The APP intracellular domain (AICD) potentiates ER stress-induced apoptosis

Neurobiology of Aging

Volumn 33, Issue 9, 2012, Pages 2200-2209

  Kögel, Donat ^a   Concannon, Caoimhín G ^b   Müller, Thorsten ^c   König, Hildegard ^a   Bonner, Caroline ^b   Poeschel, Simone ^b   Chang, Steffi ^a   Egensperger, Rupert ^d   Prehn, Jochen H M ^b  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^c RUHR UNIVERSITY BOCHUM   (Germany)

^d UNIVERSITY OF MUNICH   (Germany)

Author keywords

Alzheimer's disease; Amyloid precursor protein; Apoptosis; Caspases; ER stress; Transcription; Unfolded protein response

Indexed keywords

AMYLOID PRECURSOR PROTEIN; AMYLOID PRECURSOR PROTEIN INTRACELLULAR DOMAIN; CASPASE; CLUSTERIN; GLUCOSE REGULATED PROTEIN 78; MESSENGER RNA; STAUROSPORINE; THAPSIGARGIN; TUNICAMYCIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; APOPTOSIS; ARTICLE; CLUSTERIN GENE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVATION; GENE; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE REPRESSION; GENE SILENCING; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; HUMAN CELL; NERVE CELL NECROSIS; NEUROBLASTOMA CELL; NEUROMODULATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REPORTER GENE; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE;

APOPTOSIS; CELL LINE, TUMOR; CLUSTERIN; CYTIDINE DEAMINASE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; ENDOPLASMIC RETICULUM STRESS; ENZYME INHIBITORS; FLOW CYTOMETRY; GENE EXPRESSION REGULATION; GREEN FLUORESCENT PROTEINS; HEAT-SHOCK PROTEINS; HUMANS; NEUROBLASTOMA; RNA, MESSENGER; SIGNAL TRANSDUCTION; THAPSIGARGIN; TIME FACTORS; TRANSFECTION; TUNICAMYCIN; UNFOLDED PROTEIN RESPONSE;

EID: 84863497043     PISSN: 01974580     EISSN: 15581497     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2011.06.012     Document Type: Article

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