Sensitivity of glioblastomas to clinically available MEK inhibitors is defined by neurofibromin 1 deficiency

Cancer Research

Volumn 72, Issue 13, 2012, Pages 3350-3359

  See, Wendy L ^a,b   Tan, I L ^a,b   Mukherjee, Joydeep ^a,b   Nicolaides, Theodore ^a,b   Pieper, Russell O ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 HYDROXYPHENYL) 4 MORPHOLINOPYRIDO[3',2':4,5]FURO[3,2 D]PYRIMIDINE; CYCLIN D1; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; N (2,3 DIHYDROXYPROPOXY) 3,4 DIFLUORO 2 (2 FLUORO 4 IODOANILINO)BENZAMIDE; NEUROFIBROMIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN P27; SELUMETINIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER INHIBITION; CANCER RESISTANCE; CHEMOSENSITIVITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; G1 PHASE CELL CYCLE CHECKPOINT; GLIOBLASTOMA; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPLETION; TREATMENT RESPONSE;

ANIMALS; APOPTOSIS; BRAIN NEOPLASMS; CELL LINE, TUMOR; GLIOBLASTOMA; HUMANS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NEUROFIBROMIN 1; PROTEIN KINASE INHIBITORS;

EID: 84863594749     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-12-0334     Document Type: Article

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