Molecular mechanisms of the inhibitory effects of bovine lactoferrin on lipopolysaccharide-mediated osteoclastogenesis

Journal of Biological Chemistry

Volumn 287, Issue 28, 2012, Pages 23527-23536

  Inubushi, Toshihiro ^a   Kawazoe, Aki ^a   Miyauchi, Mutsumi ^a   Kudo, Yasusei ^a   Ao, Min ^a   Ishikado, Atsushi ^b   Makino, Taketoshi ^b   Takata, Takashi ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b Sunstar Inc   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BONE DESTRUCTION; BONE RESORPTION; BONE TISSUE; CHRONIC INFLAMMATORY DISEASE; CO-CULTURE SYSTEM; DNA BINDING ACTIVITY; IMMUNE RESPONSE; IN-VIVO; INFLAMMATORY DISEASE; INHIBITORY EFFECT; INTERLEUKIN-1; LACTOFERRIN; MAP KINASE; MOLECULAR MECHANISM; NUCLEAR FACTORS; OSTEOCLASTOGENESIS; POLYUBIQUITINATION; PRE-TREATMENT; RECEPTOR ACTIVATOR; RHEUMATOID ARTHRITIS; SIGNALING PATHWAYS; THERAPEUTIC AGENTS;

BONE; DEGRADATION; DISEASES; ENZYME ACTIVITY; MAMMALS; PHOSPHORYLATION; TISSUE;

CHEMICAL ACTIVATION;

DNA; I KAPPA B ALPHA; I KAPPA B BETA; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 1; INTERLEUKIN 1BETA; LACTOFERRIN; LIPOPOLYSACCHARIDE; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; LYSINE; MITOGEN ACTIVATED PROTEIN KINASE; OSTEOCLAST DIFFERENTIATION FACTOR; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CHRONIC INFLAMMATION; COCULTURE; COW; CYTOKINE PRODUCTION; DNA BINDING; ENDOCYTOSIS; ENZYME ACTIVATION; ENZYME DEGRADATION; INHIBITION KINETICS; MOLECULAR MECHANICS; MOUSE; NONHUMAN; OSTEOBLAST; OSTEOCLASTOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UBIQUITINATION;

ANIMALS; ANTIGENS, CD14; BLOTTING, WESTERN; BONE MARROW CELLS; CATTLE; CELL LINE; CELLS, CULTURED; COCULTURE TECHNIQUES; GENE EXPRESSION; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; LACTOFERRIN; LIPOPOLYSACCHARIDES; MICE; NF-KAPPA B; OSTEOBLASTS; OSTEOGENESIS; PHOSPHORYLATION; RANK LIGAND; RECEPTORS, LDL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6; TUMOR NECROSIS FACTOR-ALPHA; TUMOR SUPPRESSOR PROTEINS; UBIQUITINATION;

BOVINAE;

EID: 84863630839     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.324673     Document Type: Article

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