Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 10, 2009, Pages 2654-2660

  Wu, Yong Jin ^a   Zhang, Yunhui ^a   Good, Andrew C ^a   Burton, Catherine R ^a   Toyn, Jeremy H ^a   Albright, Charles F ^a   Macor, John E ^a   Thompson, Lorin A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Alzheimer's disease; BACE inhibitor; Phenylcarboxyamides

Indexed keywords

[1 (3,5 DIFLUOROPHENYL) 3 HYDROXY 4 (3 METHOXYBENZYLAMINO)BUTAN 2 YL]BENZAMIDE DERIVATIVE; AMIDE; BETA SECRETASE; BETA SECRETASE INHIBITOR; ETHYLAMINE; HYDROXYETHYLAMINE; UNCLASSIFIED DRUG;

ARTICLE; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; IC 50; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMYLOID PRECURSOR PROTEIN SECRETASES; BENZAMIDES; CELL LINE; HUMANS; PROTEASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 65349100664     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.144     Document Type: Article

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