Effect of hydrogen sulfide on the phosphatidylinositol 3-kinase-protein kinase B pathway and on caerulein-induced cytokine production in isolated mouse pancreatic acinar cells

Journal of Pharmacology and Experimental Therapeutics

Volumn 329, Issue 3, 2009, Pages 1166-1177

  Tamizhselvi, Ramasamy ^a   Sun, Jia ^a   Koh, Yung Hua ^a   Bhatia, Madhav ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CERULETIDE; HYDROGEN SULFIDE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

ACINAR CELL; ACUTE PANCREATITIS; ANIMAL CELL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CAERULEIN; CHROMONES; CYTOKINES; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HYDROGEN SULFIDE; I-KAPPA B PROTEINS; MICE; MICE, INBRED STRAINS; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; NF-KAPPA B; PANCREAS, EXOCRINE; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 66749153928     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.109.150532     Document Type: Article

References (39)

1. Abe K and Kimura H (1996) The possible role of hydrogen sulfide as an endogenous neuromodulator. J Neurosci 16:1066-1071. (Pubitemid 26140863)
2. Bang OS, Ha BG, Park EK, and Kang SS (2000) Activation of Akt is induced by heat shock and involved in suppression of heat-shock-induced apoptosis of NIH3T3 cells. Biochem Biophys Res Commun 278:306-311.
3. Beutler B and Grau GE (1993) Tumor necrosis factor in the pathogenesis of infectious diseases. Crit Care Med 10 (Suppl 10:S423-S425. (Pubitemid 23304332)
4. Bhatia M (2002) Novel therapeutic targets for acute pancreatitis and associated multiple organ dysfunction syndrome. Curr Drug Targets Inflamm Allergy 1:343-351.
5. Bhatia M (2004) Apoptosis versus necrosis in acute pancreatitis. Am J Physiol Gastrointest Liver Physiol 286:G189-G196. (Pubitemid 38134029)
6. Bhatia M, Neoptolemos JP, and Slavin J (2001) Inflammatory mediators as therapeutic targets in acute pancreatitis. Curr Opin Investig Drugs 2:496-501. (Pubitemid 32401137)
7. Bhatia M, Saluja AK, Hofbauer B, Frossard JL, Lee HS, Castagliuolo I, Wang CC, Gerard N, Pothoulakis C, and Steer ML (1998) Role of substance P and the neurokinin 1 receptor in acute pancreatitis and pancreatitis-associated lung injury. Proc Natl Acad Sci U S A 95:4760-4765. (Pubitemid 28207987)
8. Bhatia M, Zhi L, Zhang H, Ng SW, and Moore PK (2006) Role of substance P in hydrogen sulfide-induced pulmonary inflammation in mice. Am J Physiol Lung Cell Mol Physiol 291:L896-L904. (Pubitemid 44772051)
9. Blinman TA, Gukovsky I, Mouria M, Zaninovic V, Livingston E, Pandol SJ, and Gukovskaya AS (2001) Activation of pancreatic acinar cells on isolation from tissue: cytokine upregulation via p38 MAP kinase. Am J Physiol Cell Physiol 279:C1993-C2003.
10. Cantley LC (2002) The phosphoinositide 3-kinase pathway. Science 296:1655-1657. (Pubitemid 34579158)
11. Cao Y, Adhikari S, Ang AD, Moore PK, and Bhatia M (2006) Mechanism of induction of pancreatic acinar cell apoptosis by hydrogen sulfide. Am J Physiol Cell Physiol 291:C503-C510. (Pubitemid 44343633)
12. Chan TO, Rittenhouse SE, and Tsichlis PN (1999) AKT/PKB and other D3 phosphoinositide-regulated kinases: kinase activation by phosphoinositide- dependent phosphorylation. Annu Rev Biochem 68:965-1014. (Pubitemid 29449213)
13. Coffer PJ, Jin J, and Woodgett JR (1998) Protein kinase B (c-Akt): a multifunctional mediator of phosphatidylinositol 3-kinase activation. Biochem J 335:1-13. (Pubitemid 28477043)
14. Geng B, Yang J, Qi Y, Zhao J, Pang Y, Du J, and Tang C (2004) H2S generated by heart in rat and its effects on cardiac function. Biochem Biophys Res Commun 313:362-368. (Pubitemid 37543594)
15. Gharbi SI, Zvelebil MJ, Shuttleworth SJ, Hancox T, Saghir N, Timms JF, and Waterfield MD (2007) Exploring the specificity of the PI3K family inhibitor LY294002. Biochem J 404:15-21. (Pubitemid 46788080)
16. Karin M and Ben-Neriah Y (2000) Phosphorylation meets ubiquitination: the control of NF-kB activity. Annu Rev Immunol 18:621-663. (Pubitemid 30365393)
17. Kim AH, Khursigara G, Sun X, Franke TF, and Chao MV (2001) AKT phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol 21:893-901. (Pubitemid 32104737)
18. Labarca C and Paigen K (1980) A simple, rapid, and sensitive DNA assay procedure. Anal Biochem 102:344-352. (Pubitemid 10115803)
19. Leach SD, Modlin IM, Scheele GA, and Gorelick FS (1991) Intracellular activation of digestive zymogens in rat pancreatic acini: stimulation by high doses of cholecystokinin. J Clin Invest 87:362-366.
20. Li L, Bhatia M, Zhu YZ, Zhu YC, Ramnath RD, Wang ZJ, Anuar FB, Whiteman M, Salto-Tellez M, and Moore PK (2005) Hydrogen sulfide is a novel mediator of lipopolysaccharide-induced inflammation in the mouse. FASEB J 19:1196-1198. (Pubitemid 40946463)
21. Liu JF, Crépin M, Liu JM, Barritault D, and Ledoux D (2002) FGF-2 and TPA induce matrixmetalloproteinase-9 secretion in MCF-7 cells through PKC activation of the Ras/ERK pathway. Biochem Biophys Res Commun 293:1174-1182. (Pubitemid 34681065)
22. Luyendyk JP, Schabbauer GA, Tencati M, Holscher T, Pawlinski R, and Mackman N (2008) Genetic analysis of the role of the PI3K/AKT pathway lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes/macrophages. J Immunol 180:4218-4226.
23. Martin M, Rehani K, Jope RS, and Michalek SM (2005) Toll-like receptor mediated cytokine production is differentially regulated by glycogen synthase kinase 3. Nat Immunol 6:777-784. (Pubitemid 43090463)
24. Rommel C, Clarke BA, Zimmermann S, Nuñez L, Rossman R, Reid K, Moelling K, Yancopoulos GD, and Glass DJ (1999) Differentiation stage specific inhibition of the Raf-MEK-ERK pathway by AKT. Science 286:1738-1741. (Pubitemid 129515881)
25. Roux PP and Blenis J (2004) ERK and p38 MAPK-activated protein kinases: a family of protein kinases with diverse biological functions. Microbiol Mol Biol Rev 68:320-344. (Pubitemid 38756868)
26. Singh VP, Saluja AK, Bhagat L, van Acker GJ, Song AM, Soltoff SP, Cantley LC, and Steer ML (2001) Phosphatidylinositol 3-kinase dependent activation of trypsinogen modulates the severity of acute pancreatitis. J Clin Invest 108:1387-1395. (Pubitemid 33107767)
27. Sunamura M, Shibuya K, Yamauchi J, and Matsuno S (1999) Microcirculatory derangement and ischemia of the pancreas. Nippon Geka Gakkai Zasshi 100:342-346.
28. Tamizhselvi R, Moore PK, and Bhatia M (2007) The mechanism by which hydrogen sulfide acts as a mediator of inflammation in acute pancreatitis: in vitro studies using isolated mouse pancreatic acinar cells. J Cell Mol Med 11:1-12.
29. Toker A and Cantley LC (1997) Signalling through the lipid products of phosphoinositide-3-OH kinase. Nature 387:673-676. (Pubitemid 27270600)
30. Vanhaesebroeck B and Waterfield MD (1999) Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res 253:239-254.
31. Ward SG and Finan P (2003) Isoform-specific phosphoinositide 3-kinase inhibitors as therapeutic agents. Curr Opin Pharmacol 3:426-434. (Pubitemid 36908947)
32. Wurmser AE, Gary JD, and Emr SD (1999) Domain-containing effectors as regulators of vacuolar/lysosomal membrane trafficking pathways. J Biol Chem 274:9129-9132.
33. Yan SK, Chang T, Wang H, Wu L, Wang R, and Meng QH (2006) Effects of hydrogen sulfide on homocysteine-induced oxidative stress in vascular smooth muscle cells. Biochem Biophys Res Commun 351:485-491. (Pubitemid 44755144)
34. Yong QC, Lee SW, Foo CS, Neo KL, Chen X, and Bian JS (2008) Endogenous hydrogen sulphide mediates the cardioprotection induced by ischemic postconditioning. Am J Physiol Heart Circ Physiol 295:H1330-H1340.
35. Zanardo RC, Brancaleone V, Distrutti E, Fiorucci S, Cirino G, and Wallace JL (2006) Hydrogen sulfide is an endogenous modulator of leukocyte-mediated inflammation. FASEB J 20:2118-2120. (Pubitemid 44953872)
36. Zhang H, Hegde A, Ng SW, Adhikari S, Moochhala SM, and Bhatia M (2007a) Hydrogen sulfide up-regulates Substance P in polymicrobial sepsis-associated lung injury. J Immunol 179:4153-4160.
37. Zhang H, Zhi L, Moochhala S, Moore PK, and Bhatia M (2007b) Hydrogen sulfide acts as an inflammatory mediator in cecal ligation and puncture induced sepsis in mice by up-regulating the production of cytokines and chemokines via NF-{kappa}B. Am J Physiol Lung Cell Mol Physiol 292:L960-L971. (Pubitemid 46608243)
38. 2S as a novel endogenous gaseous KATP channel opener. EMBO J 20:6008-6016.
39. Zhi L, Ang AD, Zhang H, Moore PK, and Bhatia M (2007) Hydrogen sulfide induces the synthesis of proinflammatory cytokines in human monocyte cell line U937 via the ERK-NF-{kappa}B pathway. J Leukoc Biol 81:1322-1332. (Pubitemid 46702052)