Dose-dependent alterations in gene expression in mouse liver induced by diethylnitrosamine and ethylnitrosourea and determined by quantitative real-time PCR

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 673, Issue 1, 2009, Pages 9-20

  Watanabe, Takashi ^a   Tanaka, Gotaro ^b   Hamada, Shuichi ^c   Namiki, Chiaki ^d   Suzuki, Takayoshi ^e   Nakajima, Madoka ^f   Furihata, Chie ^a  

^a AOYAMA GAKUIN UNIVERSITY   (Japan)

^b TAIHO PHARMACEUTICAL CO LTD   (Japan)

^c Genetic Toxicology Group   (Japan)

^d SSP CO LTD   (Japan)

^e NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^f Biosafety Research Center   (Japan)

Author keywords

Dose dependent alteration; Genotoxic carcinogens; Hierarchical clustering; IPA; k means clustering

Indexed keywords

COMPLEMENTARY DNA; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYTOCHROME P450 4A; DIETHYLNITROSAMINE; ETHYLNITROSOUREA; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 45; GROWTH DIFFERENTIATION FACTOR 15; HEAT SHOCK PROTEIN; METHYL CPG BINDING PROTEIN; MYC PROTEIN; POLO LIKE KINASE; PROTEIN BAX; PROTEIN FOS; PROTEIN MDM2;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CYCLE ARREST; CELL DEATH; CHEMICAL CARCINOGENESIS; DNA RECOMBINATION; DNA REPAIR; DNA REPLICATION; GENE EXPRESSION; GENE ISOLATION; GENE MUTATION; GENETIC ASSOCIATION; GENOTOXICITY; INDUCED MUTATION; LIVER CARCINOGENESIS; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION; RNA ISOLATION; TISSUE SECTION;

ALGORITHMS; ANIMALS; CARCINOGENS; DIETHYLNITROSAMINE; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLNITROSOUREA; GENE EXPRESSION REGULATION; LIVER; MALE; MICE; POLYMERASE CHAIN REACTION;

MUS;

EID: 58749108439     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2008.11.004     Document Type: Article

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