Embelin, an inhibitor of X chromosome-linked inhibitor-of-apoptosis protein, blocks nuclear factor-κB (NF-κB) signaling pathway leading to suppression of NF-κB-regulated antiapoptotic and metastatic gene products

Molecular Pharmacology

Volumn 71, Issue 1, 2007, Pages 209-219

  Kwang, Seok Ahn ^a   Sethi, Gautam ^a   Aggarwal, Bharat B ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CIGARETTE SMOKE; DOXORUBICIN; EMBELIN; GENE PRODUCT; HYDROGEN PEROXIDE; I KAPPA B KINASE ALPHA; I KAPPA B KINASE ALPHA KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LIPOPOLYSACCHARIDE; NUCLEAR FACTOR KAPPA B INDUCING KINASE; OKADAIC ACID; ONCOFETAL ANTIGEN; P65 ANTIGEN; PACLITAXEL; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHOTRANSFERASE; TNFR1 ASSOCIATED DEATH DOMAIN PROTEIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2; UNCLASSIFIED DRUG; X LINKED INHIBITOR OF APOPTOSIS;

ACETYLATION; APOPTOSIS; ARTICLE; CELL INVASION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME DEGRADATION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; METASTASIS; PRIORITY JOURNAL; REPORTER GENE; SIGNAL TRANSDUCTION;

ADENOCARCINOMA; APOPTOSIS; BENZOQUINONES; CARCINOMA, SQUAMOUS CELL; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CYCLOOXYGENASE 2; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENES, REPORTER; HUMANS; I-KAPPA B PROTEINS; INHIBITOR OF APOPTOSIS PROTEINS; KIDNEY; LUNG NEOPLASMS; MULTIPLE MYELOMA; NEOPLASM INVASIVENESS; NF-KAPPA B; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); SIGNAL TRANSDUCTION; TUMOR NECROSIS FACTOR-ALPHA; X CHROMOSOME;

EID: 33845883544     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.106.028787     Document Type: Article

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