The presence of Tregs does not preclude immunity to reinfection with Leishmania braziliensis

International Journal for Parasitology

Volumn 42, Issue 8, 2012, Pages 771-780

  C Falcão, Sarah ^a   de Moura, Tatiana R ^a,d   Clarêncio, Jorge ^a   Brodskyn, Cláudia ^a,b,c   Barral, Aldina ^a,b,c   de Oliveira, Camila I ^a,c  

^a INSTITUTO OSWALDO CRUZ   (Brazil)

^b FEDERAL UNIVERSITY OF BAHIA   (Brazil)

^c Instituto Nacional de Ciência e Tecnologia iii INCT   (Brazil)

^d FEDERAL UNIVERSITY OF SERGIPE   (Brazil)

Author keywords

CD4+CD25+; Leishmania braziliensis; Treg

Indexed keywords

CD103 ANTIGEN; CD4 ANTIGEN; FORKHEAD TRANSCRIPTION FACTOR; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; INTERLEUKIN 10; TRANSCRIPTION FACTOR FOXP3; WINGED HELIX TRANSCRIPTION FACTOR;

DISEASE; ETIOLOGY; IMMUNE RESPONSE; IMMUNITY; PARASITE; PATHOLOGY; SMALL MAMMAL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL FUNCTION; CELLULAR DISTRIBUTION; DISEASE DURATION; FEMALE; IMMUNE RESPONSE; IMMUNITY; INOCULATION; LEISHMANIA BRAZILIENSIS; LEISHMANIASIS; MOUSE; NONHUMAN; OUTCOME ASSESSMENT; PHENOTYPE; PROTEIN EXPRESSION; PURIFICATION; REGULATORY T LYMPHOCYTE; REINFECTION; SUPPRESSOR CELL;

ANIMALS; FEMALE; HUMANS; IMMUNITY; LEISHMANIA BRAZILIENSIS; LEISHMANIASIS; MICE; MICE, INBRED BALB C; T-LYMPHOCYTES, REGULATORY;

LEISHMANIA BRAZILIENSIS; LEISHMANIA MAJOR; MUS;

EID: 84863844163     PISSN: 00207519     EISSN: 18790135     Source Type: Journal    
DOI: 10.1016/j.ijpara.2012.05.006     Document Type: Article

References (51)

1. Anderson C.F., Oukka M., Kuchroo V.J., Sacks D. CD4(+)CD25(-)Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J. Exp. Med. 2007, 204:285-297.
2. + T cells. J. Immunol. 2002, 169:3232-3241.
3. Belkaid Y. The role of CD4(+)CD25(+) regulatory T cells in Leishmania infection. Exp. Opin. Biol. Th. 2003, 3:875-885.
4. Belkaid Y., Blank R.B., Suffia I. Natural regulatory T cells and parasites: a common quest for host homeostasis. Immunol. Rev. 2006, 212:287-300.
5. Belkaid Y., Hoffmann K., Mendez S., Kamhawi S., Udey M., Wynn T., Sacks D. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J. Exp. Med. 2001, 194:1497-1506.
6. + regulatory T cells control Leishmania major persistence and immunity. Nature 2002, 420:502-507.
7. Belkaid Y., Sun C.M., Bouladoux N. Parasites and immunoregulatory T cells. Curr. Opin. Immunol. 2006, 18:406-412.
8. Bittencourt, A., Barral-Netto, M., 1995. Leishmaniasis. In: Seifert, G., Doerr, W. (Eds), Tropical Pathology, Springer, Berlin, pp. 597-651.
9. Bogdan C., Donhauser N., Doring R., Rollinghoff M., Diefenbach A., Rittig M. Fibroblasts as host cells in latent leishmaniosis. J. Exp. Med. 2000, 191:2121-2130.
10. Bopp T., Becker C., Klein M., Klein-Hessling S., Palmetshofer A., Serfling E., Heib V., Becker M., Kubach J., Schmitt S., Stoll S., Schild H., Staege M.S., Stassen M., Jonuleit H., Schmitt E. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J. Exp. Med. 2007, 204:1303-1310.
11. Bourreau E., Ronet C., Darcissac E., Lise M.C., Sainte Marie D., Clity E., Tacchini-Cottier F., Couppie P., Launois P. Intralesional regulatory T-cell suppressive function during human acute and chronic cutaneous leishmaniasis due to Leishmania guyanensis. Infect. Immun. 2009, 77:1465-1474.
12. Campanelli, A.P., Roselino, A.M., Cavassani, K.A., Pereira, M.S., Mortara, R.A., Brodskyn, C.I., Goncalves, H.S., Belkaid, Y., Barral-Netto, M., Barral, A., Silva, J.S., 2006. CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells. J. Infec. Dis. 193, 1313-1322.
13. Collison L.W., Workman C.J., Kuo T.T., Boyd K., Wang Y., Vignali K.M., Cross R., Sehy D., Blumberg R.S., Vignali D.A. The inhibitory cytokine IL-35 contributes to regulatory T-cell function. Nature 2007, 450:566-569.
14. + T cell response to Leishmania major. J. Immunol. 2010, 185:2416-2423.
15. Costa D.L., Carregaro V., Lima-Junior D.S., Silva N.M., Milanezi C.M., Cardoso C.R., Giudice A., de Jesus A.R., Carvalho E.M., Almeida R.P., Silva J.S. BALB/c mice infected with antimony treatment refractory isolate of Leishmania braziliensis present severe lesions due to IL-4 production. PLoS Negl. Trop. Dis. 2011, 5:e965.
16. Coutinho, S.G., Pirmez, C., Da-Cruz, A.M., 2002. Parasitological and immunological follow-up of American tegumentary leishmaniasis patients. T. Roy. Soc. Trop. Med. H., S173-S178.
17. de Moura T.R., Novais F.O., Oliveira F., Clarencio J., Noronha A., Barral A., Brodskyn C., de Oliveira C.I. Toward a novel experimental model of infection to study American cutaneous leishmaniasis caused by Leishmania braziliensis. Infect. Immun. 2005, 73:5827-5834.
18. + regulatory T cells. Nat. Immunol. 2003, 4:330-336.
19. Hesse M., Piccirillo C.A., Belkaid Y., Prufer J., Mentink-Kane M., Leusink M., Cheever A.W., Shevach E.M., Wynn T.A. The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells. J. Immunol. 2004, 172:3157-3166.
20. + T cell-mediated pulmonary hyperinflammation driven by Pneumocystis carinii in immunodeficient mice. Eur. J. Immunol. 2002, 32:1282-1291.
21. Hori S., Nomura T., Sakaguchi S. Control of regulatory T cell development by the transcription factor Foxp3. Science 2003, 299:1057-1061.
22. Hsu A., Scott P. Leishmania mexicana infection induces impaired lymph node expansion and Th1 cell differentiation despite normal T cell proliferation. J. Immunol. 2007, 179:8200.
23. Jankovic D., Kullberg M.C., Feng C.G., Goldszmid R.S., Collazo C.M., Wilson M., Wynn T.A., Kamanaka M., Flavell R.A., Sher A. Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J. Exp. Med. 2007, 204:273-283.
24. + regulatory T cells restrain pathogenic responses during Leishmania amazonensis infection. J. Immunol. 2005, 174:7147-7153.
25. Kane M.M., Mosser D.M. The role of IL-10 in promoting disease progression in leishmaniasis. J. Immunol. 2001, 166:1141-1147.
26. + T regulatory cells. Nat. Immunol. 2003, 4:337-342.
27. Kullberg M.C., Jankovic D., Gorelick P.L., Caspar P., Letterio J.J., Cheever A.W., Sher A. Bacteria-triggered CD4(+) T regulatory cells suppress Helicobacter hepaticus-induced colitis. J. Exp. Med. 2002, 196:505-515.
28. Lages C.S., Suffia I., Velilla P.A., Huang B., Warshaw G., Hildeman D.A., Belkaid Y., Chougnet C. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. J. Immunol. 2008, 181:1835-1848.
29. + subsets during murine Leishmania major infection. Res. Immunol. 1991, 142:28-32.
30. Makala L.H., Baban B., Lemos H., El-Awady A.R., Chandler P.R., Hou D.Y., Munn D.H., Mellor A.L. Leishmania major attenuates host immunity by stimulating local indoleamine 2,3-dioxygenase expression. J. Infect. Dis. 2011, 203:715-725.
31. Mendez S., Reckling S., Piccirillo C., Sacks D., Belkaid Y. Role for CD4(+) CD25(+) regulatory T cells in reactivation of persistent leishmaniasis and control of concomitant immunity. J. Exp. Med. 2004, 200:201-210.
32. Moll H., Flohe S., Blank C. Dendritic cells seclude Leishmania parasites that persist in cured mice - a role in the maintenance of T-cell memory?. Adv. Exp. Med. Biol. 1995, 378:507-509.
33. Murray H., Nathan C. Macrophage microbicidal mechanisms in vivo: reactive nitrogen versus oxygen intermediates in the killing of intracellular visceral Leishmania donovani. J. Exp. Med. 1999, 189:741-746.
34. + (Foxp3) regulatory T cells in human visceral leishmaniasis. J. Exp. Med. 2007, 204:805-817.
35. Okwor I., Uzonna J. Vaccines and vaccination strategies against human cutaneous leishmaniasis. Hum. Vaccines 2009, 5:230-291.
36. + T cells. Nat. Immunol. 2007, 8:1353-1362.
37. Peters N.C., Kimblin N., Secundino N., Kamhawi S., Lawyer P., Sacks D.L. Vector transmission of Leishmania abrogates vaccine-induced protective immunity. PLoS Pathog. 2009, 5:e1000484.
38. + immunoregulatory cells. J. Immunol. 2001, 167:1137-1140.
39. Powrie F., Read S., Mottet C., Uhlig H., Maloy K. Control of immune pathology by regulatory T cells. Novartis Foundat. Sympos. 2003, 252:92-98.
40. Ramirez J.L., Guevara P. Persistent infections by Leishmania (Viannia) braziliensis. Mem. Inst. Oswaldo Cruz 1997, 92:333-338.
41. Rocha, F., Schleicher, U., Mattner, J., Alber, G., Bogdan, C., 2007. Cytokines, signaling pathways, and effector molecules required for the control of Leishmania (Viannia) braziliensis in mice. Infect. Immun. i3823-i3832.
42. Rodrigues O.R., Marques C., Soares-Clemente M., Ferronha M.H., Santos-Gomes G.M. Identification of regulatory T cells during experimental Leishmania infantum infection. Immunobiology 2009, 214:101-111.
43. + regulatory t cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol. 2004, 22:531-562.
44. Sakaguchi S., Sakaguchi N., Asano M., Itoh M., Toda M. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995, 155:1151-1164.
45. + T-cell subsets in the regulation of parasite immunity and disease. Immunol. Rev. 1989, 112:161-182.
46. + T cells. Eur. J. Immunol. 2006, 36:1764-1771.
47. + natural regulatory T cells are specific for microbial antigens. J. Exp. Med. 2006, 203:777-788.
48. Tabbara K.S., Peters N.C., Afrin F., Mendez S., Bertholet S., Belkaid Y., Sacks D.L. Conditions influencing the efficacy of vaccination with live organisms against Leishmania major infection. Infect. Immun. 2005, 73:4714-4722.
49. Takahashi T., Tagami T., Yamazaki S., Uede T., Shimizu J., Sakaguchi N., Mak T.W., Sakaguchi S. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J. Exp. Med. 2000, 192:303-310.
50. + regulatory T cell: a jack of all trades, master of regulation. Nat. Immunol. 2008, 9:239-244.
51. + regulatory T cells suppress differentiation and functions of Th1 and Th2 cells, Leishmania major infection, and colitis in mice. J. Immunol. 2003, 170:394-399.