-
1
-
-
34247868133
-
Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c ]pyrazoles as multitargeted receptor tyrosine kinase inhibitors
-
Akritopoulou-Zanze, I., Albert, D. H., Bousquet, P. F., et al. (2007). Synthesis and biological evaluation of 5-substituted 1,4-dihydroindeno[1,2-c ]pyrazoles as multitargeted receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 17 (11), 3136-3140.
-
(2007)
Bioorg Med Chem Lett.
, vol.17
, Issue.11
, pp. 3136-3140
-
-
Akritopoulou-Zanze, I.1
Albert, D.H.2
Bousquet, P.F.3
-
2
-
-
33646586669
-
Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor
-
Albert, D. H., Tapang, P., Magoc, T. J., et al. (2006). Preclinical activity of ABT-869, a multitargeted receptor tyrosine kinase inhibitor. Mol Cancer Ther. 5 (4), 995-1006.
-
(2006)
Mol Cancer Ther.
, vol.5
, Issue.4
, pp. 995-1006
-
-
Albert, D.H.1
Tapang, P.2
Magoc, T.J.3
-
3
-
-
0034597072
-
Pyrrolo[2,3-d ]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of Lck I
-
Arnold, L. D., Calderwood, D. J., Dixon, R. W., et al. (2000). Pyrrolo[2,3-d ]pyrimidines containing an extended 5-substituent as potent and selective inhibitors of Lck I. Bioorg Med Chem Lett. 10 (19), 2167-2170.
-
(2000)
Bioorg Med Chem Lett.
, vol.10
, Issue.19
, pp. 2167-2170
-
-
Arnold, L.D.1
Calderwood, D.J.2
Dixon, R.W.3
-
4
-
-
0037967272
-
Tumorigenesis and the angiogenic switch
-
Bergers, G., and Benjamin, L. E. (2003). Tumorigenesis and the angiogenic switch. Nat Rev Cancer. 3 (6), 401-410.
-
(2003)
Nat Rev Cancer.
, vol.3
, Issue.6
, pp. 401-410
-
-
Bergers, G.1
Benjamin, L.E.2
-
5
-
-
0033617532
-
Effects of angiogenesis inhibitors on multistage carcinogenesis in mice
-
Bergers, G., Javaherian, K., Lo, K. M., et al. (1999). Effects of angiogenesis inhibitors on multistage carcinogenesis in mice. Science. 284 (5415), 808-812.
-
(1999)
Science.
, vol.284
, Issue.5415
, pp. 808-812
-
-
Bergers, G.1
Javaherian, K.2
Lo, K.M.3
-
6
-
-
0038476608
-
Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
-
Bergers, G., Song, S., Meyer-Morse, N., et al. (2003). Benefits of targeting both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest. 111 (9), 1287-1295.
-
(2003)
J Clin Invest.
, vol.111
, Issue.9
, pp. 1287-1295
-
-
Bergers, G.1
Song, S.2
Meyer-Morse, N.3
-
7
-
-
36148933709
-
Poorly soluble marketed drugs display solvation limited solubility
-
Bergström, C. A., Wassvik, C. M., Johansson, K., et al. (2007). Poorly soluble marketed drugs display solvation limited solubility. J Med Chem. 50 (23), 5858-5862.
-
(2007)
J Med Chem.
, vol.50
, Issue.23
, pp. 5858-5862
-
-
Bergström, C.A.1
Wassvik, C.M.2
Johansson, K.3
-
8
-
-
84889814310
-
Bone marrow recovery following cyclophosphamide ablation
-
(Unpublished results.)
-
Bousquet, P. F. (2002). Bone marrow recovery following cyclophosphamide ablation. (Unpublished results.)
-
(2002)
-
-
Bousquet, P.F.1
-
9
-
-
0037124207
-
Pyrazolo[3,4-d ] pyrimidines containing an extended 3-substituent as potent inhibitors of Lck - a selectivity insight
-
Burchat, A. F., Calderwood, D. J., Friedman, M. M., et al. (2002). Pyrazolo[3,4-d ] pyrimidines containing an extended 3-substituent as potent inhibitors of Lck - a selectivity insight. Bioorg Med Chem Lett. 12 (12), 1687-1690.
-
(2002)
Bioorg Med Chem Lett.
, vol.12
, Issue.12
, pp. 1687-1690
-
-
Burchat, A.F.1
Calderwood, D.J.2
Friedman, M.M.3
-
10
-
-
0025103317
-
Fibroblast-mediated acceleration of human epithelial tumor growth in vivo
-
Camps, J. L., Chang, S. M., Hsu, T. C., et al. (1990). Fibroblast-mediated acceleration of human epithelial tumor growth in vivo. Proc Natl Acad Sci USA. 87 (1), 75-79.
-
(1990)
Proc Natl Acad Sci USA.
, vol.87
, Issue.1
, pp. 75-79
-
-
Camps, J.L.1
Chang, S.M.2
Hsu, T.C.3
-
11
-
-
0037699955
-
Angiogenesis in health and disease
-
Carmeliet, P. (2003). Angiogenesis in health and disease. Nat Med. 9 (6), 653-660.
-
(2003)
Nat Med.
, vol.9
, Issue.6
, pp. 653-660
-
-
Carmeliet, P.1
-
12
-
-
3843140692
-
Isoindolinone ureas: a novel class of KDR kinase inhibitors
-
Curtin, M. L., Frey, R. R., Heyman, H. R., et al. (2004). Isoindolinone ureas: a novel class of KDR kinase inhibitors. Bioorg Med Chem Lett. 14 (17), 4505-4509.
-
(2004)
Bioorg Med Chem Lett.
, vol.14
, Issue.17
, pp. 4505-4509
-
-
Curtin, M.L.1
Frey, R.R.2
Heyman, H.R.3
-
13
-
-
5144226672
-
A 13C NMR approach to categorizing potential limitations of alpha,beta-unsaturated carbonyl systems in drug-like molecules
-
Cusack, K. P., Arnold, L. D., Barberis, C. E., et al. (2004). A 13C NMR approach to categorizing potential limitations of alpha,beta-unsaturated carbonyl systems in drug-like molecules. Bioorg Med Chem Lett. 14 (22), 5503-5507.
-
(2004)
Bioorg Med Chem Lett.
, vol.14
, Issue.22
, pp. 5503-5507
-
-
Cusack, K.P.1
Arnold, L.D.2
Barberis, C.E.3
-
14
-
-
24944543833
-
Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors
-
Dai, Y., Guo, Y., Frey, R. R., et al. (2005). Thienopyrimidine ureas as novel and potent multitargeted receptor tyrosine kinase inhibitors. J Med Chem. 48 (19), 6066-6083.
-
(2005)
J Med Chem.
, vol.48
, Issue.19
, pp. 6066-6083
-
-
Dai, Y.1
Guo, Y.2
Frey, R.R.3
-
15
-
-
34147137124
-
Discovery of N-(4-(3-amino-1H-indazol-4-yl) phenyl)-N ′-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor
-
Dai, Y., Hartandi, K., Ji, Z., et al. (2007). Discovery of N-(4-(3-amino-1H-indazol-4-yl) phenyl)-N ′-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitor. J Med Chem. 50 (7), 1584-1597.
-
(2007)
J Med Chem.
, vol.50
, Issue.7
, pp. 1584-1597
-
-
Dai, Y.1
Hartandi, K.2
Ji, Z.3
-
16
-
-
37549019605
-
Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors
-
Dai, Y., Hartandi, K., Soni, N. B., et al. (2008). Identification of aminopyrazolopyridine ureas as potent VEGFR/PDGFR multitargeted kinase inhibitors. Bioorg Med Chem Lett. 18 (1), 386-390.
-
(2008)
Bioorg Med Chem Lett.
, vol.18
, Issue.1
, pp. 386-390
-
-
Dai, Y.1
Hartandi, K.2
Soni, N.B.3
-
17
-
-
33745699207
-
Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c ]pyrazoles as a novel class of KDR kinase inhibitors
-
Dinges, J., Akritopoulou-Zanze, I., Arnold, L. D., et al. (2006a). Hit-to-lead optimization of 1,4-dihydroindeno[1,2-c ]pyrazoles as a novel class of KDR kinase inhibitors. Bioorg Med Chem Lett. 16 (16), 4371-4375.
-
(2006)
Bioorg Med Chem Lett.
, vol.16
, Issue.16
, pp. 4371-4375
-
-
Dinges, J.1
Akritopoulou-Zanze, I.2
Arnold, L.D.3
-
18
-
-
33745699182
-
1,4-Dihydroindeno[1,2-c ]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors
-
Dinges, J., Ashworth, K. L., Akritopoulou-Zanze, I., et al. (2006b). 1,4-Dihydroindeno[1,2-c ]pyrazoles as novel multitargeted receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 16 (16), 4266-4271.
-
(2006)
Bioorg Med Chem Lett.
, vol.16
, Issue.16
, pp. 4266-4271
-
-
Dinges, J.1
Ashworth, K.L.2
Akritopoulou-Zanze, I.3
-
19
-
-
34247609167
-
1,4-Dihydroindeno[1,2-c ]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel
-
Dinges, J., Albert, D. H., Arnold, L. D., et al. (2007). 1,4-Dihydroindeno[1,2-c ]pyrazoles with acetylenic side chains as novel and potent multitargeted receptor tyrosine kinase inhibitors with low affinity for the hERG ion channel. J Med Chem. 50 (9), 2011-2029.
-
(2007)
J Med Chem.
, vol.50
, Issue.9
, pp. 2011-2029
-
-
Dinges, J.1
Albert, D.H.2
Arnold, L.D.3
-
20
-
-
84889824402
-
Bayer Pharmaceuticals Corporation, assignee. Preparation of pyrrolotriazine urea derivatives useful for treating hyperproliferative disorders and diseases associated with angiogenesis
-
WO2005121147. 22 December 2005.
-
Dixon, J. A., Brennan, C., Miranda, K., et al. (2005). Bayer Pharmaceuticals Corporation, assignee. Preparation of pyrrolotriazine urea derivatives useful for treating hyperproliferative disorders and diseases associated with angiogenesis. WO2005121147. 22 December 2005.
-
(2005)
-
-
Dixon, J.A.1
Brennan, C.2
Miranda, K.3
-
21
-
-
0037699954
-
The biology of VEGF and its receptors
-
Ferrara, N., Gerber, H. P., and LeCouter, J. (2003). The biology of VEGF and its receptors. Nat Med. 9 (6), 669-676.
-
(2003)
Nat Med.
, vol.9
, Issue.6
, pp. 669-676
-
-
Ferrara, N.1
Gerber, H.P.2
LeCouter, J.3
-
22
-
-
0028929803
-
Angiogenesis in cancer, vascular, rheumatoid and other disease
-
Folkman, J. (1995). Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med. 1 (1), 27-31.
-
(1995)
Nat Med.
, vol.1
, Issue.1
, pp. 27-31
-
-
Folkman, J.1
-
23
-
-
0002396792
-
Angiogenesis and angiogenesis inhibition: an overview
-
I. D. Goldberg and E. M. Rosen (eds.), Basel, Switzerland : Birkhauser Verlag.
-
Folkman, J. (1996). Angiogenesis and angiogenesis inhibition: an overview. In : I. D. Goldberg and E. M. Rosen (eds.) Regulation of Angiogenesis, pp. 1-8. Basel, Switzerland : Birkhauser Verlag.
-
(1996)
Regulation of Angiogenesis
, pp. 1-8
-
-
Folkman, J.1
-
24
-
-
46849112796
-
7-Aminopyrazol[1,5-a]pyrimidines as potent multitargeted receptor tyrosine kinase inhibitors
-
Frey, R. R., Curtin, M. L., Albert, D. H., et al. (2008). 7-Aminopyrazol[1,5-a]pyrimidines as potent multitargeted receptor tyrosine kinase inhibitors. J Med Chem. 51 (13), 777-3787.
-
(2008)
J Med Chem.
, vol.51
, Issue.13
, pp. 777-3787
-
-
Frey, R.R.1
Curtin, M.L.2
Albert, D.H.3
-
25
-
-
0037280306
-
The role of VEGF in normal and neoplastic hematopoiesis
-
Gerber, H.-P., and Ferrara, N. (2003). The role of VEGF in normal and neoplastic hematopoiesis. J Mol Med. 81 (1), 20-31.
-
(2003)
J Mol Med.
, vol.81
, Issue.1
, pp. 20-31
-
-
Gerber, H.-P.1
Ferrara, N.2
-
26
-
-
84889803609
-
Effect of ABT-869 on the proliferation of mast and B cells expressing FLT3-WT or mutated FLT3
-
(Unplublished results.)
-
Glaser, K. (2008). Effect of ABT-869 on the proliferation of mast and B cells expressing FLT3-WT or mutated FLT3. (Unplublished results.)
-
(2008)
-
-
Glaser, K.1
-
27
-
-
0035253739
-
Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer
-
Gordon, M. S., Margolin, K., Talpaz, M., et al. (2001). Phase I safety and pharmacokinetic study of recombinant human anti-vascular endothelial growth factor in patients with advanced cancer. J Clin Oncol. 19 (3), 843-850.
-
(2001)
J Clin Oncol.
, vol.19
, Issue.3
, pp. 843-850
-
-
Gordon, M.S.1
Margolin, K.2
Talpaz, M.3
-
28
-
-
0035800507
-
Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
-
Gorre, M. E., Mohammed, M., Ellwood, K., et al. (2001). Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science. 293 (5531), 876-880.
-
(2001)
Science.
, vol.293
, Issue.5531
, pp. 876-880
-
-
Gorre, M.E.1
Mohammed, M.2
Ellwood, K.3
-
29
-
-
41849136167
-
Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors
-
Gracias, V., Ji, Z., Akritopoulou-Zanze, I., et al. (2008). Scaffold oriented synthesis. Part 2: Design, synthesis and biological evaluation of pyrimido-diazepines as receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 18 (8), 2691-2695.
-
(2008)
Bioorg Med Chem Lett.
, vol.18
, Issue.8
, pp. 2691-2695
-
-
Gracias, V.1
Ji, Z.2
Akritopoulou-Zanze, I.3
-
30
-
-
33646559845
-
Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors
-
Guo, J., Marcotte, P. A., McCall, J. O., et al. (2006). Inhibition of phosphorylation of the colony-stimulating factor-1 receptor (c-Fms) tyrosine kinase in transfected cells by ABT-869 and other tyrosine kinase inhibitors. Mol Cancer Ther. 5 (4), 1007-1013.
-
(2006)
Mol Cancer Ther.
, vol.5
, Issue.4
, pp. 1007-1013
-
-
Guo, J.1
Marcotte, P.A.2
McCall, J.O.3
-
31
-
-
84889766072
-
Pharmacokinetic comparison of multiple receptor tyrosine kinase inhibitor ABT-869 in Asian and Caucasian populations
-
San Francisco, CA
-
Gupta, N., Goh, B.-C., Soo, R., et al. (2007a). Pharmacokinetic comparison of multiple receptor tyrosine kinase inhibitor ABT-869 in Asian and Caucasian populations. In :AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications, San Francisco, CA, p. C 148.
-
(2007)
AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications
-
-
Gupta, N.1
Goh, B.-C.2
Soo, R.3
-
32
-
-
84889773553
-
Relative bioavailability study of multiple receptor tyrosine kinase inhibitor ABT-869 for comparison of oral solution and Meltrex ® tablet formulations
-
San Francisco, CA
-
Gupta, N., Goh, B.-C., Soo, R., et al. (2007b). Relative bioavailability study of multiple receptor tyrosine kinase inhibitor ABT-869 for comparison of oral solution and Meltrex ® tablet formulations. In : AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications, San Francisco, CA, p. C149.
-
(2007)
AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics: Discovery, Biology, and Clinical Applications
-
-
Gupta, N.1
Goh, B.-C.2
Soo, R.3
-
33
-
-
33846902851
-
Thienopyridine urea inhibitors of KDR kinase
-
Heyman, H. R., Frey, R. R., Bousquet, P. F., et al. (2007). Thienopyridine urea inhibitors of KDR kinase. Bioorg Med Chem Lett. 17 (5), 1246-1249.
-
(2007)
Bioorg Med Chem Lett.
, vol.17
, Issue.5
, pp. 1246-1249
-
-
Heyman, H.R.1
Frey, R.R.2
Bousquet, P.F.3
-
34
-
-
11844254414
-
Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy
-
Jain, R. K. (2005). Normalization of tumor vasculature: an emerging concept in antiangiogenic therapy. Science. 307 (5706), 58-62.
-
(2005)
Science.
, vol.307
, Issue.5706
, pp. 58-62
-
-
Jain, R.K.1
-
35
-
-
55549129243
-
ABT-869, a multi-targeted tyrosine kinase inhibitor, in combination with rapamycin is effective for hepatocellular carcinoma (HCC) in vivo
-
Jasinghe, V. J., Xie, Z., Zhou, J., et al. (2008). ABT-869, a multi-targeted tyrosine kinase inhibitor, in combination with rapamycin is effective for hepatocellular carcinoma (HCC) in vivo. J Hepatol. 49 (6), 985-997.
-
(2008)
J Hepatol.
, vol.49
, Issue.6
, pp. 985-997
-
-
Jasinghe, V.J.1
Xie, Z.2
Zhou, J.3
-
36
-
-
33745713211
-
Isothiazolopyrimidines and isoxazolopyrimidines as novel multi-targeted inhibitors of receptor tyrosine kinases
-
Ji, Z., Ahmed, A. A., Albert, D. H., et al. (2006). Isothiazolopyrimidines and isoxazolopyrimidines as novel multi-targeted inhibitors of receptor tyrosine kinases. Bioorg Med Chem Lett. 16 (16), 4326-4330.
-
(2006)
Bioorg Med Chem Lett.
, vol.16
, Issue.16
, pp. 4326-4330
-
-
Ji, Z.1
Ahmed, A.A.2
Albert, D.H.3
-
37
-
-
41649089003
-
3-Amino-benzo[ d ] isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases
-
Ji, Z., Ahmed, A. A., Albert, D. H., Bouska, J. J., et al. (2008). 3-Amino-benzo[ d ] isoxazoles as novel multitargeted inhibitors of receptor tyrosine kinases. J Med Chem. 51 (5), 1231-1244.
-
(2008)
J Med Chem.
, vol.51
, Issue.5
, pp. 1231-1244
-
-
Ji, Z.1
Ahmed, A.A.2
Albert, D.H.3
Bouska, J.J.4
-
38
-
-
0024818355
-
Vascular endothelial growth factor is a secreted angiogenic mitogen
-
Leung, D. W., Cachianes, G., Kuang, W. J., et al. (1989). Vascular endothelial growth factor is a secreted angiogenic mitogen. Science. 246 (4935), 1306-1309.
-
(1989)
Science.
, vol.246
, Issue.4935
, pp. 1306-1309
-
-
Leung, D.W.1
Cachianes, G.2
Kuang, W.J.3
-
39
-
-
33748050780
-
Hypoxia-inducible factor-1 inhibition in combination with temozolomide treatment exhibits robust antitumor efficacy in vivo
-
Li, L., Lin, X., Shoemaker, A. R., et al. (2006). Hypoxia-inducible factor-1 inhibition in combination with temozolomide treatment exhibits robust antitumor efficacy in vivo. Clin Cancer Res. 12 (15), 4747-4754.
-
(2006)
Clin Cancer Res.
, vol.12
, Issue.15
, pp. 4747-4754
-
-
Li, L.1
Lin, X.2
Shoemaker, A.R.3
-
40
-
-
0032519768
-
c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities
-
Lyman, S. D., and Jacobsen, S. E. W. (1998). c-kit ligand and Flt3 ligand: stem/progenitor cell factors with overlapping yet distinct activities. Blood. 91 (4), 1101-1134.
-
(1998)
Blood.
, vol.91
, Issue.4
, pp. 1101-1134
-
-
Lyman, S.D.1
Jacobsen, S.E.W.2
-
41
-
-
0034751861
-
Adult tissue angiogenesis: evidence for negative regulation by estrogen in the uterus
-
Ma, W., Tan, J., Matsumoto, H., et al. (2001). Adult tissue angiogenesis: evidence for negative regulation by estrogen in the uterus. Mol Endocrinol. 15 (11), 1983-1992.
-
(2001)
Mol Endocrinol.
, vol.15
, Issue.11
, pp. 1983-1992
-
-
Ma, W.1
Tan, J.2
Matsumoto, H.3
-
42
-
-
84889872384
-
Protein binding of [3H]A-741439 to mouse, rat, dog, monkey and human plasma
-
(Unpublished results.)
-
Mandli, M., and Darbyshire, J. (2006). Protein binding of [3H]A-741439 to mouse, rat, dog, monkey and human plasma. (Unpublished results.)
-
(2006)
-
-
Mandli, M.1
Darbyshire, J.2
-
43
-
-
84889786891
-
Preclinical pharmacokinetics of ABT-869
-
(Unpublished results.)
-
Marsh, K. C. (2003). Preclinical pharmacokinetics of ABT-869. (Unpublished results.)
-
(2003)
-
-
Marsh, K.C.1
-
44
-
-
0034210658
-
Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells
-
McKenna, H. J., Stocking, K. L., Miller, R. E., et al. (2000). Mice lacking flt3 ligand have deficient hematopoiesis affecting hematopoietic progenitor cells, dendritic cells, and natural killer cells. Blood. 95 (11), 3489-3497.
-
(2000)
Blood.
, vol.95
, Issue.11
, pp. 3489-3497
-
-
McKenna, H.J.1
Stocking, K.L.2
Miller, R.E.3
-
45
-
-
20244380969
-
Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors
-
Miyazaki, Y., Matsunaga, S., Tang, J., et al. (2005). Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors. Bioorg Med Chem Lett. 15 (9), 2203-2207.
-
(2005)
Bioorg Med Chem Lett.
, vol.15
, Issue.9
, pp. 2203-2207
-
-
Miyazaki, Y.1
Matsunaga, S.2
Tang, J.3
-
46
-
-
33845668264
-
Design and effective synthesis of novel templates, 3,7-diphenyl-4-amino-thieno and furo-[3,2-c ]pyridines as protein kinase inhibitors and in vitro evaluation targeting angiogenetic kinases
-
Miyazaki, Y., Nakano, M., Sato, H., et al. (2007a). Design and effective synthesis of novel templates, 3,7-diphenyl-4-amino-thieno and furo-[3,2-c ]pyridines as protein kinase inhibitors and in vitro evaluation targeting angiogenetic kinases. Bioorg Med Chem Lett. 17 (1), 250-254.
-
(2007)
Bioorg Med Chem Lett.
, vol.17
, Issue.1
, pp. 250-254
-
-
Miyazaki, Y.1
Nakano, M.2
Sato, H.3
-
47
-
-
33847159338
-
Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2
-
Miyazaki, Y., Tang, J., Maeda, Y., et al. (2007b). Orally active 4-amino-5-diarylurea-furo[2,3-d]pyrimidine derivatives as anti-angiogenic agent inhibiting VEGFR2 and Tie-2. Bioorg Med Chem Lett. 17 (6), 1773-1778.
-
(2007)
Bioorg Med Chem Lett.
, vol.17
, Issue.6
, pp. 1773-1778
-
-
Miyazaki, Y.1
Tang, J.2
Maeda, Y.3
-
48
-
-
84889830013
-
BASF Aktiengesellschaft, assignee. Preparation of 2-pyrazolin-5-ones as inhibitors of serine/threonine and tyrosine kinase activity
-
WO01009121. 8 February 2001.
-
Moset Marina, M., Berlanga, J. M. C., Fernandez, I. F., et al. (2001). BASF Aktiengesellschaft, assignee. Preparation of 2-pyrazolin-5-ones as inhibitors of serine/threonine and tyrosine kinase activity. WO01009121. 8 February 2001.
-
(2001)
-
-
Moset Marina, M.1
Berlanga, J.M.C.2
Fernandez, I.F.3
-
49
-
-
84889780852
-
BASF Aktiengesellschaft, assignee. Preparation and effects of benzothiazinones and benzoxazinones as protein kinase inhibitors
-
WO00/075139. 14 December 2000.
-
Rafferty, P., Calderwood, D., Arnold, L. D., et al. (2000). BASF Aktiengesellschaft, assignee. Preparation and effects of benzothiazinones and benzoxazinones as protein kinase inhibitors. WO00/075139. 14 December 2000.
-
(2000)
-
-
Rafferty, P.1
Calderwood, D.2
Arnold, L.D.3
-
50
-
-
0345374198
-
Estradiol-induced vascular endothelial growth factor-A expression in breast tumor cells is biphasic and regulated by estrogen receptor-alpha dependent pathway
-
Sengupta, K., Banerjee, S., Saxena, N., et al. (2003). Estradiol-induced vascular endothelial growth factor-A expression in breast tumor cells is biphasic and regulated by estrogen receptor-alpha dependent pathway. Int J Oncol. 22 (3), 609-614.
-
(2003)
Int J Oncol.
, vol.22
, Issue.3
, pp. 609-614
-
-
Sengupta, K.1
Banerjee, S.2
Saxena, N.3
-
51
-
-
9144262956
-
A novel orally bioavailable inhibitor of kinase insert domain-containing receptor induces antiangiogenic effects and prevents tumor growth in vivo
-
Sepp-Lorenzino, L., Rands, E., Mao, X., et al. (2004). A novel orally bioavailable inhibitor of kinase insert domain-containing receptor induces antiangiogenic effects and prevents tumor growth in vivo. Cancer Res. 64 (2), 751-756.
-
(2004)
Cancer Res.
, vol.64
, Issue.2
, pp. 751-756
-
-
Sepp-Lorenzino, L.1
Rands, E.2
Mao, X.3
-
52
-
-
34147102941
-
ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia
-
Shankar, D. B., Li, J., Tapang, P., et al. (2007). ABT-869, a multitargeted receptor tyrosine kinase inhibitor: inhibition of FLT3 phosphorylation and signaling in acute myeloid leukemia. Blood. 109 (8), 3400-3408.
-
(2007)
Blood.
, vol.109
, Issue.8
, pp. 3400-3408
-
-
Shankar, D.B.1
Li, J.2
Tapang, P.3
-
53
-
-
0141465061
-
The role of FLT3 in haematopoietic malignancies
-
Stirewalt, D. L., and Radich, J. P. (2003). The role of FLT3 in haematopoietic malignancies . Nat Rev Cancer. 3 (9), 650-665.
-
(2003)
Nat Rev Cancer.
, vol.3
, Issue.9
, pp. 650-665
-
-
Stirewalt, D.L.1
Radich, J.P.2
-
54
-
-
0001100609
-
A Phase I and biologic correlative study of an oral vascular endothelial growth factor receptor-2 (VEGFR -2) tyrosine kinase inhibitor, CP-547,632, in patients (pts) with advanced solid tumors
-
21 Abstract #334.
-
Tolcher, A. W., O'Leary, J. J., DeBono, J. S., et al. (2002). A Phase I and biologic correlative study of an oral vascular endothelial growth factor receptor-2 (VEGFR -2) tyrosine kinase inhibitor, CP-547,632, in patients (pts) with advanced solid tumors. Proc Am Soc Clin Oncol. 21 Abstract #334.
-
(2002)
Proc Am Soc Clin Oncol.
-
-
Tolcher, A.W.1
O'Leary, J.J.2
DeBono, J.S.3
-
55
-
-
0036595143
-
Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412
-
Weisberg, E., Boulton, C., Kelly, L. M., et al. (2002). Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412. Cancer Cell. 1 (5), 433-443.
-
(2002)
Cancer Cell.
, vol.1
, Issue.5
, pp. 433-443
-
-
Weisberg, E.1
Boulton, C.2
Kelly, L.M.3
-
56
-
-
65449117656
-
Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML
-
Zhou, J., Bi, C., Janakakumara, J. V., et al. (2009). Enhanced activation of STAT pathways and overexpression of survivin confer resistance to FLT3 inhibitors and could be therapeutic targets in AML. Blood. 113 (7), 4052-4062.
-
(2009)
Blood.
, vol.113
, Issue.7
, pp. 4052-4062
-
-
Zhou, J.1
Bi, C.2
Janakakumara, J.V.3
-
57
-
-
41949108249
-
In vivo activity of ABT-869, a multi-target kinase inhibitor, against acute myeloid leukemia with wild-type FLT3 receptor
-
Zhou, J., Khng, J., Jasinghe, V. J., et al. (2008b). In vivo activity of ABT-869, a multi-target kinase inhibitor, against acute myeloid leukemia with wild-type FLT3 receptor . Leuk Res. 32 (7), 1091-1100.
-
(2008)
Leuk Res.
, vol.32
, Issue.7
, pp. 1091-1100
-
-
Zhou, J.1
Khng, J.2
Jasinghe, V.J.3
-
58
-
-
38349075768
-
Synergistic antileukemic effects between ABT-869 and chemotherapy involve downregulation of cell cycle-regulated genes and c-Mos-mediated MAPK pathway
-
Zhou, J., Pan, M., Xie, Z., et al. (2008c). Synergistic antileukemic effects between ABT-869 and chemotherapy involve downregulation of cell cycle-regulated genes and c-Mos-mediated MAPK pathway. Leukemia. 22 (1), 138-146.
-
(2008)
Leukemia.
, vol.22
, Issue.1
, pp. 138-146
-
-
Zhou, J.1
Pan, M.2
Xie, Z.3
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