메뉴 건너뛰기




Volumn 18, Issue 2, 2012, Pages 191-199

Silencing poly (ADP-Ribose) glycohydrolase (PARG) expression inhibits growth of human colon cancer cells in vitro via PI3K/Akt/NFκ-B pathway

Author keywords

NF B; PARG; PARP; PI3K Akt pathway

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LENTIVIRUS VECTOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SHORT HAIRPIN RNA;

EID: 84863482663     PISSN: 12194956     EISSN: 15322807     Source Type: Journal    
DOI: 10.1007/s12253-011-9428-1     Document Type: Article
Times cited : (19)

References (37)
  • 2
    • 19944418213 scopus 로고    scopus 로고
    • Failure to degrade poly (ADP-ribose) increased sensitivity to cytotoxicity and early embryonic lethality
    • Koh DW, Lawler AM, Poitras MF et al (2004) Failure to degrade poly (ADP-ribose) increased sensitivity to cytotoxicity and early embryonic lethality. PNAS 101:17699-17704
    • (2004) PNAS , vol.101 , pp. 17699-17704
    • Koh, D.W.1    Lawler, A.M.2    Poitras, M.F.3
  • 3
    • 34547783237 scopus 로고    scopus 로고
    • Spatial and functional relationship between poly (ADP-ribose) polymerase-1 and Poly (ADP-ribose) glycohydrolase in the brain
    • Poitras MF, Koh DW, Yu SW et al (2007) Spatial and functional relationship between poly (ADP-ribose) polymerase-1 and Poly (ADP-ribose) glycohydrolase in the brain. Neuroscience 148:198-211
    • (2007) Neuroscience , vol.148 , pp. 198-211
    • Poitras, M.F.1    Koh, D.W.2    Yu, S.W.3
  • 4
    • 0141537080 scopus 로고    scopus 로고
    • Human poly (ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23)
    • Meyer RG, Meyer-Ficca ML, Jacobson EL, Jacobson MK (2003) Human poly (ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23). Gene 314:181-190
    • (2003) Gene , vol.314 , pp. 181-190
    • Meyer, R.G.1    Meyer-Ficca, M.L.2    Jacobson, E.L.3    Jacobson, M.K.4
  • 5
    • 34547225606 scopus 로고    scopus 로고
    • Poly (ADPribose) polymerase 1 accelerates single-strand break repair in concert with poly (ADP-ribose) glycohydrolase
    • Fisher AEO, Hochegger H, Takeda S et al (2007) Poly (ADPribose) polymerase 1 accelerates single-strand break repair in concert with poly (ADP-ribose) glycohydrolase. Mol Cell Biol 27:5597-5605
    • (2007) Mol Cell Biol , vol.27 , pp. 5597-5605
    • Fisher, A.E.O.1    Hochegger, H.2    Takeda, S.3
  • 6
    • 39749118619 scopus 로고    scopus 로고
    • The roles of poly (ADP-ribose)-metabolising enzymes in alkylation-induced cell death
    • Cohausz O, Blenn C, Malanga M et al (2008) The roles of poly (ADP-ribose)-metabolising enzymes in alkylation-induced cell death. Cell Mol Life Sci 65:644-655
    • (2008) Cell Mol Life Sci , vol.65 , pp. 644-655
    • Cohausz, O.1    Blenn, C.2    Malanga, M.3
  • 7
    • 71749119589 scopus 로고    scopus 로고
    • Global analysis of transcriptional regulation by poly (ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells
    • Frizzell KM, Gamble MJ, Berrocal JG (2009) Global analysis of transcriptional regulation by poly (ADP-ribose) polymerase-1 and poly(ADP-ribose) glycohydrolase in MCF-7 human breast cancer cells. J Biol Chem 284:33926-33938
    • (2009) J Biol Chem , vol.284 , pp. 33926-33938
    • Frizzell, K.M.1    Gamble, M.J.2    Berrocal, J.G.3
  • 8
    • 61849091444 scopus 로고    scopus 로고
    • Proteomic investigation of phosphorylation sites in poly (ADP-ribose) polymerase-1 and poly (ADP-ribose) glycohydrolase
    • Gagne JP, Moreel X, Gagne P et al (2009) Proteomic investigation of phosphorylation sites in poly (ADP-ribose) polymerase-1 and poly (ADP-ribose) glycohydrolase. J Proteome Res 8:1014-1029
    • (2009) J Proteome Res , vol.8 , pp. 1014-1029
    • Gagne, J.P.1    Moreel, X.2    Gagne, P.3
  • 9
    • 25644445311 scopus 로고    scopus 로고
    • The role of akt and mitogen-activated protein kinase systems in the protective effect of poly (ADP-Ribose) polymerase inhibition in langendorff perfused and in isoproterenol-damaged rat hearts
    • Palfi A, Toth A, Kulcsar G et al (2005) The role of akt and mitogen-activated protein kinase systems in the protective effect of poly (ADP-Ribose) polymerase inhibition in langendorff perfused and in isoproterenol-damaged rat hearts. JPET 315:273-282
    • (2005) JPET , vol.315 , pp. 273-282
    • Palfi, A.1    Toth, A.2    Kulcsar, G.3
  • 10
    • 27444446861 scopus 로고    scopus 로고
    • Pivotal role of Akt activation in mitochondrial protection and cell survival by poly (ADP-ribose) polymerase-1 inhibition in oxidative stress
    • Tapodi A, Debreceni B, Hanto K et al (2005) Pivotal role of Akt activation in mitochondrial protection and cell survival by poly (ADP-ribose) polymerase-1 inhibition in oxidative stress. JBC 280:35767-35775
    • (2005) JBC , vol.280 , pp. 35767-35775
    • Tapodi, A.1    Debreceni, B.2    Hanto, K.3
  • 11
    • 0037446371 scopus 로고    scopus 로고
    • Decrease of the inflammatory response and induction of the Akt/protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock
    • Veres B, Gallyas F Jr, Varbiro G et al (2003) Decrease of the inflammatory response and induction of the Akt/protein kinase B pathway by poly-(ADP-ribose) polymerase 1 inhibitor in endotoxin-induced septic shock. Biochem Pharmacol 65:1373-1382
    • (2003) Biochem Pharmacol , vol.65 , pp. 1373-1382
    • Veres, B.1    Gallyas Jr., F.2    Varbiro, G.3
  • 13
    • 28844448182 scopus 로고    scopus 로고
    • Oncogenic PI3K deregulates transcription and translation
    • Bader AG, Khang S, Li Z et al (2005) Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 5:921-929
    • (2005) Nat Rev Cancer , vol.5 , pp. 921-929
    • Bader, A.G.1    Khang, S.2    Li, Z.3
  • 14
    • 36148964068 scopus 로고    scopus 로고
    • Id-1 activation of PI3K/Akt/NFkB signaling pathway and its significance in promoting survival of esophageal cancer cells
    • Li B, Cheung PY, Wang X et al (2007) Id-1 activation of PI3K/Akt/NFkB signaling pathway and its significance in promoting survival of esophageal cancer cells. Carcinogenesis 28:2313-2320
    • (2007) Carcinogenesis , vol.28 , pp. 2313-2320
    • Li, B.1    Cheung, P.Y.2    Wang, X.3
  • 15
    • 9644253003 scopus 로고    scopus 로고
    • The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-κB and c-Myc in pancreatic cancer cells
    • Asano T, Yao Y, Zhu J et al (2004) The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-κB and c-Myc in pancreatic cancer cells. Oncogene 23:8571-8580
    • (2004) Oncogene , vol.23 , pp. 8571-8580
    • Asano, T.1    Yao, Y.2    Zhu, J.3
  • 16
    • 0033519453 scopus 로고    scopus 로고
    • Induction of NFkappaB by the Akt/PKB kinase
    • Kane LP, Shapiro VS, Stokoe D et al (1999) Induction of NFkappaB by the Akt/PKB kinase. Curr Biol 9:601-604
    • (1999) Curr Biol , vol.9 , pp. 601-604
    • Kane, L.P.1    Shapiro, V.S.2    Stokoe, D.3
  • 17
    • 0033517190 scopus 로고    scopus 로고
    • NF-kappaB is a target of AKT in antiapoptotic PDGF signalling
    • Romashkova JA, Makarov SS (1999) NF-kappaB is a target of AKT in antiapoptotic PDGF signalling. Nature 401:86-90
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 18
    • 0036733355 scopus 로고    scopus 로고
    • The therapeutic potential of poly (ADPribose) polymerase inhibitors
    • Virag L, Szabo C (2002) The therapeutic potential of poly (ADPribose) polymerase inhibitors. Pharmacol Rev 54:375-429
    • (2002) Pharmacol Rev , vol.54 , pp. 375-429
    • Virag, L.1    Szabo, C.2
  • 19
    • 67649592959 scopus 로고    scopus 로고
    • A poly (ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells
    • Li M, Threadgill MD, Wang YL, Cai L, Lin X (2009) A poly (ADP-ribose) polymerase inhibition down-regulates expression of metastasis-related genes in CT26 colon carcinoma cells. Pathobiology 76:108-116
    • (2009) Pathobiology , vol.76 , pp. 108-116
    • Li, M.1    Threadgill, M.D.2    Wang, Y.L.3    Cai, L.4    Lin, X.5
  • 20
    • 67449162124 scopus 로고    scopus 로고
    • Relationship of PARG with colorectal carcinoma PARP, VEGF and b-FGF in colorectal carcinoma
    • Lin L, Li J, Wang YL et al (2009) Relationship of PARG with colorectal carcinoma PARP, VEGF and b-FGF in colorectal carcinoma. Chin J Cancer Res 21:135-141
    • (2009) Chin J Cancer Res , vol.21 , pp. 135-141
    • Lin, L.1    Li, J.2    Wang, Y.L.3
  • 21
    • 33644777616 scopus 로고    scopus 로고
    • Drosophilia poly (ADP-Ribose) glycohydrolase mediates chromatin structure and SIR2-dependent silencing
    • Tulin A, Naumova NM, Menon AK et al (2006) Drosophilia poly (ADP-Ribose) glycohydrolase mediates chromatin structure and SIR2-dependent silencing. Genetics 172:363-371
    • (2006) Genetics , vol.172 , pp. 363-371
    • Tulin, A.1    Naumova, N.M.2    Menon, A.K.3
  • 22
    • 70349658096 scopus 로고    scopus 로고
    • Dual role of poly(ADPribose) glycohydrolase in the regulation of cell death in oxidatively stresses A549 cells
    • Erdelyi K, Bai P, Kovacs I et al (2009) Dual role of poly(ADPribose) glycohydrolase in the regulation of cell death in oxidatively stresses A549 cells. FASEB 23:3553-3563
    • (2009) FASEB , vol.23 , pp. 3553-3563
    • Erdelyi, K.1    Bai, P.2    Kovacs, I.3
  • 23
    • 78149393537 scopus 로고    scopus 로고
    • PARP and PARG inhibitorsnew therapeutic targets in cancer treatment
    • Fauzee NJS, Juan P, Wang YL (2010) PARP and PARG inhibitorsnew therapeutic targets in cancer treatment. Pathol Oncol Res 4:469-478
    • (2010) Pathol Oncol Res , vol.4 , pp. 469-478
    • Fauzee, N.J.S.1    Juan, P.2    Wang, Y.L.3
  • 24
    • 0036546501 scopus 로고    scopus 로고
    • NFκB in cancer: From innocent bystander to major culprit
    • Karin M, Cao Y, Greten FR et al (2002) NFκB in cancer: from innocent bystander to major culprit. Nat Rev Cancer 2:301-310
    • (2002) Nat Rev Cancer , vol.2 , pp. 301-310
    • Karin, M.1    Cao, Y.2    Greten, F.R.3
  • 25
    • 3042544529 scopus 로고    scopus 로고
    • Regulation of kinase cascades and transcripition factors by a poly (ADP-Ribose) polymerase-1 inhibitor, 4-Hydroxyquinazoline, in lipopolysaccharideinduced inflammation in mice
    • Veres B, Radnai B, Gallyas F et al (2004) Regulation of kinase cascades and transcripition factors by a poly (ADP-Ribose) polymerase-1 inhibitor, 4-Hydroxyquinazoline, in lipopolysaccharideinduced inflammation in mice. JPET 310:247-255
    • (2004) JPET , vol.310 , pp. 247-255
    • Veres, B.1    Radnai, B.2    Gallyas, F.3
  • 26
    • 30444446344 scopus 로고    scopus 로고
    • Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion
    • Kovacs K, Toth A, Deres P et al (2006) Critical role of PI3-kinase/Akt activation in the PARP inhibitor induced heart function recovery during ischemia-reperfusion. Biochem Pharmacol 71:441-452
    • (2006) Biochem Pharmacol , vol.71 , pp. 441-452
    • Kovacs, K.1    Toth, A.2    Deres, P.3
  • 27
    • 32244436294 scopus 로고    scopus 로고
    • The role of NF-κB in protein breakdown in immobilization, aging, and exercise from basic processes to promotion of health
    • Bar-Shai M, Carmeli E, Reznick AZ (2005) The role of NF-κB in protein breakdown in immobilization, aging, and exercise from basic processes to promotion of health. Ann NY Acad Sci 1057:431-447
    • (2005) Ann NY Acad Sci , vol.1057 , pp. 431-447
    • Bar-Shai, M.1    Carmeli, E.2    Reznick, A.Z.3
  • 28
    • 5444262078 scopus 로고    scopus 로고
    • IKKβ/NF-κB activation causes severe muscle wasting in mice
    • Cai D, Frantz JD, Tawa NE et al (2004) IKKβ/NF-κB activation causes severe muscle wasting in mice. Cell 119:285-298
    • (2004) Cell , vol.119 , pp. 285-298
    • Cai, D.1    Frantz, J.D.2    Tawa, N.E.3
  • 29
    • 77956825183 scopus 로고    scopus 로고
    • Expressions of Poly (ADP-ribose) Glycohydrolase (PARG) and membrane Type1 Matrix Metalloproteinase (MT1-MMP) in Colorectal Carcinoma
    • Xian L, Guang-jie D, Wang Y et al (2010) Expressions of Poly (ADP-ribose) Glycohydrolase (PARG) and membrane Type1 Matrix Metalloproteinase (MT1-MMP) in Colorectal Carcinoma. Chin J Cancer Res 22:186-193
    • (2010) Chin J Cancer Res , vol.22 , pp. 186-193
    • Xian, L.1    Guang-Jie, D.2    Wang, Y.3
  • 30
    • 0027082986 scopus 로고
    • Induction of NF-KB-Like Activity by Platelet-Derived Growth Factor in Mouse Fibroblasts
    • Olashaw NE, Kowalik TF, Huang EH et al (1992) Induction of NF-KB-Like Activity by Platelet-Derived Growth Factor in Mouse Fibroblasts. Mol Biol Cell 3:1131-1139
    • (1992) Mol Biol Cell , vol.3 , pp. 1131-1139
    • Olashaw, N.E.1    Kowalik, T.F.2    Huang, E.H.3
  • 31
    • 0035437862 scopus 로고    scopus 로고
    • NF-κB mediates FGF signal regulation of msx-1 expression
    • Bushdid PB, Chen CL, Brantley DM et al (2001) NF-κB mediates FGF signal regulation of msx-1 expression. Dev Biol 237:107-115
    • (2001) Dev Biol , vol.237 , pp. 107-115
    • Bushdid, P.B.1    Chen, C.L.2    Brantley, D.M.3
  • 32
    • 33750435582 scopus 로고    scopus 로고
    • NF-κB and the immune response
    • Hayden MS, West AP, Ghosh S (2006) NF-κB and the immune response. Oncogene 119:6758-6780
    • (2006) Oncogene , vol.119 , pp. 6758-6780
    • Hayden, M.S.1    West, A.P.2    Ghosh, S.3
  • 33
    • 72449194919 scopus 로고    scopus 로고
    • Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt
    • Bai D, Ueno L, Vogt PK (2009) Akt-mediated regulation of NFκB and the essentialness of NFκB for the oncogenicity of PI3K and Akt. Int J Cancer 125:2863-2870
    • (2009) Int J Cancer , vol.125 , pp. 2863-2870
    • Bai, D.1    Ueno, L.2    Vogt, P.K.3
  • 34
    • 0037199972 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells
    • Guha M, Mackman N (2002) The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. JBC 277:32124-32132
    • (2002) JBC , vol.277 , pp. 32124-32132
    • Guha, M.1    MacKman, N.2
  • 35
    • 66749153928 scopus 로고    scopus 로고
    • Effect of hydrogen sulfide on the phosphatidylinositol 3-kinase-protein kinase B pathway and on caerulein-induced cytokine production in isolated mouse pancreatic acinar cells
    • Tamizhselvi R, Sun J, Koh YH et al (2009) Effect of hydrogen sulfide on the phosphatidylinositol 3-kinase-protein kinase B pathway and on caerulein-induced cytokine production in isolated mouse pancreatic acinar cells. JPET 329:1166-1178
    • (2009) JPET , vol.329 , pp. 1166-1178
    • Tamizhselvi, R.1    Sun, J.2    Koh, Y.H.3
  • 36
    • 78650465278 scopus 로고    scopus 로고
    • Attenuation of cardiac dysfunction by HSPA12B in endotoxin-induced sepsis in mice through a PI3Kdependent mechanism
    • Zhou H, Qian J, Li C et al (2011) Attenuation of cardiac dysfunction by HSPA12B in endotoxin-induced sepsis in mice through a PI3Kdependent mechanism. Cardiovasc Res 89:109-118
    • (2011) Cardiovasc Res , vol.89 , pp. 109-118
    • Zhou, H.1    Qian, J.2    Li, C.3
  • 37
    • 40849118049 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase/Akt pathway negatively regulates Nod2-mediated NF-kB pathway
    • Zhao L, Lee JY, Hwang DH (2008) The phosphatidylinositol 3-kinase/Akt pathway negatively regulates Nod2-mediated NF-kB pathway. Biochempharm 75:1515-1525
    • (2008) Biochempharm , vol.75 , pp. 1515-1525
    • Zhao, L.1    Lee, J.Y.2    Hwang, D.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.