A molecular mechanism for eflornithine resistance in African trypanosomes

PLoS Pathogens

Volumn 6, Issue 11, 2010, Pages

  Vincent, Isabel M ^a   Creek, Darren ^a   Watson, David G ^b   Kamleh, Mohammed A ^b,d   Woods, Debra J ^c   Wong, Pui Ee ^a   Burchmore, Richard J S ^a   Barrett, Michael P ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

^b UNIVERSITY OF STRATHCLYDE   (United Kingdom)

^c PFIZER INC   (United States)

^d IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSPORTER; EFLORNITHINE; NIFURTIMOX; ORNITHINE DECARBOXYLASE; PENTAMIDINE; POLYAMINE; TBAAT 6 PROTEIN; UNCLASSIFIED DRUG; ANTITRYPANOSOMAL AGENT; SMALL INTERFERING RNA;

AFRICAN TRYPANOSOMIASIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG RESISTANCE; DRUG SENSITIVITY; FEMALE; GENE DELETION; GENE EXPRESSION; IC 50; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; TRYPANOSOMA BRUCEI; WILD TYPE; ANIMAL; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; PARASITOLOGY; PATHOGENICITY; PHYLOGENY; SOUTHERN BLOTTING;

PROTOZOA; TRYPANOSOMA BRUCEI;

AMINO ACID TRANSPORT SYSTEMS; ANIMALS; BLOTTING, SOUTHERN; DRUG RESISTANCE; EFLORNITHINE; HUMANS; MICE; ORNITHINE DECARBOXYLASE; PHYLOGENY; POLYAMINES; RNA, SMALL INTERFERING; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI; TRYPANOSOMIASIS, AFRICAN;

EID: 78951481408     PISSN: 15537366     EISSN: 15537374     Source Type: Journal    
DOI: 10.1371/journal.ppat.1001204     Document Type: Article

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