Defining an EPOR- regulated transcriptome for primary progenitors, including tnfr-sf13c as a novel mediator of EPO- dependent erythroblast formation

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Singh, Seema ^a   de v, Arvind ^a   Verma, Rakesh ^a   Pradeep, Anamika ^a   Sathyanarayana, Pradeep ^a   Green, Jennifer M ^b   Narayanan, Aishwarya ^c   Wojchowski, Don M ^a  

^a Maine Medical Center Research Institute   (United States)

^b AFFYMAX RESEARCH INSTITUTE   (United States)

^c Strand Life Sciences ^*  (India)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CELL PROTEIN; CYCLIN B1 1P 1; CYCLIN D2; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN G2; ERYTHROPOIETIN RECEPTOR; JANUS KINASE 2; MEMBRANE PROTEIN; PROTEIN BTG3; PROTEIN EAF1; PROTEIN GAS5; PROTEIN KINASE PIM 1; PROTEIN LYL1; PROTEIN PIM3; PROTEIN SF13C; PROTEIN SPRED1; PROTEIN SPRED2; PROTEIN TRIB3; PROTEIN TYROSINE PHOSPHATASE; SERPINA 3G PROTEIN; STAT5 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 2; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSCRIPTOME; TUMOR NECROSIS FACTOR RECEPTOR; UNCLASSIFIED DRUG;

ANEMIA; ANIMAL CELL; ARTICLE; CELL CYCLE REGULATION; CELL SURVIVAL; CONTROLLED STUDY; ERYTHROBLAST; ERYTHROPOIESIS; GENETIC REGULATION; HEMATOPOIETIC STEM CELL; MOUSE; NEGATIVE FEEDBACK; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TRANSCRIPTOMICS;

ANIMALS; BONE MARROW; CELL CYCLE PROTEINS; CELL DIFFERENTIATION; ERYTHROBLASTS; ERYTHROPOIESIS; ERYTHROPOIETIN; GENE EXPRESSION REGULATION; GENE KNOCK-IN TECHNIQUES; MICE; MICE, TRANSGENIC; PROTEIN ISOFORMS; RECEPTORS, ERYTHROPOIETIN; RECEPTORS, TUMOR NECROSIS FACTOR; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTOME;

EID: 84863758134     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0038530     Document Type: Article

References (53)

1. Wojchowski DM, Sathyanarayana P, Dev A, (2010) Erythropoietin receptor response circuits. Curr Opin Hematol 17: 169-176.
2. Lombardero M, Kovacs K, Scheithauer BW, (2011) Erythropoietin: a hormone with multiple functions. Pathobiology 78: 41-53.
3. Nairz M, Schroll A, Moschen AR, Sonnweber T, Theurl M, et al. (2011) Erythropoietin contrastingly affects bacterial infection and experimental colitis by inhibiting nuclear factor-kappaB-inducible immune pathways. Immunity 34: 61-74.
4. Choi D, Schroer SA, Lu SY, Wang L, Wu X, et al. (2010) Erythropoietin protects against diabetes through direct effects on pancreatic beta cells. J Exp Med 207: 2831-2842.
5. Krapf R, Hulter HN, (2009) Arterial hypertension induced by erythropoietin and erythropoiesis-stimulating agents (ESA). Clin J Am Soc Nephrol 4: 470-480.
6. Dicato M, Plawny L, (2010) Erythropoietin in cancer patients: pros and cons. Curr Opin Oncol 22: 307-311.
7. Lu X, Gross AW, Lodish HF, (2006) Active conformation of the erythropoietin receptor: random and cysteine-scanning mutagenesis of the extracellular juxtamembrane and transmembrane domains. J Biol Chem 281: 7002-7011.
8. Huang LJ, Constantinescu SN, Lodish HF, (2001) The N-terminal domain of Janus kinase 2 is required for Golgi processing and cell surface expression of erythropoietin receptor. Mol Cell 8: 1327-1338.
9. Klingmuller U, Wu H, Hsiao JG, Toker A, Duckworth BC, et al. (1997) Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci U S A 94: 3016-3021.
10. Huddleston H, Tan B, Yang FC, White H, Wenning MJ, et al. (2003) Functional p85alpha gene is required for normal murine fetal erythropoiesis. Blood 102: 142-145.
11. Arcasoy MO, Karayal AF, (2005) Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain. Biochim Biophys Acta 1740: 17-28.
12. Menon MP, Karur V, Bogacheva O, Bogachev O, Cuetara B, et al. (2006) Signals for stress erythropoiesis are integrated via an erythropoietin receptor-phosphotyrosine-343-Stat5 axis. J Clin Invest 116: 683-694.
13. Menon MP, Fang J, Wojchowski DM, (2006) Core erythropoietin receptor signals for late erythroblast development. Blood 107: 2662-2672.
14. Guihard S, Clay D, Cocault L, Saulnier N, Opolon P, et al. (2010) The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis. Blood 115: 3686-3694.
15. Teglund S, McKay C, Schuetz E, van Deursen JM, Stravopodis D, et al. (1998) Stat5a and Stat5b proteins have essential and nonessential, or redundant, roles in cytokine responses. Cell 93: 841-850.
16. Socolovsky M, Fallon AE, Wang S, Brugnara C, Lodish HF, (1999) Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction. Cell 98: 181-191.
17. Hennighausen L, Robinson GW, (2008) Interpretation of cytokine signaling through the transcription factors STAT5A and STAT5B. Genes Dev 22: 711-721.
18. Rhodes MM, Kopsombut P, Bondurant MC, Price JO, Koury MJ, (2005) Bcl-x(L) prevents apoptosis of late-stage erythroblasts but does not mediate the antiapoptotic effect of erythropoietin. Blood 106: 1857-1863.
19. Sathyanarayana P, Dev A, Fang J, Houde E, Bogacheva O, et al. (2008) EPO receptor circuits for primary erythroblast survival. Blood 111: 5390-5399.
20. Sathyanarayana P, Menon MP, Bogacheva O, Bogachev O, Niss K, et al. (2007) Erythropoietin modulation of podocalyxin and a proposed erythroblast niche. Blood 110: 509-518.
21. Fang J, Menon M, Kapelle W, Bogacheva O, Bogachev O, et al. (2007) EPO modulation of cell-cycle regulatory genes, and cell division, in primary bone marrow erythroblasts. Blood 110: 2361-2370.
22. Mihalcik SA, Huddleston PM 3rd, Wu X, Jelinek DF (2010) The structure of the TNFRSF13C promoter enables differential expression of BAFF-R during B cell ontogeny and terminal differentiation. J Immunol 185: 1045-1054.
23. Rauch M, Tussiwand R, Bosco N, Rolink AG, (2009) Crucial role for BAFF-BAFF-R signaling in the survival and maintenance of mature B cells. PLoS One 4: e5456.
24. Dev A, Fang J, Sathyanarayana P, Pradeep A, Emerson C, et al. (2010) During EPO or anemia challenge, erythroid progenitor cells transit through a selectively expandable proerythroblast pool. Blood 116: 5334-5346.
25. Gotea V, Ovcharenko I, (2008) DiRE: identifying distant regulatory elements of co-expressed genes. Nucleic Acids Res 36: W133-139.
26. Pennacchio LA, Loots GG, Nobrega MA, Ovcharenko I, (2007) Predicting tissue-specific enhancers in the human genome. Genome Res 17: 201-211.
27. Wu H, Liu X, Jaenisch R, Lodish HF, (1995) Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 83: 59-67.
28. Perry JM, Harandi OF, Paulson RF, (2007) BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors. Blood 109: 4494-4502.
29. Quelle FW, Wang D, Nosaka T, Thierfelder WE, Stravopodis D, et al. (1996) Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol Cell Biol 16: 1622-1631.
30. Fox CJ, Hammerman PS, Thompson CB, (2005) The Pim kinases control rapamycin-resistant T cell survival and activation. J Exp Med 201: 259-266.
31. Souroullas GP, Salmon JM, Sablitzky F, Curtis DJ, Goodell MA, (2009) Adult hematopoietic stem and progenitor cells require either Lyl1 or Scl for survival. Cell Stem Cell 4: 180-186.
32. Winkler GS, (2010) The mammalian anti-proliferative BTG/Tob protein family. J Cell Physiol 222: 66-72.
33. Chung B, Verdier F, Matak P, Deschemin JC, Mayeux P, et al. (2010) Oncostatin M is a potent inducer of hepcidin, the iron regulatory hormone. FASEB J 24: 2093-2103.
34. Hookham MB, Elliott J, Suessmuth Y, Staerk J, Ward AC, et al. (2007) The myeloproliferative disorder-associated JAK2 V617F mutant escapes negative regulation by suppressor of cytokine signaling 3. Blood 109: 4924-4929.
35. Bundschu K, Walter U, Schuh K, (2007) Getting a first clue about SPRED functions. Bioessays 29: 897-907.
36. Koury MJ, Bondurant MC, (1990) Erythropoietin retards DNA breakdown and prevents programmed death in erythroid progenitor cells. Science 248: 378-381.
37. Mourtada-Maarabouni M, Hasan AM, Farzaneh F, Williams GT, (2010) Inhibition of human T-cell proliferation by mammalian target of rapamycin (mTOR) antagonists requires noncoding RNA growth-arrest-specific transcript 5 (GAS5). Mol Pharmacol 78: 19-28.
38. Ponassi R, Biasotti B, Tomati V, Bruno S, Poggi A, et al. (2008) A novel Bim-BH3-derived Bcl-XL inhibitor: biochemical characterization, in vitro, in vivo and ex-vivo anti-leukemic activity. Cell Cycle 7: 3211-3224.
39. Pop R, Shearstone JR, Shen Q, Liu Y, Hallstrom K, et al. (2010) A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression. PLoS Biol 8.
40. Wan Z, Zhi N, Wong S, Keyvanfar K, Liu D, et al. (2010) Human parvovirus B19 causes cell cycle arrest of human erythroid progenitors via deregulation of the E2F family of transcription factors. J Clin Invest 120: 3530-3544.
41. Zadjali F, Pike AC, Vesterlund M, Sun J, Wu C, et al. (2011) Structural basis for c-KIT inhibition by the suppressor of cytokine signaling 6 (SOCS6) ubiquitin ligase. J Biol Chem 286: 480-490.
42. Suenobu S, Takakura N, Inada T, Yamada Y, Yuasa H, et al. (2002) A role of EphB4 receptor and its ligand, ephrin-B2, in erythropoiesis. Biochem Biophys Res Commun 293: 1124-1131.
43. Niu J, Li H, Zhang Y, Li J, Xie M, et al. (2010) Aberrant expression of CKLF-like MARVEL transmembrane member 5 (CMTM5) by promoter methylation in myeloid leukemia. Leuk Res.
44. Levine AJ, Brivanlou AH, (2006) GDF3 at the crossroads of TGF-beta signaling. Cell Cycle 5: 1069-1073.
45. Tai YT, Li XF, Breitkreutz I, Song W, Neri P, et al. (2006) Role of B-cell-activating factor in adhesion and growth of human multiple myeloma cells in the bone marrow microenvironment. Cancer Res 66: 6675-6682.
46. Eaton SA, Funnell AP, Sue N, Nicholas H, Pearson RC, et al. (2008) A network of Kruppel-like Factors (Klfs). Klf8 is repressed by Klf3 and activated by Klf1 in vivo. J Biol Chem 283: 26937-26947.
47. Pina C, May G, Soneji S, Hong D, Enver T, (2008) MLLT3 regulates early human erythroid and megakaryocytic cell fate. Cell Stem Cell 2: 264-273.
48. Inuzuka H, Shaik S, Onoyama I, Gao D, Tseng A, et al. (2011) SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature 471: 104-109.
49. Milenkovic D, Ramming T, Muller JM, Wenz LS, Gebert N, et al. (2009) Identification of the signal directing Tim9 and Tim10 into the intermembrane space of mitochondria. Mol Biol Cell 20: 2530-2539.
50. Zhang DL, Hughes RM, Ollivierre-Wilson H, Ghosh MC, Rouault TA, (2009) A ferroportin transcript that lacks an iron-responsive element enables duodenal and erythroid precursor cells to evade translational repression. Cell Metab 9: 461-473.
51. Doherty L, Sheen MR, Vlachos A, Choesmel V, O'Donohue MF, et al. (2010) Ribosomal protein genes RPS10 and RPS26 are commonly mutated in Diamond-Blackfan anemia. Am J Hum Genet 86: 222-228.
52. Barlow JL, Drynan LF, Trim NL, Erber WN, Warren AJ, et al. (2010) New insights into 5q- syndrome as a ribosomopathy. Cell Cycle 9: 4286-4293.
53. Dutt S, Narla A, Lin K, Mullally A, Abayasekara N, et al. (2011) Haploinsufficiency for ribosomal protein genes causes selective activation of p53 in human erythroid progenitor cells. Blood 117: 2567-2576.