Antibody-independent, CD4+ T-cell-dependent protection against pneumococcal colonization elicited by intranasal immunization with purified pneumococcal proteins

Infection and Immunity

Volumn 75, Issue 11, 2007, Pages 5460-5464

  Basset, Alan ^a   Thompson, Claudette M ^b   Hollingshead, Susan K ^c   Briles, David E ^c   Ades, Edwin W ^d   Lipsitch, Marc ^b   Malley, Richard ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c University of Alabama at Birmingham   (United States)

^d NATIONAL CENTER FOR IMMUNIZATION AND RESPIRATORY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADHESIN A; BACTERIAL PROTEIN; INTERLEUKIN 17; PNEUMOCOCCAL SURFACE PROTEIN C; PNEUMOCOCCUS VACCINE; PNEUMOLYSIN; PNEUMOLYSOID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COLONIZATION; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; IMMUNIZATION; MOUSE; NONHUMAN; NOSE CAVITY; PRIORITY JOURNAL; SPLEEN CELL; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PNEUMONIAE; T LYMPHOCYTE ACTIVATION;

ADMINISTRATION, INTRANASAL; ANIMALS; ANTIBODIES, BACTERIAL; BACTERIAL PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; COLONY COUNT, MICROBIAL; FEMALE; IMMUNIZATION; IMMUNOGLOBULINS; INTERLEUKIN-17; LYMPHOCYTE DEPLETION; MICE; MICE, INBRED C57BL; PNEUMOCOCCAL INFECTIONS; PNEUMOCOCCAL VACCINES; SPLEEN; STREPTOCOCCUS PNEUMONIAE; TRACHEA;

EID: 35648964189     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00773-07     Document Type: Article

References (25)

1. Alexander, J. E., R. A. Lock, C. C. Peeters, J. T. Poolman, P. W. Andrew, T. J. Mitchell, D. Hansman, and J. C. Paton. 1994. Immunization of mice with pneumolysin toxoid confers a significant degree of protection against at least nine serotypes of Streptococcus pneumoniae. Infect. Immun. 62:5683-5688.
2. Arulanandam, B. P., J. M. Lynch, D. E. Briles, S. Hollingshead, and D. W. Metzger. 2001. Intranasal vaccination with pneumococcal surface protein A and interleukin-12 augments antibody-mediated opsonization and protective immunity against Streptococcus pneumoniae infection. Infect. Immun. 69:6718-6724.
3. Austrian, R. 1986. Some aspects of the pneumococcal carrier state. J. Antimicrob. Chemother. 18(Suppl. A):35-45.
4. Balachandran, P., A. Brooks-Walter, A. Virolainen-Julkunen, S. K. Hollingshead, and D. E. Briles. 2002. Role of pneumococcal surface protein C in nasopharyngeal carriage and pneumonia and its ability to elicit protection against carriage of Streptococcus pneumoniae. Infect. Immun. 70:2526-2534.
5. Baril, L., J. Dietemann, M. Essevaz-Roulet, L. Beniguel, P. Coan, D. E. Briles, B. Guy, and G. Cozon. 2006. Pneumococcal surface protein A (PspA) is effective at eliciting T cell-mediated responses during invasive pneumococcal disease in adults. Clin. Exp. Immunol. 145:277-286.
6. Briles, D. E., E. Ades, J. C. Paton, J. S. Sampson, G. M. Carlone, R. C. Huebner, A. Virolainen, E. Swiatlo, and S. K. Hollingshead. 2000. Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae. Infect. Immun. 68:796-800.
7. Briles, D. E., S. K. Hollingshead, G. S. Nabors, J. C. Paton, and A. Brooks-Walter. 2000. The potential for using protein vaccines to protect against otitis media caused by Streptococcus pneumoniae. Vaccine 19(Suppl. 1):S87-S95.
8. Briles, D. E., S. K. Hollingshead, J. C. Paton, E. W. Ades, L. Novak, F. W. van Ginkel, and W. H. Benjamin, Jr. 2003. Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae. J. Infect. Dis. 188:339-348.
9. Centers for Disease Control and Prevention. 2005. Direct and indirect effects of routine vaccination of children with 7-valent pneumococcal conjugate vaccine on incidence of invasive pneumococcal disease - United States, 1998-2003. Morb. Mortal. Wkly. Rep. 54:893-897.
10. Dagan, R., N. Givon-Lavi, D. Fraser, M. Lipsitch, G. R. Siber, and R. Kohberger. 2005. Serum serotype-specific pneumococcal anticapsular immunoglobulin G concentrations after immunization with a 9-valent conjugate pneumococcal vaccine correlate with nasopharyngeal acquisition of pneumococcus. J. Infect. Dis. 192:367-376.
11. Goldblatt, D., M. Hussain, N. Andrews, L. Ashton, C. Virta, A. Melegaro, R. Pebody, R. George, A. Soininen, J. Edmunds, N. Gay, H. Kayhty, and E. Miller. 2005. Antibody responses to nasopharyngeal carriage of Streptococcus pneumoniae in adults: a longitudinal household study. J. Infect. Dis. 192:387-393.
12. Högberg, L., P. Geli, H. Ringberg, E. Melander, M. Lipsitch, and K. Ekdahl. 2007. Age- and serogroup-related differences in the observed duration of nasopharyngeal carriage of penicillin-resistant pneumococci. J. Clin. Microbiol. 45:948-952.
13. Kitamura, D., J. Roes, R. Kuhn, and K. Rajewsky. 1991. A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature 350:423-426.
14. Malley, R., P. Henneke, S. C. Morse, M. J. Cieslewicz, M. Lipsitch, C. M. Thompson, E. Kurt-Jones, J. C. Paton, M. R. Wessels, and D. T. Golenbock. 2003. Recognition of pneumolysin by Toll-like receptor 4 confers resistance to pneumococcal infection. Proc. Natl. Acad. Sci. USA 100:1966-1971.
15. Malley, R., M. Lipsitch, A. Stack, R. Saladino, G. Fleisher, S. Pelton, C. Thompson, D. E. Briles, and P. Anderson. 2001. Intranasal immunization with killed unencapsulated whole cells prevents colonization and invasive disease by encapsulated pneumococci. Infect. Immun. 69:4870-4873.
16. Malley, R., A. Srivastava, M. Lipsitch, C. M. Thompson, C. Watkins, A. Tzianabos, and P. W. Anderson. 2006. Antibody-independent, interleukin-17A-mediated, cross-serotype immunity to pneumococci in mice immunized intranasally with the cell wall polysaccharide. Infect. Immun. 74:2187-2195.
17. Malley, R., A. M. Stack, M. L. Ferretti, C. M. Thompson, and R. A. Saladino. 1998. Anticapsular polysaccharide antibodies and nasopharyngeal colonization with Streptococcus pneumoniae in infant rats. J. Infect. Dis. 178:878-882.
18. Malley, R., K. Trzcinski, A. Srivastava, C. M. Thompson, P. W. Anderson, and M. Lipsitch. 2005. CD4+ T cells mediate antibody-independent acquired immunity to pneumococcal colonization. Proc. Natl. Acad. Sci. USA 102:4848-4853.
19. Ogunniyi, A. D., R. L. Folland, D. E. Briles, S. K. Hollingshead, and J. C. Paton. 2000. Immunization of mice with combinations of pneumococcal virulence proteins elicits enhanced protection against challenge with Streptococcus pneumoniae. Infect. Immun. 68:3028-3033.
20. Paton, J. C., R. A. Lock, C. J. Lee, J. P. Li, A. M. Berry, T. J. Mitchell, P. W. Andrew, D. Hansman, and G. J. Boulnois. 1991. Purification and immunogenicity of genetically obtained pneumolysin toxoids and their conjugation to Streptococcus pneumoniae type 19F polysaccharide. Infect. Immun. 59:2297-2304.
21. Pimenta, F. C., E. N. Miyaji, A. P. Areas, M. L. Oliveira, A. L. de Andrade, P. L. Ho, S. K. Hollingshead, and L. C. Leite. 2006. Intranasal immunization with the cholera toxin B subunit-pneumococcal surface antigen A fusion protein induces protection against colonization with Streptococcus pneumoniae and has negligible impact on the nasopharyngeal and oral microbiota of mice. Infect. Immun. 74:4939-4944.
22. Romero-Steiner, S., J. Caba, G. Rajam, T. Langley, A. Floyd, S. E. Johnson, J. S. Sampson, G. M. Carlone, and E. W. Ades. 2006. Adherence of recombinant pneumococcal surface adhesin A (rPsaA)-coated particles to human nasopharnygeal epithelial cells for the evaluation of anti-PsaA functional antibodies. Vaccine 24:3224-3231.
23. World Health Organization. 2006. State of the art of new vaccines: research and development. www.who.int/vaccines-documents/DocsPDF06/814.pdf.
24. Wu, H. Y., M. H. Nahm, Y. Guo, M. W. Russell, and D. E. Briles. 1997. Intranasal immunization of mice with PspA (pneumococcal surface protein A) can prevent intranasal carriage, pulmonary infection, and sepsis with Streptococcus pneumoniae. J. Infect. Dis. 175:839-846.
25. Zhang, Q., L. Bagrade, J. Bernatoniene, E. Clarke, J. C. Paton, T. J. Mitchell, D. A. Nunez, and A. Finn. 2007. Low CD4 T cell immunity to pneumolysin is associated with nasopharyngeal carriage of pneumococci in children. J. Infect. Dis. 195:1194-1202.