Glutathione suppresses TGF-β-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 293, Issue 5, 2007, Pages

  Vayalil, Praveen K ^a   Iles, Karen E ^a,b   Choi, Jinah ^c   Yi, Ae Kyung ^d   Postlethwait, Edward M ^a   Liu, Rui Ming ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

Mitogen activated protein kinase; Plasminogen activator inhibitor 1; Transforming growth factor

Indexed keywords

DIPHENYLIODONIUM SALT; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; OLIGONUCLEOTIDE; PLASMINOGEN ACTIVATOR INHIBITOR 1; REACTIVE OXYGEN METABOLITE; SMAD PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL CELL; ARTICLE; CATALYSIS; CONTROLLED STUDY; GENE EXPRESSION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION;

ANIMALS; ANTINEOPLASTIC AGENTS; BLOTTING, NORTHERN; BLOTTING, WESTERN; CELLS, CULTURED; ENZYME INHIBITORS; GENE EXPRESSION; GLUTATHIONE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MICE; NIH 3T3 CELLS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROMOTER REGIONS (GENETICS); PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SMAD PROTEINS; SP1 TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP-1; TRANSFORMING GROWTH FACTOR BETA;

EID: 36349007768     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00128.2007     Document Type: Article

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