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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 14, 2012, Pages 4740-4744

Synthesis and structure-activity relationship studies of 1,3-disubstituted 2-propanols as BACE-1 inhibitors

(4) Kumar, Arun Babu a Anderson, Jordan Micheal a Melendez, Anthony Lester a Manetsch, Roman a

a UNIVERSITY OF SOUTH FLORIDA (United States)

Author keywords

Secretase; 1,3 Disubstituted 2 propanol; BACE 1; Blood brain barrier; Cathepsin D; HEA; Hydroxyethylamines; Small molecule inhibitor

Indexed keywords

BETA SECRETASE INHIBITOR; CATHEPSIN D; PROPANOL;

ARTICLE; BLOOD BRAIN BARRIER; DRUG ACTIVITY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; IC 50; PHYSICAL CHEMISTRY; STRUCTURE ACTIVITY RELATION;

2-PROPANOL; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; BLOOD-BRAIN BARRIER; CATHEPSIN D; MOLECULAR STRUCTURE; PHYSICOCHEMICAL PHENOMENA; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863464364 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.05.072 Document Type: Article

Times cited : (17)

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