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Volumn 25, Issue 1, 2012, Pages 150-161

Excess body fat in obese and normal-weight subjects

Author keywords

Adiposity; Body fat distribution; Metabolic phenotypes; Obesity

Indexed keywords

ABDOMINAL OBESITY; ADIPOSE TISSUE; BODY COMPOSITION; BODY FAT; BODY FAT DISTRIBUTION; BODY MASS; BODY WEIGHT; CARDIOMETABOLIC RISK; CARDIOVASCULAR DISEASE; GENETIC ASSOCIATION; GENETIC VARIABILITY; GLUCOSE INTOLERANCE; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; INTRAABDOMINAL FAT; LIFESTYLE MODIFICATION; LIPID STORAGE; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OBESITY; PHENOTYPE; REVIEW; SEX DIFFERENCE; WAIST CIRCUMFERENCE; WEIGHT REDUCTION;

EID: 84863704753     PISSN: 09544224     EISSN: 14752700     Source Type: Journal    
DOI: 10.1017/S0954422412000054     Document Type: Review
Times cited : (130)

References (149)
  • 1
    • 84856478018 scopus 로고    scopus 로고
    • Social inequalities in obesity and overweight in 11 OECD countries
    • Epublication ahead of print version 6 June 2011
    • Devaux M & Sassi F (2011) Social inequalities in obesity and overweight in 11 OECD countries. Eur J Public Health (epublication ahead of print version 6 June 2011).
    • (2011) Eur. J. Public Health
    • Devaux, M.1    Sassi, F.2
  • 2
    • 84856781274 scopus 로고    scopus 로고
    • Statistics from Health Survey for England
    • National Obesity Observatory (2010) Statistics from Health Survey for England.
    • (2010) National Obesity Observatory
  • 3
  • 4
    • 21444461532 scopus 로고    scopus 로고
    • Validity of body composition methods across ethnic population groups
    • Deurenberg P & Deurenberg-Yap M (2003) Validity of body composition methods across ethnic population groups. Forum Nutr 56, 299-301.
    • (2003) Forum. Nutr. , vol.56 , pp. 299-301
    • Deurenberg, P.1    Deurenberg-Yap, M.2
  • 5
    • 27644563811 scopus 로고    scopus 로고
    • A farewell to body-mass index
    • Kragelund C & Omland T (2005) A farewell to body-mass index? Lancet 366, 1589-1591.
    • (2005) Lancet , vol.366 , pp. 1589-1591
    • Kragelund, C.1    Omland, T.2
  • 6
    • 77952290167 scopus 로고    scopus 로고
    • Diagnostic performance of body mass index to identify obesity as defined by body adiposity: A systematic review and meta-analysis
    • Okorodudu DO, Jumean MF, Montori VM, et al. (2010) Diagnostic performance of body mass index to identify obesity as defined by body adiposity: a systematic review and meta-analysis. Int J Obes 34, 791-799.
    • (2010) Int. J. Obes , vol.34 , pp. 791-799
    • Okorodudu, D.O.1    Jumean, M.F.2    Montori, V.M.3
  • 7
    • 84655167784 scopus 로고    scopus 로고
    • The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat
    • Thomas EL, Parkinson JR, Frost GS, et al. (2012) The missing risk: MRI and MRS phenotyping of abdominal adiposity and ectopic fat. Obesity 20, 76-87.
    • (2012) Obesity , vol.20 , pp. 76-87
    • Thomas, E.L.1    Parkinson, J.R.2    Frost, G.S.3
  • 8
    • 81855221882 scopus 로고    scopus 로고
    • Role of BMIassociated loci identified in GWAS meta-analyses in the context of common childhood obesity in european americans
    • Zhao J, Bradfield JP, Zhang H, et al. (2011) Role of BMIassociated loci identified in GWAS meta-analyses in the context of common childhood obesity in European Americans. Obesity 19, 2436-2439.
    • (2011) Obesity , vol.19 , pp. 2436-2439
    • Zhao, J.1    Bradfield, J.P.2    Zhang, H.3
  • 9
    • 76249116215 scopus 로고    scopus 로고
    • A new highly penetrant form of obesity due to deletions on chromosome 16p11.2
    • Walters RG, Jacquemont S, Valsesia A, et al. (2010) A new highly penetrant form of obesity due to deletions on chromosome 16p11.2. Nature 463, 671-675.
    • (2010) Nature , vol.463 , pp. 671-675
    • Walters, R.G.1    Jacquemont, S.2    Valsesia, A.3
  • 10
    • 34249883032 scopus 로고    scopus 로고
    • Waist circumference and cardiometabolic risk: A consensus statement from shaping americas health: Association for weight management and obesity prevention NAASO the obesity society the american society for nutrition and the american diabetes association
    • Klein S, Allison DB, Heymsfield SB, et al. (2007) Waist circumference and cardiometabolic risk: a consensus statement from shaping America's health: Association for Weight Management and Obesity Prevention; NAASO, the Obesity Society; the American Society for Nutrition; and the American Diabetes Association. Diabetes Care 30, 1647-1652.
    • (2007) Diabetes Care , vol.30 , pp. 1647-1652
    • Klein, S.1    Allison, D.B.2    Heymsfield, S.B.3
  • 11
    • 0028299585 scopus 로고
    • Waist circumference and abdominal sagittal diameter: Best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women
    • Pouliot MC, Després JP, Lemieux S, et al. (1994) Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. Am J Cardiol 73, 460-468.
    • (1994) Am. J. Cardiol. , vol.73 , pp. 460-468
    • Pouliot, M.C.1    Després, J.P.2    Lemieux, S.3
  • 12
    • 0029015738 scopus 로고
    • Waist circumference as a measure for indicating need for weight management
    • Lean ME, Han TS & Morrison CE (1995) Waist circumference as a measure for indicating need for weight management. BMJ 311, 158-161.
    • (1995) BMJ , vol.311 , pp. 158-161
    • Lean, M.E.1    Han, T.S.2    Morrison, C.E.3
  • 13
    • 0037078283 scopus 로고    scopus 로고
    • Body mass index waist circumference and health risk: Evidence in support of current national institutes of health guidelines
    • Janssen I, Katzmarzyk PT & Ross R (2002) Body mass index, waist circumference, and health risk: evidence in support of current National Institutes of Health guidelines. Arch Intern Med 162, 2074-2079.
    • (2002) Arch. Intern. Med. , vol.162 , pp. 2074-2079
    • Janssen, I.1    Katzmarzyk, P.T.2    Ross, R.3
  • 14
    • 15744387573 scopus 로고    scopus 로고
    • Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men
    • Wang Y, Rimm EB, Stampfer MJ, et al. (2005) Comparison of abdominal adiposity and overall obesity in predicting risk of type 2 diabetes among men. Am J Clin Nutr 81, 555-563.
    • (2005) Am. J. Clin. Nutr. , vol.81 , pp. 555-563
    • Wang, Y.1    Rimm, E.B.2    Stampfer, M.J.3
  • 15
    • 0029777444 scopus 로고    scopus 로고
    • Limitations of the bioelectrical impedance method for the assessment of body fat in severe obesity
    • Deurenberg P (1996) Limitations of the bioelectrical impedance method for the assessment of body fat in severe obesity. Am J Clin Nutr 64, Suppl. 3, S449-S452.
    • (1996) Am. J. Clin. Nutr. , vol.64 , Issue.3
    • Deurenberg, P.1
  • 16
    • 0029553536 scopus 로고
    • Is it possible to derive a reliable estimate of human visceral and subcutaneous abdominal adipose tissue from simple anthropometric measurements
    • Bonora E, Micciolo R, Ghiatas AA, et al. (1995) Is it possible to derive a reliable estimate of human visceral and subcutaneous abdominal adipose tissue from simple anthropometric measurements? Metabolism 44, 1617-1625.
    • (1995) Metabolism , vol.44 , pp. 1617-1625
    • Bonora, E.1    Micciolo, R.2    Ghiatas, A.A.3
  • 17
    • 0029806795 scopus 로고    scopus 로고
    • Comparisons between fat measurements by dual-energy X-ray absorptiometry underwater weighing and magnetic resonance imaging in healthy women
    • Tothill P, Han TS, Avenell A, et al. (1996) Comparisons between fat measurements by dual-energy X-ray absorptiometry, underwater weighing and magnetic resonance imaging in healthy women. Eur J Clin Nutr 50, 747-752.
    • (1996) Eur. J. Clin. Nutr. , vol.50 , pp. 747-752
    • Tothill, P.1    Han, T.S.2    Avenell, A.3
  • 18
    • 0031769331 scopus 로고    scopus 로고
    • Magnetic resonance imaging of total body fat
    • Thomas EL, Saeed N, Hajnal JV, et al. (1998) Magnetic resonance imaging of total body fat. J Appl Physiol 85, 1778-1785.
    • (1998) J. Appl. Physiol. , vol.85 , pp. 1778-1785
    • Thomas, E.L.1    Saeed, N.2    Hajnal, J.V.3
  • 19
    • 64749100502 scopus 로고    scopus 로고
    • Patterns of abdominal fat distribution: The framingham heart study
    • Pou KM, Massaro JM, Hoffmann U, et al. (2009) Patterns of abdominal fat distribution: the Framingham Heart Study. Diabetes Care 32, 481-485.
    • (2009) Diabetes Care , vol.32 , pp. 481-485
    • Pou, K.M.1    Massaro, J.M.2    Hoffmann, U.3
  • 20
    • 77954353659 scopus 로고    scopus 로고
    • Proton magnetic resonance spectroscopy and ultrasound for hepatic fat quantification
    • Mehta SR, Thomas EL, Patel N, et al. (2010) Proton magnetic resonance spectroscopy and ultrasound for hepatic fat quantification. Hepatol Res 40, 399-406.
    • (2010) Hepatol. Res. , vol.40 , pp. 399-406
    • Mehta, S.R.1    Thomas, E.L.2    Patel, N.3
  • 21
    • 77952040673 scopus 로고    scopus 로고
    • Estimation of abdominal fat compartments by bioelectrical impedance: The validity of the viscan measurement system in comparison with MRI
    • Thomas EL, Collins AL, McCarthy J, et al. (2010) Estimation of abdominal fat compartments by bioelectrical impedance: the validity of the ViScan measurement system in comparison with MRI. Eur J Clin Nutr 64, 525-533.
    • (2010) Eur. J. Clin. Nutr. , vol.64 , pp. 525-533
    • Thomas, E.L.1    Collins, A.L.2    McCarthy, J.3
  • 22
    • 0025821043 scopus 로고
    • Total and subcutaneous adipose tissue in women: The measurement of distribution and accurate prediction of quantity by using magnetic resonance imaging
    • Fowler PA, Fuller MF, Glasbey CA, et al. (1991) Total and subcutaneous adipose tissue in women: the measurement of distribution and accurate prediction of quantity by using magnetic resonance imaging. Am J Clin Nutr 54, 18-25.
    • (1991) Am. J. Clin. Nutr. , vol.54 , pp. 18-25
    • Fowler, P.A.1    Fuller, M.F.2    Glasbey, C.A.3
  • 23
    • 0026537975 scopus 로고
    • Quantification of adipose tissue by MRI: Relationship with anthropometric variables
    • Ross R, Léger L, Morris D, et al. (1992) Quantification of adipose tissue by MRI: relationship with anthropometric variables. J Appl Physiol 72, 787-795.
    • (1992) J. Appl. Physiol. , vol.72 , pp. 787-795
    • Ross, R.1    Léger, L.2    Morris, D.3
  • 24
    • 0030158110 scopus 로고    scopus 로고
    • Development of a rapid and efficient magnetic resonance imaging technique for analysis of body fat distribution
    • Barnard ML, Schwieso JE, Thomas EL, et al. (1996) Development of a rapid and efficient magnetic resonance imaging technique for analysis of body fat distribution. NMR Biomed 9, 156-164.
    • (1996) NMR Biomed , vol.9 , pp. 156-164
    • Barnard, M.L.1    Schwieso, J.E.2    Thomas, E.L.3
  • 25
    • 0031829972 scopus 로고    scopus 로고
    • Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography
    • Mitsiopoulos N, Baumgartner RN, Heymsfield SB, et al. (1998) Cadaver validation of skeletal muscle measurement by magnetic resonance imaging and computerized tomography. J Appl Physiol 85, 115-122.
    • (1998) J. Appl. Physiol. , vol.85 , pp. 115-122
    • Mitsiopoulos, N.1    Baumgartner, R.N.2    Heymsfield, S.B.3
  • 26
    • 0037325462 scopus 로고    scopus 로고
    • Influence of undersampling on magnetic resonance imaging measurements of intraabdominal adipose tissue
    • Thomas EL & Bell JD (2003) Influence of undersampling on magnetic resonance imaging measurements of intraabdominal adipose tissue. Int J Obes Relat Metab Disord 27, 211-218.
    • (2003) Int. J. Obes. Relat. Metab. Disord. , vol.27 , pp. 211-218
    • Thomas, E.L.1    Bell, J.D.2
  • 27
    • 15944404922 scopus 로고    scopus 로고
    • Standardized assessment of whole body adipose tissue topography by MRI
    • Machann J, Thamer C, Schnoedt B, et al. (2005) Standardized assessment of whole body adipose tissue topography by MRI. J Magn Reson Imaging 21, 455-462.
    • (2005) J. Magn. Reson Imaging , vol.21 , pp. 455-462
    • MacHann, J.1    Thamer, C.2    Schnoedt, B.3
  • 28
    • 0027487898 scopus 로고
    • Adipose tissue distribution as assessed by magnetic resonance imaging and total body fat by magnetic resonance imaging underwater weighing and body-water dilution in healthy women
    • Sohlström A, Wahlund LO & Forsum E (1993) Adipose tissue distribution as assessed by magnetic resonance imaging and total body fat by magnetic resonance imaging, underwater weighing, and body-water dilution in healthy women. Am J Clin Nutr 58, 830-838.
    • (1993) Am. J. Clin. Nutr. , vol.58 , pp. 830-838
    • Sohlström, A.1    Wahlund, L.O.2    Forsum, E.3
  • 29
    • 0036167475 scopus 로고    scopus 로고
    • Fast and reproducible method for the direct quantitation of adipose tissue in newborn infants
    • Harrington TA, Thomas EL, Modi N, et al. (2002) Fast and reproducible method for the direct quantitation of adipose tissue in newborn infants. Lipids 37, 95-100.
    • (2002) Lipids , vol.37 , pp. 95-100
    • Harrington, T.A.1    Thomas, E.L.2    Modi, N.3
  • 30
    • 0344413851 scopus 로고    scopus 로고
    • Studies on human body composition during the first 4 months of life using magnetic resonance imaging and isotope dilution
    • Olhager E, Flinke E, Hannerstad U, et al. (2003) Studies on human body composition during the first 4 months of life using magnetic resonance imaging and isotope dilution. Pediatr Res 54, 906-912.
    • (2003) Pediatr. Res. , vol.54 , pp. 906-912
    • Olhager, E.1    Flinke, E.2    Hannerstad, U.3
  • 32
    • 77954758782 scopus 로고    scopus 로고
    • Quantitative assessment of intrahepatic lipids using fat-selective imaging with spectral-spatial excitation and in-opposedphase gradient echo imaging techniques within a study population of extremely obese patients: Feasibility on a short wide-bore MR scanner
    • Springer F, Machann J, Schwenzer NF, et al. (2010) Quantitative assessment of intrahepatic lipids using fat-selective imaging with spectral-spatial excitation and in-/opposedphase gradient echo imaging techniques within a study population of extremely obese patients: feasibility on a short wide-bore MR scanner. Invest Radiol 45 484-490.
    • (2010) Invest. Radiol.. , vol.45 , pp. 484-490
    • Springer, F.1    MacHann, J.2    Schwenzer, N.F.3
  • 33
    • 42449104466 scopus 로고    scopus 로고
    • Quantification of pancreatic lipomatosis and liver steatosis by MRI: Comparison of in opposed-phase and spectralspatial excitation techniques
    • Schwenzer NF, Machann J, Martirosian P, et al. (2008) Quantification of pancreatic lipomatosis and liver steatosis by MRI: comparison of in/opposed-phase and spectralspatial excitation techniques. Invest Radiol 43, 330-337.
    • (2008) Invest. Radiol. , vol.43 , pp. 330-337
    • Schwenzer, N.F.1    MacHann, J.2    Martirosian, P.3
  • 34
    • 58149359687 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Rapid evaluation of liver fat content with inphase and out-of-phase MR imaging
    • Borra RJ, Salo S, Dean K, et al. (2009) Nonalcoholic fatty liver disease: rapid evaluation of liver fat content with inphase and out-of-phase MR imaging. Radiology 250, 130-136.
    • (2009) Radiology , vol.250 , pp. 130-136
    • Borra, R.J.1    Salo, S.2    Dean, K.3
  • 35
    • 77950187257 scopus 로고    scopus 로고
    • Comparison of fatwater MRI and single-voxel MRS in the assessment of hepatic and pancreatic fat fractions in humans
    • Hu HH, Kim HW, Nayak KS, et al. (2010) Comparison of fatwater MRI and single-voxel MRS in the assessment of hepatic and pancreatic fat fractions in humans. Obesity 18, 841-847.
    • (2010) Obesity , vol.18 , pp. 841-847
    • Hu, H.H.1    Kim, H.W.2    Nayak, K.S.3
  • 36
    • 79952309399 scopus 로고    scopus 로고
    • Estimation of hepatic proton-density fat fraction by using MR imaging at 3.0 T
    • Yokoo T, Shiehmorteza M, Hamilton G, et al. (2011) Estimation of hepatic proton-density fat fraction by using MR imaging at 3.0 T. Radiology 258, 749-759.
    • (2011) Radiology , vol.258 , pp. 749-759
    • Yokoo, T.1    Shiehmorteza, M.2    Hamilton, G.3
  • 37
    • 64949095273 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease: Diagnostic and fat-grading accuracy of low-flip-angle multiecho gradient-recalled-echo MR imaging at 1.5 T
    • Yokoo T, Bydder M, Hamilton G, et al. (2009) Nonalcoholic fatty liver disease: diagnostic and fat-grading accuracy of low-flip-angle multiecho gradient-recalled-echo MR imaging at 1.5 T. Radiology 25, 67-76.
    • (2009) Radiology , vol.25 , pp. 67-76
    • Yokoo, T.1    Bydder, M.2    Hamilton, G.3
  • 38
    • 79952291566 scopus 로고    scopus 로고
    • Quantification of hepatic steatosis with T1-independent T2-corrected MR imaging with spectral modelling of fat: Blinded comparison with MR spectroscopy
    • Meisamy S, Hines CD, Hamilton G, et al. (2011) Quantification of hepatic steatosis with T1-independent, T2-corrected MR imaging with spectral modelling of fat: blinded comparison with MR spectroscopy. Radiology 258, 767-775.
    • (2011) Radiology , vol.258 , pp. 767-775
    • Meisamy, S.1    Hines, C.D.2    Hamilton, G.3
  • 39
    • 79955021088 scopus 로고    scopus 로고
    • Assessment of abdominal adipose tissue and organ fat content by magnetic resonance imaging
    • Hu HH, Nayak KS & Goran MI (2011) Assessment of abdominal adipose tissue and organ fat content by magnetic resonance imaging. Obes Rev 12, e504-e515.
    • (2011) Obes. Rev. , vol.12
    • Hu, H.H.1    Nayak, K.S.2    Goran, M.I.3
  • 40
    • 0027457161 scopus 로고
    • Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: Two lipid compartments in muscle tissue
    • Schick F, Eismann B, Jung WI, et al. (1993) Comparison of localized proton NMR signals of skeletal muscle and fat tissue in vivo: two lipid compartments in muscle tissue. Magn Reson Med 29, 158-167.
    • (1993) Magn. Reson. Med. , vol.29 , pp. 158-167
    • Schick, F.1    Eismann, B.2    Jung, W.I.3
  • 41
    • 0030946601 scopus 로고    scopus 로고
    • In vivo determination of intra-myocellular lipids in human muscle by means of localized 1H-MR-spectroscopy
    • Boesch C, Slotboom J, Hoppeler H, et al. (1997) In vivo determination of intra-myocellular lipids in human muscle by means of localized 1H-MR-spectroscopy. Magn Reson Med 37, 484-493.
    • (1997) Magn. Reson. Med. , vol.37 , pp. 484-493
    • Boesch, C.1    Slotboom, J.2    Hoppeler, H.3
  • 42
    • 0345533861 scopus 로고    scopus 로고
    • Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by 1 H-MRS
    • Rico-Sanz J, Thomas EL, Jenkinson G, et al. (1999) Diversity in levels of intracellular total creatine and triglycerides in human skeletal muscles observed by (1)H-MRS. J Appl Physiol 87, 2068-2072.
    • (1999) J. Appl. Physiol. , vol.87 , pp. 2068-2072
    • Rico-Sanz, J.1    Thomas, E.L.2    Jenkinson, G.3
  • 43
    • 0033007207 scopus 로고    scopus 로고
    • Measurement of intracellular triglyceride stores by 1H spectroscopy: Validation in vivo
    • Szczepaniak LS, Babcock EE, Schick F, et al. (1999) Measurement of intracellular triglyceride stores by 1H spectroscopy: validation in vivo. Am J Physiol 276, E977-E989.
    • (1999) Am. J. Physiol. , vol.276
    • Szczepaniak, L.S.1    Babcock, E.E.2    Schick, F.3
  • 44
    • 0036085441 scopus 로고    scopus 로고
    • Content of intramyocellular lipids derived by electron microscopy biochemical assays and 1 H-MR spectroscopy
    • Howald H, Boesch C, Kreis R, et al. (2002) Content of intramyocellular lipids derived by electron microscopy, biochemical assays, and (1)H-MR spectroscopy. J Appl Physiol 92, 2264-2272.
    • (2002) J. Appl. Physiol. , vol.92 , pp. 2264-2272
    • Howald, H.1    Boesch, C.2    Kreis, R.3
  • 45
    • 10844240700 scopus 로고    scopus 로고
    • Hepatic triglyceride content and its relation to body adiposity: A magnetic resonance imaging and proton magnetic resonance spectroscopy study
    • Thomas EL, Hamilton G, Patel N, et al. (2005) Hepatic triglyceride content and its relation to body adiposity: a magnetic resonance imaging and proton magnetic resonance spectroscopy study. Gut 54, 122-127.
    • (2005) Gut , vol.54 , pp. 122-127
    • Thomas, E.L.1    Hamilton, G.2    Patel, N.3
  • 46
    • 12144259379 scopus 로고    scopus 로고
    • Magnetic resonance spectroscopy to measure hepatic triglyceride content: Prevalence of hepatic steatosis in the general population
    • Szczepaniak LS, Nurenberg P, Leonard D, et al. (2005) Magnetic resonance spectroscopy to measure hepatic triglyceride content: prevalence of hepatic steatosis in the general population. Am J Physiol Endocrinol Metab 288, E462-E468.
    • (2005) Am. J. Physiol. Endocrinol. Metab. , vol.288
    • Szczepaniak, L.S.1    Nurenberg, P.2    Leonard, D.3
  • 47
    • 80051586308 scopus 로고    scopus 로고
    • In vivo characterization of the liver fat 1 H MR spectrum
    • Hamilton G, Yokoo T, Bydder M, et al. (2010) In vivo characterization of the liver fat (1)H MR spectrum. NMR Biomed 24, 784-790.
    • (2010) NMR Biomed , vol.24 , pp. 784-790
    • Hamilton, G.1    Yokoo, T.2    Bydder, M.3
  • 48
    • 33645786275 scopus 로고    scopus 로고
    • Hepatic lipid accumulation in healthy subjects: A comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopy
    • Machann J, Thamer C, Schnoedt B, et al. (2006) Hepatic lipid accumulation in healthy subjects: a comparative study using spectral fat-selective MRI and volume-localized 1H-MR spectroscopy. Magn Reson Med 55, 913-917.
    • (2006) Magn. Reson. Med. , vol.55 , pp. 913-917
    • MacHann, J.1    Thamer, C.2    Schnoedt, B.3
  • 49
    • 17544385213 scopus 로고    scopus 로고
    • MR proton spectroscopy in liver examinations of healthy individuals in vivo
    • Tarasów E, Siergiejczyk L, Panasiuk A, et al. (2002) MR proton spectroscopy in liver examinations of healthy individuals in vivo. Med Sci Monit 8, MT36-MT40.
    • (2002) Med. Sci. Monit. , vol.8
    • Tarasów, E.1    Siergiejczyk, L.2    Panasiuk, A.3
  • 50
    • 72049101012 scopus 로고    scopus 로고
    • Intra-cellular fat accumulation mechanisms and implications for health
    • Thomas EL & Bell JD (2006) Intra-cellular fat accumulation, mechanisms and implications for health. Int J Body Comp Res 4, 39-43.
    • (2006) Int. J. Body Comp Res. , vol.4 , pp. 39-43
    • Thomas, E.L.1    Bell, J.D.2
  • 51
  • 52
    • 0037371754 scopus 로고    scopus 로고
    • Myocardial triglycerides and systolic function in humans: In vivo evaluation by localized proton spectroscopy and cardiac imaging
    • Szczepaniak LS, Dobbins RL & Metzger GJ (2003) Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging. Magn Reson Med 49, 417-423.
    • (2003) Magn. Reson. Med. , vol.49 , pp. 417-423
    • Szczepaniak, L.S.1    Dobbins, R.L.2    Metzger, G.J.3
  • 53
    • 55849106967 scopus 로고    scopus 로고
    • Visceral adiposity and its anatomical distribution as predictors of the metabolic syndrome and cardiometabolic risk factor levels
    • Demerath EW, Reed D, Rogers N, et al. (2008) Visceral adiposity and its anatomical distribution as predictors of the metabolic syndrome and cardiometabolic risk factor levels. Am J Clin Nutr 88, 1263-1271.
    • (2008) Am. J. Clin. Nutr. , vol.88 , pp. 1263-1271
    • Demerath, E.W.1    Reed, D.2    Rogers, N.3
  • 54
    • 70349326750 scopus 로고    scopus 로고
    • Intrahepatic fat not visceral fat is linked with metabolic complications of obesity
    • U S A
    • Fabbrini E, Magkos F, Mohammed BS, et al. (2009) Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity. Proc Natl Acad Sci U S A 106, 15430-15435.
    • (2009) Proc. Natl. Acad. Sci. , vol.106 , pp. 15430-15435
    • Fabbrini, E.1    Magkos, F.2    Mohammed, B.S.3
  • 55
    • 37149001609 scopus 로고    scopus 로고
    • Increased intrahepatic triglyceride is associated with peripheral insulin resistance: In vivo MR imaging and spectroscopy studies
    • Hwang JH, Stein DT, Barzilai N, et al. (2007) Increased intrahepatic triglyceride is associated with peripheral insulin resistance: in vivo MR imaging and spectroscopy studies. Am J Physiol Endocrinol Metab 293, E1663-E1669.
    • (2007) Am. J. Physiol. Endocrinol. Metab. , vol.293
    • Hwang, J.H.1    Stein, D.T.2    Barzilai, N.3
  • 56
    • 66549117879 scopus 로고    scopus 로고
    • Abdominal subcutaneous adipose tissue: A protective fat depot
    • Porter SA, Massaro JM, Hoffmann U, et al. (2009) Abdominal subcutaneous adipose tissue: a protective fat depot? Diabetes Care 32, 1068-1075.
    • (2009) Diabetes Care , vol.32 , pp. 1068-1075
    • Porter, S.A.1    Massaro, J.M.2    Hoffmann, U.3
  • 57
    • 0031054698 scopus 로고    scopus 로고
    • Depot-and sex-specific differences in human leptin mRNA expression: Implications for the control of regional fat distribution
    • Montague CT, Prins JB, Sanders L, et al. (1997) Depot-and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution. Diabetes 46, 342-347.
    • (1997) Diabetes , vol.46 , pp. 342-347
    • Montague, C.T.1    Prins, J.B.2    Sanders, L.3
  • 58
    • 0036181202 scopus 로고    scopus 로고
    • Resting metabolic rate plasma leptin concentrations leptin receptor expression and adipose tissue measured by whole-body magnetic resonance imaging in women with prader-willi syndrome
    • Goldstone AP, Brynes AE, Thomas EL, et al. (2002) Resting metabolic rate, plasma leptin concentrations, leptin receptor expression, and adipose tissue measured by whole-body magnetic resonance imaging in women with Prader-Willi syndrome. Am J Clin Nutr 75, 468-475.
    • (2002) Am. J. Clin. Nutr. , vol.75 , pp. 468-475
    • Goldstone, A.P.1    Brynes, A.E.2    Thomas, E.L.3
  • 59
    • 13444304435 scopus 로고    scopus 로고
    • Free and bound plasma leptin in normal weight and obese men and women: Relationship with body composition resting energy expenditure insulin-sensitivity lipid profile and macronutrient preference
    • Magni P, Liuzzi A, Ruscica M, et al. (2005) Free and bound plasma leptin in normal weight and obese men and women: relationship with body composition, resting energy expenditure, insulin-sensitivity, lipid profile and macronutrient preference. Clin Endocrinol 62, 189-196.
    • (2005) Clin. Endocrinol. , vol.62 , pp. 189-196
    • Magni, P.1    Liuzzi, A.2    Ruscica, M.3
  • 60
    • 0032775947 scopus 로고    scopus 로고
    • Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in european and south asian men
    • Forouhi NG, Jenkinson G, Thomas EL, et al. (1999) Relation of triglyceride stores in skeletal muscle cells to central obesity and insulin sensitivity in European and South Asian men. Diabetologia 42, 932-935.
    • (1999) Diabetologia , vol.42 , pp. 932-935
    • Forouhi, N.G.1    Jenkinson, G.2    Thomas, E.L.3
  • 61
    • 0036224883 scopus 로고    scopus 로고
    • Assessment of skeletal muscle triglyceride content by 1 H nuclear magnetic resonance spectroscopy in lean and obese adolescents: Relationships to insulin sensitivity total body fat and central adiposity
    • Sinha R, Dufour S, Petersen KF, et al. (2002) Assessment of skeletal muscle triglyceride content by (1)H nuclear magnetic resonance spectroscopy in lean and obese adolescents: relationships to insulin sensitivity, total body fat, and central adiposity. Diabetes 51, 1022-1027.
    • (2002) Diabetes , vol.51 , pp. 1022-1027
    • Sinha, R.1    Dufour, S.2    Petersen, K.F.3
  • 62
    • 1542545607 scopus 로고    scopus 로고
    • Insulin action regional fat and myocyte lipid: Altered relationships with increased adiposity
    • Gan SK, Kriketos AD, Poynten AM, et al. (2003) Insulin action, regional fat, and myocyte lipid: altered relationships with increased adiposity. Obes Res 11, 1295-1305.
    • (2003) Obes. Res. , vol.11 , pp. 1295-1305
    • Gan, S.K.1    Kriketos, A.D.2    Poynten, A.M.3
  • 63
    • 0029671156 scopus 로고    scopus 로고
    • An in vivo 13C magnetic resonance spectroscopic study of the relationship between diet and adipose tissue composition
    • Thomas EL, Frost G, Barnard ML, et al. (1996) An in vivo 13C magnetic resonance spectroscopic study of the relationship between diet and adipose tissue composition. Lipids 31, 145-151.
    • (1996) Lipids , vol.31 , pp. 145-151
    • Thomas, E.L.1    Frost, G.2    Barnard, M.L.3
  • 64
    • 0041629156 scopus 로고    scopus 로고
    • In vivo characterization of fatty acids in human adipose tissue using natural abundance 1H decoupled 13C MRS at 1.5 T: Clinical applications to dietary therapy
    • Hwang JH, Bluml S, Leaf A, et al. (2003) In vivo characterization of fatty acids in human adipose tissue using natural abundance 1H decoupled 13C MRS at 1.5 T: clinical applications to dietary therapy. NMR Biomed 16, 160-167.
    • (2003) NMR Biomed , vol.16 , pp. 160-167
    • Hwang, J.H.1    Bluml, S.2    Leaf, A.3
  • 65
    • 2442474007 scopus 로고    scopus 로고
    • Body-composition differences between african american and white women: Relation to resting energy requirements
    • Jones A Jr, Shen W, St-Onge MP, et al. (2004) Body-composition differences between African American and white women: relation to resting energy requirements. Am J Clin Nutr 79, 780-786.
    • (2004) Am. J. Clin. Nutr. , vol.79 , pp. 780-786
    • Jones, Jr.A.1    Shen, W.2    St-Onge, M.P.3
  • 66
    • 39349106660 scopus 로고    scopus 로고
    • Interethnic differences in muscle liver and abdominal fat partitioning in obese adolescents
    • Liska D, Dufour S, Zern TL, et al. (2007) Interethnic differences in muscle, liver and abdominal fat partitioning in obese adolescents. PLoS One 2, e569.
    • (2007) PLoS One , vol.2
    • Liska, D.1    Dufour, S.2    Zern, T.L.3
  • 67
    • 79951685702 scopus 로고    scopus 로고
    • Ethnic differences in pancreatic fat accumulation and its relationship with other fat depots and inflammatory markers
    • Lê KA, Ventura EE, Fisher JQ, et al. (2011) Ethnic differences in pancreatic fat accumulation and its relationship with other fat depots and inflammatory markers. Diabetes Care 34, 485-490.
    • (2011) Diabetes Care , vol.34 , pp. 485-490
    • Lê, K.A.1    Ventura, E.E.2    Fisher, J.Q.3
  • 68
    • 1242297043 scopus 로고    scopus 로고
    • Distribution of adipose tissue in the newborn
    • Harrington TA, Thomas EL, Frost G, et al. (2004) Distribution of adipose tissue in the newborn. Pediatr Res 55, 437-441.
    • (2004) Pediatr. Res. , vol.55 , pp. 437-441
    • Harrington, T.A.1    Thomas, E.L.2    Frost, G.3
  • 69
    • 33747619398 scopus 로고    scopus 로고
    • Determinants of adiposity during preweaning postnatal growth in appropriately grown and growth-restricted term infants
    • Modi N, Thomas EL, Harrington TA, et al. (2006) Determinants of adiposity during preweaning postnatal growth in appropriately grown and growth-restricted term infants. Pediatr Res 60, 345-348.
    • (2006) Pediatr. Res. , vol.60 , pp. 345-348
    • Modi, N.1    Thomas, E.L.2    Harrington, T.A.3
  • 70
    • 67449155935 scopus 로고    scopus 로고
    • Influence of sex on total and regional fat loss in overweight and obese men and women
    • Kuk JL & Ross R (2009) Influence of sex on total and regional fat loss in overweight and obese men and women. Int J Obes 33, 629-634.
    • (2009) Int. J. Obes , vol.33 , pp. 629-634
    • Kuk, J.L.1    Ross, R.2
  • 71
    • 33749017409 scopus 로고    scopus 로고
    • The human obesity gene map: The 2005 update
    • Rankinen T, Zuberi A, Chagnon YC, et al. (2006) The human obesity gene map: the 2005 update. Obesity 14, 529-644.
    • (2006) Obesity , vol.14 , pp. 529-644
    • Rankinen, T.1    Zuberi, A.2    Chagnon, Y.C.3
  • 72
    • 79960895140 scopus 로고    scopus 로고
    • Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
    • Kilpeläinen TO, Zillikens MC, Stančákova A, et al. (2011) Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet 43, 753-760.
    • (2011) Nat. Genet , vol.43 , pp. 753-760
    • Kilpeläinen, T.O.1    Zillikens, M.C.2    Stančákova, A.3
  • 73
    • 78049337953 scopus 로고    scopus 로고
    • Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
    • Speliotes EK, Willer CJ, Berndt SI, et al. (2010) Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 42, 937-948.
    • (2010) Nat. Genet. , vol.42 , pp. 937-948
    • Speliotes, E.K.1    Willer, C.J.2    Berndt, S.I.3
  • 74
    • 67651236725 scopus 로고    scopus 로고
    • Genomewide association scan meta-analysis identifies three loci influencing adiposity and fat distribution
    • Lindgren CM, Heid IM, Randall JC, et al. (2009) Genomewide association scan meta-analysis identifies three loci influencing adiposity and fat distribution. PLoS Genet 5, e1000508.
    • (2009) PLoS Genet. , vol.5
    • Lindgren, C.M.1    Heid, I.M.2    Randall, J.C.3
  • 75
    • 78049349396 scopus 로고    scopus 로고
    • Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
    • Heid IM, Jackson AU, Randall JC, et al. (2010) Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet 42, 949-960.
    • (2010) Nat. Genet , vol.42 , pp. 949-960
    • Heid, I.M.1    Jackson, A.U.2    Randall, J.C.3
  • 76
    • 77952680758 scopus 로고    scopus 로고
    • Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: The framingham heart study
    • Speliotes EK, Massaro JM, Hoffmann U, et al. (2010) Fatty liver is associated with dyslipidemia and dysglycemia independent of visceral fat: the Framingham Heart Study. Hepatology 51, 1979-1987.
    • (2010) Hepatology , vol.51 , pp. 1979-1987
    • Speliotes, E.K.1    Massaro, J.M.2    Hoffmann, U.3
  • 77
    • 0032742418 scopus 로고    scopus 로고
    • The disease burden associated with overweight and obesity
    • Must A, Spadano J, Coakley EH, et al. (1999) The disease burden associated with overweight and obesity. JAMA 282, 1523-1529.
    • (1999) JAMA , vol.282 , pp. 1523-1529
    • Must, A.1    Spadano, J.2    Coakley, E.H.3
  • 78
    • 44849093847 scopus 로고    scopus 로고
    • Abdominal obesity and the metabolic syndrome: Contribution to global cardiometabolic risk
    • Després JP, Lemieux I, Bergeron J, et al. (2008) Abdominal obesity and the metabolic syndrome: contribution to global cardiometabolic risk. Arterioscler Thromb Vasc Biol 28, 1039-1049.
    • (2008) Arterioscler. Thromb. Vasc. Biol. , vol.28 , pp. 1039-1049
    • Després, J.P.1    Lemieux, I.2    Bergeron, J.3
  • 79
    • 33646946281 scopus 로고    scopus 로고
    • Visceral fat is an independent predictor of all-cause mortality in men
    • Kuk JL, Katzmarzyk PT, Nichaman MZ, et al. (2006) Visceral fat is an independent predictor of all-cause mortality in men. Obesity 14, 336-341.
    • (2006) Obesity , vol.14 , pp. 336-341
    • Kuk, J.L.1    Katzmarzyk, P.T.2    Nichaman, M.Z.3
  • 80
    • 49449092403 scopus 로고    scopus 로고
    • Identification and characterization of metabolically benign obesity in humans
    • Stefan N, Kantartzis K, Machann J, et al. (2008) Identification and characterization of metabolically benign obesity in humans. Arch Intern Med 168, 1609-1616.
    • (2008) Arch. Intern. Med. , vol.168 , pp. 1609-1616
    • Stefan, N.1    Kantartzis, K.2    MacHann, J.3
  • 81
    • 49449106657 scopus 로고    scopus 로고
    • The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: Prevalence and correlates of 2 phenotypes among the US population NHANES 1999-2004
    • Wildman RP, Muntner P, Reynolds K, et al. (2008) The obese without cardiometabolic risk factor clustering and the normal weight with cardiometabolic risk factor clustering: prevalence and correlates of 2 phenotypes among the US population (NHANES 1999-2004). Arch Intern Med 168, 1617-1624.
    • (2008) Arch. Intern. Med. , vol.168 , pp. 1617-1624
    • Wildman, R.P.1    Muntner, P.2    Reynolds, K.3
  • 83
    • 80052776606 scopus 로고    scopus 로고
    • Metabolic normality in overweight and obese subjects which parameters which risks
    • Pataky Z, Makoundou V & Nilsson P (2011) Metabolic normality in overweight and obese subjects. Which parameters? Which risks? Int J Obes 35, 1208-1215.
    • (2011) Int. J. Obes , vol.35 , pp. 1208-1215
    • Pataky, Z.1    Makoundou, V.2    Nilsson, P.3
  • 84
    • 2942657651 scopus 로고    scopus 로고
    • Metabolic and body composition factors in subgroups of obesity: What do we know
    • Karelis AD, St-Pierre DH, Conus F, et al. (2004) Metabolic and body composition factors in subgroups of obesity: what do we know? J Clin Endocrinol Metab 89, 2569-2575.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 2569-2575
    • Karelis, A.D.1    St-Pierre, D.H.2    Conus, F.3
  • 85
    • 0030884698 scopus 로고    scopus 로고
    • Insulin resistance and hypersecretion in obesity
    • European Group for the Study of Insulin Resistance EGIR
    • Ferrannini E, Natali A, Bell P, et al. (1997) Insulin resistance and hypersecretion in obesity. European Group for the Study of Insulin Resistance (EGIR). J Clin Invest 100, 1166-1173.
    • (1997) J. Clin. Invest. , vol.100 , pp. 1166-1173
    • Ferrannini, E.1    Natali, A.2    Bell, P.3
  • 86
    • 0031710787 scopus 로고    scopus 로고
    • Prevalence of insulin resistance in metabolic disorders: The bruneck study
    • Bonora E, Kiechl S, Willeit J, et al. (1998) Prevalence of insulin resistance in metabolic disorders: the Bruneck Study. Diabetes 47, 1643-1649.
    • (1998) Diabetes , vol.47 , pp. 1643-1649
    • Bonora, E.1    Kiechl, S.2    Willeit, J.3
  • 88
    • 0038759323 scopus 로고    scopus 로고
    • Cardiorespiratory fitness body composition and all-cause and cardiovascular disease mortality in men
    • Lee CD, Blair SN & Jackson AS (1999) Cardiorespiratory fitness, body composition, and all-cause and cardiovascular disease mortality in men. Am J Clin Nutr 69, 373-380.
    • (1999) Am. J. Clin. Nutr. , vol.69 , pp. 373-380
    • Lee, C.D.1    Blair, S.N.2    Jackson, A.S.3
  • 89
    • 0032749573 scopus 로고    scopus 로고
    • Relationship between low cardiorespiratory fitness and mortality in normal-weight overweight and obese men
    • Wei M, Kampert JB, Barlow CE, et al. (1999) Relationship between low cardiorespiratory fitness and mortality in normal-weight, overweight, and obese men. JAMA 282, 1547-1553.
    • (1999) JAMA , vol.282 , pp. 1547-1553
    • Wei, M.1    Kampert, J.B.2    Barlow, C.E.3
  • 90
    • 72049128308 scopus 로고    scopus 로고
    • Fat distribution in men of different waist girth fitness level and exercise habit
    • O'Donovan G, Thomas EL, McCarthy JP, et al. (2009) Fat distribution in men of different waist girth, fitness level and exercise habit. Int J Obes 33, 1356-1362.
    • (2009) Int. J. Obes , vol.33 , pp. 1356-1362
    • Odonovan, G.1    Thomas, E.L.2    McCarthy, J.P.3
  • 91
    • 0025748673 scopus 로고
    • Metabolic implications of body fat distribution
    • Björntorp P (1991) Metabolic implications of body fat distribution. Diabetes Care 14, 1132-1143.
    • (1991) Diabetes Care , vol.14 , pp. 1132-1143
    • Björntorp, P.1
  • 92
    • 0035052940 scopus 로고    scopus 로고
    • What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women
    • Brochu M, Tchernof A, Dionne IJ, et al. (2001) What are the physical characteristics associated with a normal metabolic profile despite a high level of obesity in postmenopausal women? J Clin Endocrinol Metab 86, 1020-1025.
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 1020-1025
    • Brochu, M.1    Tchernof, A.2    Dionne, I.J.3
  • 93
    • 0030923193 scopus 로고    scopus 로고
    • Pathophysiology and molecular mechanisms of visceral fat syndrome: The japanese experience
    • Matsuzawa Y (1997) Pathophysiology and molecular mechanisms of visceral fat syndrome: the Japanese experience. Diabetes Metab Rev 13, 3-13.
    • (1997) Diabetes Metab. Rev. , vol.13 , pp. 3-13
    • Matsuzawa, Y.1
  • 95
    • 61449115926 scopus 로고    scopus 로고
    • Does physical activity ameliorate the health hazards of obesity
    • Lee DC, Sui X & Blair SN (2009) Does physical activity ameliorate the health hazards of obesity? Br J Sports Med 43, 49-51.
    • (2009) Br. J. Sports Med. , vol.43 , pp. 49-51
    • Lee, D.C.1    Sui, X.2    Blair, S.N.3
  • 98
    • 33749133898 scopus 로고    scopus 로고
    • Normal weight obese NWO women: An evaluation of a candidate new syndrome
    • De Lorenzo A, Martinoli R, Vaia F, et al. (2006) Normal weight obese (NWO) women: an evaluation of a candidate new syndrome. Nutr Metab Cardiovasc Dis 6 513-523.
    • (2006) Nutr. Metab. Cardiovasc. Dis. , vol.6 , pp. 513-523
    • De Lorenzo, A.1    Martinoli, R.2    Vaia, F.3
  • 99
    • 6344254567 scopus 로고    scopus 로고
    • Metabolic and behavioral characteristics of metabolically obese but normal-weight women
    • Conus F, Allison DB, Rabasa-Lhoret R, et al. (2004) Metabolic and behavioral characteristics of metabolically obese but normal-weight women. J Clin Endocrinol Metab 89, 5013-5020.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 5013-5020
    • Conus, F.1    Allison, D.B.2    Rabasa-Lhoret, R.3
  • 100
    • 4444334616 scopus 로고    scopus 로고
    • Metabolic syndrome in normal-weight americans: New definition of the metabolically obese normal-weight individual
    • St-Onge MP, Janssen I & Heymsfield SB (2004) Metabolic syndrome in normal-weight Americans: new definition of the metabolically obese, normal-weight individual. Diabetes Care 27, 2222-2228.
    • (2004) Diabetes Care , vol.27 , pp. 2222-2228
    • St-Onge, M.P.1    Janssen, I.2    Heymsfield, S.B.3
  • 101
    • 0043025606 scopus 로고    scopus 로고
    • Increased visceral fat and serum levels of triglyceride are associated with insulin resistance in Japanese metabolically obese normal weight subjects with normal glucose tolerance
    • Katsuki A, Sumida Y, Urakawa H, et al. (2003) Increased visceral fat and serum levels of triglyceride are associated with insulin resistance in Japanese metabolically obese, normal weight subjects with normal glucose tolerance. Diabetes Care 26, 2341-2344.
    • (2003) Diabetes Care , vol.26 , pp. 2341-2344
    • Katsuki, A.1    Sumida, Y.2    Urakawa, H.3
  • 102
    • 0032737303 scopus 로고    scopus 로고
    • Phenotypic characteristics associated with insulin resistance in metabolically obese but normal-weight young women
    • Dvorak RV, DeNino WF, Ades PA, et al. (1999) Phenotypic characteristics associated with insulin resistance in metabolically obese but normal-weight young women. Diabetes 48, 2210-2214.
    • (1999) Diabetes , vol.48 , pp. 2210-2214
    • Dvorak, R.V.1    Denino, W.F.2    Ades, P.A.3
  • 103
    • 0031944785 scopus 로고    scopus 로고
    • The metabolically obese normal-weight individual revisited
    • Ruderman N, Chisholm D, Pi-Sunyer X, et al. (1998) The metabolically obese, normal-weight individual revisited. Diabetes 47, 699-713.
    • (1998) Diabetes , vol.47 , pp. 699-713
    • Ruderman, N.1    Chisholm, D.2    Pi-Sunyer, X.3
  • 104
    • 0029444525 scopus 로고
    • Visceral fat accumulation and cardiovascular disease
    • Matsuzawa Y, Nakamura T, Shimomura I, et al. (1995) Visceral fat accumulation and cardiovascular disease. Obes Res 3, Suppl. 5, 645S-647S.
    • (1995) Obes. Res. , vol.3 , Issue.5
    • Matsuzawa, Y.1    Nakamura, T.2    Shimomura, I.3
  • 105
    • 33845886915 scopus 로고    scopus 로고
    • Abdominal obesity and metabolic syndrome
    • Després JP & Lemieux I (2006) Abdominal obesity and metabolic syndrome. Nature 444, 881-887.
    • (2006) Nature , vol.444 , pp. 881-887
    • Després, J.P.1    Lemieux, I.2
  • 106
    • 0033514956 scopus 로고    scopus 로고
    • Regulation of fatty acid homeostasis in cells: Novel role of leptin
    • U S A
    • Unger RH, Zhou YT & Orci L (1999) Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc Natl Acad Sci U S A 96, 2327-2332.
    • (1999) Proc. Natl. Acad. Sci. , vol.96 , pp. 2327-2332
    • Unger, R.H.1    Zhou, Y.T.2    Orci, L.3
  • 107
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity dependent NIDDM genetic and clinical implications
    • Unger RH (1995) Lipotoxicity in the pathogenesis of obesity dependent NIDDM. Genetic and clinical implications. Diabetes 44, 863-870.
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 108
    • 0345374579 scopus 로고    scopus 로고
    • Minireview: Weapons of lean body mass destruction: The role of ectopic lipids in the metabolic syndrome
    • Unger RH (2003) Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome. Endocrinology 144, 5159-5165.
    • (2003) Endocrinology , vol.144 , pp. 5159-5165
    • Unger, R.H.1
  • 109
    • 12444318666 scopus 로고    scopus 로고
    • Ectopic fat storage in heart blood vessels and kidneys in the pathogenesis of cardiovascular diseases
    • Montani JP, Carroll JF, Dwyer TM, et al. (2004) Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases. Int J Obes Relat Metab Disord 28, S58-S65.
    • (2004) Int. J. Obes. Relat. Metab. Disord. , vol.28
    • Montani, J.P.1    Carroll, J.F.2    Dwyer, T.M.3
  • 110
    • 0036114844 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy
    • Petersen KF, Oral EA, Dufour S, et al. (2002) Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. J Clin Invest 109, 1345-1350.
    • (2002) J. Clin. Invest , vol.109 , pp. 1345-1350
    • Petersen, K.F.1    Oral, E.A.2    Dufour, S.3
  • 111
    • 34548148047 scopus 로고    scopus 로고
    • Thematic review series: Adipocyte biology lipodystrophies: Windows on adipose biology and metabolism
    • Hegele RA, Joy TR, Al-Attar SA, et al. (2007) Thematic review series: Adipocyte biology. Lipodystrophies: windows on adipose biology and metabolism. J Lipid Res 48, 1433-1444.
    • (2007) J. Lipid Res. , vol.48 , pp. 1433-1444
    • Hegele, R.A.1    Joy, T.R.2    Al-Attar, S.A.3
  • 112
    • 0018769372 scopus 로고
    • Studies on the utilization and mobilization of lipid in skeletal muscles from streptozotocin-diabetic and control rats
    • Stearns SB, Tepperman HM & Tepperman J (1979) Studies on the utilization and mobilization of lipid in skeletal muscles from streptozotocin-diabetic and control rats. J Lipid Res 20, 654-662.
    • (1979) J. Lipid Res. , vol.20 , pp. 654-662
    • Stearns, S.B.1    Tepperman, H.M.2    Tepperman, J.3
  • 113
    • 0018827012 scopus 로고
    • Muscle triglycerides in diabetic subjects effect of insulin deficiency and exercise
    • Standl E, Lotz N, Dexel T, et al. (1980) Muscle triglycerides in diabetic subjects. Effect of insulin deficiency and exercise. Diabetologia 18, 463-469.
    • (1980) Diabetologia , vol.18 , pp. 463-469
    • Standl, E.1    Lotz, N.2    Dexel, T.3
  • 114
    • 0023868703 scopus 로고
    • Carbohydrate and lipid metabolism of skeletal muscle in type 2 diabetic patients
    • Falholt K, Jensen I, Lindkaer Jensen S, et al. (1988) Carbohydrate and lipid metabolism of skeletal muscle in type 2 diabetic patients. Diabet Med 5, 27-31.
    • (1988) Diabet. Med. , vol.5 , pp. 27-31
    • Falholt, K.1    Jensen, I.2    Lindkaer Jensen, S.3
  • 115
    • 0026087478 scopus 로고
    • Influence of dietary fat composition on development of insulin resistance in rats relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipids
    • Storlien LH, Jenkins AB, Chisholm DJ, et al. (1991) Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipid. Diabetes 40, 280-289.
    • (1991) Diabetes , vol.40 , pp. 280-289
    • Storlien, L.H.1    Jenkins, A.B.2    Chisholm, D.J.3
  • 116
    • 0026040907 scopus 로고
    • Development of muscle insulin resistance after liver insulin resistance in high fat-fed rats
    • Kraegen EW, Clark PW, Jenkins AB, et al. (1991) Development of muscle insulin resistance after liver insulin resistance in high fat-fed rats. Diabetes 40, 1397-1403.
    • (1991) Diabetes , vol.40 , pp. 1397-1403
    • Kraegen, E.W.1    Clark, P.W.2    Jenkins, A.B.3
  • 117
    • 0029787329 scopus 로고    scopus 로고
    • Intramuscular triglyceride and muscle insulin sensitivity: Evidence for a relationship in non diabetic subjects
    • Phillips DI, Caddy S, Ilic V, et al. (1996) Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in non diabetic subjects. Metabolism 45, 947-950.
    • (1996) Metabolism , vol.45 , pp. 947-950
    • Phillips, D.I.1    Caddy, S.2    Ilic, V.3
  • 118
    • 0030969532 scopus 로고    scopus 로고
    • Skeletal muscle triglyceride levels are inversely related to insulin action
    • Pan DA, Lillioja S, Kriketos AD, et al. (1997) Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46, 983-988.
    • (1997) Diabetes , vol.46 , pp. 983-988
    • Pan, D.A.1    Lillioja, S.2    Kriketos, A.D.3
  • 119
    • 84863642498 scopus 로고
    • Saccharine diabetes
    • Pepper W (1884) Saccharine diabetes. Med Rec 25, 9-12.
    • (1884) Med. Rec. , vol.25 , pp. 9-12
    • Pepper, W.1
  • 120
    • 78651041767 scopus 로고
    • The liver in obesity
    • Zelman S (1952) The liver in obesity. Arch Int Med 90, 141-156.
    • (1952) Arch. Int. Med. , vol.90 , pp. 141-156
    • Zelman, S.1
  • 121
    • 2542588319 scopus 로고
    • Fatty infiltration of the liver and the development of cirrhosis in diabetes and chronic alcoholism
    • Connor CL (1938) Fatty infiltration of the liver and the development of cirrhosis in diabetes and chronic alcoholism. Am J Pathol 14, 347-364.
    • (1938) Am. J. Pathol. , vol.14 , pp. 347-364
    • Connor, C.L.1
  • 122
    • 0005616549 scopus 로고
    • Diabetes mellitus and liver dysfunction-etiological and therapeutic considerations
    • Leevy CM, Ryan CM & Fineberg JC (1950) Diabetes mellitus and liver dysfunction -etiological and therapeutic considerations. Am J Med 8, 290-299.
    • (1950) Am. J. Med. , vol.8 , pp. 290-299
    • Leevy, C.M.1    Ryan, C.M.2    Fineberg, J.C.3
  • 123
    • 0015907655 scopus 로고
    • Fatty metamorphosis of the liver in morbid obesity
    • Kern WH, Heger AH & Payne JH (1973) Fatty metamorphosis of the liver in morbid obesity. Arch Pathol 96, 342-346.
    • (1973) Arch. Pathol. , vol.96 , pp. 342-346
    • Kern, W.H.1    Heger, A.H.2    Payne, J.H.3
  • 124
    • 33750606061 scopus 로고    scopus 로고
    • Longterm follow-up of patients with NAFLD and elevated liver enzymes
    • Ekstedt M, Franzén LE, Mathiesen UL, et al. (2006) Longterm follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 44, 865-873.
    • (2006) Hepatology , vol.44 , pp. 865-873
    • Ekstedt, M.1    Franzén, L.E.2    Mathiesen, U.L.3
  • 125
    • 65449156905 scopus 로고    scopus 로고
    • NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: An eleven-year follow-up study
    • Adams LA, Waters OR, Knuiman MW, et al. (2009) NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up study. Am J Gastroenterol 104, 861-867.
    • (2009) Am. J. Gastroenterol. , vol.104 , pp. 861-867
    • Adams, L.A.1    Waters, O.R.2    Knuiman, M.W.3
  • 126
    • 0025178612 scopus 로고
    • The natural history of non-alcoholic steatohepatitis: A follow-up study of forty-two patients for up to 21 years
    • Powell EE, Cooksley WG, Hanson R, et al. (1990) The natural history of non-alcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. Hepatology 11, 74-80.
    • (1990) Hepatology , vol.11 , pp. 74-80
    • Powell, E.E.1    Cooksley, W.G.2    Hanson, R.3
  • 127
    • 79960029926 scopus 로고    scopus 로고
    • Systematic review: The epidemiology and natural history of nonalcoholic fatty liver disease and non-alcoholic steatohepatitis in adults
    • Vernon G, Baranova A & Younossi ZM (2011) Systematic review: the epidemiology and natural history of nonalcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 34, 274-285.
    • (2011) Aliment Pharmacol. Ther. , vol.34 , pp. 274-285
    • Vernon, G.1    Baranova, A.2    Younossi, Z.M.3
  • 128
    • 1442352339 scopus 로고    scopus 로고
    • Role of the adipocyte, free fatty acids and ectopic fat in pathogenesis of type 2 diabetes mellitus: Peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach
    • Bays H, Mandarino L & DeFronzo RA (2004) Role of the adipocyte, free fatty acids, and ectopic fat in pathogenesis of type 2 diabetes mellitus: peroxisomal proliferator-activated receptor agonists provide a rational therapeutic approach. J Clin Endocrinol Metab 89, 463-478.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 463-478
    • Bays, H.1    Mandarino, L.2    Defronzo, R.A.3
  • 129
    • 12444334643 scopus 로고    scopus 로고
    • Lipotoxicity an imbalance between lipogenesis de novo and fatty acid oxidation
    • Lelliott C & Vidal-Puig AJ (2004) Lipotoxicity, an imbalance between lipogenesis de novo and fatty acid oxidation. Int J Obes Relat Metab Disord 28, Suppl. 4, S22-S28.
    • (2004) Int. J. Obes. Relat. Metab. Disord , vol.28 , Issue.4
    • Lelliott, C.1    Vidal-Puig, A.J.2
  • 130
    • 71849092184 scopus 로고    scopus 로고
    • Validity of real time ultrasound in the diagnosis of hepatic steatosis: A prospective study
    • Dasarathy S, Dasarathy J, Khiyami A, et al. (2009) Validity of real time ultrasound in the diagnosis of hepatic steatosis: a prospective study. J Hepatol 51, 1061-1067.
    • (2009) J. Hepatol. , vol.51 , pp. 1061-1067
    • Dasarathy, S.1    Dasarathy, J.2    Khiyami, A.3
  • 131
    • 85027927359 scopus 로고    scopus 로고
    • Increased whole-body adiposity without a concomitant increase in liver fat is not associated with augmented metabolic dysfunction
    • Magkos F, Fabbrini E, Mohammed BS, et al. (2010) Increased whole-body adiposity without a concomitant increase in liver fat is not associated with augmented metabolic dysfunction. Obesity 18, 1510-1515.
    • (2010) Obesity , vol.18 , pp. 1510-1515
    • Magkos, F.1    Fabbrini, E.2    Mohammed, B.S.3
  • 132
    • 34548321236 scopus 로고    scopus 로고
    • Intermuscular adipose tissue rivals visceral adipose tissue in independent associations with cardiovascular risk
    • Yim JE, Heshka S, Albu J, et al. (2007) Intermuscular adipose tissue rivals visceral adipose tissue in independent associations with cardiovascular risk. Int J Obes 31, 1400-1405.
    • (2007) Int. J. Obes , vol.31 , pp. 1400-1405
    • Yim, J.E.1    Heshka, S.2    Albu, J.3
  • 133
    • 0030765908 scopus 로고    scopus 로고
    • Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat
    • Goodpaster BH, Thaete FL, Simoneau JA, et al. (1997) Subcutaneous abdominal fat and thigh muscle composition predict insulin sensitivity independently of visceral fat. Diabetes 46, 1579-1585.
    • (1997) Diabetes , vol.46 , pp. 1579-1585
    • Goodpaster, B.H.1    Thaete, F.L.2    Simoneau, J.A.3
  • 134
    • 0033862402 scopus 로고    scopus 로고
    • Preferential loss of visceral fat following aerobic exercise measured by magnetic resonance imaging
    • Thomas EL, Brynes AE, McCarthy J, et al. (2000) Preferential loss of visceral fat following aerobic exercise, measured by magnetic resonance imaging. Lipids 35, 769-776.
    • (2000) Lipids , vol.35 , pp. 769-776
    • Thomas, E.L.1    Brynes, A.E.2    McCarthy, J.3
  • 135
    • 79955801002 scopus 로고    scopus 로고
    • Weight-loss diet alone or combined with resistance training induces different regional visceral fat changes in obese women
    • Idoate F, Ibañez J, Gorostiaga EM, et al. (2011) Weight-loss diet alone or combined with resistance training induces different regional visceral fat changes in obese women. Int J Obes 35, 700-713.
    • (2011) Int. J. Obes , vol.35 , pp. 700-713
    • Idoate, F.1    Ibañez, J.2    Gorostiaga, E.M.3
  • 136
    • 75749084440 scopus 로고    scopus 로고
    • A 12-week aerobic exercise program reduces hepatic fat accumulation and insulin resistance in obese hispanic adolescents
    • van der Heijden GJ, Wang ZJ, Chu ZD, et al. (2010) A 12-week aerobic exercise program reduces hepatic fat accumulation and insulin resistance in obese, Hispanic adolescents. Obesity 18, 384-390.
    • (2010) Obesity , vol.18 , pp. 384-390
    • Van Der Heijden, G.J.1    Wang, Z.J.2    Chu, Z.D.3
  • 137
    • 70350072281 scopus 로고    scopus 로고
    • Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss
    • Johnson NA, Sachinwalla T, Walton DW, et al. (2009) Aerobic exercise training reduces hepatic and visceral lipids in obese individuals without weight loss. Hepatology 50, 1105-1112.
    • (2009) Hepatology , vol.50 , pp. 1105-1112
    • Johnson, N.A.1    Sachinwalla, T.2    Walton, D.W.3
  • 138
    • 4644229516 scopus 로고    scopus 로고
    • Exercise-induced reduction in obesity and insulin resistance in women: A randomized controlled trial
    • Ross R, Janssen I, Dawson J, et al. (2004) Exercise-induced reduction in obesity and insulin resistance in women: a randomized controlled trial. Obes Res 12, 789-798.
    • (2004) Obes. Res. , vol.12 , pp. 789-798
    • Ross, R.1    Janssen, I.2    Dawson, J.3
  • 139
    • 33746419647 scopus 로고    scopus 로고
    • Effect of calorie restriction with or without exercise on insulin sensitivity b-cell function fat cell size and ectopic lipid in overweight subjects
    • Larson-Meyer DE, Heilbronn LK, Redman LM, et al. (2006) Effect of calorie restriction with or without exercise on insulin sensitivity, b-cell function, fat cell size, and ectopic lipid in overweight subjects. Diabetes Care 29, 1337-1344.
    • (2006) Diabetes Care , vol.29 , pp. 1337-1344
    • Larson-Meyer, D.E.1    Heilbronn, L.K.2    Redman, L.M.3
  • 140
    • 33750122264 scopus 로고    scopus 로고
    • Effect of nutritional counselling on hepatic muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease
    • Thomas EL, Brynes AE, Hamilton G, et al. (2006) Effect of nutritional counselling on hepatic, muscle and adipose tissue fat content and distribution in non-alcoholic fatty liver disease. World J Gastroenterol 12, 5813-5819.
    • (2006) World J. Gastroenterol. , vol.12 , pp. 5813-5819
    • Thomas, E.L.1    Brynes, A.E.2    Hamilton, G.3
  • 141
    • 65549085856 scopus 로고    scopus 로고
    • Visceral fat loss induced by a low-calorie diet: A direct comparison between women and men
    • Gasteyger C, Larsen TM, Vercruysse F, et al. (2009) Visceral fat loss induced by a low-calorie diet: a direct comparison between women and men. Diabetes Obes Metab 11, 596-602.
    • (2009) Diabetes Obes. Metab. , vol.11 , pp. 596-602
    • Gasteyger, C.1    Larsen, T.M.2    Vercruysse, F.3
  • 142
    • 0036514610 scopus 로고    scopus 로고
    • Effects of an energy-restrictive diet with or without exercise on abdominal fat intermuscular fat and metabolic risk factors in obese women
    • Janssen I, Fortier A, Hudson R, et al. (2002) Effects of an energy-restrictive diet with or without exercise on abdominal fat, intermuscular fat, and metabolic risk factors in obese women. Diabetes Care 25, 431-438.
    • (2002) Diabetes Care , vol.25 , pp. 431-438
    • Janssen, I.1    Fortier, A.2    Hudson, R.3
  • 143
    • 0036228656 scopus 로고    scopus 로고
    • Reduction of visceral adipose tissue during weight loss
    • Doucet E, St-Pierre S, Alméras N, et al. (2002) Reduction of visceral adipose tissue during weight loss. Eur J Clin Nutr 56, 297-304.
    • (2002) Eur. J. Clin. Nutr. , vol.56 , pp. 297-304
    • Doucet, E.1    St-Pierre, S.2    Alméras, N.3
  • 144
    • 0027465473 scopus 로고
    • Visceral fat loss measured by magnetic resonance imaging in relation to changes in serum lipid levels of obese men and women
    • Leenen R, van der Kooy K, Droop A, et al. (1993) Visceral fat loss measured by magnetic resonance imaging in relation to changes in serum lipid levels of obese men and women. Arterioscler Thromb 13, 487-494.
    • (1993) Arterioscler. Thromb. , vol.13 , pp. 487-494
    • Leenen, R.1    Van Der Kooy, K.2    Droop, A.3
  • 145
    • 16744368147 scopus 로고    scopus 로고
    • Human gene for physical performance
    • Montgomery HE, Marshall R, Hemingway H, et al. (1998) Human gene for physical performance. Nature 393, 221-222.
    • (1998) Nature , vol.393 , pp. 221-222
    • Montgomery, H.E.1    Marshall, R.2    Hemingway, H.3
  • 146
    • 77951453042 scopus 로고    scopus 로고
    • Advances in exercise fitness and performance genomics
    • Rankinen T, Roth SM, Bray MS, et al. (2010) Advances in exercise, fitness, and performance genomics. Med Sci Sports Exerc 42, 835-846.
    • (2010) Med. Sci. Sports Exerc. , vol.42 , pp. 835-846
    • Rankinen, T.1    Roth, S.M.2    Bray, M.S.3
  • 147
    • 56849128391 scopus 로고    scopus 로고
    • Gene-environment interactions in the etiology of obesity: Defining the fundamentals
    • Bouchard C (2008) Gene-environment interactions in the etiology of obesity: defining the fundamentals. Obesity 3, Suppl., S5-S10.
    • (2008) Obesity , vol.3
    • Bouchard, C.1
  • 148
    • 79951683261 scopus 로고    scopus 로고
    • Liver and pancreatic fat content and metabolism in healthy monozygotic twins with discordant physical activity
    • Hannukainen JC, Borra R, Linderborg K, et al. (2011) Liver and pancreatic fat content and metabolism in healthy monozygotic twins with discordant physical activity. J Hepatol 54, 545-552.
    • (2011) J. Hepatol. , vol.54 , pp. 545-552
    • Hannukainen, J.C.1    Borra, R.2    Linderborg, K.3
  • 149
    • 50349102028 scopus 로고    scopus 로고
    • Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity
    • Mustelin L, Pietiläinen KH & Rissanen A (2008) Acquired obesity and poor physical fitness impair expression of genes of mitochondrial oxidative phosphorylation in monozygotic twins discordant for obesity. Am J Physiol Endocrinol Metab 295, E148-E154.
    • (2008) Am. J. Physiol. Endocrinol. Metab. , vol.295
    • Mustelin, L.1    Pietiläinen, K.H.2    Rissanen, A.3


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