The MAPK ERK1 is a negative regulator of the adult steady-state splenic erythropoiesis

Blood

Volumn 115, Issue 18, 2010, Pages 3686-3694

  Guihard, Soizic ^a   Clay, Denis ^b,c,d   Cocault, Laurence ^b,c,d   Saulnier, Nathalie ^a   Opolon, Paule ^e   Souyri, Michèle ^b,c,d   Pagès, Gilles ^f   Pouysségur, Jacques ^f   Porteu, Françoise ^a   Gaudry, Murielle ^a  

^a INSTITUT COCHIN   (France)

^b INSTITUT ANDRÉ LWOFF   (France)

^c UNIVERSITÉ PARIS SACLAY   (France)

^d HÔPITAL PAUL BROUSSE   (France)

^e CNRS   (France)

^f UNIVERSITÉ CÔTE D'AZUR   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 4; ERYTHROPOIETIN; ERYTHROPOIETIN RECEPTOR; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 3; PHENYLHYDRAZINE; OXIDIZING AGENT; PHENYLHYDRAZINE DERIVATIVE;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD SAMPLING; BONE MARROW; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; BURST FORMING UNIT E; CELL LINEAGE; CELL POPULATION; CONTROLLED STUDY; ERYTHROID PRECURSOR CELL; ERYTHROPOIESIS; EXERCISE TEST; HEMATOPOIESIS; IN VIVO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; PROTEIN FUNCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPLEEN; SPLENOMEGALY; STEADY STATE; ANIMAL; APOPTOSIS; C57BL MOUSE; CHEMICALLY INDUCED DISORDER; CLONOGENIC ASSAY; CYTOLOGY; FLOW CYTOMETRY; GENETICS; METABOLISM; PATHOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANEMIA; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; BONE MARROW TRANSPLANTATION; BONE MORPHOGENETIC PROTEIN 4; COLONY-FORMING UNITS ASSAY; ERYTHROID PRECURSOR CELLS; ERYTHROPOIESIS; ERYTHROPOIETIN; FLOW CYTOMETRY; MICE; MICE, INBRED C57BL; MITOGEN-ACTIVATED PROTEIN KINASE 3; OXIDANTS; PHENYLHYDRAZINES; RECEPTORS, ERYTHROPOIETIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SPLEEN;

EID: 77952574986     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-09-242487     Document Type: Article

References (43)

1. Broudy VC, Lin NL, Priestley GV, Nocka K, Wolf NS. Interaction of stem cell factor and its receptor c-kit mediates lodgment and acute expansion of hematopoietic cells in the murine spleen. Blood. 1996;88(1):75-81. (Pubitemid 26230673)
2. Bauer A, Tronche F, Wessely O, et al. The glucocorticoid receptor is required for stress erythropoiesis. Genes Dev. 1999;13(22):2996-3002.
3. Testa U. Apoptotic mechanisms in the control of erythropoiesis. Leukemia. 2004;18(7):1176-1199.
4. Socolovsky M. Molecular insights into stress erythropoiesis. Curr Opin Hematol. 2007;14(3): 215-224.
5. Perry JM, Harandi OF, Paulson RF. BMP4, SCF, and hypoxia cooperatively regulate the expansion of murine stress erythroid progenitors. Blood. 2007;109(10):4494-4502.
6. Perry JM, Harandi OF, Porayette P, Hegde S, Kannan AK, Paulson RF. Maintenance of the BMP4-dependent stress erythropoiesis pathway in the murine spleen requires hedgehog signaling. Blood. 2009;113(4):911-918.
7. Subramanian A, Hegde S, Porayette P, Yon M, Hankey P, Paulson RF. Friend virus utilizes the BMP4-dependent stress erythropoiesis pathway to induce erythroleukemia. J Virol. 2008;82(1): 382-393. (Pubitemid 350309153)
8. Chang L, Karin M. Mammalian MAP kinase signalling cascades. Nature. 2001;410(6824):37-40. (Pubitemid 32225829)
9. Johnson GL, Lapadat R. Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases. Science. 2002;298(5600): 1911-1912. (Pubitemid 35425238)
10. Rouyez MC, Boucheron C, Gisselbrecht S, Dusanter-Fourt I, Porteu F. Control of thrombopoietin-induced megakaryocytic differentiation by the mitogen-activated protein kinase pathway. Mol Cell Biol. 1997;17(9):4991-5000. (Pubitemid 27357598)
11. Marshall CJ. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell. 1995;80(2):179-185.
12. Nagata Y, Takahashi N, Davis RJ, Todokoro K. Activation of p38 MAP kinase and JNK but not ERK is required for erythropoietin-induced erythroid differentiation. Blood. 1998;92(6):1859-1869. (Pubitemid 28446674)
13. Sui X, Krantz SB, You M, Zhao Z. Synergistic activation of MAP kinase (ERK1/2) by erythropoietin and stem cell factor is essential for expanded erythropoiesis. Blood. 1998;92(4):1142-1149. (Pubitemid 28369026)
14. Matsuzaki T, Aisaki K, Yamamura Y, Noda M, Ikawa Y. Induction of erythroid differentiation by inhibition of Ras/ERK pathway in a friend murine leukemia cell line. Oncogene. 2000;19(12):1500-1508. (Pubitemid 30175671)
15. Witt O, Sand K, Pekrun A. Butyrate-induced erythroid differentiation of human K562 leukemia cells involves inhibition of ERK and activation of p38 MAP kinase pathways. Blood. 2000;95(7): 2391-2396. (Pubitemid 30167741)
16. von Lindern M, Deiner EM, Dolznig H, et al. Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis. Oncogene. 2001;20(28): 3651-3664. (Pubitemid 32624957)
17. Dazy S, Damiola F, Parisey N, Beug H, Gandrillon O. The MEK-1/ERKs signalling pathway is differentially involved in the self-renewal of early and late avian erythroid progenitor cells. Oncogene. 2003;22(58): 9205-9216. (Pubitemid 38122032)
18. Kolonics A, Apati A, Janossy J, et al. Activation of Raf/ERK1/2 MAP kinase pathway is involved in GM-CSF-induced proliferation and survival but not in erythropoietin-induced differentiation of TF-1 cells. Cell Signal. 2001;13(10):743-754. (Pubitemid 32800824)
19. Schaefer A, Kosa F, Bittorf T, et al. Opposite effects of inhibitors of mitogen-activated protein kinase pathways on the egr-1 and beta-globin expression in erythropoietin-responsive murine erythroleukemia cells. Cell Signal. 2004;16(2): 223-234. (Pubitemid 37431171)
20. Zhang J, Lodish HF. Constitutive activation of the MEK/ERK pathway mediates all effects of oncogenic H-ras expression in primary erythroid progenitors. Blood. 2004;104(6):1679-1687. (Pubitemid 39202274)
21. Fichelson S, Freyssinier JM, Picard F, et al. Megakaryocyte growth and development factor-induced proliferation and differentiation are regulated by the mitogen-activated protein kinase pathway in primitive cord blood hematopoietic progenitors. Blood. 1999;94(5):1601-1613. (Pubitemid 29411310)
22. Uchida M, Kirito K, Shimizu R, Miura Y, Ozawa K, Komatsu N. A functional role of mitogen-activated protein kinases, erk1 and erk2, in the differentiation of a human leukemia cell line, UT-7/GM: a possible key factor for cell fate determination toward erythroid and megakaryocytic lineages. Int J Hematol. 2001;73(1):78-83. (Pubitemid 33758842)
23. Saba-El-Leil MK, Vella FD, Vernay B, et al. An essential function of the mitogen-activated protein kinase Erk2 in mouse trophoblast development. EMBO Rep. 2003;4(10):964-968. (Pubitemid 37407464)
24. Hatano N, Mori Y, Oh-hora M, et al. Essential role for ERK2 mitogen-activated protein kinase in placental development. Genes Cells. 2003;8(11): 847-856. (Pubitemid 37428014)
25. Yao Y, Li W, Wu J, et al. Extracellular signal-regulated kinase 2 is necessary for mesoderm differentiation. Proc Natl Acad Sci U S A. 2003; 100(22):12759-12764. (Pubitemid 37339972)
26. Bost F, Aouadi M, Caron L, et al. The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes. 2005;54(2):402-411.
27. Pagès G, Guerin S, Grall D, et al. Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice. Science. 1999;286(5443):1374-1377. (Pubitemid 129516242)
28. Mazzucchelli C, Vantaggiato C, Ciamei A, et al. Knockout of ERK1 MAP kinase enhances synaptic plasticity in the striatum and facilitates striatal-mediated learning and memory. Neuron. 2002; 34(5):807-820. (Pubitemid 34628742)
29. Selcher JC, Nekrasova T, Paylor R, Landreth GE, Sweatt JD. Mice lacking the ERK1 isoform of MAP kinase are unimpaired in emotional learning. Learn Mem. 2001;8(1):11-19. (Pubitemid 32167883)
30. Lefloch R, Pouyssegur J, Lenormand P. Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels. Mol Cell Biol. 2008;28(1):511-527.
31. Lee LG, Chen CH, Chiu LA. Thiazole orange: a new dye for reticulocyte analysis. Cytometry. 1986;7(6):508-517.
32. Lenox LE, Perry JM, Paulson RF. BMP4 and Madh5 regulate the erythroid response to acute anemia. Blood. 2005;105(7):2741-2748.
33. Letourneux C, Rocher G, Porteu F. B56-containing PP2A dephosphorylate ERK and their activity is controlled by the early gene IEX-1 and ERK. EMBO J. 2006;25(4):727-738. (Pubitemid 43292435)
34. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 2001;29(9):e45.
35. Bogacheva O, Bogachev O, Menon M, et al. DYRK3 dual-specificity kinase attenuates erythropoiesis during anemia. J Biol Chem. 2008; 283(52):36665-36675.
36. Liu Y, Pop R, Sadegh C, Brugnara C, Haase VH, Socolovsky M. Suppression of Fas-FasL coexpression by erythropoietin mediates erythroblast expansion during the erythropoietic stress response in vivo. Blood. 2006;108(1):123-133. (Pubitemid 43990620)
37. Socolovsky M, Nam H, Fleming MD, Haase VH, Brugnara C, Lodish HF. Ineffective erythropoiesis in Stat5a(-/-)5b(-/-) mice due to decreased survival of early erythroblasts. Blood. 2001; 98(12):3261-3273.
38. Halupa A, Bailey ML, Huang K, Iscove NN, Levy DE, Barber DL. A novel role for STAT1 in regulating murine erythropoiesis: deletion of STAT1 results in overall reduction of erythroid progenitors and alters their distribution. Blood. 2005;105(2): 552-561. (Pubitemid 40070736)
39. Kazama H, Yonehara S. Oncogenic K-Ras and basic fibroblast growth factor prevent Fas-mediated apoptosis in fibroblasts through activation of mitogen-activated protein kinase. J Cell Biol. 2000;148(3):557-566.
40. Rubiolo C, Piazzolla D, Meissl K, et al. A balance between Raf-1 and Fas expression sets the pace of erythroid differentiation. Blood. 2006;108(1): 152-159. (Pubitemid 43990623)
41. Syed RS, Reid SW, Li C, et al. Efficiency of signalling through cytokine receptors depends critically on receptor orientation. Nature. 1998;395 (6701):511-516. (Pubitemid 28462447)
42. Jegalian AG, Acurio A, Dranoff G, Wu H. Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukin 3. Blood. 2002; 99(7):2603-2605. (Pubitemid 34525452)
43. Fischer AM, Katayama CD, Pages G, Pouyssegur J, Hedrick SM. The role of erk1 and erk2 in multiple stages of T cell development. Immunity. 2005;23(4): 431-443. (Pubitemid 41443444)