An amino acid position at crossroads of evolution of protein function: Antibiotic sensor domain of BlaR1 protein from Staphylococcus aureus versus class D β-lactamases

Journal of Biological Chemistry

Volumn 287, Issue 11, 2012, Pages 8232-8241

  Kumarasiri, Malika ^a   Llarrull, Leticia I ^a   Borbulevych, Oleg ^a   Fishovitz, Jennifer ^a   Lastochkin, Elena ^a   Baker, Brian M ^a   Mobashery, Shahriar ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CLASS-D; DYNAMICS SIMULATION; GRAM-NEGATIVE BACTERIA; HIGH RESOLUTION; INTEGRAL MEMBRANE PROTEINS; LACTAMASES; MEMBRANE-BOUND RECEPTORS; MOLECULAR TEMPLATE; MUTANT PROTEINS; PERIPLASMIC ENZYMES; PROTEIN FUNCTIONS; SENSOR DOMAINS; STAPHYLOCOCCUS AUREUS; WATER MOLECULE; X-RAY STRUCTURE;

AMINO ACIDS; ANTIBIOTICS; BACTERIA; BIOLOGICAL MEMBRANES; ENZYMES; GENE EXPRESSION; SENSORS; SUBSTRATES; X RAYS;

PROTEINS;

AMPICILLIN; BETA LACTAMASE; BLAR1 PROTEIN; CEFALOTIN; CEFTAZIDIME; CEPHALOSPORIN; CEPHALOSPORIN C; IMIPENEM; MEMBRANE PROTEIN; MEROPENEM; MUTANT PROTEIN; NITROCEFIN; PENICILLIN G; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSOR DOMAIN; ARTICLE; BINDING SITE; BIOSENSOR; CONTROLLED STUDY; CRYSTAL STRUCTURE; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN STRUCTURE; SEQUENCE HOMOLOGY; SIGNAL TRANSDUCTION; SIMULATION; STAPHYLOCOCCUS AUREUS; WILD TYPE;

AMINO ACID SUBSTITUTION; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMASES; BETA-LACTAMS; BINDING SITES; CATALYSIS; CEPHALOSPORINS; CRYSTALLOGRAPHY, X-RAY; EVOLUTION, MOLECULAR; METALLOENDOPEPTIDASES; MUTATION, MISSENSE; STAPHYLOCOCCUS AUREUS;

NEGIBACTERIA; STAPHYLOCOCCUS AUREUS;

EID: 84858042485     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.333179     Document Type: Article

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