Induction of LacZ mutations in Muta™Mouse can distinguish carcinogenic from non-carcinogenic analogues of diaminotoluenes and nitronaphthalenes

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 608, Issue 1, 2006, Pages 88-96

  Kirkland, David ^a   Beevers, Carol ^a  

^a UK   (United Kingdom)

Author keywords

Carcinogenic mutagens; CAS 581 89 5; CAS 823 40 5; CAS 86 57 7; CAS 95 80 7; LacZ mutations; Muta Mouse; Non carcinogenic mutagens; Transgenic mice

Indexed keywords

1 NITRONAPHTHALENE; 2 NITRONAPHTHALENE; 2,4 DIAMINOTOLUENE; 2,6 DIAMINOTOLUENE; BETA GALACTOSIDASE; CARCINOGEN; LIVER ENZYME; NAPHTHALENE DERIVATIVE; TOLUENE DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLADDER TUMOR; CARCINOGENESIS; CARCINOGENIC ACTIVITY; CARCINOGENICITY; CONTROLLED STUDY; DNA DAMAGE; DNA SYNTHESIS; ENZYME ACTIVATION; GENE INDUCTION; GENE MUTATION; GENOTOXICITY; LIVER TUMOR; MALE; METABOLIC ACTIVATION; MOUSE; NONHUMAN; OCCUPATIONAL EXPOSURE; PRIORITY JOURNAL;

ANIMALS; CARCINOGENICITY TESTS; CARCINOGENS; KIDNEY; LAC OPERON; LIVER; MALE; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; MUTAGENS; MUTATION; NAPHTHALENES; PHENYLENEDIAMINES; SKIN; URINARY BLADDER;

MUS MUSCULUS;

EID: 33747781714     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2006.05.004     Document Type: Article

References (44)

1. Gold L.S. The Carcinogenic Potency Project (2004). http://www.potency.berkeley.edu/cpdb.html
2. Ashby J., and Tennant R.W. Definitive relationships among chemical structure, carcinogenicity and mutagenicity for 301 chemicals tested by the US NTP. Mutat. Res. 257 (1991) 229-306
3. Greene E.J., Friedman M.A., and Sherrod J.A. In vitro mutagenicity and cell transformation testing of four toluene diamine isomers. Environ. Mutagen. 1 (1979) 194
4. Haworth S., Lawlor T., Mortelmans K., Speck W., and Zeiger E. Salmonella mutagenicity test results for 250 chemicals. Environ. Mutagen. Suppl. 1 (1983) 3-142
5. Furlong B.B., Weaver R.P., and Goldstein J.A. Covalent binding to DNA and mutagenicity of 2,4-diaminotoluene metabolites produced by isolated hepatocytes and 9000 × g supernatant from Fischer 344 rats. Carcinogenesis 8 (1987) 247-251
6. Zeiger E., Anderson B., Haworth S., Lawlor T., and Mortelmans K. Salmonella mutagenicity tests. IV. Results from the testing of 300 chemicals. Environ. Mol. Mutagen. 11 Suppl. 2 (1988) 1-158
7. Bermudez E., Tillery D., and Butterworth B.E. The effect of 2,4-diaminotoluene and isomers of diaminotoluene on unscheduled DNA synthesis in primary rat hepatocytes. Environ. Mutagen. 1 (1979) 391-398
8. Butterworth B.E., Earle L.L., Strom S., Jirtle R., and Michalopoulos G. Measurement of chemically induced DNA repair in human hepatocytes. Proc. Am. Assoc. Cancer Res. 24 (1983) 69
9. Fassina G., Abbondandolo A., and Parodi S. Mutation induction by aromatic amines in V79 Chinese hamster cells. Mutat. Res. 147 (1985) 292-293
10. Coppinger W.J., Brennan S.A., Carver J.H., and Thompson E.D. Locus specificity of mutagenicity of 2,4-diaminotoluene in both L5178Y mouse lymphoma and AT3-2 Chinese hamster ovary cells. Mutat. Res. 135 (1984) 115-123
11. Séverin I., Jondeau A., Dahbi L., and Chagnon M.-C. 2,4-Diaminotoluene (2,4-DAT)-induced DNA damage, DNA repair and micronucleus formation in the human hepatoma cell line HepG2. Toxicology 213 (2005) 138-146
12. Gulati D.K., Witt K., Anderson B., Zeiger E., and Shelby M.D. Chromosome aberration and sister chromatid exchange tests in Chinese hamster ovary cells in vitro. III. Results with 27 chemicals. Environ. Mol. Mutagen. 13 (1989) 133-193
13. Sofuni T., Matsuoka A., Sawada M., Ishidate Jr. M., Zeiger E., and Shelby M.D. A comparison of chromosome aberration induction by 25 compounds tested by two Chinese hamster cell (CHL and CHO) systems in culture. Mutat. Res. 241 (1990) 175-213
14. George E., and Westmoreland C. Evaluation of the in vivo genotoxicity of the structural analogues 2,6-diaminotoluene and 2,4-diaminotoluene using the rat micronucleus test and rat liver UDS assay. Carcinogenesis 12 (1991) 2233-2237
15. Greene E.J., Salerno A.J., and Friedman M.A. Effect of 4 toluene diamine isomers on murine testicular DNA synthesis. Mutat. Res. 91 (1981) 75-79
16. Parodi S., Zunino A., Ottagio L., De Ferrari M., and Santi L. Lack of correlation between the capability of inducing sister-chromatid exchanges in vivo and carcinogenic potency, for 16 aromatic amines and azo derivatives. Mutat. Res. 108 (1983) 225-238
17. Parodi S., Taningher M., Russo P., Pala M., Tamaro M., and Mouti-Bragadin C. DNA-damaging activity in vivo and bacterial mutagenicity of sixteen aromatic amines and azo-derivatives, as related quantitatively to their carcinogenicity. Carcinogenesis 2 (1981) 1317-1326
18. Brambilla G., Carlo P., Finollo R., and Ledda A. Visometric detection of liver DNA fragmentation in rats treated with ten aromatic amines. Discrepancies with results provided by the alkaline elution technique. Carcinogenesis 6 (1985) 1285-1288
19. Suter W., Ahiabor R., Blanco B., Locher F., Mantovani F., Robinson M., Sreenan G., Staedtler F., Swingler T., Vignutelli A., and Perentes E. Evaluation of the in vivo genotoxic potential of three carcinogenic aromatic amines using the Big Blue™ transgenic mouse mutation assay. Environ. Mol. Mutagen 28 (1996) 354-362
20. Delclos K.B., Blaydes B., Heflich R.H., and Smith B.A. Assessment of DNA adducts and the frequency of 6-thioguanine resistant T-lymphocytes in F344 rats fed 2,4-toluenediamine or implanted with a toluenediisocyanate-containing polyester polyurethane foam. Mutat. Res. 367 (1996) 209-218
21. Mirsalis J.C., Tyson C.K., and Butterworth B.E. Detection of genotoxic carcinogens in the in vivo-in vitro hepatocyte DNA repair assay. Environ. Mutagen. 4 (1982) 553-562
22. Sasaki Y.F., Fujikawa K., Ishida K., Kawamura N., Nishikawa Y., Ohta S., Satoh M., Madarame H., Ueno S., Susa N., Matsusaka N., and Tsuda S. The alkaline single cell gel electrophoresis assay with mouse multiple organs: results with 30 aromatic amines evaluated by the IARC and U. S. NTP. Mutat. Res. 440 (1999) 1-18
23. Taningher M., Peluso M., Parodi S., Ledda-Columbano G.M., and Columbano A. Genotoxic and non-genotoxic activities of 2,4- and 2,6-diaminotoluene, as evaluated in Fischer-344 rat liver. Toxicology 99 (1995) 1-10
24. Cunningham M.L., Hayward J.J., Shane B.S., and Tindall K.R. Distinction of mutagenic carcinogens from a mutagenic noncarcinogen in the Big Blue transgenic mouse. Environ. Health Perspect. 104 Suppl. 3 (1996) 683-686
25. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 46, 1989, p. 303.
26. Bioassay of 1-nitronaphthalene for possible carcinogenicity. National Cancer Institute Technical Report Series, vol. 64, 1978.
27. Purchase I.F.H., Kalinowski A.E., Ishmael J., Wilson J., Gore C.W., and Chart I.S. Lifetime carcinogenicity study of 1-naphthylamine and 2-naphthylamine in dogs. Br. J. Cancer 44 (1981) 301-892
28. J. Kielhorn, U. Wahnschaffe, I. Mangelsdorf, Selected nitro- and nitro-oxy-polycyclic aromatic hydrocarbons, Environmental Health Criteria, 229, published by the International Programme on Chemical Safety, World Health Organisation, 2003.
29. Sasaki J., Arey J., and Atkinson D.A. Gene specific mutagenicity induced in human lymphoblasts by atmospheric reaction products of naphthalene. Environ. Mol. Mutagen. 27 Suppl. (1996) 57
30. Sasaki J.C., Arey J., Eastmond D.A., Parks K.K., and Grosovsky A.J. Evidence for oxidative metabolism in the genotoxicity of 2-nitronaphthalene and 2-nitrodibenzopyranone. Environ. Mol. Mutagen. 28 Suppl. (1997) 44
31. Sasaki J.C., Arey J., Eastmond D.A., Parks K.K., and Grosovsky A.J. Genotoxicity induced in human lymphoblasts by atmospheric reaction products of naphthalene and phenanthrene. Mutat. Res. 393 (1997) 23-35
32. A.J. Grosovsky, J.C. Sasaki, J. Arey, D.A. Eastmond, K.K. Parks, R. Atkinson, Evaluation of the potential health effects of the atmospheric reaction products of polycyclic aromatic hydrocarbons, Health Effects Institute, Research Report No. 84, Cambridge, Massachusetts, 1999.
33. Batiste-Alentorn M., Xamena N., Creus A., and Marcos R. Genotoxicity testing of five compounds in three Drosophila short-term somatic assays. Mutat. Res. 341 (1995) 161-167
34. Delgado-Rodriguez A., Ortiz-Marttelo R., Graf U., Villalobos-Pietrini R., and Gomez-Arroyo S. Genotoxic activity of environmentally important aromatic hydrocarbons and their nitro derivatives in the wing spot test of Drosophila melanogaster. Mutat. Res. 341 (1995) 235-247
35. Simmon V.F., Rosenkranz H.S., Zeiger E., and Poirier L.A. Mutagenic activity of chemical carcinogens and related compounds in the intraperitoneal host-mediated assay. J. Natl. Cancer Inst. 62 (1979) 911-918
36. Lambert I.B., Singer T.M., Boucher S.E., and Douglas G.R. Detailed review of transgenic rodent mutation assays. Mutat. Res. 590 (2005) 1-280
37. Dean S.W., Brooks T.M., Burlinson B., Mirsalis J., Myhr B., Recio L., and Thybaud V. Transgenic mouse mutation assay systems can play an important role in regulatory mutagenicity testing in vivo for the detection of site-of-contact mutagens. Mutagenesis 14 (1999) 141-151
38. Gossen J.A., de Leeuw W.J.F., Tan C.H.T., Zwarthoff E.C., Berends F., Lohman P.H.M., Knook D.L., and Vijg J. Efficient rescue of integrated shuttle vectors from transgenic mice: a model for studying mutations in vivo. Proc. Natl. Acad. Sci. U.S.A. 86 (1989) 7971-7975
39. - phage using a galactose-sensitive E. coli host. Biotechniques 14 (1993) 3326-3330
40. - phage. Mutagenesis 9 (1994) 183-185
41. Heddle J.A., Dean S., Nohmi T., Boerrigter M., Casciano D., Douglas G.R., Glickman B.W., Gorelick N.J., Mirsalis J.C., Martus H.-J., Skopek T.R., Thybaud V., Tindall K.R., and Yajima N. In vivo transgenic mutation assays. Environ. Mol. Mutagen. 35 (2000) 253-259
42. Thybaud V., Dean S., Nohmi T., de Boer J., Douglas G.R., Glickman B.W., Gorelick N.J., Heddle J.A., Heflich R.H., Lambert I., Martus H.-J., Mirsalis J.C., Suzuki T., and Yajima N. In vivo transgenic mutation assays. Mutat. Res. 540 (2003) 141-151
43. Hein D.W. Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis. Mutat. Res. 506/507 (2002) 65-77
44. Freudenthal R.I., Stephens E., and Anderson D.P. Determining the potential of aromatic amines to induce cancer of the urinary bladder. Int. J. Toxicol. 18 (1999) 353-359