Untargeted metabolomics reveals a lack of synergy between nifurtimox and eflornithine against trypanosoma brucei

PLoS Neglected Tropical Diseases

Volumn 6, Issue 5, 2012, Pages

  Vincent, Isabel M ^a   Creek, Darren J ^a,b   Burgess, Karl ^a,b   Woods, Debra J ^c   Burchmore, Richard J S ^a,b   Barrett, Michael P ^a,b  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGINASE; DRUG METABOLITE; EFLORNITHINE; LIPID; MELARSOPROL; NIFURTIMOX; NUCLEOTIDE; ORNITHINE; PENTAMIDINE; PEPTIDE; POLYAMINE; PUTRESCINE; SURAMIN; XENOBIOTIC AGENT; ANTITRYPANOSOMAL AGENT;

AFRICAN TRYPANOSOMIASIS; ARTICLE; CARBOHYDRATE METABOLISM; DRUG POTENTIATION; DRUG TARGETING; ENERGY METABOLISM; IC 50; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLOMICS; MONOTHERAPY; NONHUMAN; NUCLEOTIDE METABOLISM; TRYPANOSOMA BRUCEI; ANIMAL; BIOTRANSFORMATION; CHEMISTRY; DRUG EFFECT; DRUG INTERACTION; HUMAN; METABOLISM; METABOLOME; METHODOLOGY;

ANIMALS; BIOTRANSFORMATION; CHROMATOGRAPHY, LIQUID; DRUG INTERACTIONS; EFLORNITHINE; HUMANS; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; NIFURTIMOX; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

EID: 84863682324     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001618     Document Type: Article

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