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Volumn 185, Issue 3, 2010, Pages 1755-1762

Secretory-IgA antibodies play an important role in the immunity to Streptococcus pneumoniae

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; FLT3 LIGAND; GAMMA INTERFERON; IMMUNOGLOBULIN A ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 17; INTERLEUKIN 4; PNEUMOCOCCAL SURFACE PROTEIN A; STREPTOCOCCUS VACCINE; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; BACTERIAL VACCINE; BACTERIUM ANTIBODY; FLT3 LIGAND PROTEIN; IMMUNOLOGICAL ADJUVANT; MEMBRANE PROTEIN; SECRETORY IMMUNOGLOBULIN;

EID: 77956418082     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1000831     Document Type: Article
Times cited : (79)

References (48)
  • 1
    • 0030756394 scopus 로고    scopus 로고
    • Natural polyreactive secretory immunoglobulin A autoantibodies as a possible barrier to infection in humans
    • Quan, C. P., A. Berneman, R. Pires, S. Avrameas, and J. P. Bouvet. 1997. Natural polyreactive secretory immunoglobulin A autoantibodies as a possible barrier to infection in humans. Infect. Immun. 65: 3997-4004.
    • (1997) Infect. Immun. , vol.65 , pp. 3997-4004
    • Quan, C.P.1    Berneman, A.2    Pires, R.3    Avrameas, S.4    Bouvet, J.P.5
  • 2
    • 0032533818 scopus 로고    scopus 로고
    • Secretory component delays the conversion of secretory IgA into antigen-binding competent F(ab9)2: A possible implication for mucosal defense
    • Crottet, P., and B. Corthésy. 1998. Secretory component delays the conversion of secretory IgA into antigen-binding competent F(ab9)2: a possible implication for mucosal defense. J. Immunol. 161: 5445-5453.
    • (1998) J. Immunol. , vol.161 , pp. 5445-5453
    • Crottet, P.1    Corthésy, B.2
  • 3
    • 84882860611 scopus 로고    scopus 로고
    • Biological activities of IgA
    • 3rd ed. J. Mestecky, M. E. Lamm, W. Strober, J. Bienenstock, J. R. McGhee, and L. Mayer, eds. Elsevier Academic Press, Amsterdam, The Netherlands
    • Russell, M. W., and M. Kilian. 2005. Biological activities of IgA. In Mucosal Immunology, 3rd ed. J. Mestecky, M. E. Lamm, W. Strober, J. Bienenstock, J. R. McGhee, and L. Mayer, eds. Elsevier Academic Press, Amsterdam, The Netherlands, p. 267-289.
    • (2005) Mucosal Immunology , pp. 267-289
    • Russell, M.W.1    Kilian, M.2
  • 4
    • 0029863522 scopus 로고    scopus 로고
    • B-1 cells and their reactivity with the murine intestinal microflora
    • Kroese, F. G., R. de Waard, and N. A. Bos. 1996. B-1 cells and their reactivity with the murine intestinal microflora. Semin. Immunol. 8: 11-18.
    • (1996) Semin. Immunol. , vol.8 , pp. 11-18
    • Kroese, F.G.1    De Waard, R.2    Bos, N.A.3
  • 5
    • 0029155360 scopus 로고
    • Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut
    • Shroff, K. E., K. Meslin, and J. J. Cebra. 1995. Commensal enteric bacteria engender a self-limiting humoral mucosal immune response while permanently colonizing the gut. Infect. Immun. 63: 3904-3913.
    • (1995) Infect. Immun. , vol.63 , pp. 3904-3913
    • Shroff, K.E.1    Meslin, K.2    Cebra, J.J.3
  • 6
    • 0031940494 scopus 로고    scopus 로고
    • In vitro comparison of the biologic activities of monoclonal monomeric IgA, polymeric IgA, and secretory IgA
    • Renegar, K. B., G. D. Jackson, and J. Mestecky. 1998. In vitro comparison of the biologic activities of monoclonal monomeric IgA, polymeric IgA, and secretory IgA. J. Immunol. 160: 1219-1223.
    • (1998) J. Immunol. , vol.160 , pp. 1219-1223
    • Renegar, K.B.1    Jackson, G.D.2    Mestecky, J.3
  • 7
    • 0019256014 scopus 로고
    • Epidemiologic studies of Streptococcus pneumoniae in infants: Acquisition, carriage, and infection during the first 24 months of life
    • Gray, B. M., G. M. Converse, 3rd, and H. C. Dillon, Jr. 1980. Epidemiologic studies of Streptococcus pneumoniae in infants: acquisition, carriage, and infection during the first 24 months of life. J. Infect. Dis. 142: 923-933.
    • (1980) J. Infect. Dis. , vol.142 , pp. 923-933
    • Gray, B.M.1    Converse III, G.M.2    Dillon Jr., H.C.3
  • 8
    • 0034063425 scopus 로고    scopus 로고
    • Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children
    • Northern California Kaiser Permanente Vaccine Study Center Group
    • Black, S., H. Shinefield, B. Fireman, E. Lewis, P. Ray, J. R. Hansen, L. Elvin, K. M. Ensor, J. Hackell, G. Siber, et al; Northern California Kaiser Permanente Vaccine Study Center Group. 2000. Efficacy, safety and immunogenicity of heptavalent pneumococcal conjugate vaccine in children. Pediatr. Infect. Dis. J. 19: 187-195.
    • (2000) Pediatr. Infect. Dis. J. , vol.19 , pp. 187-195
    • Black, S.1    Shinefield, H.2    Fireman, B.3    Lewis, E.4    Ray, P.5    Hansen, J.R.6    Elvin, L.7    Ensor, K.M.8    Hackell, J.9    Siber, G.10
  • 9
    • 0242684416 scopus 로고    scopus 로고
    • Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine
    • Active Bacterial Core Surveillance of the Emerging Infections Program Network
    • Whitney, C. G., M. M. Farley, J. Hadler, L. H. Harrison, N. M. Bennett, R. Lynfield, A. Reingold, P. R. Cieslak, T. Pilishvili, D. Jackson, et al; Active Bacterial Core Surveillance of the Emerging Infections Program Network. 2003. Decline in invasive pneumococcal disease after the introduction of protein-polysaccharide conjugate vaccine. N. Engl. J. Med. 348: 1737-1746.
    • (2003) N. Engl. J. Med. , vol.348 , pp. 1737-1746
    • Whitney, C.G.1    Farley, M.M.2    Hadler, J.3    Harrison, L.H.4    Bennett, N.M.5    Lynfield, R.6    Reingold, A.7    Cieslak, P.R.8    Pilishvili, T.9    Jackson, D.10
  • 11
    • 34247498668 scopus 로고    scopus 로고
    • Invasive pneumococcal disease caused by nonvaccine serotypes among alaska native children with high levels of 7-valent pneumococcal conjugate vaccine coverage
    • Singleton, R. J., T. W. Hennessy, L. R. Bulkow, L. L. Hammitt, T. Zulz, D. A. Hurlburt, J. C. Butler, K. Rudolph, and A. Parkinson. 2007. Invasive pneumococcal disease caused by nonvaccine serotypes among alaska native children with high levels of 7-valent pneumococcal conjugate vaccine coverage. JAMA 297: 1784-1792.
    • (2007) JAMA , vol.297 , pp. 1784-1792
    • Singleton, R.J.1    Hennessy, T.W.2    Bulkow, L.R.3    Hammitt, L.L.4    Zulz, T.5    Hurlburt, D.A.6    Butler, J.C.7    Rudolph, K.8    Parkinson, A.9
  • 12
    • 0034773167 scopus 로고    scopus 로고
    • Intranasal vaccination with pneumococcal surface protein A and interleukin-12 augments antibody-mediated opsonization and protective immunity against Streptococcus pneumoniae infection
    • Arulanandam, B. P., J. M. Lynch, D. E. Briles, S. K. Hollingshead, and D. W. Metzger. 2001. Intranasal vaccination with pneumococcal surface protein A and interleukin-12 augments antibody-mediated opsonization and protective immunity against Streptococcus pneumoniae infection. Infect. Immun. 69: 6718-6724.
    • (2001) Infect. Immun. , vol.69 , pp. 6718-6724
    • Arulanandam, B.P.1    Lynch, J.M.2    Briles, D.E.3    Hollingshead, S.K.4    Metzger, D.W.5
  • 13
    • 0042665483 scopus 로고    scopus 로고
    • Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae
    • Briles, D. E., S. K. Hollingshead, J. C. Paton, E. W. Ades, L. Novak, F. W. van Ginkel, and W. H. Benjamin, Jr. 2003. Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae. J. Infect. Dis. 188: 339-348.
    • (2003) J. Infect. Dis. , vol.188 , pp. 339-348
    • Briles, D.E.1    Hollingshead, S.K.2    Paton, J.C.3    Ades, E.W.4    Novak, L.5    Van Ginkel, F.W.6    Benjamin Jr., W.H.7
  • 14
    • 33845980590 scopus 로고    scopus 로고
    • Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae
    • Ogunniyi, A. D., M. Grabowicz, D. E. Briles, J. Cook, and J. C. Paton. 2007. Development of a vaccine against invasive pneumococcal disease based on combinations of virulence proteins of Streptococcus pneumoniae. Infect. Immun. 75: 350-357.
    • (2007) Infect. Immun. , vol.75 , pp. 350-357
    • Ogunniyi, A.D.1    Grabowicz, M.2    Briles, D.E.3    Cook, J.4    Paton, J.C.5
  • 15
    • 0033680686 scopus 로고    scopus 로고
    • Immunization of humans with recombinant pneumococcal surface protein A (rPspA) elicits antibodies that passively protect mice from fatal infection with Streptococcus pneumoniae bearing heterologous PspA
    • Briles, D. E., S. K. Hollingshead, J. King, A. Swift, P. A. Braun, M. K. Park, L. M. Ferguson, M. H. Nahm, and G. S. Nabors. 2000. Immunization of humans with recombinant pneumococcal surface protein A (rPspA) elicits antibodies that passively protect mice from fatal infection with Streptococcus pneumoniae bearing heterologous PspA. J. Infect. Dis. 182: 1694-1701.
    • (2000) J. Infect. Dis. , vol.182 , pp. 1694-1701
    • Briles, D.E.1    Hollingshead, S.K.2    King, J.3    Swift, A.4    Braun, P.A.5    Park, M.K.6    Ferguson, L.M.7    Nahm, M.H.8    Nabors, G.S.9
  • 16
    • 0030934988 scopus 로고    scopus 로고
    • Intranasal immunization of mice with PspA (pneumococcal surface protein A) can prevent intranasal carriage, pulmonary infection, and sepsis with Streptococcus pneumoniae
    • Wu, H. Y., M. H. Nahm, Y. Guo, M. W. Russell, and D. E. Briles. 1997. Intranasal immunization of mice with PspA (pneumococcal surface protein A) can prevent intranasal carriage, pulmonary infection, and sepsis with Streptococcus pneumoniae. J. Infect. Dis. 175: 839-846.
    • (1997) J. Infect. Dis. , vol.175 , pp. 839-846
    • Wu, H.Y.1    Nahm, M.H.2    Guo, Y.3    Russell, M.W.4    Briles, D.E.5
  • 17
  • 18
    • 0031867253 scopus 로고    scopus 로고
    • Differential kinetics and distribution of antibodies in serum and nasal and vaginal secretions after nasal and oral vaccination of humans
    • Rudin, A., E. L. Johansson, C. Bergquist, and J. Holmgren. 1998. Differential kinetics and distribution of antibodies in serum and nasal and vaginal secretions after nasal and oral vaccination of humans. Infect. Immun. 66: 3390-3396.
    • (1998) Infect. Immun. , vol.66 , pp. 3390-3396
    • Rudin, A.1    Johansson, E.L.2    Bergquist, C.3    Holmgren, J.4
  • 19
    • 0033023394 scopus 로고    scopus 로고
    • Antibody responses in the lower respiratory tract and male urogenital tract in humans after nasal and oral vaccination with cholera toxin B subunit
    • Rudin, A., G. C. Riise, and J. Holmgren. 1999. Antibody responses in the lower respiratory tract and male urogenital tract in humans after nasal and oral vaccination with cholera toxin B subunit. Infect. Immun. 67: 2884-2890.
    • (1999) Infect. Immun. , vol.67 , pp. 2884-2890
    • Rudin, A.1    Riise, G.C.2    Holmgren, J.3
  • 20
    • 17644371966 scopus 로고    scopus 로고
    • Mucosal immunity and vaccines
    • Holmgren, J., and C. Czerkinsky. 2005. Mucosal immunity and vaccines. Nat. Med. 11(4 Suppl): S45-S53.
    • (2005) Nat. Med. , vol.11 , Issue.4 SUPPL.
    • Holmgren, J.1    Czerkinsky, C.2
  • 22
    • 0033984377 scopus 로고    scopus 로고
    • Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae
    • Briles, D. E., E. Ades, J. C. Paton, J. S. Sampson, G. M. Carlone, R. C. Huebner, A. Virolainen, E. Swiatlo, and S. K. Hollingshead. 2000. Intranasal immunization of mice with a mixture of the pneumococcal proteins PsaA and PspA is highly protective against nasopharyngeal carriage of Streptococcus pneumoniae. Infect. Immun. 68: 796-800.
    • (2000) Infect. Immun. , vol.68 , pp. 796-800
    • Briles, D.E.1    Ades, E.2    Paton, J.C.3    Sampson, J.S.4    Carlone, G.M.5    Huebner, R.C.6    Virolainen, A.7    Swiatlo, E.8    Hollingshead, S.K.9
  • 23
    • 0033104726 scopus 로고    scopus 로고
    • Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other Ig isotypes
    • Harriman, G. R., M. Bogue, P. Rogers, M. Finegold, S. Pacheco, A. Bradley, Y. Zhang, and I. N. Mbawuike. 1999. Targeted deletion of the IgA constant region in mice leads to IgA deficiency with alterations in expression of other Ig isotypes. J. Immunol. 162: 2521-2529.
    • (1999) J. Immunol. , vol.162 , pp. 2521-2529
    • Harriman, G.R.1    Bogue, M.2    Rogers, P.3    Finegold, M.4    Pacheco, S.5    Bradley, A.6    Zhang, Y.7    Mbawuike, I.N.8
  • 24
    • 0030030669 scopus 로고    scopus 로고
    • IgA class switch in I alpha exon-deficient mice. Role of germline transcription in class switch recombination
    • Harriman, G. R., A. Bradley, S. Das, P. Rogers-Fani, and A. C. Davis. 1996. IgA class switch in I alpha exon-deficient mice. Role of germline transcription in class switch recombination. J. Clin. Invest. 97: 477-485.
    • (1996) J. Clin. Invest. , vol.97 , pp. 477-485
    • Harriman, G.R.1    Bradley, A.2    Das, S.3    Rogers-Fani, P.4    Davis, A.C.5
  • 25
    • 0028603597 scopus 로고
    • Localization of protection-eliciting epitopes on PspA of Streptococcus pneumoniae between amino acid residues 192 and 260
    • McDaniel, L. S., B. A. Ralph, D. O. McDaniel, and D. E. Briles. 1994. Localization of protection-eliciting epitopes on PspA of Streptococcus pneumoniae between amino acid residues 192 and 260. Microb. Pathog. 17: 323-337.
    • (1994) Microb. Pathog. , vol.17 , pp. 323-337
    • McDaniel, L.S.1    Ralph, B.A.2    McDaniel, D.O.3    Briles, D.E.4
  • 26
    • 0026501145 scopus 로고
    • Structural properties and evolutionary relationships of PspA, a surface protein of Streptococcus pneumoniae, as revealed by sequence analysis
    • Yother, J., and D. E. Briles. 1992. Structural properties and evolutionary relationships of PspA, a surface protein of Streptococcus pneumoniae, as revealed by sequence analysis. J. Bacteriol. 174: 601-609.
    • (1992) J. Bacteriol. , vol.174 , pp. 601-609
    • Yother, J.1    Briles, D.E.2
  • 32
    • 49749137544 scopus 로고    scopus 로고
    • A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migration
    • Sekine, S., K. Kataoka, Y. Fukuyama, Y. Adachi, J. Davydova, M. Yamamoto, R. Kobayashi, K. Fujihashi, H. Suzuki, D. T. Curiel, et al. 2008. A novel adenovirus expressing Flt3 ligand enhances mucosal immunity by inducing mature nasopharyngeal-associated lymphoreticular tissue dendritic cell migration. J. Immunol. 180: 8126-8134.
    • (2008) J. Immunol. , vol.180 , pp. 8126-8134
    • Sekine, S.1    Kataoka, K.2    Fukuyama, Y.3    Adachi, Y.4    Davydova, J.5    Yamamoto, M.6    Kobayashi, R.7    Fujihashi, K.8    Suzuki, H.9    Curiel, D.T.10
  • 33
    • 0026542944 scopus 로고
    • Strong association between capsular type and virulence for mice among human isolates of Streptococcus pneumoniae
    • Briles, D. E., M. J. Crain, B. M. Gray, C. Forman, and J. Yother. 1992. Strong association between capsular type and virulence for mice among human isolates of Streptococcus pneumoniae. Infect. Immun. 60: 111-116.
    • (1992) Infect. Immun. , vol.60 , pp. 111-116
    • Briles, D.E.1    Crain, M.J.2    Gray, B.M.3    Forman, C.4    Yother, J.5
  • 35
    • 68449085481 scopus 로고    scopus 로고
    • Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice
    • Zhang, Z., T. B. Clarke, and J. N. Weiser. 2009. Cellular effectors mediating Th17-dependent clearance of pneumococcal colonization in mice. J. Clin. Invest. 119: 1899-1909.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1899-1909
    • Zhang, Z.1    Clarke, T.B.2    Weiser, J.N.3
  • 36
    • 73349104954 scopus 로고    scopus 로고
    • Intranasal immunization promotes th17 immune responses
    • Zygmunt, B. M., F. Rharbaoui, L. Groebe, and C. A. Guzman. 2009. Intranasal immunization promotes th17 immune responses. J. Immunol. 183: 6933-6938.
    • (2009) J. Immunol. , vol.183 , pp. 6933-6938
    • Zygmunt, B.M.1    Rharbaoui, F.2    Groebe, L.3    Guzman, C.A.4
  • 37
    • 0032720303 scopus 로고    scopus 로고
    • Killing of Streptococcus pneumoniae by capsular polysaccharide- specific polymeric IgA, complement, and phagocytes
    • Janoff, E. N., C. Fasching, J. M. Orenstein, J. B. Rubins, N. L. Opstad, and A. P. Dalmasso. 1999. Killing of Streptococcus pneumoniae by capsular polysaccharide- specific polymeric IgA, complement, and phagocytes. J. Clin. Invest. 104: 1139-1147.
    • (1999) J. Clin. Invest. , vol.104 , pp. 1139-1147
    • Janoff, E.N.1    Fasching, C.2    Orenstein, J.M.3    Rubins, J.B.4    Opstad, N.L.5    Dalmasso, A.P.6
  • 38
    • 66849111904 scopus 로고    scopus 로고
    • Characterization of protective mucosal and systemic immune responses elicited by pneumococcal surface protein PspA and PspC nasal vaccines against a respiratory pneumococcal challenge in mice
    • Ferreira, D. M., M. Darrieux, D. A. Silva, L. C. Leite, J. M. Ferreira, Jr., P. L. Ho, E. N. Miyaji, and M. L. Oliveira. 2009. Characterization of protective mucosal and systemic immune responses elicited by pneumococcal surface protein PspA and PspC nasal vaccines against a respiratory pneumococcal challenge in mice. Clin. Vaccine Immunol. 16: 636-645.
    • (2009) Clin. Vaccine Immunol. , vol.16 , pp. 636-645
    • Ferreira, D.M.1    Darrieux, M.2    Silva, D.A.3    Leite, L.C.4    Ferreira Jr., J.M.5    Ho, P.L.6    Miyaji, E.N.7    Oliveira, M.L.8
  • 39
    • 58749105673 scopus 로고    scopus 로고
    • MyD88 signaling is not essential for induction of antigen-specific B cell responses but is indispensable for protection against Streptococcus pneumoniae infection following oral vaccination with attenuated Salmonella expressing PspA antigen
    • Park, S. M., H. J. Ko, D. H. Shim, J. Y. Yang, Y. H. Park, R. Curtiss, 3rd, and M. N. Kweon. 2008. MyD88 signaling is not essential for induction of antigen-specific B cell responses but is indispensable for protection against Streptococcus pneumoniae infection following oral vaccination with attenuated Salmonella expressing PspA antigen. J. Immunol. 181: 6447-6455.
    • (2008) J. Immunol. , vol.181 , pp. 6447-6455
    • Park, S.M.1    Ko, H.J.2    Shim, D.H.3    Yang, J.Y.4    Park, Y.H.5    Curtiss III, R.6    Kweon, M.N.7
  • 40
    • 4644242435 scopus 로고    scopus 로고
    • An important role for polymeric Ig receptor-mediated transport of IgA in protection against Streptococcus pneumoniae nasopharyngeal carriage
    • Sun, K., F. E. Johansen, L. Eckmann, and D. W. Metzger. 2004. An important role for polymeric Ig receptor-mediated transport of IgA in protection against Streptococcus pneumoniae nasopharyngeal carriage. J. Immunol. 173: 4576-4581.
    • (2004) J. Immunol. , vol.173 , pp. 4576-4581
    • Sun, K.1    Johansen, F.E.2    Eckmann, L.3    Metzger, D.W.4
  • 41
    • 42049088120 scopus 로고    scopus 로고
    • Optimized immune response elicited by a DNA vaccine expressing pneumococcal surface protein a is characterized by a balanced immunoglobulin G1 (IgG1)/IgG2a ratio and proinflammatory cytokine production
    • Ferreira, D. M., M. Darrieux, M. L. Oliveira, L. C. Leite, and E. N. Miyaji. 2008. Optimized immune response elicited by a DNA vaccine expressing pneumococcal surface protein a is characterized by a balanced immunoglobulin G1 (IgG1)/IgG2a ratio and proinflammatory cytokine production. Clin. Vaccine Immunol. 15: 499-505.
    • (2008) Clin. Vaccine Immunol. , vol.15 , pp. 499-505
    • Ferreira, D.M.1    Darrieux, M.2    Oliveira, M.L.3    Leite, L.C.4    Miyaji, E.N.5
  • 42
    • 33846141477 scopus 로고    scopus 로고
    • Mucosal delivery of a pneumococcal vaccine using Lactococcus lactis affords protection against respiratory infection
    • Hanniffy, S. B., A. T. Carter, E. Hitchin, and J. M. Wells. 2007. Mucosal delivery of a pneumococcal vaccine using Lactococcus lactis affords protection against respiratory infection. J. Infect. Dis. 195: 185-193.
    • (2007) J. Infect. Dis. , vol.195 , pp. 185-193
    • Hanniffy, S.B.1    Carter, A.T.2    Hitchin, E.3    Wells, J.M.4
  • 43
    • 67349273778 scopus 로고    scopus 로고
    • Intranasal immunization with a mixture of PspA and a Toll-like receptor agonist induces specific antibodies and enhances bacterial clearance in the airways of mice
    • Oma, K., J. Zhao, H. Ezoe, Y. Akeda, S. Koyama, K. J. Ishii, K. Kataoka, and K. Oishi. 2009. Intranasal immunization with a mixture of PspA and a Toll-like receptor agonist induces specific antibodies and enhances bacterial clearance in the airways of mice. Vaccine 27: 3181-3188.
    • (2009) Vaccine , vol.27 , pp. 3181-3188
    • Oma, K.1    Zhao, J.2    Ezoe, H.3    Akeda, Y.4    Koyama, S.5    Ishii, K.J.6    Kataoka, K.7    Oishi, K.8
  • 44
    • 0033037090 scopus 로고    scopus 로고
    • Treatment of community-acquired pneumonia - IDSA guidelines
    • Infectious Diseases Society of America
    • Bernstein, J. M.; Infectious Diseases Society of America. 1999. Treatment of community-acquired pneumonia - IDSA guidelines. Chest 115(3 Suppl): 9S-13S.
    • (1999) Chest , vol.115 , Issue.3 SUPPL.
    • Bernstein, J.M.1
  • 46
    • 0033954496 scopus 로고    scopus 로고
    • Immunity to influenza in the elderly
    • Webster, R. G. 2000. Immunity to influenza in the elderly. Vaccine 18: 1686-1689.
    • (2000) Vaccine , vol.18 , pp. 1686-1689
    • Webster, R.G.1
  • 47
    • 0030983708 scopus 로고    scopus 로고
    • Mortality by cause for eight regions of the world: Global Burden of Disease Study
    • Murray, C. J., and A. D. Lopez. 1997. Mortality by cause for eight regions of the world: Global Burden of Disease Study. Lancet 349: 1269-1276.
    • (1997) Lancet , vol.349 , pp. 1269-1276
    • Murray, C.J.1    Lopez, A.D.2


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