Effects of mitochondrial inhibitors on cell viability in U937 monocytes under glucose deprivation

Archives of Pharmacal Research

Volumn 31, Issue 6, 2008, Pages 749-757

  Han, Mijin ^a   Im, Dong Soon ^a  

^a Pusan National University   (South Korea)

Author keywords

Akt; Calcium; Cytotoxicity; Mitochondria; MMP; Signaling; Viability

Indexed keywords

ADENOSINE TRIPHOSPHATE; AMP ACTIVATED PROTEIN KINASES; AMP-ACTIVATED PROTEIN KINASES; CALCIUM; ENZYME INHIBITOR; GLUCOSE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; MULTIENZYME COMPLEX; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCOUPLING PROTEIN;

ANIMAL; APOPTOSIS; ARTICLE; CELL STRAIN; CELL STRAIN U937; CELL SURVIVAL; DRUG ANTAGONISM; DRUG EFFECT; ENZYMOLOGY; HUMAN; METABOLISM; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MONOCYTE; PATHOLOGY; RAT; TIME;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; CALCIUM; CELL SURVIVAL; ELECTRON TRANSPORT CHAIN COMPLEX PROTEINS; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUCOSE; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MONOCYTES; MULTIENZYME COMPLEXES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PC12 CELLS; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; REACTIVE OXYGEN SPECIES; TIME FACTORS; U937 CELLS; UNCOUPLING AGENTS;

EID: 45749157626     PISSN: 02536269     EISSN: 19763786     Source Type: Journal    
DOI: 10.1007/s12272-001-1222-5     Document Type: Article

References (9)

1. 2+ in the U937 monocyte cell line. Arch. Pharm. Res., 29, 657-665 (2006).
2. Hooks, S. B., Santos, W. L., Im, D. S., Heise, C. E., Macdonald, T. L., and Lynch, K. R., Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent. J. Biol. Chem., 276, 4611-4621 (2001).
3. Im, Y. J., Lee, Y. K., Chung, H. Y., and Im, D. S., Multiple actions of lysophosphatidylcholine in human Jurkat T cells. Acta. Pharmacol. Sin., 27, 700-707 (2006).
4. Kim, H. S., Lee, E. H., Ko, S. R., Choi, K. J., Park, J. H., and Im, D. S., Effects of ginsenosides Rg3 and Rh2 on the proliferation of prostate cancer cells. Arch. Pharm. Res., 27, 429-435 (2004).
5. 2+ influx induced by dimethylphytosphingosine and lysophosphatidylcholine in U937 monocytes. Biochem. Biophys. Res. Commun., 348, 1116-1122 (2006).
6. Lee, Y. K., Kim, H. L., Kim, Y. L., and Im, D. S., Multiple actions of dimethylsphingosine in 1321N1 astrocytes. Mol. Cells, 23, 11-16 (2007).
7. Metrailler-Ruchonnet, I., Pagano, A., Carnesecchi, S., Ody, C., Donati, Y., and Barazzone Argiroffo, C., Bcl-2 protects against hyperoxia-induced apoptosis through inhibition of the mitochondria-dependent pathway. Free Radic. Biol. Med., 42, 1062-1074 (2007).
8. Park, M. T., Kang, J. A., Choi, J. A., Kang, C. M., Kim, T. H., Bae, S., Kang, S., Kim, S., Choi, W. I., Cho, C. K., Chung, H. Y., Lee, Y. S., and Lee, S. J., Phytosphingosine induces apoptotic cell death via caspase 8 activation and Bax translocation in human cancer cells. Clin. Cancer Res., 9, 878-885 (2003).
9. Watabe, M. and Nakaki, T., ATP depletion does not account for apoptosis induced by inhibition of mitochondrial electron transport chain in human dopaminergic cells. Neuropharmacology, 52, 536-541 (2007).