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Volumn 46, Issue 5, 2009, Pages 389-399

Modulation of sclerostin expression by mechanical loading and bone morphogenetic proteins in osteogenic cells

Author keywords

BMP; Fluid flow; Osteoblast; Osteocyte; Shear stress; Sost

Indexed keywords

BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 6; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN 5; MESSENGER RNA; SCLEROSTIN; WNT PROTEIN;

EID: 72949088669     PISSN: 0006355X     EISSN: None     Source Type: Journal    
DOI: 10.3233/BIR-2009-0550     Document Type: Article
Times cited : (56)

References (36)
  • 1
    • 0008294029 scopus 로고    scopus 로고
    • Localization of the gene for sclerosteosis to the van Buchem disease - Gene region on chromosome 17q12-q21
    • W. Balemans, J. Van Den Ende, A. Freire Paes-Alves, F.G. Dikkers et al., Localization of the gene for sclerosteosis to the van Buchem disease - gene region on chromosome 17q12-q21, Am. J. Hum. Genet. 64 (1999), 1661-1669.
    • (1999) Am. J. Hum. Genet. , vol.64 , pp. 1661-1669
    • Balemans, W.1    Ende Den J.Van2    Freire Paes-Alves, A.3    Dikkers, F.G.4
  • 2
    • 0035282968 scopus 로고    scopus 로고
    • Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST)
    • W. Balemans, M. Ebeling, N. Patel, E. Van Hul et al., Increased bone density in sclerosteosis is due to the deficiency of a novel secreted protein (SOST), Hum. Mol. Genet. 10 (2001), 537-543.
    • (2001) Hum. Mol. Genet. , vol.10 , pp. 537-543
    • Balemans, W.1    Ebeling, M.2    Patel, N.3    Van Hul, E.4
  • 3
    • 26844521277 scopus 로고    scopus 로고
    • Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: A novel mechanism for hormonal control of osteoblastogenesis
    • T. Bellido, A.A. Ali, I. Gubrij, L.I. Plotkin et al., Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: A novel mechanism for hormonal control of osteoblastogenesis, Endocrinology 146 (2005), 4577-4583.
    • (2005) Endocrinology , vol.146 , pp. 4577-4583
    • Bellido, T.1    Ali, A.A.2    Gubrij, I.3    Plotkin, L.I.4
  • 4
    • 73949150499 scopus 로고    scopus 로고
    • Human primary osteocyte differentiation in a threedimensional culture system
    • to appear
    • F. Boukhechba, T. Balaguer, J.F. Michiels, K. Ackermann et al., Human primary osteocyte differentiation in a threedimensional culture system, J. Bone Miner. Res. (2009), to appear.
    • (2009) J. Bone Miner. Res.
    • Boukhechba, F.1    Balaguer, T.2    Michiels, J.F.3    Ackermann, K.4
  • 5
    • 0035089781 scopus 로고    scopus 로고
    • Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein
    • M.E. Brunkow, J.C. Gardner, J. Van Ness, B.W. Paeper et al., Bone dysplasia sclerosteosis results from loss of the SOST gene product, a novel cystine knot-containing protein, Am. J. Hum. Genet. 68 (2001), 577-589.
    • (2001) Am. J. Hum. Genet. , vol.68 , pp. 577-589
    • Brunkow, M.E.1    Gardner, J.C.2    Van Ness, J.3    Paeper, B.W.4
  • 6
    • 0029001247 scopus 로고
    • Function of osteocytes in bone - Their role in mechanotransduction
    • E.H. Burger, J. Klein-Nulend, A. van der Plas and P.J. Nijweide, Function of osteocytes in bone - their role in mechanotransduction, J. Nutr. 125 (1995), 2020S-2023S.
    • (1995) J. Nutr. , vol.125
    • Burger, E.H.1    Klein-Nulend, J.2    Plas Der A.Van3    Nijweide, P.J.4
  • 7
    • 0242668869 scopus 로고    scopus 로고
    • Bone morphogenetic proteins, their antagonists, and the skeleton
    • E. Canalis, A.N. Economides and E. Gazzerro, Bone morphogenetic proteins, their antagonists, and the skeleton, Endocr. Rev. 24 (2003), 218-235.
    • (2003) Endocr. Rev. , vol.24 , pp. 218-235
    • Canalis, E.1    Economides, A.N.2    Gazzerro, E.3
  • 8
    • 0025764715 scopus 로고
    • Candidates for the mechanosensory system in bone
    • S.C. Cowin, L. Moss-Salentijn and M.L. Moss, Candidates for the mechanosensory system in bone, J. Biomech. Eng. 113 (1991), 191-197.
    • (1991) J. Biomech. Eng. , vol.113 , pp. 191-197
    • Cowin, S.C.1    Moss-Salentijn, L.2    Moss, M.L.3
  • 9
    • 0034037735 scopus 로고    scopus 로고
    • Gap junctions and biophysical regulation of bone cell differentiation
    • H.J. Donahue, Gap junctions and biophysical regulation of bone cell differentiation, Bone 26 (2000), 417-422.
    • (2000) Bone , vol.26 , pp. 417-422
    • Donahue, H.J.1
  • 10
    • 0028807366 scopus 로고
    • Mechanotransduction and the functional response of bone to mechanical strain
    • R.L. Duncan and C.H. Turner, Mechanotransduction and the functional response of bone to mechanical strain, Calcif. Tissue Int. 57 (1995), 344-358.
    • (1995) Calcif. Tissue Int. , vol.57 , pp. 344-358
    • Duncan, R.L.1    Turner, C.H.2
  • 11
    • 0029998565 scopus 로고    scopus 로고
    • Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo
    • M.R. Forwood, Inducible cyclo-oxygenase (COX-2) mediates the induction of bone formation by mechanical loading in vivo, J. Bone Miner. Res. 11 (1996), 1688-1693.
    • (1996) J. Bone Miner. Res. , vol.11 , pp. 1688-1693
    • Forwood, M.R.1
  • 13
    • 0032535785 scopus 로고    scopus 로고
    • Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts
    • E. Gazzerro, V. Gangji and E. Canalis, Bone morphogenetic proteins induce the expression of noggin, which limits their activity in cultured rat osteoblasts, J. Clin. Invest. 102 (1998), 2106-2114.
    • (1998) J. Clin. Invest. , vol.102 , pp. 2106-2114
    • Gazzerro, E.1    Gangji, V.2    Canalis, E.3
  • 14
    • 34249871139 scopus 로고    scopus 로고
    • Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes
    • D.C. Genetos, C.J. Kephart, Y. Zhang, C.E. Yellowley et al., Oscillating fluid flow activation of gap junction hemichannels induces ATP release from MLO-Y4 osteocytes, J. Cell Physiol. 212 (2007), 207-214.
    • (2007) J. Cell Physiol. , vol.212 , pp. 207-214
    • Genetos, D.C.1    Kephart, C.J.2    Zhang, Y.3    Yellowley, C.E.4
  • 15
    • 18044386744 scopus 로고    scopus 로고
    • LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    • Y. Gong, R.B. Slee, N. Fukai, G. Rawadi et al., LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development, Cell 107 (2001), 513-523.
    • (2001) Cell , vol.107 , pp. 513-523
    • Gong, Y.1    Slee, R.B.2    Fukai, N.3    Rawadi, G.4
  • 16
    • 0029617377 scopus 로고
    • Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts - Correlation with prostaglandin upregulation
    • J. Klein-Nulend, C.M. Semeins, N.E. Ajubi, P.J. Nijweide et al., Pulsating fluid flow increases nitric oxide (NO) synthesis by osteocytes but not periosteal fibroblasts - correlation with prostaglandin upregulation, Biochem. Biophys. Res. Commun. 217 (1995), 640-648.
    • (1995) Biochem. Biophys. Res. Commun. , vol.217 , pp. 640-648
    • Klein-Nulend, J.1    Semeins, C.M.2    Ajubi, N.E.3    Nijweide, P.J.4
  • 17
    • 0025252249 scopus 로고
    • A theoretical model for stress-generated fluid flow in the canaliculi-lacunae network in bone tissue
    • R.H. Kufahl and S. Saha, A theoretical model for stress-generated fluid flow in the canaliculi-lacunae network in bone tissue, J. Biomech. 23 (1990), 171-180.
    • (1990) J. Biomech. , vol.23 , pp. 171-180
    • Kufahl, R.H.1    Saha, S.2
  • 18
    • 0038267120 scopus 로고    scopus 로고
    • Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity
    • N. Kusu, J. Laurikkala, M. Imanishi, H. Usui et al., Sclerostin is a novel secreted osteoclast-derived bone morphogenetic protein antagonist with unique ligand specificity, J. Biol. Chem. 278 (2003), 24113-24117.
    • (2003) J. Biol. Chem. , vol.278 , pp. 24113-24117
    • Kusu, N.1    Laurikkala, J.2    Imanishi, M.3    Usui, H.4
  • 19
    • 21244480924 scopus 로고    scopus 로고
    • Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling
    • X. Li, Y. Zhang, H. Kang, W. Liu et al., Sclerostin binds to LRP5/6 and antagonizes canonical Wnt signaling, J. Biol. Chem. 280 (2005), 19883-19887.
    • (2005) J. Biol. Chem. , vol.280 , pp. 19883-19887
    • Li, X.1    Zhang, Y.2    Kang, H.3    Liu, W.4
  • 20
    • 0036138175 scopus 로고    scopus 로고
    • A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait
    • R.D. Little, J.P. Carulli, R.G. Del Mastro, J. Dupuis et al., A mutation in the LDL receptor-related protein 5 gene results in the autosomal dominant high-bone-mass trait, Am. J. Hum. Genet. 70 (2002), 11-19.
    • (2002) Am. J. Hum. Genet. , vol.70 , pp. 11-19
    • Little, R.D.1    Carulli, J.P.2    Mastro Del, R.G.3    Dupuis, J.4
  • 21
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • San Diego, CA
    • K.J. Livak and T.D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method, Methods (San Diego, CA) 25 (2001), 402-408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 22
    • 34250660114 scopus 로고    scopus 로고
    • The role of actin cytoskeleton in oscillatory fluid flow-induced signaling in MC3T3-E1 osteoblasts
    • A.M. Malone, N.N. Batra, G. Shivaram, R.Y. Kwon et al., The role of actin cytoskeleton in oscillatory fluid flow-induced signaling in MC3T3-E1 osteoblasts, Am. J. Physiol. Cell Physiol. 292 (2007), C1830-C1836.
    • (2007) Am. J. Physiol. Cell Physiol. , vol.292
    • Malone, A.M.1    Batra, N.N.2    Shivaram, G.3    Kwon, R.Y.4
  • 23
    • 1342283036 scopus 로고    scopus 로고
    • Fluid shear stress induction of COX-2 protein and prostaglandin release in cultured MC3T3-E1 osteoblasts does not require intact microfilaments or microtubules
    • S.M. Norvell, S.M. Ponik, D.K. Bowen, R. Gerard et al., Fluid shear stress induction of COX-2 protein and prostaglandin release in cultured MC3T3-E1 osteoblasts does not require intact microfilaments or microtubules, J. Appl. Physiol. 96 (2004), 957-966.
    • (2004) J. Appl. Physiol. , vol.96 , pp. 957-966
    • Norvell, S.M.1    Ponik, S.M.2    Bowen, D.K.3    Gerard, R.4
  • 24
    • 0034520158 scopus 로고    scopus 로고
    • Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts
    • R.C. Pereira, A.N. Economides and E. Canalis, Bone morphogenetic proteins induce gremlin, a protein that limits their activity in osteoblasts, Endocrinology 141 (2000), 4558-4563.
    • (2000) Endocrinology , vol.141 , pp. 4558-4563
    • Pereira, R.C.1    Economides, A.N.2    Canalis, E.3
  • 25
    • 3042558631 scopus 로고    scopus 로고
    • Formation of focal adhesions on fibronectin promotes fluid shear stress induction of COX-2 and PGE2 release in MC3T3-E1 osteoblasts
    • S.M. Ponik and F.M. Pavalko, Formation of focal adhesions on fibronectin promotes fluid shear stress induction of COX-2 and PGE2 release in MC3T3-E1 osteoblasts, J. Appl. Physiol. 97 (2004), 135-142.
    • (2004) J. Appl. Physiol. , vol.97 , pp. 135-142
    • Ponik, S.M.1    Pavalko, F.M.2
  • 26
    • 27744461726 scopus 로고    scopus 로고
    • Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation
    • K.E. Poole, R.L. van Bezooijen, N. Loveridge, H. Hamersma et al., Sclerostin is a delayed secreted product of osteocytes that inhibits bone formation, FASEB J. 19 (2005), 1842-1844.
    • (2005) FASEB J. , vol.19 , pp. 1842-1844
    • Poole, K.E.1    Bezooijen Van, R.L.2    Loveridge, N.3    Hamersma, H.4
  • 28
    • 41949089764 scopus 로고    scopus 로고
    • Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin
    • A.G. Robling, P.J. Niziolek, L.A. Baldridge, K.W. Condon et al., Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin, J. Biol. Chem. 283 (2008), 5866-5875.
    • (2008) J. Biol. Chem. , vol.283 , pp. 5866-5875
    • Robling, A.G.1    Niziolek, P.J.2    Baldridge, L.A.3    Condon, K.W.4
  • 29
    • 3242664450 scopus 로고    scopus 로고
    • Unique regulation of SOST, the sclerosteosis gene, by BMP and steroid hormones in human osteoblasts
    • M.K. Sutherland, J.C. Geoghegan, C. Yu, D.G.Winkler et al., Unique regulation of SOST, the sclerosteosis gene, by BMP and steroid hormones in human osteoblasts, Bone 35 (2004), 448-454.
    • (2004) Bone , vol.35 , pp. 448-454
    • Sutherland, M.K.1    Geoghegan, J.C.2    Yu, C.3    Winkler, D.G.4
  • 30
    • 12144286871 scopus 로고    scopus 로고
    • Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist
    • R.L. van Bezooijen, B.A. Roelen, A. Visser, L. van der Wee-Pals et al., Sclerostin is an osteocyte-expressed negative regulator of bone formation, but not a classical BMP antagonist, J. Exp. Med. 199 (2004), 805-814.
    • (2004) J. Exp. Med. , vol.199 , pp. 805-814
    • Bezooijen Van, R.L.1    Roelen, B.A.2    Visser, A.3    Wee-Pals Der L.Van4
  • 31
    • 0028386524 scopus 로고
    • A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses
    • S. Weinbaum, S.C. Cowin and Y. Zeng, A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses, J. Biomech. 27 (1994), 339-360.
    • (1994) J. Biomech. , vol.27 , pp. 339-360
    • Weinbaum, S.1    Cowin, S.C.2    Zeng, Y.3
  • 32
    • 9144265626 scopus 로고    scopus 로고
    • Patients with Van Buchem disease, an osteosclerotic genetic disease, have elevated bone formation markers, higher bone density, and greater derived polar moment of inertia than normal
    • J.E. Wergedal, K. Veskovic, M. Hellan, C. Nyght et al., Patients with Van Buchem disease, an osteosclerotic genetic disease, have elevated bone formation markers, higher bone density, and greater derived polar moment of inertia than normal, J. Clin. Endocrinol. Metab. 88 (2003), 5778-5783.
    • (2003) J. Clin. Endocrinol. Metab. , vol.88 , pp. 5778-5783
    • Wergedal, J.E.1    Veskovic, K.2    Hellan, M.3    Nyght, C.4
  • 33
    • 10744221383 scopus 로고    scopus 로고
    • Osteocyte control of bone formation via sclerostin, a novel BMP antagonist
    • D.G. Winkler, M.K. Sutherland, J.C. Geoghegan, C. Yu et al., Osteocyte control of bone formation via sclerostin, a novel BMP antagonist, EMBO J. 22 (2003), 6267-6276.
    • (2003) EMBO J. , vol.22 , pp. 6267-6276
    • Winkler, D.G.1    Sutherland, M.K.2    Geoghegan, J.C.3    Yu, C.4
  • 34
    • 13244298422 scopus 로고    scopus 로고
    • Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins
    • D.G. Winkler, M.S. Sutherland, E. Ojala, E. Turcott et al., Sclerostin inhibition of Wnt-3a-induced C3H10T1/2 cell differentiation is indirect and mediated by bone morphogenetic proteins, J. Biol. Chem. 280 (2005), 2498-2502.
    • (2005) J. Biol. Chem. , vol.280 , pp. 2498-2502
    • Winkler, D.G.1    Sutherland, M.S.2    Ojala, E.3    Turcott, E.4
  • 35
    • 57449116084 scopus 로고    scopus 로고
    • Gene expression signatures of a fibroblastoid preosteoblast and cuboidal osteoblast cell model compared to the MLO-Y4 osteocyte cell model
    • W. Yang, M.A. Harris, J.G. Heinrich, D. Guo et al., Gene expression signatures of a fibroblastoid preosteoblast and cuboidal osteoblast cell model compared to the MLO-Y4 osteocyte cell model, Bone 44 (2009), 32-45.
    • (2009) Bone , vol.44 , pp. 32-45
    • Yang, W.1    Harris, M.A.2    Heinrich, J.G.3    Guo, D.4
  • 36
    • 33846405735 scopus 로고    scopus 로고
    • PTH-induced actin depolymerization increases mechanosensitive channel activity to enhance mechanically stimulated Ca2+ signaling in osteoblasts
    • J. Zhang, K.D. Ryder, J.A. Bethel, R. Ramirez et al., PTH-induced actin depolymerization increases mechanosensitive channel activity to enhance mechanically stimulated Ca2+ signaling in osteoblasts, J. Bone Miner. Res. 21 (2006), 1729-1737.
    • (2006) J. Bone Miner. Res. , vol.21 , pp. 1729-1737
    • Zhang, J.1    Ryder, K.D.2    Bethel, J.A.3    Ramirez, R.4


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