Chronic hepatitis C virus infection breaks tolerance and drives polyclonal expansion of autoreactive B cells

Clinical and Vaccine Immunology

Volumn 19, Issue 7, 2012, Pages 1027-1037

  Roughan, Jill E ^a   Reardon, Kathryn M ^a   Cogburn, Kristin E ^a   Quendler, Heribert ^a,c   Pockros, Paul J ^b   Law, Mansun ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b SCRIPPS CLINIC   (United States)

^c UNIVERSITY OF AGRICULTURAL SCIENCES   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; B LYMPHOCYTE RECEPTOR; IMMUNOGLOBULIN M;

ADULT; AGED; ANTIBODY PRODUCTION; ARTICLE; CELL EXPANSION; CELL POPULATION; CLINICAL FEATURE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE SEQUENCE; GENETIC ANALYSIS; HEPATITIS C; HUMAN; HUMAN CELL; IMMUNOGLOBULIN HEAVY CHAIN GENE; IMMUNOLOGICAL TOLERANCE; IMMUNOREACTIVITY; LIVER INJURY; MAJOR CLINICAL STUDY; MALE; MEMORY CELL; MOLECULAR CLONING; PRIORITY JOURNAL; RISK ASSESSMENT; SOMATIC HYPERMUTATION; VIRUS LOAD;

ADULT; AGED; AUTOANTIBODIES; AUTOIMMUNE DISEASES; B-LYMPHOCYTE SUBSETS; B-LYMPHOCYTES; FEMALE; HEPATITIS C, CHRONIC; HUMANS; IMMUNE TOLERANCE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN M; IMMUNOGLOBULIN VARIABLE REGION; IMMUNOLOGIC MEMORY; MALE; MIDDLE AGED;

EID: 84863542166     PISSN: 15566811     EISSN: 1556679X     Source Type: Journal    
DOI: 10.1128/CVI.00194-12     Document Type: Article

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