메뉴 건너뛰기




Volumn 237, Issue 6, 2012, Pages 694-702

Mucosal immunization with caseinolytic protease X elicited cross-protective immunity against pneumococcal infection in mice

Author keywords

ClpX; Heat shock protein; Mucosal immunity; Streptococcus pneumoniae; Vaccine

Indexed keywords

ADENOSINE TRIPHOSPHATASE; CASEINOLYTIC PROTEASE 10; IMMUNOGLOBULIN G ANTIBODY; MEMBRANE PROTEIN; UNCLASSIFIED DRUG; VACCINE;

EID: 84863815959     PISSN: 15353702     EISSN: 15353699     Source Type: Journal    
DOI: 10.1258/ebm.2012.011383     Document Type: Article
Times cited : (7)

References (49)
  • 1
    • 40949162838 scopus 로고    scopus 로고
    • The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease
    • Kadioglu A, Weiser JN, Paton JC, Andrew PW. The role of Streptococcus pneumoniae virulence factors in host respiratory colonization and disease. Nat Rev Microbiol 2008;6:288-301
    • (2008) Nat Rev Microbiol , vol.6 , pp. 288-301
    • Kadioglu, A.1    Weiser, J.N.2    Paton, J.C.3    Andrew, P.W.4
  • 3
    • 63149104710 scopus 로고    scopus 로고
    • Streptococcus pneumoniae: Epidemiology, risk factors, and strategies for prevention
    • Lynch JP, Zhanel GG. Streptococcus pneumoniae: epidemiology, risk factors, and strategies for prevention. Semin Respir Crit Care Med 2009;30:189-209
    • (2009) Semin Respir Crit Care Med , vol.30 , pp. 189-209
    • Lynch, J.P.1    Zhanel, G.G.2
  • 5
    • 79955509218 scopus 로고    scopus 로고
    • Effect of pneumococcal conjugate vaccination on serotype-specific carriage and invasive disease in England: A cross-sectional study
    • Fasche S, Van Hoek AJ, Sheasby E, Waight P, Andrews N, Sheppard C, George R, Miller E. Effect of pneumococcal conjugate vaccination on serotype-specific carriage and invasive disease in England: a cross-sectional study. PLoS Med 2011;8:e1001017
    • (2011) PLoS Med , vol.8
    • Fasche, S.1    Van Hoek, A.J.2    Sheasby, E.3    Waight, P.4    Andrews, N.5    Sheppard, C.6    George, R.7    Miller, E.8
  • 6
    • 80052347582 scopus 로고    scopus 로고
    • The future of pneumococcal disease prevention
    • Rodgers GL, Klugman PK. The future of pneumococcal disease prevention. Vaccine 2011;29S:C43-8
    • (2011) Vaccine , vol.29 S
    • Rodgers, G.L.1    Klugman, P.K.2
  • 7
    • 46249112163 scopus 로고    scopus 로고
    • Pneumococcal vaccines: Mechanism of action, impact on epidemiology and adaption of the species
    • Pletz MW, Maus U, Krug N, Welte T, Lode H. Pneumococcal vaccines: mechanism of action, impact on epidemiology and adaption of the species. Int J Antimicrob Agents 2008;32:199-206
    • (2008) Int J Antimicrob Agents , vol.32 , pp. 199-206
    • Pletz, M.W.1    Maus, U.2    Krug, N.3    Welte, T.4    Lode, H.5
  • 8
    • 0142029153 scopus 로고    scopus 로고
    • Novel vaccine strategies with protein antigens of Streptococcus pneumoniae
    • Swiatlo E, Ware D. Novel vaccine strategies with protein antigens of Streptococcus pneumoniae. FEMS Immunol Med Microbiol 2003;38:1-7
    • (2003) FEMS Immunol Med Microbiol , vol.38 , pp. 1-7
    • Swiatlo, E.1    Ware, D.2
  • 9
    • 0028028168 scopus 로고
    • Immunization of mice with pneumolysin toxid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae
    • Alexander JE, Lock RA, Peeters CC, Poolman JT, Andrew PW, Mitchell TJ, Hansman D, Paton JC. Immunization of mice with pneumolysin toxid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae. Infect Immun 1994;62:5683-8
    • (1994) Infect Immun , vol.62 , pp. 5683-5688
    • Alexander, J.E.1    Lock, R.A.2    Peeters, C.C.3    Poolman, J.T.4    Andrew, P.W.5    Mitchell, T.J.6    Hansman, D.7    Paton, J.C.8
  • 10
    • 19744368834 scopus 로고    scopus 로고
    • Intradermal immunization of mice with cholera toxin B-pneumococcal surface protein A fusion protein is protective against intraperitoneal challenge with Streptococcus pneumoniae
    • Arêas AP, Oliveria ML, Miyaji EN, Leite LC, Ho PL. Intradermal immunization of mice with cholera toxin B-pneumococcal surface protein A fusion protein is protective against intraperitoneal challenge with Streptococcus pneumoniae. Infect Immun 2005;73:3810-3
    • (2005) Infect Immun , vol.73 , pp. 3810-3813
    • Arêas, A.P.1    Oliveria, M.L.2    Miyaji, E.N.3    Leite, L.C.4    Ho, P.L.5
  • 11
    • 0032721182 scopus 로고    scopus 로고
    • The pspC gene of Streptococcus pneumoniae encodes a polymorphic protein, PspC, which elicits cross-reactive antibodies to PspA and provides immunity to pneumococcal bacteremia
    • Brooks-Walter A, Briles DE, Hollingshead SK. The pspC gene of Streptococcus pneumoniae encodes a polymorphic protein, PspC, which elicits cross-reactive antibodies to PspA and provides immunity to pneumococcal bacteremia. Infect Immun 1999;67:6533-42
    • (1999) Infect Immun , vol.67 , pp. 6533-6542
    • Brooks-Walter, A.1    Briles, D.E.2    Hollingshead, S.K.3
  • 12
    • 66849111904 scopus 로고    scopus 로고
    • Characterization of protective mucosal and systemic immune responses elicited by pneumococcal surface protein PspA and PspC nasal vaccine against a respiratory pneumococcal challenge in mice
    • Ferreira DM, Darrieux M, Silva DA, Leite LC, Ferreira JM Jr, Ho PL, Miyaji EN, Oliveira ML. Characterization of protective mucosal and systemic immune responses elicited by pneumococcal surface protein PspA and PspC nasal vaccine against a respiratory pneumococcal challenge in mice. Clin Vaccine Immunol 2009;16:634-45
    • (2009) Clin Vaccine Immunol , vol.16 , pp. 634-645
    • Ferreira, D.M.1    Darrieux, M.2    Silva, D.A.3    Leite, L.C.4    Ferreira Jr., J.M.5    Ho, P.L.6    Miyaji, E.N.7    Oliveira, M.L.8
  • 13
    • 0033984377 scopus 로고    scopus 로고
    • Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae
    • Briles DE, Ades E, Paton JC, Sampson JS, Carlone GM, Huebner RC, Virolainen A, Swiatlo E, Hollingshead SK. Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae. Infect Immun 2000;68:798-800
    • (2000) Infect Immun , vol.68 , pp. 798-800
    • Briles, D.E.1    Ades, E.2    Paton, J.C.3    Sampson, J.S.4    Carlone, G.M.5    Huebner, R.C.6    Virolainen, A.7    Swiatlo, E.8    Hollingshead, S.K.9
  • 14
    • 33845580503 scopus 로고    scopus 로고
    • Genetic diversity of pneumococcal surface protein A of Streptococcus pneumoniae meningitis in German children
    • Heeg C, Franken C, van der Linden M, Al-Lahham A, Reinert RR. Genetic diversity of pneumococcal surface protein A of Streptococcus pneumoniae meningitis in German children. Vaccine 2007;25:1030-5
    • (2007) Vaccine , vol.25 , pp. 1030-1035
    • Heeg, C.1    Franken, C.2    van der Linden, M.3    Al-Lahham, A.4    Reinert, R.R.5
  • 15
    • 0038737428 scopus 로고    scopus 로고
    • Role of heat shock proteins in protection from and pathogenesis of infectious diseases
    • Zü gel U, Kaufmann SH. Role of heat shock proteins in protection from and pathogenesis of infectious diseases. Clin Microbiol Rev 1999;12: 19-39
    • (1999) Clin Microbiol Rev , vol.12 , pp. 19-39
    • Zügel, U.1    Kaufmann, S.H.2
  • 16
    • 77949654449 scopus 로고    scopus 로고
    • Effect of adjuvants on immune response and protective immunity elicited by recombinant Hsp60 (GroEL) of Saomonella typhi against S. typhi infection
    • Bansal A, Paliwal PK, Sagi SS, Sairam M. Effect of adjuvants on immune response and protective immunity elicited by recombinant Hsp60 (GroEL) of Saomonella typhi against S. typhi infection. Mol Cell Biochem 2010;337:213-21
    • (2010) Mol Cell Biochem , vol.337 , pp. 213-221
    • Bansal, A.1    Paliwal, P.K.2    Sagi, S.S.3    Sairam, M.4
  • 17
    • 33747331699 scopus 로고    scopus 로고
    • Immunogenicity and protective efficacy of DnaJ (hsp40) of Streptococcus pneumoniae against lethal infection in mice
    • Khan MN, Bansal A, Shukla D, Paliwal P, Sarada SK, Mustoori SR, Banerjee PK. Immunogenicity and protective efficacy of DnaJ (hsp40) of Streptococcus pneumoniae against lethal infection in mice. Vaccine 2006;24:6225-31
    • (2006) Vaccine , vol.24 , pp. 6225-6231
    • Khan, M.N.1    Bansal, A.2    Shukla, D.3    Paliwal, P.4    Sarada, S.K.5    Mustoori, S.R.6    Banerjee, P.K.7
  • 18
    • 77954956888 scopus 로고    scopus 로고
    • Enhanced protection against tuberculosis by vaccination with recombinant BCG over-expressing HspX protein
    • Shi C, Chen L, Chen Z, Zhang Y, Zhou Z, Lu J, Fu R, Wang C, Fang Z, Fan X. Enhanced protection against tuberculosis by vaccination with recombinant BCG over-expressing HspX protein. Vaccine 2010;28:5237-44
    • (2010) Vaccine , vol.28 , pp. 5237-5244
    • Shi, C.1    Chen, L.2    Chen, Z.3    Zhang, Y.4    Zhou, Z.5    Lu, J.6    Fu, R.7    Wang, C.8    Fang, Z.9    Fan, X.10
  • 20
    • 33846942977 scopus 로고    scopus 로고
    • Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram-positive bacteria
    • Frees D, Savijoki K, Varmanen P, Ingmer H. Clp ATPases and ClpP proteolytic complexes regulate vital biological processes in low GC, Gram-positive bacteria. Mol Microbiol 2007;63:1285-95
    • (2007) Mol Microbiol , vol.63 , pp. 1285-1295
    • Frees, D.1    Savijoki, K.2    Varmanen, P.3    Ingmer, H.4
  • 21
    • 0037407981 scopus 로고    scopus 로고
    • Essentiality of clpX, but not clpP, clpL, clpC, or clpE, in Streptococcus pneumoniae R6
    • Robertson GT, Ng WL, Gilmour R, Winkler ME. Essentiality of clpX, but not clpP, clpL, clpC, or clpE, in Streptococcus pneumoniae R6. J Bacteriol 2003;185:2961-6
    • (2003) J Bacteriol , vol.185 , pp. 2961-2966
    • Robertson, G.T.1    Ng, W.L.2    Gilmour, R.3    Winkler, M.E.4
  • 22
    • 34447277341 scopus 로고    scopus 로고
    • Distribution of the clpX gene in Brachyspira species and reactivity of recombinant Brachyspira pilosicoli ClpX with sera from mice and humans
    • Movahedi A, Hampson DJ. Distribution of the clpX gene in Brachyspira species and reactivity of recombinant Brachyspira pilosicoli ClpX with sera from mice and humans. J Med Microbiol 2007;56:930-6
    • (2007) J Med Microbiol , vol.56 , pp. 930-936
    • Movahedi, A.1    Hampson, D.J.2
  • 23
    • 79952709493 scopus 로고    scopus 로고
    • Immunization with DnaJ (hsp40) could elicit protection against nasopharyngeal colonization and invasive infection caused by different strains of Streptococcus pneumoniae
    • Cui Y, Zhang X, Gong Y, Niu S, YinN, Yao R, XuW, Li D, Wang H, He Y, Cao J, Yin Y. Immunization with DnaJ (hsp40) could elicit protection against nasopharyngeal colonization and invasive infection caused by different strains of Streptococcus pneumoniae. Vaccine 2011;29:1736-44
    • (2011) Vaccine , vol.29 , pp. 1736-1744
    • Cui, Y.1    Zhang, X.2    Gong, Y.3    Niu, S.4    Yin, N.5    Yao, R.6    Xu, W.7    Li, D.8    Wang, H.9    He, Y.10    Cao, J.11    Yin, Y.12
  • 24
    • 34548479248 scopus 로고    scopus 로고
    • Strepcococcus pneumoniae surface-exposed glutamyl tRNA synthetase, a putative adhesion, is able to induce a partially protective immune response in mice
    • Mizrachi Nebenzahl Y, Bernstein A, Portnoi M, Shagan M, Rom S, Porgador A, Dagan R. Strepcococcus pneumoniae surface-exposed glutamyl tRNA synthetase, a putative adhesion, is able to induce a partially protective immune response in mice. J Infect Dis 2007;196:945-53
    • (2007) J Infect Dis , vol.196 , pp. 945-953
    • Mizrachi Nebenzahl, Y.1    Bernstein, A.2    Portnoi, M.3    Shagan, M.4    Rom, S.5    Porgador, A.6    Dagan, R.7
  • 25
    • 46249115466 scopus 로고    scopus 로고
    • Streptococcus pneumoniae surface protein PcpA elicits protection against lung infection and fatal sepsis
    • Glover DT, Hollingshead SK, Briles DE. Streptococcus pneumoniae surface protein PcpA elicits protection against lung infection and fatal sepsis. Infect Immun 2008;76:2767-76
    • (2008) Infect Immun , vol.76 , pp. 2767-2776
    • Glover, D.T.1    Hollingshead, S.K.2    Briles, D.E.3
  • 26
    • 0028298752 scopus 로고
    • Novel surface attachment mechanism of Streptococcus pneumoniae protein PspA
    • Yother J, White JM. Novel surface attachment mechanism of Streptococcus pneumoniae protein PspA. J Bacteriol 1994;176:2976-85
    • (1994) J Bacteriol , vol.176 , pp. 2976-2985
    • Yother, J.1    White, J.M.2
  • 27
    • 73449094219 scopus 로고    scopus 로고
    • Characterization of novel b-galactosidase activity that contributes to glycoprotein degradation and virulence in Streptococcus pneumoniae
    • Terra VS, Homer KA, Rao SG, Andrew PW, Yesilkaya H. Characterization of novel b-galactosidase activity that contributes to glycoprotein degradation and virulence in Streptococcus pneumoniae. Infect Immun 2010;78:348-57
    • (2010) Infect Immun , vol.78 , pp. 348-357
    • Terra, V.S.1    Homer, K.A.2    Rao, S.G.3    Andrew, P.W.4    Yesilkaya, H.5
  • 28
    • 80052359601 scopus 로고    scopus 로고
    • Prevention of pneumococcal disease through vaccination
    • Gentile A, Bazán V. Prevention of pneumococcal disease through vaccination. Vaccine 2011;29:C15-25
    • (2011) Vaccine , vol.29
    • Gentile, A.1    Bazán, V.2
  • 29
    • 73449088379 scopus 로고    scopus 로고
    • Vaccines: The fourth century
    • Plotkin SA. Vaccines: the fourth century. Clin Vaccine Immunol 2009;16:1709-19
    • (2009) Clin Vaccine Immunol , vol.16 , pp. 1709-1719
    • Plotkin, S.A.1
  • 30
    • 1442299471 scopus 로고    scopus 로고
    • Streptococcus pneumoniae colonization: The key to pneumococcal diseases
    • Bogaert D, De Groot R, Hermans PW. Streptococcus pneumoniae colonization: the key to pneumococcal diseases. Lancet Infect Dis 2004;4:144-54
    • (2004) Lancet Infect Dis , vol.4 , pp. 144-154
    • Bogaert, D.1    De Groot, R.2    Hermans, P.W.3
  • 31
    • 0026604355 scopus 로고
    • Infections caused by Streptococcus pneumoniae: Clinical spectrum, pathogenesis, immunity, and treatment
    • Musher DM. Infections caused by Streptococcus pneumoniae: clinical spectrum, pathogenesis, immunity, and treatment. Clin Infect Dis 1992;14:801-7
    • (1992) Clin Infect Dis , vol.14 , pp. 801-807
    • Musher, D.M.1
  • 32
    • 0032527622 scopus 로고    scopus 로고
    • Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bidirectional pathway
    • Ring A, Weiser JN, Tuomanen EI. Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bidirectional pathway. J Clin Invest 1998;102:347-60
    • (1998) J Clin Invest , vol.102 , pp. 347-360
    • Ring, A.1    Weiser, J.N.2    Tuomanen, E.I.3
  • 33
    • 0022553595 scopus 로고
    • Some aspects of the pneumococcal carrier state
    • Austrain R. Some aspects of the pneumococcal carrier state. J Antimicrob Chemother 1986;18:35-45
    • (1986) J Antimicrob Chemother , vol.18 , pp. 35-45
    • Austrain, R.1
  • 34
    • 27744437978 scopus 로고    scopus 로고
    • Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model
    • van Rossum AM, Lysenko ES, Weiser JN. Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. Infect Immun 2005;73:7718-26
    • (2005) Infect Immun , vol.73 , pp. 7718-7726
    • van Rossum, A.M.1    Lysenko, E.S.2    Weiser, J.N.3
  • 36
    • 35648964189 scopus 로고    scopus 로고
    • Antibody-independent, CD4{thorn} T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins
    • Basset A, ThompsonCM, HollingsheadSK, BrilesDE, AdesEW, LipsitchM, Malley R. Antibody-independent, CD4{thorn} T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins. Infect Immun 2007;75:5460-4
    • (2007) Infect Immun , vol.75 , pp. 5460-5464
    • Basset, A.1    Thompson, C.M.2    Hollingshead, S.K.3    Briles, D.E.4    Ades, E.W.5    Lipsitch, M.6    Malley, R.7
  • 38
    • 73349104954 scopus 로고    scopus 로고
    • Intranasal immunization promotes Th17 immune responses
    • Zygmunt BM, Rharbaoui F, Groebe L, Guzman CA. Intranasal immunization promotes Th17 immune responses. J Immunol 2011;183:6933-8
    • (2011) J Immunol , vol.183 , pp. 6933-6938
    • Zygmunt, B.M.1    Rharbaoui, F.2    Groebe, L.3    Guzman, C.A.4
  • 39
    • 33644836224 scopus 로고    scopus 로고
    • Mucosal vaccines: The promise and the challenge
    • Neutra MR, Kozlowshi PA. Mucosal vaccines: the promise and the challenge. Nat Rev Immunol 2006;6:148-58
    • (2006) Nat Rev Immunol , vol.6 , pp. 148-158
    • Neutra, M.R.1    Kozlowshi, P.A.2
  • 41
    • 0034069269 scopus 로고    scopus 로고
    • Mechanisms involved in protective immune response generated by secretory proteins of Mycobacterium habana against experimental tuberculosis
    • Divya Jyothi M, Garg SK, Singh NB. Mechanisms involved in protective immune response generated by secretory proteins of Mycobacterium habana against experimental tuberculosis. Scand J Immunol 2000;51:502-10
    • (2000) Scand J Immunol , vol.51 , pp. 502-510
    • Divya Jyothi, M.1    Garg, S.K.2    Singh, N.B.3
  • 42
    • 33846849093 scopus 로고    scopus 로고
    • Intranasal vaccination with a secreted Chlamydial protein enhances resolution of genital Chlamydia muridarum infection, protects against oviduct pathology, and is highly dependent upon endogenous gamma interferon production
    • Murthy AK, Chambers JP, Meier PA, Zhong G, Arulanandam BP. Intranasal vaccination with a secreted Chlamydial protein enhances resolution of genital Chlamydia muridarum infection, protects against oviduct pathology, and is highly dependent upon endogenous gamma interferon production. Infect Immun 2007;75:666-76
    • (2007) Infect Immun , vol.75 , pp. 666-676
    • Murthy, A.K.1    Chambers, J.P.2    Meier, P.A.3    Zhong, G.4    Arulanandam, B.P.5
  • 43
    • 80051667576 scopus 로고    scopus 로고
    • Evaluation of the immunogenicity and the protective efficacy of a novel identified immunogenic protein, SsPepO, of Streptococcus suis serotype 2
    • Li J, Xia J, Tan C, Zhou Y, Wang Y, Zheng C, Chen H, Bei W. Evaluation of the immunogenicity and the protective efficacy of a novel identified immunogenic protein, SsPepO, of Streptococcus suis serotype 2. Vaccine 2011;29:6514-9
    • (2011) Vaccine , vol.29 , pp. 6514-6519
    • Li, J.1    Xia, J.2    Tan, C.3    Zhou, Y.4    Wang, Y.5    Zheng, C.6    Chen, H.7    Bei, W.8
  • 44
    • 79957729510 scopus 로고    scopus 로고
    • Next generation pneumococcal vaccines
    • Moffitt KL, Malley R. Next generation pneumococcal vaccines. Curr Opin Immunol 2011;23:407-13
    • (2011) Curr Opin Immunol , vol.23 , pp. 407-413
    • Moffitt, K.L.1    Malley, R.2
  • 46
    • 33845980590 scopus 로고    scopus 로고
    • Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae
    • Ogunniyi AD, Grabowicz M, Briles DE, Cook J, Paton JC. Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae. Infect Immun 2007;75:350-7
    • (2007) Infect Immun , vol.75 , pp. 350-357
    • Ogunniyi, A.D.1    Grabowicz, M.2    Briles, D.E.3    Cook, J.4    Paton, J.C.5
  • 47
    • 77349111486 scopus 로고    scopus 로고
    • Immunization with a combination of three pneumococcal proteins confers additive and broad protection agaist Streptococcus pneumoniae infection in mice
    • Wu K, Zhang X, Shi J, Li N, Li D, Luo M, Cao J, Yin N, Wang H, Xu W, He Y, Yin Y. Immunization with a combination of three pneumococcal proteins confers additive and broad protection agaist Streptococcus pneumoniae infection in mice. Infect Immun 2010;78:1276-83
    • (2010) Infect Immun , vol.78 , pp. 1276-1283
    • Wu, K.1    Zhang, X.2    Shi, J.3    Li, N.4    Li, D.5    Luo, M.6    Cao, J.7    Yin, N.8    Wang, H.9    Xu, W.10    He, Y.11    Yin, Y.12
  • 48
    • 0034114443 scopus 로고    scopus 로고
    • Immunization of mice with combinations of pneumococcal virulence proteins elicits enhanced protection against challenge with Streptococcus pneumoniae
    • Ogunniyi AD, Folland RL, Briles DE, Hollingshead SK, Paton JC. Immunization of mice with combinations of pneumococcal virulence proteins elicits enhanced protection against challenge with Streptococcus pneumoniae. Infect Immun 2000;68:3028-33
    • (2000) Infect Immun , vol.68 , pp. 3028-3033
    • Ogunniyi, A.D.1    Folland, R.L.2    Briles, D.E.3    Hollingshead, S.K.4    Paton, J.C.5
  • 49
    • 79251523147 scopus 로고    scopus 로고
    • Immunization with a ZmpB-based protein vaccine could protect against pneumococcal diseases in mice
    • Gong Y, Xu W, Cui Y, Zhang X, Yao R, Li D, Wang H, He Y, Cao J, Yin Y. Immunization with a ZmpB-based protein vaccine could protect against pneumococcal diseases in mice. Infect Immun 2011; 79:867-78
    • (2011) Infect Immun , vol.79 , pp. 867-878
    • Gong, Y.1    Xu, W.2    Cui, Y.3    Zhang, X.4    Yao, R.5    Li, D.6    Wang, H.7    He, Y.8    Cao, J.9    Yin, Y.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.