Homocysteine as a Predictive Factor for Hip Fracture in Older Persons

New England Journal of Medicine

Volumn 350, Issue 20, 2004, Pages 2042-2049

  McLean, Robert R ^a,e   Jacques, Paul F ^b   Selhub, Jacob ^b   Tucker, Katherine L ^b   Samelson, Elizabeth J ^a   Broe, Kerry E ^a   Hannan, Marian T ^a,d   Cupples, L Adrienne ^c   Kiel, Douglas P ^d  

^a RESEARCH AND TRAINING INSTITUTE   (United States)

^b TUFTS UNIVERSITY   (United States)

^c BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

^e Framingham Study   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HOMOCYSTEINE;

ADULT; AGE; AGED; ARTICLE; BLOOD SAMPLING; DIETARY INTAKE; DISEASE ASSOCIATION; FEMALE; FOLLOW UP; FRAGILITY FRACTURE; GENDER; HAZARD ASSESSMENT; HIP FRACTURE; HOMOCYSTINURIA; HUMAN; MAJOR CLINICAL STUDY; MALE; OSTEOPOROSIS; PREVALENCE; PRIORITY JOURNAL; RISK FACTOR; BLOOD; HYPERHOMOCYSTEINEMIA; INCIDENCE; MIDDLE AGED; PROPORTIONAL HAZARDS MODEL;

AGED; AGED, 80 AND OVER; FEMALE; FOLLOW-UP STUDIES; HIP FRACTURES; HOMOCYSTEINE; HUMANS; HYPERHOMOCYSTEINEMIA; INCIDENCE; MALE; MIDDLE AGED; OSTEOPOROSIS; PROPORTIONAL HAZARDS MODELS; RISK FACTORS;

EID: 2342464257     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJMoa032739     Document Type: Article

References (41)

1. Grieco AJ. Homocystinuria: pathogenetic mechanisms. Am J Med Sci 1977;273:120-32.
2. Boushey CJ, Beresford SA, Omenn GS, Motulsky AG. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: probable benefits of increasing folic acid intakes. JAMA 1995;274:1049-57.
3. Clarke R. An updated review of the published studies of homocysteine and cardiovascular disease. Int J Epidemiol 2002;31:70-1.
4. Morreels CL Jr, Fletcher BD, Weilbaecher KG, Dorst JP. The roentgenographic features of homocystinuria. Radiology 1968;90:1150-8.
5. Mudd SH, Skovby F, Levy HL, et al. The natural history of homocystinuria due to cystathionine beta-synthase deficiency. Am J Hum Genet 1985;37:1-31.
6. Cooper C. The crippling consequences of fractures and their impact on quality of life. Am J Med 1997;103:Suppl 2A:12S-19S.
7. Ray NF, Chan JK, Thamer M, Melton LJ III. Medical expenditures for the treatment of osteoporotic fractures in the United States in 1995: report from the National Osteoporosis Foundation. J Bone Miner Res 1997;12:24-35.
8. Browner WS, Pressman AR, Nevitt MC, Cummings SR. Mortality following fractures in older women: the Study of Osteoporotic Fractures. Arch Intern Med 1996;156:1521-5.
9. Dawber TR, Meadors GF, Moore FE Jr. Epidemiological approaches to heart disease: the Framingham Study. Am J Public Health 1951;41:279-81.
10. Araki A, Sako Y. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection. J Chromatogr 1987;422:43-52.
11. Ueland PM, Refsum H, Stabler SP, Malinow MR, Andersson A, Allen RH. Total homocysteine in plasma or serum: methods and clinical applications. Clin Chem 1993;39:1764-79.
12. Selhub J, Jacques PF, Wilson PW, Rush D, Rosenberg IH. Vitamin status and intake as primary determinants of homocysteinemia in an elderly population. JAMA 1993;270:2693-8.
13. Kiel DP, Felson DT, Anderson JJ, Wilson PWF, Moskowitz MA. Hip fracture and the use of estrogens in postmenopausal women: the Framingham Study. N Engl J Med 1987;317:1169-74.
14. Kiel DP, Felson DT, Hannan MT, Anderson JJ, Wilson PW. Caffeine and the risk of hip fracture: the Framingham Study. Am J Epidemiol 1990;132:675-84.
15. Felson DT, Kiel DP, Anderson JJ, Kannel WB. Alcohol consumption and hip fractures: the Framingham Study. Am J Epidemiol 1988;128:1102-10.
16. Kannel WB, Wolf PA, Garrison RJ, eds. The Framingham Heart Study: an epidemiological investigation of cardiovascular disease. Section 35. Survival following cardiovascular events: 30 year follow-up. Bethesda, Md.: National Heart, Lung, and Blood Institute, May 1988. (NIH publication no. 88-2969.)
17. Nagi SZ. An epidemiology of disability among adults in the United States. Milbank Mem Fund Q Health Soc 1976;54:439-67.
18. Jette AM, Pinsky JL, Branch LG, Wolf PA, Feinleib M. The Framingham Disability Study: physical disability among community-dwelling survivors of stroke. J Clin Epidemiol 1988;41:719-26.
19. Folstein MF, Folstein SE, McHugh PR. "Mini-Mental State": a practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-98.
20. Bachman DL, Wolf PA, Linn RT, et al. Incidence of dementia and probable Alzheimer's disease in a general population: the Framingham Study. Neurology 1993;43:515-9.
21. Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med 2002;346:476-83.
22. McKusick VA. Heritable disorders of connective tissue. 3rd ed. St. Louis: C.V. Mosby, 1966:150.
23. Kang AH, Trelstad RL. A collagen defect in homocystinuria. J Clin Invest 1973;52:2571-8.
24. Lubec B, Fang-Kircher S, Lubec T, Blom HJ, Boers GH. Evidence for McKusick's hypothesis of deficient collagen cross-linking in patients with homocystinuria. Biochim Biophys Acta 1996;1315:159-62.
25. Masse PG, Boskey AL, Ziv J, et al. Chemical and biomechanical characterization of hyperhomocysteinemic bone disease in an animal model. BMC Musculoskelet Disord 2003;4:2.
26. Browner WS, Malinow MR. Homocyst(e)inaemia and bone density in elderly women. Lancet 1991;338:1470.
27. Goyette P, Sumner JS, Milos R, et al. Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nat Genet 1994;7:195-200. [Erratum, Nat Genet 1994;7:551.]
28. Goyette P, Sumner JS, Milos R, et al. Human methylenetetrahydrofolate reductase: isolation of cDNA, mapping and mutation identification. Nat Genet 1994;7:195-200. [Erratum, Nat Genet 1994;7:551.]
29. Jacques PF, Bostom AG, Williams RR, et al. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations. Circulation 1996;93:7-9.
30. Miyao M, Morita H, Hosoi T, et al. Association of methylenetetrahydrofolate reductase (MTHFR) Polymorphism with bone mineral density in postmenopausal Japanese women. Calcif Tissue Int 2000;66:190-4.
31. Abrahamsen B, Madsen JS, Tofteng CL, et al. A common methylenetetrahydrofolate reductase (C677T) polymorphism is associated with low bone mineral density and increased fracture incidence after menopause: longitudinal data from the Danish Osteoporosis Prevention Study. J Bone Miner Res 2003;18:723-9.
32. Jorgensen HL, Madsen JS, Madsen B, et al. Association of a common allelic polymorphism (C677T) in the methylene tetrahydrofolate reductase gene with a reduced risk of osteoporotic fractures: a case control study in Danish postmenopausal women. Calcif Tissue Int 2002;71:386-92.
33. McLean RR, Karasik D, Selhub J, et al. Association of a common polymorphism in the methylenetetrahydrofolate reductase (MTHFR) gene with bone phenotypes depends on plasma folate status. J Bone Miner Res 2004;19:410-8.
34. Food standards: amendment of standards of identity for enriched grain products to require addition of folic acid. Fed Regist 1996;61(44):8781-97.
35. Jacques PF, Selhub J, Bostom AG, Wilson PWF, Rosenberg IH. The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med 1999;340:1449-54.
36. Nurk E, Tell GS, Nygard O, Refsum H, Ueland PM, Vollset SE. Plasma total homocysteine is influenced by prandial status in humans: the Hordaland Homocysteine Study. J Nutr 2001;131:1214-6.
37. Clarke R, Lewington S, Donald A, et al. Underestimation of the importance of homocysteine as a risk factor for cardiovascular disease in epidemiological studies. J Cardiovasc Risk 2001;8:363-9.
38. Johnson MA, Hawthorne NA, Brackett WK, et al. Hyperhomocysteinemia and vitamin B-12 deficiency in elderly using Title IIIc nutrition services. Am J Clin Nutr 2003;77:211-20.
39. Eastell R, Vieira NE, Yergey AL, et al. Pernicious anaemia as a risk factor for osteoporosis. Clin Sci (Lond) 1992;82:681-5.
40. Goerss JB, Kim CH, Atkinson EJ, Eastell R, O'Fallon WM, Melton LJ III. Risk of fractures in patients with pernicious anemia. J Bone Miner Res 1992;7:573-9.
41. Dhonukshe-Rutten RA, Lips M, de Jong N, et al. Vitamin B-12 status is associated with bone mineral content and bone mineral density in frail elderly women but not in men. J Nutr 2003;133:801-7.