메뉴 건너뛰기




Volumn 13, Issue 1, 2012, Pages

Selenium preserves mitochondrial function, stimulates mitochondrial biogenesis, and reduces infarct volume after focal cerebral ischemia

Author keywords

Cerebral ischemia; Glutamate; Hypoxia; Mitochondrial biogenesis; Respiratory complexes; Selenium

Indexed keywords

BECLIN 1; GLUTAMIC ACID; MICROTUBULE ASSOCIATED PROTEIN 1; NUCLEAR RESPIRATORY FACTOR 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; REACTIVE OXYGEN METABOLITE; SODIUM SELENITE;

EID: 84863514207     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-13-79     Document Type: Article
Times cited : (141)

References (48)
  • 1
    • 0029097980 scopus 로고
    • Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain
    • Almeida A, Allen KL, Bates TE, Clark JB. Effect of reperfusion following cerebral ischaemia on the activity of the mitochondrial respiratory chain in the gerbil brain. J Neurochem 1995, 65:1698-1703.
    • (1995) J Neurochem , vol.65 , pp. 1698-1703
    • Almeida, A.1    Allen, K.L.2    Bates, T.E.3    Clark, J.B.4
  • 2
    • 0030060186 scopus 로고    scopus 로고
    • Mitochondrial generation of reactive oxygen species after brain ischemia in the rat
    • Piantadosi CA, Zhang J. Mitochondrial generation of reactive oxygen species after brain ischemia in the rat. Stroke 1996, 27:327-331.
    • (1996) Stroke , vol.27 , pp. 327-331
    • Piantadosi, C.A.1    Zhang, J.2
  • 3
    • 0028936986 scopus 로고
    • Bioenergetic and oxidative stress in neurodegenerative diseases
    • Bowling AC, Beal MF. Bioenergetic and oxidative stress in neurodegenerative diseases. Life Sci 1995, 56:1151-1171.
    • (1995) Life Sci , vol.56 , pp. 1151-1171
    • Bowling, A.C.1    Beal, M.F.2
  • 4
    • 0034662094 scopus 로고    scopus 로고
    • The importance of selenium to human health
    • Rayman MP. The importance of selenium to human health. Lancet 2000, 356:233-241.
    • (2000) Lancet , vol.356 , pp. 233-241
    • Rayman, M.P.1
  • 5
    • 49549106630 scopus 로고    scopus 로고
    • Selenium: its role as antioxidant in human health
    • Tinggi U. Selenium: its role as antioxidant in human health. Environ Health Prev Med 2008, 13:102-108.
    • (2008) Environ Health Prev Med , vol.13 , pp. 102-108
    • Tinggi, U.1
  • 8
    • 0034636170 scopus 로고    scopus 로고
    • Impairment of synaptic transmission by transient hypoxia in hippocampal slices: improved recovery in glutathione peroxidase transgenic mice
    • Furling D, Ghribi O, Lahsaini A, Mirault ME, Massicotte G. Impairment of synaptic transmission by transient hypoxia in hippocampal slices: improved recovery in glutathione peroxidase transgenic mice. Proc Natl Acad Sci U S A 2000, 97:4351-4356.
    • (2000) Proc Natl Acad Sci U S A , vol.97 , pp. 4351-4356
    • Furling, D.1    Ghribi, O.2    Lahsaini, A.3    Mirault, M.E.4    Massicotte, G.5
  • 9
    • 15844415950 scopus 로고    scopus 로고
    • Effects of dietary selenium on post-ischemic expression of antioxidant mRNA
    • Venardos K, Ashton K, Headrick J, Perkins A. Effects of dietary selenium on post-ischemic expression of antioxidant mRNA. Mol Cell Biochem 2005, 270:131-138.
    • (2005) Mol Cell Biochem , vol.270 , pp. 131-138
    • Venardos, K.1    Ashton, K.2    Headrick, J.3    Perkins, A.4
  • 10
    • 0034678558 scopus 로고    scopus 로고
    • Selenium deficiency potentiates methamphetamine-induced nigral neuronal loss; comparison with MPTP model
    • Kim H, Jhoo W, Shin E, Bing G. Selenium deficiency potentiates methamphetamine-induced nigral neuronal loss; comparison with MPTP model. Brain Res 2000, 862:247-252.
    • (2000) Brain Res , vol.862 , pp. 247-252
    • Kim, H.1    Jhoo, W.2    Shin, E.3    Bing, G.4
  • 11
    • 0034801462 scopus 로고    scopus 로고
    • Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury
    • Crack PJ, Taylor JM, Flentjar NJ, de Haan J, Hertzog P, Iannello RC, Kola I. Increased infarct size and exacerbated apoptosis in the glutathione peroxidase-1 (Gpx-1) knockout mouse brain in response to ischemia/reperfusion injury. J Neurochem 2001, 78:1389-1399.
    • (2001) J Neurochem , vol.78 , pp. 1389-1399
    • Crack, P.J.1    Taylor, J.M.2    Flentjar, N.J.3    de Haan, J.4    Hertzog, P.5    Iannello, R.C.6    Kola, I.7
  • 13
    • 0141642104 scopus 로고    scopus 로고
    • Glutathione peroxidase overexpression inhibits cytochrome C release and proapoptotic mediators to protect neurons from experimental stroke
    • Hoehn B, Yenari MA, Sapolsky RM, Steinberg GK. Glutathione peroxidase overexpression inhibits cytochrome C release and proapoptotic mediators to protect neurons from experimental stroke. Stroke 2003, 34:2489-2494.
    • (2003) Stroke , vol.34 , pp. 2489-2494
    • Hoehn, B.1    Yenari, M.A.2    Sapolsky, R.M.3    Steinberg, G.K.4
  • 14
    • 0037316636 scopus 로고    scopus 로고
    • Dose-dependent protective effect of selenium in rat model of Parkinson's disease: neurobehavioral and neurochemical evidences
    • Zafar KS, Siddiqui A, Sayeed I, Ahmad M, Salim S, Islam F. Dose-dependent protective effect of selenium in rat model of Parkinson's disease: neurobehavioral and neurochemical evidences. J Neurochem 2003, 84:438-446.
    • (2003) J Neurochem , vol.84 , pp. 438-446
    • Zafar, K.S.1    Siddiqui, A.2    Sayeed, I.3    Ahmad, M.4    Salim, S.5    Islam, F.6
  • 15
    • 33845990232 scopus 로고    scopus 로고
    • Neuroprotection of selenite against ischemic brain injury through negatively regulating early activation of ASK1/JNK cascade via activation of PI3K/AKT pathway
    • Wang Q, Zhang QG, Wu DN, Yin XH, Zhang GY. Neuroprotection of selenite against ischemic brain injury through negatively regulating early activation of ASK1/JNK cascade via activation of PI3K/AKT pathway. Acta Pharmacol Sin 2007, 28:19-27.
    • (2007) Acta Pharmacol Sin , vol.28 , pp. 19-27
    • Wang, Q.1    Zhang, Q.G.2    Wu, D.N.3    Yin, X.H.4    Zhang, G.Y.5
  • 16
    • 0036371199 scopus 로고    scopus 로고
    • Selenite suppresses hydrogen peroxide-induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3-K/Akt pathways
    • Yoon SO, Kim MM, Park SJ, Kim D, Chung J, Chung AS. Selenite suppresses hydrogen peroxide-induced cell apoptosis through inhibition of ASK1/JNK and activation of PI3-K/Akt pathways. FASEB J 2002, 16:111-123.
    • (2002) FASEB J , vol.16 , pp. 111-123
    • Yoon, S.O.1    Kim, M.M.2    Park, S.J.3    Kim, D.4    Chung, J.5    Chung, A.S.6
  • 17
    • 0742270536 scopus 로고    scopus 로고
    • Selenium attenuates lipopolysaccharide-induced oxidative stress responses through modulation of p38 MAPK and NF-kappaB signaling pathways
    • Kim SH, Johnson VJ, Shin TY, Sharma RP. Selenium attenuates lipopolysaccharide-induced oxidative stress responses through modulation of p38 MAPK and NF-kappaB signaling pathways. Exp Biol Med (Maywood) 2004, 229:203-213.
    • (2004) Exp Biol Med (Maywood) , vol.229 , pp. 203-213
    • Kim, S.H.1    Johnson, V.J.2    Shin, T.Y.3    Sharma, R.P.4
  • 18
    • 42749093583 scopus 로고    scopus 로고
    • Mrinalini: Selenium protects the hypoxia induced apoptosis in neuroblastoma cells through upregulation of Bcl-2
    • Sarada SK, Himadri P, Ruma D, Sharma SK, Pauline T. Mrinalini: Selenium protects the hypoxia induced apoptosis in neuroblastoma cells through upregulation of Bcl-2. Brain Res 2008, 1209:29-39.
    • (2008) Brain Res , vol.1209 , pp. 29-39
    • Sarada, S.K.1    Himadri, P.2    Ruma, D.3    Sharma, S.K.4    Pauline, T.5
  • 19
    • 34147152673 scopus 로고    scopus 로고
    • Selenium plays a modulatory role against cerebral ischemia-induced neuronal damage in rat hippocampus
    • Yousuf S, Atif F, Ahmad M, Hoda MN, Khan MB, Ishrat T, Islam F. Selenium plays a modulatory role against cerebral ischemia-induced neuronal damage in rat hippocampus. Brain Res 2007, 1147:218-225.
    • (2007) Brain Res , vol.1147 , pp. 218-225
    • Yousuf, S.1    Atif, F.2    Ahmad, M.3    Hoda, M.N.4    Khan, M.B.5    Ishrat, T.6    Islam, F.7
  • 20
    • 34447556042 scopus 로고    scopus 로고
    • The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation
    • Panee J, Liu W, Nakamura K, Berry MJ. The responses of HT22 cells to the blockade of mitochondrial complexes and potential protective effect of selenium supplementation. Int J Biol Sci 2007, 3:335-341.
    • (2007) Int J Biol Sci , vol.3 , pp. 335-341
    • Panee, J.1    Liu, W.2    Nakamura, K.3    Berry, M.J.4
  • 21
    • 0038491497 scopus 로고    scopus 로고
    • Brain mitochondria are primed by moderate Ca2+ rise upon hypoxia/reoxygenation for functional breakdown and morphological disintegration
    • Schild L, Huppelsberg J, Kahlert S, Keilhoff G, Reiser G. Brain mitochondria are primed by moderate Ca2+ rise upon hypoxia/reoxygenation for functional breakdown and morphological disintegration. J Biol Chem 2003, 278:25454-25460.
    • (2003) J Biol Chem , vol.278 , pp. 25454-25460
    • Schild, L.1    Huppelsberg, J.2    Kahlert, S.3    Keilhoff, G.4    Reiser, G.5
  • 22
  • 23
    • 0032585007 scopus 로고    scopus 로고
    • Hyperglycemia-exaggerated ischemic brain damage following 30 min of middle cerebral artery occlusion is not due to capillary obstruction
    • Li PA, Gisselsson L, Keuker J, Vogel J, Smith ML, Kuschinsky W, Siesjö BK. Hyperglycemia-exaggerated ischemic brain damage following 30 min of middle cerebral artery occlusion is not due to capillary obstruction. Brain Res 1998, 804:36-44.
    • (1998) Brain Res , vol.804 , pp. 36-44
    • Li, P.A.1    Gisselsson, L.2    Keuker, J.3    Vogel, J.4    Smith, M.L.5    Kuschinsky, W.6    Siesjö, B.K.7
  • 24
    • 0022483434 scopus 로고
    • Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination
    • Bederson JB, Pitts LH, Tsuji M, Nishimura MC, Davis RL, Bartkowski H. Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination. Stroke 1986, 17:472-476.
    • (1986) Stroke , vol.17 , pp. 472-476
    • Bederson, J.B.1    Pitts, L.H.2    Tsuji, M.3    Nishimura, M.C.4    Davis, R.L.5    Bartkowski, H.6
  • 25
    • 79951509235 scopus 로고    scopus 로고
    • Manganese Superoxide Dismutase Deficiency Exacerbates Ischemic Brain Damage Under Hyperglycemic Conditions by Altering Autophagy
    • Mehta SL, Lin Y, Chen W, Yu F, Cao L, He Q, Chan PH, Li PA. Manganese Superoxide Dismutase Deficiency Exacerbates Ischemic Brain Damage Under Hyperglycemic Conditions by Altering Autophagy. Transl Stroke Res 2011, 2:42-50.
    • (2011) Transl Stroke Res , vol.2 , pp. 42-50
    • Mehta, S.L.1    Lin, Y.2    Chen, W.3    Yu, F.4    Cao, L.5    He, Q.6    Chan, P.H.7    Li, P.A.8
  • 26
    • 0034714392 scopus 로고    scopus 로고
    • Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration
    • Schmued LC, Hopkins KJ. Fluoro-Jade B: a high affinity fluorescent marker for the localization of neuronal degeneration. Brain Res 2000, 874:123-130.
    • (2000) Brain Res , vol.874 , pp. 123-130
    • Schmued, L.C.1    Hopkins, K.J.2
  • 27
    • 0035112956 scopus 로고    scopus 로고
    • Phosphorylation of extracellular signal-regulated kinase after transient cerebral ischemia in hyperglycemic rats
    • Li PA, He QP, Yi-Bing O, Hu BR, Siesjö BK. Phosphorylation of extracellular signal-regulated kinase after transient cerebral ischemia in hyperglycemic rats. Neurobiol Dis 2001, 8:127-135.
    • (2001) Neurobiol Dis , vol.8 , pp. 127-135
    • Li, P.A.1    He, Q.P.2    Yi-Bing, O.3    Hu, B.R.4    Siesjö, B.K.5
  • 28
    • 34249689057 scopus 로고    scopus 로고
    • Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission
    • Taguchi N, Ishihara N, Jofuku A, Oka T, Mihara K. Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission. J Biol Chem 2007, 282:11521-11529.
    • (2007) J Biol Chem , vol.282 , pp. 11521-11529
    • Taguchi, N.1    Ishihara, N.2    Jofuku, A.3    Oka, T.4    Mihara, K.5
  • 31
    • 0029888311 scopus 로고    scopus 로고
    • Role of oxidants in ischemic brain damage
    • Chan PH. Role of oxidants in ischemic brain damage. Stroke 1996, 27:1124-1129.
    • (1996) Stroke , vol.27 , pp. 1124-1129
    • Chan, P.H.1
  • 32
    • 0034014316 scopus 로고    scopus 로고
    • Oxidative DNA damage precedes DNA fragmentation after experimental stroke in rat brain
    • Cui J, Holmes EH, Greene TG, Liu PK. Oxidative DNA damage precedes DNA fragmentation after experimental stroke in rat brain. FASEB J 2000, 14:955-967.
    • (2000) FASEB J , vol.14 , pp. 955-967
    • Cui, J.1    Holmes, E.H.2    Greene, T.G.3    Liu, P.K.4
  • 33
    • 59249089842 scopus 로고    scopus 로고
    • The protection of selenium on ROS mediated-apoptosis by mitochondria dysfunction in cadmium-induced LLC-PK(1) cells
    • Zhou YJ, Zhang SP, Liu CW, Cai YQ. The protection of selenium on ROS mediated-apoptosis by mitochondria dysfunction in cadmium-induced LLC-PK(1) cells. Toxicol In Vitro 2009, 23:288-294.
    • (2009) Toxicol In Vitro , vol.23 , pp. 288-294
    • Zhou, Y.J.1    Zhang, S.P.2    Liu, C.W.3    Cai, Y.Q.4
  • 34
    • 0037433479 scopus 로고    scopus 로고
    • Selenium supplementation can protect cultured rat cardiomyocytes from hypoxia/reoxygenation damage
    • Bordoni A, Biagi PL, Angeloni C, Leoncini E, Muccinelli I, Hrelia S. Selenium supplementation can protect cultured rat cardiomyocytes from hypoxia/reoxygenation damage. J Agric Food Chem 2003, 51:1736-1740.
    • (2003) J Agric Food Chem , vol.51 , pp. 1736-1740
    • Bordoni, A.1    Biagi, P.L.2    Angeloni, C.3    Leoncini, E.4    Muccinelli, I.5    Hrelia, S.6
  • 35
    • 36849055559 scopus 로고    scopus 로고
    • Selenium effectively inhibits ROS-mediated apoptotic neural precursor cell death in vitro and in vivo in traumatic brain injury
    • Yeo JE, Kang SK. Selenium effectively inhibits ROS-mediated apoptotic neural precursor cell death in vitro and in vivo in traumatic brain injury. Biochim Biophys Acta 2007, 1772:1199-1210.
    • (2007) Biochim Biophys Acta , vol.1772 , pp. 1199-1210
    • Yeo, J.E.1    Kang, S.K.2
  • 36
    • 0035886724 scopus 로고    scopus 로고
    • Activity profile of glutathione-dependent enzymes and respiratory chain complexes in rats supplemented with antioxidants and treated with carcinogens
    • Desai VG, Casciano D, Feuers RJ, Aidoo A. Activity profile of glutathione-dependent enzymes and respiratory chain complexes in rats supplemented with antioxidants and treated with carcinogens. Arch Biochem Biophys 2001, 394:255-264.
    • (2001) Arch Biochem Biophys , vol.394 , pp. 255-264
    • Desai, V.G.1    Casciano, D.2    Feuers, R.J.3    Aidoo, A.4
  • 37
    • 35148823272 scopus 로고    scopus 로고
    • High selenium diet protects against TNBS-induced acute inflammation, mitochondrial dysfunction, and secondary necrosis in rat colon
    • Tirosh O, Levy E, Reifen R. High selenium diet protects against TNBS-induced acute inflammation, mitochondrial dysfunction, and secondary necrosis in rat colon. Nutrition 2007, 23:878-886.
    • (2007) Nutrition , vol.23 , pp. 878-886
    • Tirosh, O.1    Levy, E.2    Reifen, R.3
  • 38
    • 78650009028 scopus 로고    scopus 로고
    • Upregulation of human selenoprotein H in murine hippocampal neuronal cells promotes mitochondrial biogenesis and functional performance
    • Mendelev N, Mehta SL, Witherspoon S, He Q, Sexton JZ, Li PA. Upregulation of human selenoprotein H in murine hippocampal neuronal cells promotes mitochondrial biogenesis and functional performance. Mitochondrion 2011, 11:76-82.
    • (2011) Mitochondrion , vol.11 , pp. 76-82
    • Mendelev, N.1    Mehta, S.L.2    Witherspoon, S.3    He, Q.4    Sexton, J.Z.5    Li, P.A.6
  • 40
    • 55749114205 scopus 로고    scopus 로고
    • Rapidly increased neuronal mitochondrial biogenesis after hypoxic-ischemic brain injury
    • Yin W, Signore AP, Iwai M, Cao G, Gao Y, Chen J. Rapidly increased neuronal mitochondrial biogenesis after hypoxic-ischemic brain injury. Stroke 2008, 39:3057-3063.
    • (2008) Stroke , vol.39 , pp. 3057-3063
    • Yin, W.1    Signore, A.P.2    Iwai, M.3    Cao, G.4    Gao, Y.5    Chen, J.6
  • 41
    • 39849094082 scopus 로고    scopus 로고
    • Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism
    • Gutsaeva DR, Carraway MS, Suliman HB, Demchenko IT, Shitara H, Yonekawa H, Piantadosi CA. Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism. J Neurosci 2008, 28:2015-2024.
    • (2008) J Neurosci , vol.28 , pp. 2015-2024
    • Gutsaeva, D.R.1    Carraway, M.S.2    Suliman, H.B.3    Demchenko, I.T.4    Shitara, H.5    Yonekawa, H.6    Piantadosi, C.A.7
  • 42
    • 79958704151 scopus 로고    scopus 로고
    • NARP mutation and mtDNA depletion trigger mitochondrial biogenesis which can be modulated by selenite supplementation
    • Wojewoda M, Duszyński J, Szczepanowska J. NARP mutation and mtDNA depletion trigger mitochondrial biogenesis which can be modulated by selenite supplementation. Int J Biochem Cell Biol 2011, 43:1178-1186.
    • (2011) Int J Biochem Cell Biol , vol.43 , pp. 1178-1186
    • Wojewoda, M.1    Duszyński, J.2    Szczepanowska, J.3
  • 43
    • 36549041882 scopus 로고    scopus 로고
    • Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death
    • Rami A, Langhagen A, Steiger S. Focal cerebral ischemia induces upregulation of Beclin 1 and autophagy-like cell death. Neurobiol Dis 2008, 29:132-141.
    • (2008) Neurobiol Dis , vol.29 , pp. 132-141
    • Rami, A.1    Langhagen, A.2    Steiger, S.3
  • 44
    • 50249189191 scopus 로고    scopus 로고
    • Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways
    • Wen YD, Sheng R, Zhang LS, Han R, Zhang X, Zhang XD, Han F, Fukunaga K, Qin ZH. Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophagy 2008, 4:762-769.
    • (2008) Autophagy , vol.4 , pp. 762-769
    • Wen, Y.D.1    Sheng, R.2    Zhang, L.S.3    Han, R.4    Zhang, X.5    Zhang, X.D.6    Han, F.7    Fukunaga, K.8    Qin, Z.H.9
  • 45
    • 77955887349 scopus 로고    scopus 로고
    • Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia
    • Qin AP, Liu CF, Qin YY, Hong LZ, Xu M, Yang L, Liu J, Qin ZH, Zhang HL. Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia. Autophagy 2010, 6:738-753.
    • (2010) Autophagy , vol.6 , pp. 738-753
    • Qin, A.P.1    Liu, C.F.2    Qin, Y.Y.3    Hong, L.Z.4    Xu, M.5    Yang, L.6    Liu, J.7    Qin, Z.H.8    Zhang, H.L.9
  • 46
    • 34247186472 scopus 로고    scopus 로고
    • Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4
    • Scherz-Shouval R, Shvets E, Fass E, Shorer H, Gil L, Elazar Z. Reactive oxygen species are essential for autophagy and specifically regulate the activity of Atg4. EMBO J 2007, 26:1749-1760.
    • (2007) EMBO J , vol.26 , pp. 1749-1760
    • Scherz-Shouval, R.1    Shvets, E.2    Fass, E.3    Shorer, H.4    Gil, L.5    Elazar, Z.6
  • 47
    • 34848920863 scopus 로고    scopus 로고
    • ROS, mitochondria and the regulation of autophagy
    • Scherz-Shouval R, Elazar Z. ROS, mitochondria and the regulation of autophagy. Trends Cell Biol 2007, 17:422-427.
    • (2007) Trends Cell Biol , vol.17 , pp. 422-427
    • Scherz-Shouval, R.1    Elazar, Z.2
  • 48
    • 38349132592 scopus 로고    scopus 로고
    • Selenium attenuates ROS-mediated apoptotic cell death of injured spinal cord through prevention of mitochondria dysfunction; in vitro and in vivo study
    • Yeo JE, Kim JH, Kang SK. Selenium attenuates ROS-mediated apoptotic cell death of injured spinal cord through prevention of mitochondria dysfunction; in vitro and in vivo study. Cell Physiol Biochem 2008, 21:225-238.
    • (2008) Cell Physiol Biochem , vol.21 , pp. 225-238
    • Yeo, J.E.1    Kim, J.H.2    Kang, S.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.