s00774-011-0346-9     Document Type: Article
Times cited : (39)

References (52)
  • 2
    • 0037172407 scopus 로고    scopus 로고
    • Pathogenesis of bone fragility in women and men
    • Seeman E (2002) Pathogenesis of bone fragility in women and men. Lancet 359:1841-1850
    • (2002) Lancet , vol.359 , pp. 1841-1850
    • Seeman, E.1
  • 3
    • 0031662703 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of osteoporosis
    • Milano
    • Manolagas SC (1998) Cellular and molecular mechanisms of osteoporosis. Aging (Milano) 10:182-190
    • (1998) Aging , vol.10 , pp. 182-190
    • Manolagas, S.C.1
  • 4
    • 0033978735 scopus 로고    scopus 로고
    • Apoptosis and osteoporosis
    • DOI 10.1016/S0002-9343(99)00420-9, PII S0002934399004209
    • Weinstein RS, Manolagas SC (2000) Apoptosis and osteoporosis. Am J Med 108:153-164 (Pubitemid 30064426)
    • (2000) American Journal of Medicine , vol.108 , Issue.2 , pp. 153-164
    • Weinstein, R.S.1    Manolagas, S.C.2
  • 5
  • 6
    • 67349112773 scopus 로고    scopus 로고
    • Bone tissue and hyperhomocysteinemia
    • Levasseur R (2009) Bone tissue and hyperhomocysteinemia. Jt Bone Spine 76:234-240
    • (2009) Jt Bone Spine , vol.76 , pp. 234-240
    • Levasseur, R.1
  • 7
    • 0031781126 scopus 로고    scopus 로고
    • Homocystinuria due to cystathionine beta-synthase deficiency in Ireland: 25 years' experience of a newborn screened and treated population with reference to clinical outcome and biochemical control
    • DOI 10.1023/A:1005445132327
    • Yap S, Naughten E (1998) Homocystinuria due to cystathionine beta-synthase deficiency in Ireland: 25 years' experience of a newborn screened and treated population with reference to clinical outcome and biochemical control. J Inherit Metab Dis 21:738-747 (Pubitemid 28477146)
    • (1998) Journal of Inherited Metabolic Disease , vol.21 , Issue.7 , pp. 738-747
    • Yap, S.1    Naughten, E.2
  • 8
    • 76149087434 scopus 로고    scopus 로고
    • Inherited metabolic disorders and stroke part 2: Homocystinuria, organic acidurias, and urea cycle disorders
    • Testai FD, Gorelick PB (2010) Inherited metabolic disorders and stroke part 2: homocystinuria, organic acidurias, and urea cycle disorders. Arch Neurol 67:148-153
    • (2010) Arch Neurol , vol.67 , pp. 148-153
    • Testai, F.D.1    Gorelick, P.B.2
  • 9
    • 2342614847 scopus 로고    scopus 로고
    • Homocysteine levels and the risk of osteoporotic fracture
    • van Meurs JB, Dhonukshe-Rutten RA, Pluijm SM et al (2004) Homocysteine levels and the risk of osteoporotic fracture. N Engl J Med 350:2033-2041
    • (2004) N Engl J Med , vol.350 , pp. 2033-2041
    • Van Meurs, J.B.1    Dhonukshe-Rutten, R.A.2    Pluijm, S.M.3
  • 15
    • 47949099916 scopus 로고    scopus 로고
    • From endoplasmic-reticulum stress to the inflammatory response
    • Zhang K, Kaufman RJ (2008) From endoplasmic-reticulum stress to the inflammatory response. Nature 454:455-462
    • (2008) Nature , vol.454 , pp. 455-462
    • Zhang, K.1    Kaufman, R.J.2
  • 16
    • 0037960128 scopus 로고    scopus 로고
    • Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice
    • DOI 10.1016/S0016-5085(03)00276-2
    • Ji C, Kaplowitz N (2003) Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology 124:1488-1499 (Pubitemid 36531821)
    • (2003) Gastroenterology , vol.124 , Issue.5 , pp. 1488-1499
    • Ji, C.1    Kaplowitz, N.2
  • 17
    • 53149096581 scopus 로고    scopus 로고
    • Synergistic induction of ER stress by homocysteine and beta-amyloid in SH-SY5Y cells
    • Kim HJ, Cho HK, Kwon YH (2008) Synergistic induction of ER stress by homocysteine and beta-amyloid in SH-SY5Y cells. J Nutr Biochem 19:754-761
    • (2008) J Nutr Biochem , vol.19 , pp. 754-761
    • Kim, H.J.1    Cho, H.K.2    Kwon, Y.H.3
  • 18
    • 67650561176 scopus 로고    scopus 로고
    • The homocysteine-inducible endoplasmic reticulum stress protein counteracts calcium store depletion and induction of CCAAT enhancer-binding protein homologous protein in a neurotoxin model of Parkinson disease
    • Chigurupati S, Wei Z, Belal C, Vandermey M, Kyriazis GA, Arumugam TV, Chan SL (2009) The homocysteine-inducible endoplasmic reticulum stress protein counteracts calcium store depletion and induction of CCAAT enhancer-binding protein homologous protein in a neurotoxin model of Parkinson disease. J Biol Chem 284:18323-18333
    • (2009) J Biol Chem , vol.284 , pp. 18323-18333
    • Chigurupati, S.1    Wei, Z.2    Belal, C.3    Vandermey, M.4    Kyriazis, G.A.5    Arumugam, T.V.6    Chan, S.L.7
  • 19
    • 0035929641 scopus 로고    scopus 로고
    • Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response
    • Zhang C, Cai Y, Adachi MT, Oshiro S, Aso T, Kaufman RJ, Kitajima S (2001) Homocysteine induces programmed cell death in human vascular endothelial cells through activation of the unfolded protein response. J Biol Chem 276:35867-35874
    • (2001) J Biol Chem , vol.276 , pp. 35867-35874
    • Zhang, C.1    Cai, Y.2    Adachi, M.T.3    Oshiro, S.4    Aso, T.5    Kaufman, R.J.6    Kitajima, S.7
  • 21
    • 33846597048 scopus 로고    scopus 로고
    • CCAAT/Enhancer-binding protein homologous protein (CHOP) decreases bone formation and causes osteopenia
    • DOI 10.1016/j.bone.2006.09.028, PII S8756328206007423
    • Pereira RC, Stadmeyer LE, Smith DL, Rydziel S, Canalis E (2007) CCAAT/enhancer-binding protein homologous protein (CHOP) decreases bone formation and causes osteopenia. Bone 40:619-626 (Pubitemid 46187217)
    • (2007) Bone , vol.40 , Issue.3 , pp. 619-626
    • Pereira, R.C.1    Stadmeyer, L.E.2    Smith, D.L.3    Rydziel, S.4    Canalis, E.5
  • 25
    • 33746636881 scopus 로고    scopus 로고
    • Homocysteine enhances apoptosis in human bone marrow stromal cells
    • DOI 10.1016/j.bone.2006.03.004, PII S8756328206003735
    • Kim DJ, Koh JM, Lee O, Kim NJ, Lee YS, Kim YS, Park JY, Lee KU, Kim GS (2006) Homocysteine enhances apoptosis in human bone marrow stromal cells. Bone 39:582-590 (Pubitemid 44149276)
    • (2006) Bone , vol.39 , Issue.3 , pp. 582-590
    • Kim, D.J.1    Koh, J.-M.2    Lee, O.3    Kim, N.J.4    Lee, Y.-S.5    Kim, Y.S.6    Park, J.-Y.7    Lee, K.-U.8    Kim, G.S.9
  • 27
    • 1842639828 scopus 로고    scopus 로고
    • Mitochondria in apoptosis: Past, present and future
    • Degli Esposti M (2004) Mitochondria in apoptosis: past, present and future. Biochem Soc Trans 32:493-495
    • (2004) Biochem Soc Trans , vol.32 , pp. 493-495
    • Degli Esposti, M.1
  • 28
    • 67649595826 scopus 로고    scopus 로고
    • Apoptosis and cancer: The genesis of a research field
    • Cotter TG (2009) Apoptosis and cancer: the genesis of a research field. Nat Rev Cancer 9:501-507
    • (2009) Nat Rev Cancer , vol.9 , pp. 501-507
    • Cotter, T.G.1
  • 29
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO (2000) The biochemistry of apoptosis. Nature 407:770-776
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 30
    • 0034624197 scopus 로고    scopus 로고
    • Homocysteine-induced changes in mRNA levels of genes coding for cytoplasmic- and endoplasmic reticulum-resident stress proteins in neuronal cell cultures
    • Althausen S, Paschen W (2000) Homocysteine-induced changes in mRNA levels of genes coding for cytoplasmic- and endoplasmic reticulum-resident stress proteins in neuronal cell cultures. Brain Res Mol Brain Res 84:32-40
    • (2000) Brain Res Mol Brain Res , vol.84 , pp. 32-40
    • Althausen, S.1    Paschen, W.2
  • 32
    • 0027324844 scopus 로고
    • Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase
    • DOI 10.1016/0092-8674(93)90648-A
    • Cox JS, Shamu CE, Walter P (1993) Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase. Cell 73:1197-1206 (Pubitemid 23180493)
    • (1993) Cell , vol.73 , Issue.6 , pp. 1197-1206
    • Cox, J.S.1    Shamu, C.E.2    Walter, P.3
  • 33
    • 10744231292 scopus 로고    scopus 로고
    • Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts: A putative explanation for why intermittent administration is needed for bone anabolism
    • DOI 10.1074/jbc.M307444200
    • Bellido T, Ali AA, Plotkin LI, Fu Q, Gubrij I, Roberson PK, Weinstein RS, O'Brien CA, Manolagas SC, Jilka RL (2003) Proteasomal degradation of Runx2 shortens parathyroid hormone-induced anti-apoptotic signaling in osteoblasts. A putative explanation for why intermittent administration is needed for bone anabolism. J Biol Chem 278:50259-50272 (Pubitemid 37548867)
    • (2003) Journal of Biological Chemistry , vol.278 , Issue.50 , pp. 50259-50272
    • Bellido, T.1    Ali, A.A.2    Plotkin, L.I.3    Fu, Q.4    Gubrij, I.5    Roberson, P.K.6    Weinstein, R.S.7    O'Brien, C.A.8    Manolagas, S.C.9    Jilka, R.L.10
  • 36
    • 33748789479 scopus 로고    scopus 로고
    • Mediators of endoplasmic reticulum stress-induced apoptosis
    • DOI 10.1038/sj.embor.7400779, PII 7400779
    • Szegezdi E, Logue SE, Gorman AM, Samali A (2006) Mediators of endoplasmic reticulum stress-induced apoptosis. EMBO Rep 7:880-885 (Pubitemid 44523966)
    • (2006) EMBO Reports , vol.7 , Issue.9 , pp. 880-885
    • Szegezdi, E.1    Logue, S.E.2    Gorman, A.M.3    Samali, A.4
  • 37
    • 33644858343 scopus 로고    scopus 로고
    • The unfolded protein response: A stress signaling pathway critical for health and disease
    • PII 0000611420060124100018
    • Zhang K, Kaufman RJ (2006) The unfolded protein response: a stress signaling pathway critical for health and disease. Neurology 66:S102-S109 (Pubitemid 43739994)
    • (2006) Neurology , vol.66 , Issue.2 SUPPL. 1
    • Zhang, K.1    Kaufman, R.J.2
  • 38
    • 0037072937 scopus 로고    scopus 로고
    • An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12
    • Morishima N, Nakanishi K, Takenouchi H, Shibata T, Yasuhiko Y (2002) An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12. J Biol Chem 277:34287-34294
    • (2002) J Biol Chem , vol.277 , pp. 34287-34294
    • Morishima, N.1    Nakanishi, K.2    Takenouchi, H.3    Shibata, T.4    Yasuhiko, Y.5
  • 39
    • 0034665653 scopus 로고    scopus 로고
    • Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: Activation of c-Jun NH(2)-terminal kinase and promoter response element
    • Cai Y, Zhang C, Nawa T, Aso T, Tanaka M, Oshiro S, Ichijo H, Kitajima S (2000) Homocysteine-responsive ATF3 gene expression in human vascular endothelial cells: activation of c-Jun NH(2)-terminal kinase and promoter response element. Blood 96:2140-2148
    • (2000) Blood , vol.96 , pp. 2140-2148
    • Cai, Y.1    Zhang, C.2    Nawa, T.3    Aso, T.4    Tanaka, M.5    Oshiro, S.6    Ichijo, H.7    Kitajima, S.8
  • 40
    • 0035824403 scopus 로고    scopus 로고
    • Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine
    • DOI 10.1006/bbrc.2001.6044
    • Zhang C, Kawauchi J, Adachi MT, Hashimoto Y, Oshiro S, Aso T, Kitajima S (2001) Activation of JNK and transcriptional repressor ATF3/LRF1 through the IRE1/TRAF2 pathway is implicated in human vascular endothelial cell death by homocysteine. Biochem Biophys Res Commun 289:718-724 (Pubitemid 33152292)
    • (2001) Biochemical and Biophysical Research Communications , vol.289 , Issue.3 , pp. 718-724
    • Zhang, C.1    Kawauchi, J.2    Adachi, M.T.3    Hashimoto, Y.4    Oshiro, S.5    Aso, T.6    Kitajima, S.7
  • 41
    • 0030041536 scopus 로고    scopus 로고
    • Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis
    • Chen YR, Meyer CF, Tan TH (1996) Persistent activation of c-Jun N-terminal kinase 1 (JNK1) in gamma radiation-induced apoptosis. J Biol Chem 271:631-634
    • (1996) J Biol Chem , vol.271 , pp. 631-634
    • Chen, Y.R.1    Meyer, C.F.2    Tan, T.H.3
  • 42
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • DOI 10.1038/nrm2199, PII NRM2199
    • Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8:519-529 (Pubitemid 46985379)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.7 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 45
    • 0036091476 scopus 로고    scopus 로고
    • The PERK eukaryotic initiation factor 2alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas
    • DOI 10.1128/MCB.22.11.3864-3874.2002
    • Zhang P, McGrath B, Li S, Frank A, Zambito F, Reinert J, Gannon M, Ma K, McNaughton K, Cavener DR (2002) The PERK eukaryotic initiation factor 2 alpha kinase is required for the development of the skeletal system, postnatal growth, and the function and viability of the pancreas. Mol Cell Biol 22:3864-3874 (Pubitemid 34525227)
    • (2002) Molecular and Cellular Biology , vol.22 , Issue.11 , pp. 3864-3874
    • Zhang, P.1    McGrath, B.2    Li, S.3    Frank, A.4    Zambito, F.5    Reinert, J.6    Gannon, M.7    Ma, K.8    McNaughton, K.9    Cavener, D.R.10
  • 46
    • 40149105885 scopus 로고    scopus 로고
    • ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta
    • Lisse TS, Thiele F, Fuchs H et al (2008) ER stress-mediated apoptosis in a new mouse model of osteogenesis imperfecta. PLoS Genet 4:e7
    • (2008) PLoS Genet , vol.4
    • Lisse, T.S.1    Thiele, F.2    Fuchs, H.3
  • 47
    • 72949104886 scopus 로고    scopus 로고
    • Atherothrombotic events in rheumatoid arthritis are predicted by homocysteine - A six-year follow-up study
    • Berglund S, Sodergren A, Wallberg Jonsson S, Rantapaa Dahlqvist S (2009) Atherothrombotic events in rheumatoid arthritis are predicted by homocysteine - a six-year follow-up study. Clin Exp Rheumatol 27:822-825
    • (2009) Clin Exp Rheumatol , vol.27 , pp. 822-825
    • Berglund, S.1    Sodergren, A.2    Wallberg Jonsson, S.3    Rantapaa Dahlqvist, S.4
  • 49
    • 0029860742 scopus 로고    scopus 로고
    • Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis: GRP78/BiP and novel genes
    • DOI 10.1074/jbc.271.47.29659
    • Kokame K, Kato H, Miyata T (1996) Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes. J Biol Chem 271:29659-29665 (Pubitemid 26389590)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.47 , pp. 29659-29665
    • Kokame, K.1    Kato, H.2    Miyata, T.3
  • 51
    • 0036702298 scopus 로고    scopus 로고
    • ER-associated degradation in protein quality control and cellular regulation
    • Hampton RY (2002) ER-associated degradation in protein quality control and cellular regulation. Curr Opin Cell Biol 14:476-482
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 476-482
    • Hampton, R.Y.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.