A new synthetic chalcone derivative, 2-hydroxy-3',5,5'-trimethoxychalcone (DK-139), suppresses the toll-like receptor 4-mediated inflammatory response through inhibition of the Akt/NF-κB pathway in BV2 microglial cells

Experimental and Molecular Medicine

Volumn 44, Issue 6, 2012, Pages 369-377

  Lee, Young Han ^a   Jeon, Seung Hyun ^a   Kim, Se Hyun ^b   Kim, Changyoun ^a   Lee, Seung Jae ^a   Koh, Dongsoo ^c   Lim, Yoongho ^d   Ha, Kyooseob ^e   Shin, Soon Young ^a  

^a SMART Institute of Advanced Biomedical Science   (South Korea)

^b Seoul National University College of Medicine   (South Korea)

^c Dongduk Women's University   (South Korea)

^d Konkuk University   (South Korea)

^e Seoul National University Bundang Hospital   (South Korea)

Author keywords

Chalcone; Lipopolysaccharides; Microglia; NF B; Proto oncogene proteins c akt; Toll like receptor 4

Indexed keywords

2 HYDROXY 3',5,5' TRIMETHOXYCHALCONE; ANTIINFLAMMATORY AGENT; CYCLOOXYGENASE 2; DK 139; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; INTERLEUKIN 6; PROTEIN KINASE B; TOLL LIKE RECEPTOR 4; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYCLOOXYGENASE 2 GENE; DRUG MECHANISM; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE; GENE EXPRESSION; INDUCIBLE NITRIC OXIDE SYNTHASE GENE; MICROGLIA; MOLECULAR DOCKING; SIGNAL TRANSDUCTION;

EID: 84863485005     PISSN: 12263613     EISSN: 20926413     Source Type: Journal    
DOI: 10.3858/emm.2012.44.6.042     Document Type: Article

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