Early response of bone marrow osteoprogenitors to skeletal unloading and sclerostin antibody

Calcified Tissue International

Volumn 91, Issue 1, 2012, Pages 50-58

  Shahnazari, Mohammad ^a   Wronski, Thomas ^b   Chu, Vivian ^a   Williams, Alyssa ^b   Leeper, Alicia ^b   Stolina, Marina ^c   Ke, Hua Zhu ^c   Halloran, Bernard ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of Florida College of Veterinary Medicine   (United States)

^c AMGEN INC   (United States)

Author keywords

Bone; Osteoblast; Osteoclast; Sclerostin; Skeletal unloading

Indexed keywords

ALKALINE PHOSPHATASE; ANABOLIC AGENT; BIOLOGICAL MARKER; PLACEBO; PROPEPTIDE OF TYPE 1 COLLAGEN; SCLEROSTIN ANTIBODY; TARTRATE RESISTANT ACID PHOSPHATASE 5B; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE MINERALIZATION; CELL POPULATION; COLONY FORMING UNIT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; EX VIVO STUDY; HEMATOPOIETIC STEM CELL; IN VIVO STUDY; MALE; MESENCHYMAL STEM CELL; MOBILIZATION; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOCLAST ACTIVITY; OSTEOLYSIS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SURFACE PROPERTY; TREATMENT DURATION; WEIGHT BEARING;

ACID PHOSPHATASE; ANIMALS; ANTIBODIES; BONE MARROW; BONE RESORPTION; GLYCOPROTEINS; HINDLIMB SUSPENSION; ISOENZYMES; MALE; MICE; OSTEOBLASTS; OSTEOCLASTS; STEM CELLS;

EID: 84863487812     PISSN: 0171967X     EISSN: 14320827     Source Type: Journal    
DOI: 10.1007/s00223-012-9610-9     Document Type: Article

References (49)

1. Yaccoby S, Ling W, Zhan F, Walker R, Barlogie B, Shaughnessy JD Jr (2007) Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood 109:2106-2111 (Pubitemid 46348212)
2. Bodine P, Stauffer B, Ponce-de-Leon H, Bhat B, Mangine A, Seestaller-Wehr L (2007) A small molecule inhibitor of the Wnt antagonist secreted frizzled-related protein (SFRP)-1 stimulates bone formation. Abstracts of the 29th Annual Meeting of the American Society for Bone and Mineral Research
3. Kulkarni NH, Wei T, Kumar A, Dow ER, Stewart TR, Shou J, N'Cho M, Sterchi DL, Gitter BD, Higgs RE, Halladay DL, Engler TA, Martin TJ, Bryant HU, Ma YL, Onyia JE (2007) Changes in osteoblast, chondrocyte, and adipocyte lineages mediate the bone anabolic actions of PTH and small molecule GSK-3 inhibitor. J Cell Biochem 102:1504-1518 (Pubitemid 350223952)
4. Padhi D, Jang G, Stouch B, Fang L, Posvar E (2011) Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody. J Bone Miner Res 26:19-26
5. Bennett CN, Longo KA, Wright WS, Suva LJ, Lane TF, Hankenson KD, MacDougald OA (2005) Regulation of osteoblastogenesis and bone mass by Wnt10b. Proc Natl Acad Sci U S A 102:3324-3329 (Pubitemid 40328044)
6. Andrade AC, Nilsson O, Barnes KM, Baron J (2007) Wnt gene expression in the post-natal growth plate: regulation with chondrocyte differentiation. Bone 40:1361-1369 (Pubitemid 46550985)
7. Poole KE, van Bezooijen RL, Loveridge N, Hamersma H, Papapoulos SE, Lowik CW, Reeve J (2005) Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation. FASEB J 19:1842-1844 (Pubitemid 41598769)
8. Irie K, Ejiri S, Sakakura Y, Shibui T, Yajima T (2008) Matrix mineralization as a trigger for osteocyte maturation. J Histochem Cytochem 56:561-567 (Pubitemid 351702300)
9. Li X, Ominsky MS, Niu QT, Sun N, Daugherty B, D'Agostin D, Kurahara C, Gao Y, Cao J, Gong J, Asuncion F, Barrero M, Warmington K, Dwyer D, Stolina M, Morony S, Sarosi I, Kostenuik PJ, Lacey DL, Simonet WS, Ke HZ, Paszty C (2008) Targeted deletion of the sclerostin gene in mice results in increased bone formation and bone strength. J Bone Miner Res 23:860-869 (Pubitemid 351768804)
10. Li X, Warmington KS, Niu QT, Asuncion FJ, Barrero M, Grisanti M, Dwyer D, Stouch B, Thway TM, Stolina M, Ominsky MS, Kostenuik PJ, Simonet WS, Paszty C, Ke HZ (2010) Inhibition of sclerostin by monoclonal antibody increases bone formation, bone mass, and bone strength in aged male rats. J Bone Miner Res 25:2647-2656
11. Li X, Ominsky MS, Warmington KS, Morony S, Gong J, Cao J, Gao Y, Shalhoub V, Tipton B, Haldankar R, Chen Q, Winters A, Boone T, Geng Z, Niu QT, Ke HZ, Kostenuik PJ, Simonet WS, Lacey DL, Paszty C (2009) Sclerostin antibody treatment increases bone formation, bone mass, and bone strength in a rat model of postmenopausal osteoporosis. J Bone Miner Res 24:578-588
12. Glass DA 2nd, Bialek P, Ahn JD, Starbuck M, Patel MS, Clevers H, Taketo MM, Long F, McMahon AP, Lang RA, Karsenty G (2005) Canonical Wnt signaling in differentiated osteoblasts controls osteoclast differentiation. Dev Cell 8:751-764 (Pubitemid 40585297)
13. Spencer GJ, Utting JC, Etheridge SL, Arnett TR, Genever PG (2006) Wnt signalling in osteoblasts regulates expression of the receptor activator of NFkappaB ligand and inhibits osteoclastogenesis in vitro. J Cell Sci 119:1283-1296
14. - progenitors. J Leukoc Biol 87:405-414
15. Takahashi N, Maeda K, Ishihara A, Uehara S, Kobayashi Y (2011) Regulatory mechanism of osteoclastogenesis by RANKL and Wnt signals. Front Biosci 16:21-30
16. Kubota T, Michigami T, Ozono K (2009) Wnt signaling in bone metabolism. J Bone Miner Metab 27:265-271
17. Zerwekh JE, Ruml LA, Gottschalk F, Pak CY (1998) The effects of twelve weeks of bed rest on bone histology, biochemical markers of bone turnover, and calcium homeostasis in eleven normal subjects. J Bone Miner Res 13:1594-1601 (Pubitemid 28465300)
18. Wronski TJ, Morey ER (1982) Skeletal abnormalities in rats induced by simulated weightlessness. Metab Bone Dis Relat Res 4:69-75
19. Bikle DD, Halloran BP (1999) The response of bone to unloading. J Bone Miner Metab 17:233-244
20. Morey-Holton E, Globus RK, Kaplansky A, Durnova G (2005) The hindlimb unloading rat model: literature overview, technique update and comparison with space flight data. Adv Space Biol Med 10:7-40 (Pubitemid 43595889)
21. Sibonga JD, Zhang M, Evans GL, Westerlind KC, Cavolina JM, Morey-Holton E, Turner RT (2000) Effects of spaceflight and simulated weightlessness on longitudinal bone growth. Bone 27:535-540
22. Halloran BP, Bikle DD, Wronski TJ, Globus RK, Levens MJ, Morey-Holton E (1986) The role of 1,25-dihydroxyvitamin D in the inhibition of bone formation induced by skeletal unloading. Endocrinology 118:948-954 (Pubitemid 16080122)
23. Sessions ND, Halloran BP, Bikle DD, Wronski TJ, Cone CM, Morey-Holton E (1989) Bone response to normal weight bearing after a period of skeletal unloading. Am J Physiol 257:E606-E610
24. Dehority W, Halloran BP, Bikle DD, Curren T, Kostenuik PJ, Wronski TJ, Shen Y, Rabkin B, Bouraoui A, Morey-Holton E (1999) Bone and hormonal changes induced by skeletal unloading in the mature male rat. Am J Physiol 276:E62-E69 (Pubitemid 29065594)
25. Machwate M, Zerath E, Holy X, Pastoureau P, Marie PJ (1994) Insulin-like growth factor-I increases trabecular bone formation and osteoblastic cell proliferation in unloaded rats. Endocrinology 134:1031-1038 (Pubitemid 24085547)
26. Amblard D, Lafage-Proust MH, Laib A, Thomas T, Ruegsegger P, Alexandre C, Vico L (2003) Tail suspension induces bone loss in skeletally mature mice in the C57BL/6J strain but not in the C3H/HeJ strain. J Bone Miner Res 18:561-569 (Pubitemid 36241074)
27. Wronski TJ, Morey ER (1983) Inhibition of cortical and trabecular bone formation in the long bones of immobilized monkeys. Clin Orthop Relat Res 181:269-276 (Pubitemid 14215233)
28. Robling AG, Niziolek PJ, Baldridge LA, Condon KW, Allen MR, Alam I, Mantila SM, Gluhak-Heinrich J, Bellido TM, Harris SE, Turner CH (2008) Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin. J Biol Chem 283:5866-5875
29. Papanicolaou SE, Phipps RJ, Fyhrie DP, Genetos DC (2009) Modulation of sclerostin expression by mechanical loading and bone morphogenetic proteins in osteogenic cells. Biorheology 46:389-399
30. Galea GL, Sunters A, Meakin LB, Zaman G, Sugiyama T, Lanyon LE, Price JS (2011) Sost down-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4. FEBS Lett 585:2450-2454
31. Sakai A, Nakamura T (2001) Changes in trabecular bone turnover and bone marrow cell development in tail-suspended mice. J Musculoskelet Neuronal Interact 1:387-392
32. David V, Lafage-Proust MH, Laroche N, Christian A, Ruegsegger P, Vico L (2006) Two-week longitudinal survey of bone architecture alteration in the hindlimb-unloaded rat model of bone loss: sex differences. Am J Physiol Endocrinol Metab 290:E440-E447 (Pubitemid 43671689)
33. Grano M, Mori G, Minielli V, Barou O, Colucci S, Giannelli G, Alexandre C, Zallone AZ, Vico L (2002) Rat hindlimb unloading by tail suspension reduces osteoblast differentiation, induces IL-6 secretion, and increases bone resorption in ex vivo cultures. Calcif Tissue Int 70:176-185 (Pubitemid 36929597)
34. Kodama Y, Dimai HP, Wergedal J, Sheng M, Malpe R, Kutilek S, Beamer W, Donahue LR, Rosen C, Baylink DJ, Farley J (1999) Cortical tibial bone volume in two strains of mice: effects of sciatic neurectomy and genetic regulation of bone response to mechanical loading. Bone 25:183-190 (Pubitemid 29317620)
35. Basso N, Jia Y, Bellows CG, Heersche JN (2005) The effect of reloading on bone volume, osteoblast number, and osteoprogenitor characteristics: studies in hind limb unloaded rats. Bone 37:370-378 (Pubitemid 41160495)
36. Lueken SA, Arnaud SB, Taylor AK, Baylink DJ (1993) Changes in markers of bone formation and resorption in a bed rest model of weightlessness. J Bone Miner Res 8:1433-1438 (Pubitemid 23342679)
37. Minaire P, Meunier P, Edouard C, Bernard J, Courpron P (1975) Histomorphometric and biological data on osteoporosis due to immobilization. Rev Rhum Mal Osteoartic 42:479-488
38. Inoue M, Tanaka H, Moriwake T, Oka M, Sekiguchi C, Seino Y (2000) Altered biochemical markers of bone turnover in humans during 120 days of bed rest. Bone 26:281-286 (Pubitemid 30101653)
39. Tian X, Jee WS, Li X, Paszty C, Ke HZ (2011) Sclerostin antibody increases bone mass by stimulating bone formation and inhibiting bone resorption in a hindlimb-immobilization rat model. Bone 48:197-201
40. Halloran BP, Bikle DD, Harris J, Tanner S, Curren T, Morey- Holton E (1997) Regional responsiveness of the tibia to intermittent administration of parathyroid hormone as affected by skeletal unloading. J Bone Miner Res 12:1068-1074 (Pubitemid 27264220)
41. Rodda SJ, McMahon AP (2006) Distinct roles for Hedgehog and canonical Wnt signaling in specification, differentiation and maintenance of osteoblast progenitors. Development 133:3231-3244 (Pubitemid 44404346)
42. Huang JC, Sakata T, Pfleger LL, Bencsik M, Halloran BP, Bikle DD, Nissenson RA (2004) PTH differentially regulates expression of RANKL and OPG. J Bone Miner Res 19:235-244 (Pubitemid 38116737)
43. Kostenuik PJ, Halloran BP, Morey-Holton ER, Bikle DD (1997) Skeletal unloading inhibits the in vitro proliferation and differentiation of rat osteoprogenitor cells. Am J Physiol 273:E1133-E1139
44. Cao J, Venton L, Sakata T, Halloran BP (2003) Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 mice. J Bone Miner Res 18:270-277 (Pubitemid 36125919)
45. Agholme F, Isaksson H, Li X, Ke HZ, Aspenberg P (2011) Antisclerostin antibody and mechanical loading appear to influence metaphyseal bone independently in rats. Acta Orthop 82:628-632
46. Dufour C, Holy X, Marie PJ (2008) Transforming growth factorbeta prevents osteoblast apoptosis induced by skeletal unloading via PI3 K/Akt, Bcl-2, and phospho-Bad signaling. Am J Physiol Endocrinol Metab 294:E794-E801 (Pubitemid 351483605)
47. Lin C, Jiang X, Dai Z, Guo X, Weng T, Wang J, Li Y, Feng G, Gao X, He L (2009) Sclerostin mediates bone response to mechanical unloading through antagonizing Wnt/beta-catenin signaling. J Bone Miner Res 24:1651-1661
48. Weerkamp F, Baert MR, Naber BA, Koster EE, de Haas EF, Atkuri KR, van Dongen JJ, Herzenberg LA, Staal FJ (2006) Wnt signaling in the thymus is regulated by differential expression of intracellular signaling molecules. Proc Natl Acad Sci U S A 103:3322-3326 (Pubitemid 43346468)
49. + thymocytes regulate proliferation and cell adhesion. J Immunol 172:1099-1108