Streptococcus pneumoniae surface-exposed glutamyl tRNA synthetase, a putative adhesin, is able to induce a partially protective immune response in mice

Journal of Infectious Diseases

Volumn 196, Issue 6, 2007, Pages 945-953

  Nebenzahl, Yaffa Mizrachi ^a,b   Bernstein, Anka ^a,b   Portnoi, Maxim ^a,b   Shagan, Marilou ^a,b   Rom, Slava ^a,b   Porgador, Angel ^b   Dagan, Ron ^a,b  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN; BACTERIAL PROTEIN; GLUTAMATE TRANSFER RNA LIGASE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL STRAIN; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; INFANT; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRESCHOOL CHILD; PRIORITY JOURNAL; PROTEIN LOCALIZATION; STREPTOCOCCUS PNEUMONIAE;

ADULT; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL PROTEINS; CELL ADHESION; CELL LINE; CHILD, PRESCHOOL; CLONING, MOLECULAR; FEMALE; GENE EXPRESSION; GLUTAMATE-TRNA LIGASE; HUMANS; INFANT; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; PNEUMOCOCCAL VACCINES; RECOMBINANT PROTEINS; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PNEUMONIAE; SURVIVAL ANALYSIS; VACCINES, SUBUNIT;

EID: 34548479248     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/521028     Document Type: Article

References (50)

1. Dagan R, Greenberg D, Jacobs M. Pneumococcal infections. In: Feigin R, Cherry JD, Demmler GJ, Kaplan S, eds. Textbook of pediatric infectious diseases. 5th ed. Philadelphia: Saunders, 2004:1204-58.
2. Beachey EH, Giampapa CS, Abraham SN. Bacterial adherence: adhesin receptor-mediated attachment of pathogenic bacteria to mucosal surfaces. Am Rev Respir Dis 1988; 138:S45-8.
3. Tuomanen E. Molecular and cellular biology of pneumococcal infection. Curr Opin Microbiol 1999; 2:35-9.
4. Ring A, Weiser JN, Tuomanen EI. Pneumococcal trafficking across the blood-brain barrier: molecular analysis of a novel bidirectional pathway. J Clin Invest 1998; 102:347-60.
5. Jedrzejas MJ. Pneumococcal virulence factors: structure and function. Microbiol Mol Biol Rev 2001; 65:187-207.
6. Cundell DR, Gerard NP, Gerard C, Idanpaan-Heikkila I, Tuomanen EI. Streptococcus pneumoniae anchor to activated human cells by the receptor for platelet-activating factor. Nature 1995; 377:435-8.
7. Pracht D, Elm C, Gerber J, et al. PavA of Streptococcus pneumoniae modulates adherence, invasion, and meningeal inflammation. Infect Immun 2005; 73:2680-9.
8. Romero-Steiner S, Pilishvili T, Sampson JS, et al. Inhibition of pneumococcal adherence to human nasopharyngeal epithelial cells by anti-PsaA antibodies. Clin Diagn Lab Immunol 2003; 10:246-51.
9. Kerr AR, Adrian PV, Estevao S, et al. The Ami-AliA/AliB permease of Streptococcus pneumoniae is involved in nasopharyngeal colonization but not in invasive disease. Infect Immun 2004; 72:3902-6.
10. Rosenow C, Ryan P, Weiser JN, et al. Contribution of novel choline-binding proteins to adherence, colonization and immunogenicity of Streptococcus pneumoniae. Mol Microbiol 1997; 25:819-29.
11. Brooks-Walter A, Briles DE, Hollingshead SK. The pspC gene of Streptococcus pneumoniae encodes a polymorphic protein, PspC, which elicits cross-reactive antibodies to PspA and provides immunity to pneumococcal bacteremia. Infect Immun 1999; 67:6533-42.
12. Zhang JR, Mostov KE, Lamm ME, et al. The polymeric immunoglobulin receptor translocates pneumococci across human nasopharyngeal epithelial cells. Cell 2000; 102:827-37.
13. Elm C, Rohde M, Vaerman JP, Chhatwal GS, Hammerschmidt S. Characterization of the interaction of the pneumococcal surface protein SpsA with the human polymeric immunoglobulin receptor (hpIgR). Indian J Med Res 2004; 119(Suppl):61-5.
14. Hammerschmidt S, Talay SR, Brandtzaeg P, Chhatwal GS. SpsA, a novel pneumococcal surface protein with specific binding to secretory immunoglobulin A and secretory component. Mol Microbiol 1997; 25: 1113-24.
15. Lau GW, Haataja S, Lonetto M, et al. A functional genomic analysis of type 3 Streptococcus pneumoniae virulence. Mol Microbiol 2001; 40: 555-71.
16. Tuomanen EI, Masure HR. Molecular and cellular biology of pneumococcal infection. Microb Drug Resist 1997; 3:297-308.
17. Lifshitz S, Dagan R, Shani-Sekler M, et al. Age-dependent preference in human antibody responses to Streptococcus pneumoniae polypeptide antigens. Clin Exp Immunol 2002; 127:344-53.
18. Ling E, Feldman G, Portnoi M, et al. Glycolytic enzymes associated with the cell surface of Streptococcus pneumoniae are antigenic in humans and elicit protective immune responses in the mouse. Clin Exp Immunol 2004; 138:290-8.
19. Avery OT, MacLeod CM, McCarty M. Studies on the chemical nature of the substance inducing transformation of pneumococcal types: induction of transformation by a desoxyribonucleic acid fraction isolated from pneumococcus type III. 1944. Mol Med 1995; 1:344-65.
20. Watson DA, Musher DM. Interruption of capsule production in Streptococcus pneumonia serotype 3 by insertion of transposon Tn916. Infect Immun 1990; 58:3135-8.
21. Watson DA, Musher DM, Verhoef J. Pneumococcal virulence factors and host immune responses to them. Eur J Clin Microbiol Infect Dis 1995; 14:479-90.
22. Briles DE, Nahm M, Schroer K, et al. Antiphosphocholine antibodies found in normal mouse serum are protective against intravenous infection with type 3 Streptococcus pneumoniae. J Exp Med 1981; 153: 694-705.
23. Mizrachi Nebenzahl Y, Porat N, Lifshitz S, et al. Virulence of Streptococcus pneumoniae may be determined independently of capsular polysaccharide. FEMS Microbiol Lett 2004; 233:147-52.
24. Siegel JL, Hurst SF, Liberman ES, Coleman SE, Bleiweis AS. Mutanolysin-induced spheroplasts of Streptococcus mutants are true protoplasts. Infect Immun 1981; 31:808-15.
25. Sela BA, Wang JL, Edelman GM. Isolation of lectins of different specificities on a single affinity adsorbent. J Biol Chem 1975; 250:7535-8.
26. Portnoi M, Ling E, Feldman G, Dagan R, Mizrachi-Nebenzahl Y. The vaccine potential of Streptococcus pneumoniae surface lectin- and non-lectin proteins. Vaccine 2006; 24:1868-73.
27. Ausubel F, Brent R, Kingston R, Moore D. Analysis of protein. In: Seidman J, Smith J, Struhl K, eds. Current protocols in molecular biology. Vol. 10.2.1-10.8.18. Canada: Wiley & Sons, 2003.
28. Lieber M, Smith B, Szakal A, Nelson-Rees W, Todaro G. A continuous tumor-cell line from a human lung carcinoma with properties of type II alveolar epithelial cells. Int J Cancer 1976; 17:62-70.
29. Svanborg C, Bergsten G, Fischer H, et al. Adhesion, signal transduction and mucosal inflammation. In: Wilson M, ed. Bacterial adhesion to host tissues. London: Cambridge University Press, 2002:223-46.
30. Robson RL, Reed NA, Horvat RT. Differential activation of inflammatory pathways in A549 type II pneumocytes by Streptococcus pneumoniae strains with different adherence properties. BMC Infect Dis 2006; 6:71.
31. N'Guessan PD, Hippenstiel S, Etouem MO, et al. Streptococcus pneumoniae induced p38 MAPK- and NF-kappaB-dependent COX-2 expression in human lung epithelium. Am J Physiol Lung Cell Mol Physiol 2006; 290:L1131-8.
32. McDaniel LS, Sheffield JS, Delucchi P, Briles DE. PspA, a surface protein of Streptococcus pneumoniae, is capable of eliciting protection against pneumococci of more than one capsular type. Infect Immun 1991; 59: 222-8.
33. Briles DE, Ades E, Paton JC, et al. Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae. Infect Immun 2000; 68:796-800.
34. Johnston JW, Myers LE, Ochs MM, Benjamin WH Jr, Briles DE, Hollingshead SK. Lipoprotein PsaA in virulence of Streptococcus pneumoniae: surface accessibility and role in protection from superoxide. Infect Immun 2004; 72:5858-67.
35. McAllister LJ, Tseng HJ, Ogunniyi AD, Jennings MP, McEwan AG, Paton JC. Molecular analysis of the psa permease complex of Streptococcus pneumoniae. Mol Microbiol 2004; 53:889-901.
36. Luo R, Mann B, Lewis WS, et al. Solution structure of choline binding protein A, the major adhesin of Streptococcus pneumoniae. Embo J 2005; 24:34-43.
37. Alexander JE, Lock RA, Peeters CC, et al. Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae. Infect Immun 1994; 62:5683-8.
38. Musher DM, Phan HM, Baughn RE. Protection against bacteremic pneumococcal infection by antibody to pneumolysin. J Infect Dis 2001; 183:827-30.
39. Hamel J, Charland N, Pineau I, et al. Prevention of pneumococcal disease in mice immunized with conserved surface-accessible proteins. Infect Immun 2004; 72:2659-70.
40. Overweg K, Kerr A, Sluijter M, et al. The putative proteinase maturation protein A of Streptococcus pneumoniae is a conserved surface protein with potential to elicit protective immune responses. Infect Immun 2000; 68:4180-8.
41. Green BA, Zhang Y, Masi AW, et al. PppA, a surface-exposed protein of Streptococcus pneumoniae, elicits cross-reactive antibodies that reduce colonization in a murine intranasal immunization and challenge model. Infect Immun 2005; 73:981-9.
42. Daniely D, Portnoi M, Shagan M, et al. Pneumococcal 6-phosphogluconate- dehydrogenase, a putative adhesin, induces protective immune response in mice. Clin Exp Immunol 2006; 144:254-63.
43. Murdoch C, Read RC, Zhang Q, Finn A. Choline-binding protein A of Streptococcus pneumoniae elicits chemokine production and expression of intercellular adhesion molecule 1 (CD54) by human alveolar epithelial cells. J Infect Dis 2002; 186:1253-60.
44. Hammerschmidt S, Wolff S, Hocke A, Rosseau S, Muller E, Rohde M. Illustration of pneumococcal polysaccharide capsule during adherence and invasion of epithelial cells. Infect Immun 2005; 73:4653-67.
45. Balis JU, Bumgarner SD, Paciga JE, Paterson JF, Shelley SA. Synthesis of lung surfactant-associated glycoproteins by A549 cells: description of an in vitro model for human type II cell dysfunction. Exp Lung Res 1984; 6:197-213.
46. Nureki O, Vassylyev DG, Katayanagi K, et al. Architectures of class-defining and specific domains of glutamyl-tRNA synthetase. Science 1995; 267:1958-65.
47. Chhatwal GS. Anchorless adhesins and invasins of Gram-positive bacteria: a new class of virulence factors. Trends Microbiol 2002; 10:205-8.
48. Kyaw MH, Lynfield R, Schaffner W, et al. Effect of introduction of the pneumococcal conjugate vaccine on drug-resistant Streptococcus pneumoniae. N Engl J Med 2006; 354:1455-63.
49. Musher DM. Pneumococcal vaccine - direct and indirect ("herd") effects. N Engl J Med 2006; 354:1522-4.
50. Huang SS, Platt R, Rifas-Shiman SL, Pelton SI, Goldmann D, Finkelstein JA. Post-PCV7 changes in colonizing pneumococcal serotypes in 16 Massachusetts communities, 2001 and 2004. Pediatrics 2005; 116: e408-13.