Analysis of gene expression in different stages of MeIQx-induced rat hepatocarcinogenesis

Oncology Reports

Volumn 17, Issue 4, 2007, Pages 747-752

  Kang, Jin Seok ^a   Wanibuchi, Hideki ^a   Murai, Takashi ^a   Morimura, Keiichirou ^a   Kinoshita, Anna ^a   Fukushima, Shoji ^a,b  

^a OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Japan Bioassay Research Center   (Japan)

Author keywords

HCA; HCC; Liver; MeIQx; Microarray; Rat

Indexed keywords

2 AMINO 3,8 DIMETHYLIMIDAZO(4,5 F)QUINOXALINE; 2-AMINO-3,8-DIMETHYLIMIDAZO(4,5-F)QUINOXALINE; CARCINOGEN; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL; ARTICLE; CELL TRANSFORMATION; CHEMICALLY INDUCED DISORDER; DNA MICROARRAY; DRUG EFFECT; FISCHER 344 RAT; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETICS; LIVER; LIVER TUMOR; RAT;

ANIMALS; CARCINOGENS; CELL TRANSFORMATION, NEOPLASTIC; GENE EXPRESSION; GENE EXPRESSION PROFILING; LIVER; LIVER NEOPLASMS, EXPERIMENTAL; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; QUINOXALINES; RATS; RATS, INBRED F344;

EID: 34249948748     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.17.4.747     Document Type: Article

References (29)

1. Sugimura T: Studies on environmental chemical carcinogenesis in Japan. Science 233: 312-318, 1986.
2. Sugimura T, Wakabayashi K, Nakagama H and Nagao M: Heterocyclic amines: mutagens/carcinogens produced during cooking of meat and fish. Cancer Sci 95: 290-299, 2004. (Pubitemid 38519467)
3. Nagao M, Ushijima T, Toyota M, Inoue R and Sugimura T: Genetic changes induced by heterocyclic amines. Mutat Res 376: 161-167, 1997. (Pubitemid 27248599)
4. Nagao M: A new approach to risk estimation of food-borne carcinogen - heterocyclic amines - based on molecular information. Mutat Res 431: 3-12, 1999.
5. Rich KJ, Murray BP, Lewis I, Rendell NB, Davies DS, Gooderham NJ and Boobis AR: N-hydroxy-MeIQx is the major microsomal oxidation product of the dietary carcinogen MeIQx with human liver. Carcinogenesis 13: 2221-2226, 1992. (Pubitemid 23022960)
6. Turesky RJ, Lang NP, Butler MA, Teitel CH and Kadlubar FF: Metabolic activation of carcinogenic heterocyclic aromatic amines by human liver and colon. Carcinogenesis 12: 1839-1845, 1991.
7. Kato T, Ohgaki H, Hasegawa H, Sato S, Takayama S and Sugimura T: Carcinogenicity in rats of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4, 5-f]quinoxaline. Carcinogenesis 9: 71-73, 1988. (Pubitemid 18023160)
8. Kushida H, Wakabayashi K, Sato H, Katami M, Kurosaka R and Nagao M: Dose-response study of MeIQx carcinogenicity in F344 male rats. Cancer Lett 83: 31-35, 1994. (Pubitemid 24253514)
9. Ohgaki H, Hasegawa H, Suenaga M, Sato S, Takayama S and Sugimura T: Carcinogenicity in mice of a mutagenic compound, 2-amino-3,8-dimethylimidazo[4, 5-f ]quinoxaline (MeIQx) from cooked foods. Carcinogenesis 8: 665-668, 1987. (Pubitemid 17127900)
10. Butte A: The use and analysis of microarray data. Nat Rev Drug Discov 1: 951-960, 2002.
11. Clarke PA, te Poele R and Workman P: Gene expression microarray technologies in the development of new therapeutic agents. Eur J Cancer 40: 2560-2591, 2004. (Pubitemid 39487080)
12. Delpuech O, Trabut JB, Carnot F, Feuillard J, Brechot C and Kremsdorf D: Identification, using cDNA macroarray analysis, of distinct gene expression profiles associated with pathological and virological features of hepatocellular carcinoma. Oncogene 21: 2926-2937, 2002. (Pubitemid 34499393)
13. Chuma M, Sakamoto M, Yamazaki K, Ohta T, Ohki M, Asaka M and Hirohashi S: Expression profiling in multistage hepatocarcinogenesis: identification of HSP70 as a molecular marker of early hepatocellular carcinoma. Hepatology 37: 198-207, 2003. (Pubitemid 36042161)
14. Nishida K, Mine S, Utsunomiya T, Inoue H, Okamoto M, Udagawa H, Hanai T and Mori M: Global analysis of altered gene expressions during the process of esophageal squamous cell carcinogenesis in the rat: a study combined with a laser microdissection and a cDNA microarray. Cancer Res 65: 401-409, 2005.
15. Suzuki S, Asamoto M, Tsujimura K and Shirai T: Specific differences in gene expression profile revealed by cDNA microarray analysis of glutathione S-transferase placental form (GST-P) immunohistochemically positive rat liver foci and surrounding tissue. Carcinogenesis 25: 439-443, 2004. (Pubitemid 38344412)
16. Sukata T, Uwagawa S, Ozaki K, Sumida K, Kikuchi K, Kushida M, Saito K, Morimura K, Oeda K, Okuno Y, Mikami N and Fukushima S: alpha(2)-Macroglobulin: a novel cytochemical marker characterizing preneoplastic and neoplastic rat liver lesions negative for hitherto established cytochemical markers. Am J Pathol 165: 1479-1488, 2004. (Pubitemid 39435148)
17. Kasamatsu A, Endo Y, Uzawa K, Nakashima D, Koike H, Hashitani S, Numata T, Urade M and Tanzawa H: Identification of candidate genes associated with salivary adenoid cystic carcinomas using combined comparative genomic hybridization and oligonucleotide microarray analyses. Int J Biochem Cell Biol 37: 1869-1880, 2005. (Pubitemid 40961671)
18. Cariello NF, Romach EH, Colton HM, Ni H, Yoon L, Falls JG, Casey W, Creech D, Anderson SP, Benavides GR, Hoivik DJ, Brown R and Miller RT: Gene expression profiling of the PPAR-alpha agonist ciprofibrate in the cynomolgus monkey liver. Toxicol Sci 88: 250-264, 2005. (Pubitemid 41548767)
19. Greenbaum LE: Cell cycle regulation and hepatocarcinogenesis. Cancer Biol Ther 3: 1200-1207, 2004.
20. Tannapfel A and Wittekind C: Genes involved in hepatocellular carcinoma: deregulation in cell cycling and apoptosis. Virchows Arch 440: 345-352, 2002. (Pubitemid 34328064)
21. Balendiran GK, Dabur R and Fraser D: The role of glutathione in cancer. Cell Biochem Funct 22: 343-352, 2004. (Pubitemid 39518098)
22. Ketterer B: Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis. Mutat Res 202: 343-361, 1988.
23. Stalker MJ, Kocal TE, Quinn BA, Gordon SG and Hayes MA: Reduced expression of glutathione S-transferase Yb2 during progression of chemically induced hepatocellular carcinomas in Fischer 344 rats. Hepatology 20: 149-158, 1994. (Pubitemid 24196504)
24. Fukushima S: Low-dose carcinogenicity of a heterocyclic amine, 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline: relevance to risk assessment. Cancer Lett 143: 157-159, 1999.
25. Fukushima S, Wanibuchi H, Morimura K, Wei M, Nakae D, Konishi Y, Tsuda H, Uehara N, Imaida K, Shirai T, Tatematsu M, Tsukamoto T, Hirose M, Furukawa F, Wakabayashi K and Totsuka Y: Lack of a dose-response relationship for carcinogenicity in the rat liver with low doses of 2-amino-3,8- dimethylimidazo[4,5-f]quinoxaline or N -nitrosodiethylamine. Jpn J Cancer Res 93: 1076-1082, 2002. (Pubitemid 35314951)
26. Hokaiwado N, Asamoto M, Tsujimura K, Hirota T, Ichihara T, Satoh T and Shirai T: Rapid analysis of gene expression changes caused by liver carcinogens and chemopreventive agents using a newly developed three-dimensional microarray system. Cancer Sci 95: 123-130, 2004. (Pubitemid 38404312)
27. Ellinger-Ziegelbauer H, Stuart B, Wahle B, Bomann W and Ahr HJ: Characteristic expression profiles induced by genotoxic carcinogens in rat liver. Toxicol Sci 77: 19-34, 2004. (Pubitemid 38128642)
28. Bulera SJ, Eddy SM, Ferguson E, Jatkoe TA, Reindel JF, Bleavins MR and De La Iglesia FA: RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays. Hepatology 33: 1239-1258, 2001. (Pubitemid 32378225)
29. Michel C, Desdouets C, Sacre-Salem B, Gautier JC, Roberts R and Boitier E: Liver gene expression profiles of rats treated with clofibric acid: comparison of whole liver and laser capture microdissected liver. Am J Pathol 163: 2191-2199, 2003. (Pubitemid 37466464)