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Volumn 303, Issue 1, 2012, Pages

Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet

Author keywords

4 phenylbutyric acid; Chemical chaperones; Steatosis; Tauroursodeoxycholic acid; Unfolded protein response

Indexed keywords

4 PHENYLBUTYRIC ACID; ALANINE AMINOTRANSFERASE; CCAAT ENHANCER BINDING PROTEIN; CHAPERONE; CHOLESTEROL; CHOLINE; GELATINASE B; GLUCOSE REGULATED PROTEIN 78; INITIATION FACTOR 2ALPHA; INTERSTITIAL COLLAGENASE; JANUS KINASE; MESSENGER RNA; METHIONINE; TAUROURSODEOXYCHOLIC ACID; TRIACYLGLYCEROL; X BOX BINDING PROTEIN 1;

EID: 84863527817     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00052.2012     Document Type: Article
Times cited : (32)

References (49)
  • 1
    • 45849137877 scopus 로고    scopus 로고
    • Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2 9. Lee AH, Scapa EF, Cohen DE, Glimcher LH. Regulation of hepatic lipogenesis by the transcription factor XBP1
    • Berlanga JJ, Santoyo J, De Haro C. Characterization of a mammalian homolog of the GCN2 eukaryotic initiation factor 2 9. Lee AH, Scapa EF, Cohen DE, Glimcher LH. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320: 1492-1496, 2008.
    • (2008) Science , vol.320 , pp. 1492-1496
    • Berlanga, J.J.1    Santoyo, J.2    de Haro, C.3
  • 2
    • 33749492425 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress signaling in disease
    • Marciniak SJ, Ron D. Endoplasmic reticulum stress signaling in disease. Physiol Rev 86: 1133-1149, 2006.
    • (2006) Physiol Rev , vol.86 , pp. 1133-1149
    • Marciniak, S.J.1    Ron, D.2
  • 3
    • 38149136598 scopus 로고    scopus 로고
    • Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents
    • Ota T, Gayet C, Ginsberg HN. Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents. J Clin Invest 118: 316-332, 2008.
    • (2008) J Clin Invest , vol.118 , pp. 316-332
    • Ota, T.1    Gayet, C.2    Ginsberg, H.N.3
  • 6
    • 34248681601 scopus 로고    scopus 로고
    • CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis
    • Rahman SM, Schroeder-Gloeckler JM, Janssen RC, Jiang H, Qadri I, Maclean KN, Friedman JE. CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis. Hepatology 45: 1108-1117, 2007.
    • (2007) Hepatology , vol.45 , pp. 1108-1117
    • Rahman, S.M.1    Schroeder-Gloeckler, J.M.2    Janssen, R.C.3    Jiang, H.4    Qadri, I.5    Maclean, K.N.6    Friedman, J.E.7
  • 7
    • 80053319811 scopus 로고    scopus 로고
    • Will the increased prevalence of nonalcoholic steatohepatitis (NASH) in the age of better hepatitis C virus therapy make NASH the deadlier disease
    • Rinella ME. Will the increased prevalence of nonalcoholic steatohepatitis (NASH) in the age of better hepatitis C virus therapy make NASH the deadlier disease? Hepatology 54: 1118-1120, 2011.
    • (2011) Hepatology , vol.54 , pp. 1118-1120
    • Rinella, M.E.1
  • 8
    • 50049097587 scopus 로고    scopus 로고
    • Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet
    • Rinella ME, Elias MS, Smolak RR, Fu T, Borensztajn J, Green RM. Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet. J Lipid Res 49: 1068-1076, 2008.
    • (2008) J Lipid Res , vol.49 , pp. 1068-1076
    • Rinella, M.E.1    Elias, M.S.2    Smolak, R.R.3    Fu, T.4    Borensztajn, J.5    Green, R.M.6
  • 9
    • 0346689994 scopus 로고    scopus 로고
    • The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance
    • Rinella ME, Green RM. The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance. J Hepatol 40: 47-51, 2004.
    • (2004) J Hepatol , vol.40 , pp. 47-51
    • Rinella, M.E.1    Green, R.M.2
  • 10
    • 80055033307 scopus 로고    scopus 로고
    • Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis
    • Rinella ME, Siddiqui MS, Gardikiotes K, Gottstein J, Elias M, Green RM. Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis. Hepatology 54: 1600-1609, 2011.
    • (2011) Hepatology , vol.54 , pp. 1600-1609
    • Rinella, M.E.1    Siddiqui, M.S.2    Gardikiotes, K.3    Gottstein, J.4    Elias, M.5    Green, R.M.6
  • 12
    • 78049480651 scopus 로고    scopus 로고
    • Stress signaling in the methionine-choline-deficient model of murine fatty liver disease
    • Soon RK Jr, Yan JS, Grenert JP, Maher JJ. Stress signaling in the methionine-choline-deficient model of murine fatty liver disease. Gastroenterology 139: 1730-1739, 2010.
    • (2010) Gastroenterology , vol.139 , pp. 1730-1739
    • Soon Jr., R.K.1    Yan, J.S.2    Grenert, J.P.3    Maher, J.J.4
  • 13
    • 0141786790 scopus 로고    scopus 로고
    • Oxidative stress, KLF6 and transforming growth factor-β up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats
    • Starkel P, Sempoux C, Leclercq I, Herin M, Deby C, Desager JP, Horsmans Y. Oxidative stress, KLF6 and transforming growth factor-β up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats. J Hepatol 39: 538-546, 2003.
    • (2003) J Hepatol , vol.39 , pp. 538-546
    • Starkel, P.1    Sempoux, C.2    Leclercq, I.3    Herin, M.4    Deby, C.5    Desager, J.P.6    Horsmans, Y.7
  • 14
    • 24344495336 scopus 로고    scopus 로고
    • Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum stress-mediated apoptosis
    • Vilatoba M, Eckstein C, Bilbao G, Smyth CA, Jenkins S, Thompson JA, Eckhoff DE, Contreras JL. Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum stress-mediated apoptosis. Surgery 138: 342-351, 2005.
    • (2005) Surgery , vol.138 , pp. 342-351
    • Vilatoba, M.1    Eckstein, C.2    Bilbao, G.3    Smyth, C.A.4    Jenkins, S.5    Thompson, J.A.6    Eckhoff, D.E.7    Contreras, J.L.8
  • 15
    • 82255173966 scopus 로고    scopus 로고
    • The unfolded protein response: From stress pathway to homeostatic regulation
    • Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science 334: 1081-1086, 2011.
    • (2011) Science , vol.334 , pp. 1081-1086
    • Walter, P.1    Ron, D.2
  • 16
    • 30944451788 scopus 로고    scopus 로고
    • Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis
    • Wang D, Wei Y, Pagliassotti MJ. Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology 147: 943-951, 2006.
    • (2006) Endocrinology , vol.147 , pp. 943-951
    • Wang, D.1    Wei, Y.2    Pagliassotti, M.J.3
  • 17
    • 34250840799 scopus 로고    scopus 로고
    • Hepatic tumor necrosis factor signaling and nuclear factor-k{cyrillic} B: Effects on liver homeostasis and beyond
    • Wullaert A, van Loo G, Heyninck K, Beyaert R. Hepatic tumor necrosis factor signaling and nuclear factor-k{cyrillic} B: effects on liver homeostasis and beyond. Endocr Rev 28: 365-386, 2007.
    • (2007) Endocr Rev , vol.28 , pp. 365-386
    • Wullaert, A.1    van Loo, G.2    Heyninck, K.3    Beyaert, R.4
  • 18
    • 0036725164 scopus 로고    scopus 로고
    • Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation
    • Xie Q, Khaoustov VI, Chung CC, Sohn J, Krishnan B, Lewis DE, Yoffe B. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology 36: 592-601, 2002.
    • (2002) Hepatology , vol.36 , pp. 592-601
    • Xie, Q.1    Khaoustov, V.I.2    Chung, C.C.3    Sohn, J.4    Krishnan, B.5    Lewis, D.E.6    Yoffe, B.7
  • 19
    • 0001513966 scopus 로고    scopus 로고
    • Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis
    • Yang SQ, Lin HZ, Lane MD, Clemens M, Diehl AM. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc Natl Acad Sci USA 94: 2557-2562, 1997.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2557-2562
    • Yang, S.Q.1    Lin, H.Z.2    Lane, M.D.3    Clemens, M.4    Diehl, A.M.5
  • 20
    • 0023833533 scopus 로고
    • The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes
    • Yao ZM, Vance DE. The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes. J Biol Chem 263: 2998-3004, 1988.
    • (1988) J Biol Chem , vol.263 , pp. 2998-3004
    • Yao, Z.M.1    Vance, D.E.2
  • 21
    • 2942755868 scopus 로고    scopus 로고
    • Signaling the unfolded protein response from the endoplasmic reticulum
    • Zhang K, Kaufman RJ. Signaling the unfolded protein response from the endoplasmic reticulum. J Biol Chem 279: 25935-25938, 2004. kinase. Eur J Biochem 265: 754-762, 1999.
    • (2004) J Biol chem , vol.279 , pp. 25935-25938
    • Zhang, K.1    Kaufman, R.J.2
  • 23
    • 84863985147 scopus 로고    scopus 로고
    • Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway
    • Cao J, Dai DL, Yao L, Yu HH, Ning B, Zhang Q, Chen J, Cheng WH, Shen W, Yang ZX. Saturated fatty acid induction of endoplasmic reticulum stress and apoptosis in human liver cells via the PERK/ATF4/CHOP signaling pathway. Mol Cell Biochem 364: 115-129, 2012.
    • (2012) Mol Cell Biochem , vol.364 , pp. 115-129
    • Cao, J.1    Dai, D.L.2    Yao, L.3    Yu, H.H.4    Ning, B.5    Zhang, Q.6    Chen, J.7    Cheng, W.H.8    Shen, W.9    Yang, Z.X.10
  • 27
    • 70450270564 scopus 로고    scopus 로고
    • Homocysteine supplementation attenuates the unfolded protein response in a murine nutritional model of steatohepatitis
    • Henkel AS, Elias MS, Green RM. Homocysteine supplementation attenuates the unfolded protein response in a murine nutritional model of steatohepatitis. J Biol Chem 284: 31807-31816, 2009.
    • (2009) J Biol Chem , vol.284 , pp. 31807-31816
    • Henkel, A.S.1    Elias, M.S.2    Green, R.M.3
  • 28
    • 4644224457 scopus 로고    scopus 로고
    • Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet
    • Koppe SW, Sahai A, Malladi P, Whitington PF, Green RM. Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet. J Hepatol 41: 592-598, 2004.
    • (2004) J Hepatol , vol.41 , pp. 592-598
    • Koppe, S.W.1    Sahai, A.2    Malladi, P.3    Whitington, P.F.4    Green, R.M.5
  • 29
    • 45849137877 scopus 로고    scopus 로고
    • Regulation of hepatic lipogenesis by the transcription factor XBP1
    • Lee AH, Scapa EF, Cohen DE, Glimcher LH. Regulation of hepatic lipogenesis by the transcription factor XBP1. Science 320: 1492-1496, 2008.
    • (2008) Science , vol.320 , pp. 1492-1496
    • Lee, A.H.1    Scapa, E.F.2    Cohen, D.E.3    Glimcher, L.H.4
  • 30
    • 33749492425 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress signaling in disease
    • Marciniak SJ, Ron D. Endoplasmic reticulum stress signaling in disease. Physiol Rev 86: 1133-1149, 2006.
    • (2006) Physiol Rev , vol.86 , pp. 1133-1149
    • Marciniak, S.J.1    Ron, D.2
  • 31
    • 38149136598 scopus 로고    scopus 로고
    • Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents
    • Ota T, Gayet C, Ginsberg HN. Inhibition of apolipoprotein B100 secretion by lipid-induced hepatic endoplasmic reticulum stress in rodents. J Clin Invest 118: 316-332, 2008.
    • (2008) J Clin Invest , vol.118 , pp. 316-332
    • Ota, T.1    Gayet, C.2    Ginsberg, H.N.3
  • 34
    • 34248681601 scopus 로고    scopus 로고
    • CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis
    • Rahman SM, Schroeder-Gloeckler JM, Janssen RC, Jiang H, Qadri I, Maclean KN, Friedman JE. CCAAT/enhancing binding protein beta deletion in mice attenuates inflammation, endoplasmic reticulum stress, and lipid accumulation in diet-induced nonalcoholic steatohepatitis. Hepatology 45: 1108-1117, 2007.
    • (2007) Hepatology , vol.45 , pp. 1108-1117
    • Rahman, S.M.1    Schroeder-Gloeckler, J.M.2    Janssen, R.C.3    Jiang, H.4    Qadri, I.5    Maclean, K.N.6    Friedman, J.E.7
  • 35
    • 80053319811 scopus 로고    scopus 로고
    • Will the increased prevalence of nonalcoholic steatohepatitis (NASH) in the age of better hepatitis C virus therapy make NASH the deadlier disease
    • Rinella ME. Will the increased prevalence of nonalcoholic steatohepatitis (NASH) in the age of better hepatitis C virus therapy make NASH the deadlier disease? Hepatology 54: 1118-1120, 2011.
    • (2011) Hepatology , vol.54 , pp. 1118-1120
    • Rinella, M.E.1
  • 36
    • 50049097587 scopus 로고    scopus 로고
    • Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet
    • Rinella ME, Elias MS, Smolak RR, Fu T, Borensztajn J, Green RM. Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet. J Lipid Res 49: 1068-1076, 2008.
    • (2008) J Lipid Res , vol.49 , pp. 1068-1076
    • Rinella, M.E.1    Elias, M.S.2    Smolak, R.R.3    Fu, T.4    Borensztajn, J.5    Green, R.M.6
  • 37
    • 0346689994 scopus 로고    scopus 로고
    • The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance
    • Rinella ME, Green RM. The methionine-choline deficient dietary model of steatohepatitis does not exhibit insulin resistance. J Hepatol 40: 47-51, 2004.
    • (2004) J Hepatol , vol.40 , pp. 47-51
    • Rinella, M.E.1    Green, R.M.2
  • 38
    • 80055033307 scopus 로고    scopus 로고
    • Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis
    • Rinella ME, Siddiqui MS, Gardikiotes K, Gottstein J, Elias M, Green RM. Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis. Hepatology 54: 1600-1609, 2011.
    • (2011) Hepatology , vol.54 , pp. 1600-1609
    • Rinella, M.E.1    Siddiqui, M.S.2    Gardikiotes, K.3    Gottstein, J.4    Elias, M.5    Green, R.M.6
  • 40
    • 78049480651 scopus 로고    scopus 로고
    • Stress signaling in the methionine-choline-deficient model of murine fatty liver disease
    • Soon RK Jr, Yan JS, Grenert JP, Maher JJ. Stress signaling in the methionine-choline-deficient model of murine fatty liver disease. Gastroenterology 139: 1730-1739, 2010.
    • (2010) Gastroenterology , vol.139 , pp. 1730-1739
    • Soon Jr., R.K.1    Yan, J.S.2    Grenert, J.P.3    Maher, J.J.4
  • 41
    • 0141786790 scopus 로고    scopus 로고
    • Oxidative stress, KLF6 and transforming growth factor-β up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats
    • Starkel P, Sempoux C, Leclercq I, Herin M, Deby C, Desager JP, Horsmans Y. Oxidative stress, KLF6 and transforming growth factor-β up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats. J Hepatol 39: 538-546, 2003.
    • (2003) J Hepatol , vol.39 , pp. 538-546
    • Starkel, P.1    Sempoux, C.2    Leclercq, I.3    Herin, M.4    Deby, C.5    Desager, J.P.6    Horsmans, Y.7
  • 42
    • 24344495336 scopus 로고    scopus 로고
    • Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum stress-mediated apoptosis
    • Vilatoba M, Eckstein C, Bilbao G, Smyth CA, Jenkins S, Thompson JA, Eckhoff DE, Contreras JL. Sodium 4-phenylbutyrate protects against liver ischemia reperfusion injury by inhibition of endoplasmic reticulum stress-mediated apoptosis. Surgery 138: 342-351, 2005.
    • (2005) Surgery , vol.138 , pp. 342-351
    • Vilatoba, M.1    Eckstein, C.2    Bilbao, G.3    Smyth, C.A.4    Jenkins, S.5    Thompson, J.A.6    Eckhoff, D.E.7    Contreras, J.L.8
  • 43
    • 82255173966 scopus 로고    scopus 로고
    • The unfolded protein response: From stress pathway to homeostatic regulation
    • Walter P, Ron D. The unfolded protein response: from stress pathway to homeostatic regulation. Science 334: 1081-1086, 2011.
    • (2011) Science , vol.334 , pp. 1081-1086
    • Walter, P.1    Ron, D.2
  • 44
    • 30944451788 scopus 로고    scopus 로고
    • Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis
    • Wang D, Wei Y, Pagliassotti MJ. Saturated fatty acids promote endoplasmic reticulum stress and liver injury in rats with hepatic steatosis. Endocrinology 147: 943-951, 2006.
    • (2006) Endocrinology , vol.147 , pp. 943-951
    • Wang, D.1    Wei, Y.2    Pagliassotti, M.J.3
  • 45
    • 34250840799 scopus 로고    scopus 로고
    • Hepatic tumor necrosis factor signaling and nuclear factor-κ B: Effects on liver homeostasis and beyond
    • Wullaert A, van Loo G, Heyninck K, Beyaert R. Hepatic tumor necrosis factor signaling and nuclear factor-κ B: effects on liver homeostasis and beyond. Endocr Rev 28: 365-386, 2007.
    • (2007) Endocr Rev , vol.28 , pp. 365-386
    • Wullaert, A.1    van Loo, G.2    Heyninck, K.3    Beyaert, R.4
  • 46
    • 0036725164 scopus 로고    scopus 로고
    • Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation
    • Xie Q, Khaoustov VI, Chung CC, Sohn J, Krishnan B, Lewis DE, Yoffe B. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology 36: 592-601, 2002.
    • (2002) Hepatology , vol.36 , pp. 592-601
    • Xie, Q.1    Khaoustov, V.I.2    Chung, C.C.3    Sohn, J.4    Krishnan, B.5    Lewis, D.E.6    Yoffe, B.7
  • 47
    • 0001513966 scopus 로고    scopus 로고
    • Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis
    • Yang SQ, Lin HZ, Lane MD, Clemens M, Diehl AM. Obesity increases sensitivity to endotoxin liver injury: implications for the pathogenesis of steatohepatitis. Proc Natl Acad Sci USA 94: 2557-2562, 1997.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 2557-2562
    • Yang, S.Q.1    Lin, H.Z.2    Lane, M.D.3    Clemens, M.4    Diehl, A.M.5
  • 48
    • 0023833533 scopus 로고
    • The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes
    • Yao ZM, Vance DE. The active synthesis of phosphatidylcholine is required for very low density lipoprotein secretion from rat hepatocytes. J Biol Chem 263: 2998-3004, 1988.
    • (1988) J Biol Chem , vol.263 , pp. 2998-3004
    • Yao, Z.M.1    Vance, D.E.2
  • 49
    • 2942755868 scopus 로고    scopus 로고
    • Signaling the unfolded protein response from the endoplasmic reticulum
    • Zhang K, Kaufman RJ. Signaling the unfolded protein response from the endoplasmic reticulum. J Biol Chem 279: 25935-25938, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 25935-25938
    • Zhang, K.1    Kaufman, R.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.