Anticonvulsant effect of Ficus religiosa: Role of serotonergic pathways

Journal of Ethnopharmacology

Volumn 123, Issue 2, 2009, Pages 330-334

  Singh, Damanpreet ^a   Goel, Rajesh Kumar ^b  

^a GURU NANAK DEV UNIVERSITY   (India)

^b PUNJABI UNIVERSITY   (India)

Author keywords

Epilepsy; Ficus religiosa; Figs; Neurotoxicity; Serotonin

Indexed keywords

CYPROHEPTADINE; DIAZEPAM; FICUS RELIGIOSA EXTRACT; PENTETRAZOLE; PENTOBARBITAL; PHENYTOIN; PICROTOXIN; PLANT EXTRACT; SEROTONIN; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENTIATION; ELECTRIC SHOCK; HYPNOSIS; MALE; MEDICINAL PLANT; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; SEDATION; SEIZURE; SEROTONINERGIC SYSTEM; SLEEP;

ANIMALS; ANTICONVULSANTS; CYPROHEPTADINE; DIAZEPAM; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EPILEPSY; FICUS; MALE; MEDICINE, TRADITIONAL; MICE; PHENYTOIN; PLANT EXTRACTS; SEROTONIN; SEROTONIN ANTAGONISTS; TOXICITY TESTS;

ANIMALIA; FICUS RELIGIOSA; MORACEAE;

EID: 67349139902     PISSN: 03788741     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jep.2009.02.042     Document Type: Article

References (26)

1. Ali M., and Qadry J.S. Amino acid composition of fruits and seeds of medicinal plants. Journal of the Indian Chemical Society 64 (1987) 230-231
2. Bagdy G., Kecskemeti V., Riba P., and Jakus R. Serotonin and epilepsy. Journal of Neurochemistry 100 (2007) 857-873
3. Bliebtrau J.N. The Parable of the Beast (1968), Macmillan Company, New York p. 74
4. Dailey J.W., Yan Q.S., Adams L.E., Ryu J.R., Ko K.H., Mishra P.K., and Jobe P.C. Neurochemical correlates of antiepileptic drugs in the genetically epilepsy prone rat (GEPR). Life Sciences 58 (1996) 259-266
5. Han Y.F., Shiang J.C., Ruei F.C., Wang H.D., Ling L.K.H., and Rong N.H. Identification of oxalic acid and tartaric acid as major persistent pain-inducing toxins in the stinging hairs of the Nettle, Urtica thunbergiana. Annals of Botany 98 (2006) 57-65
6. Kala C.P., Dhyani P.P., and Sajwan B.S. Developing the medicinal plants sector in northern India: challenges and opportunities. Journal of Ethnobiology and Ethnomedicine 2 (2006) 32-46
7. Krall R.L., Penry J.K., White B.G., Kupferberg H.J., and Swinyard E.A. Antiepileptic drug development. Anticonvulsant drug screening. Epilepsia 19 (1978) 409-428
8. Leewanich P., Tohda M., Matsumoto K., Subhadirsakul S., Takayama H., and Watanabe H. Behavioural studies on alkaloids extracts from the leaves of Hunteria zeylanica. Biological and Pharmaceutical Bulletin 19 (1996) 394-399
9. Loscher W., and Schmidt D. Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations. Epilepsy Research 2 (1988) 145-181
10. Mainen J.M., Godeliver A.B.K., and Zakaria H.M. Plants used to treat epilepsy by Tanzanian traditional healers. Journal of Ethnopharmacology 97 (2005) 327-336
11. Meador K.J., Loring D.W., Huh K., Gallagher B.B., and King D.W. Comparative cognitive effects of anticonvulsants. Neurology 40 (1990) 391-394
12. Michael A.R. Diverse mechanisms of antiepileptic drugs in the development pipeline. Epilepsy Research 69 (2006) 273-294
13. Ratnasooriya W.D., Jayakody J.R.A.C., and Dharmasiri M.G. An aqueous extract of trunk bark of Ficus religiosa has anxiolytic activity. Medical Science Research 26 (1998) 817-819
14. Ripu M.K., and Rainer W.B. Ficus (Fig) species in Nepal: a review of diversity and indigenous uses. Lyonia 11 (2006) 85-97
15. Sonavane G.S., Palekar R.C., Kasture V.S., and Kasture S.B. Anticonvulsant and behavioural actions of Myristica Fragrans seeds. Indian Journal of Pharmacology 34 (2002) 332-338
16. Swinyard E.A., Brown W.C., and Goodman L.S. Comparative assay of antiepileptic drugs in mice and rats. Journal of Pharmacology and Experimental Therapeutics 106 (1952) 319-330
17. Trimble M.R. Anticonvulsant drugs and cognitive function-a review of the literature. Epilepsia 28 (1987) S37-S45
18. Turner R.A. Depressants of the central nervous system. In: Turner R.A. (Ed). Screening Methods in Pharmacology (1965), Academic Press, New York 69-86
19. Umar K.S., Patrick A.O., and Gregory A.C. Sedative and anticonvulsant effects of aqueous extract of Ficus sycomorus L. (Moraceae) stembark in rats. Veterinarski Arhiv 73 (2003) 103-110
20. Van Noort S., Gardiner A.J., and Tolley K.A. New records of Ficus (Moraceae) species emphasize the conservation significance of inselbergs in Mozambique. South African Journal of Botany 73 (2007) 642-649
21. Vinutha B., Prashanth D., Salma K., Sreeja S.L., Pratiti D., Padmaja R., Radhika S., Amit A., Venkateshwarlu K., and Deepak M. Screening of selected Indian medicinal plants for acetylcholinesterase inhibitory activity. Journal of Ethnopharmacology 109 (2007) 359-363
22. Vyawahare N.S., Khandelwal A.R., Batra V.R., and Nikam A.P. Herbal anticonvulsants. Journal of Herbal Medicine and Toxicology 1 (2007) 9-14
23. White H.S. Chemoconvulsants. In: Steven L.P., and Timothy E.A. (Eds). Neuropharmacology Methods in Epilepsy Research (1998), CRC Press, New York 27-40
24. White H.S., Johnson M., Wolf H.H., and Kupferberg H.J. The early identification of anticonvulsant activity: role of the maximal electroshock and subcutaneous pentylenetetrazole seizure models. Italian Journal of Science 16 (1995) 73-77
25. Yerby M.S. Teratogenicity of antiepileptic drugs. In: Pedley T.A., and Meldrum B.S. (Eds). Recent Advances in Epilepsy (1988), Churchill Livingstone, New York 93-107
26. Zhang Z.J. Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders. Life Sciences 75 (2004) 1659-1699