Sclerostin antibody increases bone mass by stimulating bone formation and inhibiting bone resorption in a hindlimb-immobilization rat model

Bone

Volumn 48, Issue 2, 2011, Pages 197-201

  Tian, XiaoYan ^a   Jee, Webster S S ^a   Li, Xiaodong ^b   Paszty, Chris ^b   Ke, Hua Zhu ^b  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b AMGEN INC   (United States)

Author keywords

Bone balance; Bone formation; Immobilization; Resorption; Sclerostin antibody

Indexed keywords

MONOCLONAL ANTIBODY; SCLEROSTIN; SCLEROSTIN MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ADIPOCYTE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BONE EROSION; BONE MARROW; BONE MASS; BONE MINERALIZATION; CONTROLLED STUDY; CORTICAL BONE; DOSE RESPONSE; DRUG DOSE COMPARISON; FEMALE; IMMOBILIZATION; METAPHYSIS; MORPHOMETRICS; MUSCLE MASS; NONHUMAN; OSSIFICATION; OSTEOLYSIS; OSTEOPENIA; PERIOSTEUM; RAT; SPRAGUE DAWLEY RAT; TIBIA; TIBIA SHAFT; TRABECULAR BONE; TREATMENT DURATION; WEIGHT REDUCTION;

ANIMALS; ANTIBODIES; BONE MORPHOGENETIC PROTEINS; BONE RESORPTION; FEMALE; GENETIC MARKERS; HINDLIMB SUSPENSION; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 78650983826     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2010.09.009     Document Type: Article

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