Bax translocation mediated mitochondrial apoptosis and caspase dependent photosensitizing effect of ficus religiosa on cancer cells

PLoS ONE

Volumn 7, Issue 7, 2012, Pages

  Haneef, Jazir ^a   M, Parvathy ^a   Thankayyan, R Santhosh Kumar ^a   Sithul, Hima ^a   Sreeharshan, Sreeja ^a  

^a RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; ALKALOID DERIVATIVE; ANTINEOPLASTIC AGENT; CASPASE 9; FICUS RELIGIOSA EXTRACT; FLAVONOID; FLUORESCEIN ISOTHIOCYANATE; GLYCOSIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHENOL DERIVATIVE; PHOTOSENSITIZING AGENT; PHYTOSTEROL; PLANT EXTRACT; PROPIDIUM IODIDE; PROTEIN BAX; REACTIVE OXYGEN METABOLITE; SAPONIN DERIVATIVE; SULFORHODAMINE B; TANNIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CELL CYCLE G0 PHASE; CHROMATIN CONDENSATION; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG CYTOTOXICITY; DRUG DETERMINATION; DRUG MECHANISM; DRUG SCREENING; ENZYME ACTIVATION; ENZYME ACTIVITY; FICUS RELIGIOSA; FLUORESCENCE RESONANCE ENERGY TRANSFER; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; PHOTOSENSITIZATION; PHYTOCHEMISTRY; PLANT LEAF; PROTEIN TRANSPORT; STAINING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BREAST NEOPLASMS; CASPASE 9; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATIN; ENZYME ACTIVATION; FEMALE; FICUS; HUMANS; MCF-7 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; PHOTOSENSITIZING AGENTS; PLANT EXTRACTS; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES;

FICUS RELIGIOSA;

EID: 84863675441     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0040055     Document Type: Article

References (51)

1. Shoeb M, (2006) Anticancer agents from medicinal plants. Bangladesh J Pharmacol 1: 35-41.
2. Aggarwal BB, Shishodia S, (2006) Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71: 1397-1421.
3. Shishodia S, Adams L, Bhatt ID, Aggarwal BB, (2006) Anticancer Potential of pomegranate. In. Seeram NP, Schulman RN and Heber D editors. Pomegranates: Ancient Roots to Modern Medicine, 1st edition. CRC Press Taylor and Francis Group, Florida, 107-116pp.
4. Aiyegoro OA, Okoh AI, (2009) Use of bioactive plant products in combination with standard antibiotics: implications in antimicrobial chemotherapy. J Med Plants. 3: 1147-1152.
5. Sreelekshmi R, Latha PG, Arafat MM, Shyamal S, Shine VJ, et al. (2007) Anti-inflammatory, analgesic and anti-lipid peroxidation studies on stem bark of Ficus religiosa Linn. Nat Prod Radiance 6: 377-381.
6. Vinutha B, Prashanth D, Salma K, Sreeja SL, Pratiti D, et al. (2007) Screening of selected Indian medicinal plants for acetyl cholinesterase inhibitory activity. J Ethnopharmacol 109: 359-363.
7. Singh D, Singh B, Goel RK, (2011) Traditional uses, phytochemistry and pharmacology of Ficus religiosa: A review, J Ethnopharmacol. 134: 565-583.
8. Sheetal A, Bagul MS, Prabia M, Rajani M, (2008) Evaluation of free radicals scavenging activity of an Ayurvedic formulation, panchvankala. Indian J Pharm Sci 70: 31-35.
9. Taskeen A, Naeem I, Mubeen H, Mehmood T, (2009) Reverse phase high performance liquid chromatographic analysis of flavonoids in two Ficus species. New York Sci J 2: 32-35.
10. Jung HW, Son HY, Minh CV, Kim YH, Park YK, (2008) Methanol extract of Ficus leaf inhibits the production of nitric oxide and Proinflammatory cytokines in LPS stimulated microglia via the MAPK pathway. Phytother Res 22: 1064-1069.
11. Naira N, Rohini RM, Syed MB, Amit KD, (2009) Wound healing activity of the hydro alcoholic extract of Ficus religiosa leaves in rats. The Internet J Altern Med 6: 2-7.
12. Choudhary GP, (2006) Evaluation of ethanolic extract of Ficus religiosa bark on incision and excision wounds in rats. Planta Indica 2: 17-19.
13. Aqil F, Ahmad I, (2003) Broad-spectrum antibacterial and antifungal properties of certain traditionally used Indian medicinal plants. World J Microbiol Biotechnol 19: 653-657.
14. Damanpreet S, Rajesh KG, (2009) Anticonvulsant effect of Ficus religiosa: role of serotonergic pathways. J Ethnopharmacol 123: 330-334.
15. Rucha R, Ashish P, Aarti J, (2010) Antidiabetic effect of Ficus religiosa extract in streptozotocin-induced diabetic rats. J Ethnopharmacol 128: 462-466.
16. Kirana H, Agrawal SS, Srinivasan BP, (2009) Aqueous extract of Ficus religiosa Linn. reduces oxidative stress in experimentally induced type 2 diabetic rats. Indian J Exp Biol 47: 822-826.
17. Ratnasooriya WD, Jayakody JR, Dharmasiri MG, (1998) An aqueous extract of trunk bark of Ficus religiosa has anxiolytic activity. Med Sci Res 26: 817-819.
18. Gulecha V, Sivakumar T, (2011) Anticancer activity of Tephrosia purpurea and Ficus religiosa using MCF 7 cell lines. Asian Pac J Trop Med 4: 526-529.
19. Kastan MB, Bartek J, (2004) Cell-cycle checkpoints and cancer. Nature 432: 316-323.
20. Kasibhatla S, Tseng B, (2003) Why target apoptosis in cancer treatment? Mol Cancer Ther 2: 573-580.
21. Trease GE, Evans WC, (2002) Pharmacognosy. London: Saunders Publishers. 15th edition 584 p.
22. Chang C, Yang M, Wen H, Chern J, (2002) Estimation of total flavonoids content in Propolis by two complementary colorimetric method. J Food Drug Anal 10: 178-182.
23. Mc Donald S, Prenzler PD, Autolovich M, Robards K, (2001) Phenolic content and antioxidant activity of Olive extracts. Food Chem 73: 73-84.
24. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C, (1995) A novel assay for apoptosis Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 184: 39-51.
25. Breckenridge DG, Stojanovic M, Marcellus RC, Shore GC, (2003) Caspase cleavage product of BAP31 induces mitochondrial fission through endoplasmic reticulum calcium signals, enhancing cytochrome c release to the cytosol. J Cell Biol 160: 1115-1127.
26. Seervi M, Joseph J, Sobhan PK, Bhavya BC, Santhosh KTR, (2011) Essential requirement of cytochrome c release for caspase activation by pro-Caspase activating compound defined by cellular models. Cell Death Dis doi:10.1038/cddis.2011.90.
27. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, et al. (2001) Proapoptotic Bax and Bak: a requisite gateway to mitochondrial dysfunction and death. Science 292: 727-730.
28. Joseph J, Seervi M, Sobhan PK, Retnabai ST, (2011) High throughput ratio imaging to profile caspase activity: potential application in multiparameter high content apoptosis analysis and drug screening. PLoS One. 2011; 6(5): e20114. Epub 2011 May 27.
29. Lam M, Oleinick NL, Nieminen AL, (2001) Photodynamic therapy-induced apoptosis in epidermoid carcinoma cells reactive oxygen species and mitochondrial inner membrane permeabilization. J Biol Chem. 276: 47379-47386.
30. Cisowska A, Wojnicz D, Hendrich AB, (2011) Anthocyanins as antimicrobial agents of natural plant origin. Nat. Prod. Commun. 6: 149-56.
31. Sirisha N, Sreenivasulu M, Sangeeta K, Chetty CM, (2010) Antioxidant Properties of Ficus Species-A review. International J Pharm Tech Research. 3: 2174-2182.
32. Grabley S, Thiericke R, (1999) (eds) Drug discovery from nature, Chap 1. Springer-Verlag, Berlin, 1-33.
33. Panchal RG, (1998) Novel therapeutic strategies to selectively kill cancer cells. Biochem Pharmacol 55: 247-252.
34. Schwartz GK, Shah MA, (2005) Targeting the cell cycle: a new approach to cancer therapy. J Clin Oncol 23: 9408-9421.
35. Lakin N, Jackson SP, (1999) Regulation of p53 in response to DNA damage. Oncogene 18: 7644-7655.
36. Choi HJ, Lim DY, Park JHY, (2009) Induction of G1 and G2/M cell cycle arrests by the dietary compound 3,3′-diindolylmethane in HT-29 human colon cancer cells. BMC Gastroenterol 9: 39.
37. Fulda S, Debatin KM, (2004) Sensitization for anticancer drug-induced apoptosis by the chemopreventive agent resveratrol. Oncogene 23: 6702-6711.
38. Elmore S, (2007) Apoptosis: A Review of Programmed Cell Death. Toxicol Pathol. 35: 495-516.
39. Okada H, Mak TW, (2004) Pathways of apoptotic and non-apoptotic death in tumor cells. Nat Rev Cancer 4: 592-603.
40. Green DR, Reed CJ, (1998) Mitochondria and apoptosis. Science 281: 1309-1312.
41. Cho SG, Choi EJ, (2002) Apoptotic signalling pathways: caspases and stress activated protein kinases. J Biochem Mol Biol 35: 24-27.
42. Janicke RU, Sprengart ML, Wati MR, Porter AG, (1998) Caspase 3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 273: 9357-9360.
43. Benjamin CW, Hiebsch RR, Jones DA, (1998) Caspase activation in MCF-7 cells responding to etoposide treatment. Mol Pharmacol 53: 446-450.
44. Janicke RU, Ng P, Sprengart ML, Porter AG, (1998) Caspase 3 is required for alpha-fordin cleavage but dispensable for cleavage of other death substrates in apoptosis. J Biol Chem 273: 15540-15545.
45. Germain M, Affar EB, D'Amours D, Dixit VM, Salvesen GS, et al. (1999) Cleavage of automodified poly(ADP-ribose) polymerase during apoptosis. Evidence for involvement of Caspase 7. J Biol Chem 274: 28379-28384.
46. Joy B, Sivadasan R, Abraham TE, John M, Sobhan PK, et al. (2010) Lysosomal Destabilization and Cathepsin B Contributes for Cytochrome c Release and Caspase Activation in Embelin-Induced Apoptosis. Mol Carcinogen 49: 324-336.
47. Van de Loosdrecht AA, Beelan RHJ, Ossenkoppele GJ, Broekhoven MG, Langenhuijsen MM, (1994) A tetrazolium-based colorimetric MTT assay to quantitate human monocyte mediated cytotoxicity against leukemic cells from cell line and patients with acute myeloid leukemia. J Immunol Methods 174: 311-320.
48. Tennant JR, (1964) Evaluation of the trypan blue technique for determination of cell viability. Transplantation 2: 685-694.
49. Meng J, Peng H, Dai B, Guo W, Wang L, et al. (2009) High level of AKT activity is associated with resistance to MEK inhibitor aZD6244 (aRRY-142886). Cancer Biol Ther 8: 2073-2080.
50. Kwang SA, Gautam S, Bharat BA, (2007) Embelin, an Inhibitor of X Chromosome-Linked Inhibitor-of Apoptosis Protein, Blocks Nuclear Factor- B (NFκB) Signaling Pathway Leading to Suppression of NFκB- Regulated Antiapoptotic and Metastatic Gene Products. Mol Pharmacol 71: 209-219.
51. Denecker G, Dooms H, Van Loo G, Vercammen D, Grooten J, et al. (2000) Phosphatidylserine exposure during apoptosis proceeds release of cytochrome c and decrease in mitochondrial transmembrane potential. FEBS Lett 465: 47-52.