X-ray structure of a dihydropyrimidinase from Thermus sp. at 1.3 Å resolution

Journal of Molecular Biology

Volumn 320, Issue 1, 2002, Pages 143-156

  Abendroth, Jan ^a   Niefind, Karsten ^a   Schomburg, Dietmar ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

Author keywords

( )8 barrel; Binuclear; Dihydropyrimidinase; Hydantoinase; Zinc

Indexed keywords

DIHYDROOROTASE; DIHYDROPYRIMIDINASE; HYDROXIDE; LYSINE; PHOSPHOTRIESTERASE; UREASE; ZINC;

ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIFFRACTION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME STRUCTURE; ENZYME SUBSTRATE; NONHUMAN; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; THERMUS; X RAY;

THERMUS; THERMUS SP.;

EID: 0036299882     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00422-9     Document Type: Article

References (60)

1. Degradation of purines and pyrimidines by microorganisms
2. Inborn errors of pyrimidine degradation: Clinical, biochemical and molecular aspects
3. Dihydropyrimidinase deficiency: Structural organisation, chromosomal localisation, and mutation analysis of he human dihydropyrimidinase gene
4. Hydrolysis and formation of hydantoins
5. Enzymatic production of L-amino acids from the corresponding 5′-substituted hydantoins by a newly isolated bacterium Bacillus brevis AJ-12299
6. Stereo- and substrate-specificity of a D-hydantoinase and a D-N-carbamyl-amino acid amidohydrolase from Arthrobacter crytallopoietes AM 2
7. Mechanism of asymmetric production of D-amino acids from the corresponding hydantoins by Pseudomonas sp.
8. Microbial hydantoinases - Industrial enzymes from the origin of life?
9. Thermostable D-hydantoinase from thermophilic Bacillus stearothermophilus SD-1: Characteristics of purified enzyme
10. An evolutionary treasure: Unification of a broad set of amidohydrolases related to urea
11. Molecular evolution of hydantoinases
12. A novel gene family defined by human dihydropyrimidinase and three related proteins with differential tissue distribution
13. Purification, crystallisation and properties of a hydantoinase from Pseudomonas striata
14. The crystal structure of urease from Klebsiella aerogenes
15. A new proposal for urease mechanism based on the crystal structures of the native and inhibited enzyme from Bacillus pasteurii: Why urea hydrolysis costs two nickels
16. Molecular structure of dihydroorotase: A paradigm for catalysis through the use of a binuclear metal centre
17. Identification of the structural similarity in the functionally related amidohydrolases acting on the cyclic amide ring
18. Catalytic and structural function of zinc for the hydantoinase from Arthrobacter aurescens DSM 3745
19. New hydantoinases from thermophilic microorganisms - Synthesis of enantiomerically pure D-amino acids
20. Crystallisation, preliminary X-ray analysis of a native and seleno methionine D-hydantoinase from Thermus sp.
21. Selenium-based MAD phasing: Setting the sites on larger structures
22. Evaluation of macromolecular electron-density map quality using the correlation of local R.M.S. density
23. A highly automated heavy-atom search procedure for macromolecular structures
24. The use of SnB to determine an anomalous scattering substructure
25. Patterson superposition and ab initio phasing
26. Automated protein model building combined with iterative structure refinement
27. Extent of N-terminal methionine excision from Escherichia coli proteins is governed by the side-chain length of the penultimate amino acid
28. High resolution X-ray structures of different metal-substituted forms of phosphotriesterase from Pseudomonas diminuta
29. Purification of a D-hydantoinase using a laboratory-scale streamline phenyl column as the initial step
30. Principles of protein-protein interactions
31. 2-komplexen
32. Chemical rescue of Klebsiella aerogenes urease variants lacking the carbamylated-lysine nickel ligand
33. Perturbations to the active site of phosphotriesterase
34. Synthesis, structure and spectroscopic properties of copper(II) compounds containing nitrogen-sulphur donor ligands; the crystal and molecular structure of aqua[1,7-bis(N-methylbenzimidazol-2′-yl)-2,6-dithiaheptane]copper(II) perchlorate
35. Jack bean urease (EC 3.5.1.5).V. On the mechanism of action on urea, formamide, acetamide, N-methylurea, and related compounds
36. 70 Years of crystalline urease: What have we learned?
37. Structural properties of the nickel ions in urease: Novel insights into the catalytic and inhibition mechanism
38. Structure-based rationalisation of urease inhibition by phosphate: Novel insights into the enzyme mechanism
39. Structure-based computational study of the catalytic inhibition mechanism of urease
40. Cryosalts: Suppression of ice formation in macromolecular crystallography
41. Processing of X-ray diffraction data collected in oscillation mode
42. New processing tools for weak and/or spatially overlapped macromolecular diffraction patterns
43. Improved R-factors for diffraction data analysis in macromolecular crystallography
44. The CCP4 suite: Programs for protein crystallography
45. Assessment of phase accuracy by cross validation: The free R value. Methods and applications
46. Dm: An automated procedure for phase improvement by density modification
47. xdlMAPMAN and xdlDATAMAN - Programs for reformatting, analysis and manipulation of biomacromolecular electron-density maps and reflection data sets
48. Improved methods for binding protein models in electron density maps and the location of errors in these models
49. FINDNCS: A program to detect non-crystallographic symmetries in protein crystals from heavy atoms sites
50. Crystallography and NMR system (CNS): A new software system for macromolecular structure determination
51. Refinement of macromolecular structures by the maximum-likelihood method
52. PROCHECK: A program to check the stereochemical quality of protein structures
53. Dictionary of protein secondary structure: Pattern recognition of hydrogen-bonded and geometrical features
54. Similarities between protein 3-D structures
55. Chemical information in 3D-space
56. An extensively modified version of MolScript that includes greatly enhanced coloring capabilities
57. Raster3D: Photorealistic molecular graphics
58. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
59. Protein structural topology: Automated analysis and diagrammatic representation