Hydroxyethylamine isostere of an HIV-1 protease inhibitor prefers its amine to the hydroxy group in binding to catalytic aspartates. A synchrotron study of HIV-1 protease in complex with a peptidomimetic inhibitor

Journal of Medicinal Chemistry

Volumn 45, Issue 7, 2002, Pages 1432-1438

  Dohnálek, Jan ^a   Hašek, Jindřich ^a   Dušková, Jarmila ^a   Petroková, Hana ^a   Hradilek, Martin ^b   Souček, Milan ^b   Konvalinka, Jan ^b   Brynda, Jiří ^c   Sedláček, Juraj ^c   Fábry, Milan ^c  

^a INSTITUTE OF MACROMOLECULAR CHEMISTRY   (Czech Republic)

^b INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^c INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; ASPARTIC ACID; DIMER; GLUTAMIC ACID; GLUTAMINE; GLYCINE; HYDROXYETHYLAMINE; HYDROXYL GROUP; PROTEINASE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL MODIFICATION; COMPLEX FORMATION; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITOR INTERACTION; ENZYME SPECIFICITY; HUMAN IMMUNODEFICIENCY VIRUS 1; HYDROGEN BOND; ISOMER; SOLVATION; STRUCTURE ANALYSIS; SYNCHROTRON; X RAY DIFFRACTION;

AMINES; AMINO ACIDS; ASPARTIC ACID; BINDING SITES; CATALYSIS; DIMERIZATION; ENDOPEPTIDASES; ETHANOLAMINES; GLYCEROL; HIV PROTEASE; HIV PROTEASE INHIBITORS; HYDROGEN BONDING; KINETICS; MODELS, CHEMICAL; MODELS, MOLECULAR; OXYGEN; PEPTIDE FRAGMENTS; PROTEIN BINDING; PROTEIN CONFORMATION; SYNCHROTRONS; X-RAY DIFFRACTION;

EID: 0037187402     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010979e     Document Type: Article

References (24)

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