Increased transforming growth factor beta 1 expression mediates ozone-induced airway fibrosis in mice

Inhalation Toxicology

Volumn 23, Issue 8, 2011, Pages 486-494

  Katre, Ashwini ^a   Ballinger, Carol ^a   Akhter, Hasina ^a   Fanucchi, Michelle ^a   Kim, Dae Kee ^b   Postlethwait, Edward ^a   Liu, Rui Ming ^a  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b Ewha Womans University   (South Korea)

Author keywords

airway fibrosis; Ozone; PAI 1; TGF

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; IN 1233; OZONE; PLASMINOGEN ACTIVATOR INHIBITOR 1; RECEPTOR BLOCKING AGENT; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

AIR POLLUTION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; LUNG ALVEOLUS EPITHELIUM; LUNG ALVEOLUS WALL; LUNG FIBROSIS; LUNG FLUID; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; TOXICOKINETICS;

ACTINS; ANIMALS; BENZAMIDES; BRONCHI; COLLAGEN; DISEASE MODELS, ANIMAL; INHALATION EXPOSURE; MALE; MICE; MICE, INBRED C57BL; OXIDANTS, PHOTOCHEMICAL; OZONE; PHOSPHORYLATION; PULMONARY FIBROSIS; QUINOLINES; SERPIN E2; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

ANIMALIA; MUS;

EID: 79959395509     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2011.584919     Document Type: Article

References (52)

1. Arthur MJ. 1994 Degradation of matrix proteins in liver fibrosis. Pathol Res Pract 190: 825-833 (Pubitemid 24370092)
2. Bellocq A, Azoulay E, Marullo S, Flahault A, Fouqueray B, Philippe C, Cadranel J, Baud L. 1999 Reactive oxygen and nitrogen intermediates increase transforming growth factor-beta1 release from human epithelial alveolar cells through two different mechanisms. Am J Respir Cell Mol Biol 21: 128-136 (Pubitemid 129508636)
3. Bergeron A, Soler P, Kambouchne M, Loiseau P, Milleron B, Valeyre D, Hance AJ, Tazi A. 2003 Cytokine profiles in idiopathic pulmonary fibrosis suggest an important role for TGF-beta and IL-10 Eur Respir J 22: 69-76 (Pubitemid 36896473)
4. Bertozzi P, Astedt B, Zenzius L, Lynch K, LeMaire F, Zapol W, Chapman HA Jr. 1990 Depressed bronchoalveolar urokinase activity in patients with adult respiratory distress syndrome. N Engl J Med 322: 890-897 (Pubitemid 20108378)
5. Bocci V, Luzzi E, Corradeschi F, Silvestri S. 1994 Studies on the biological effects of ozone: 6 Production of transforming growth factor 1 by human blood after ozone treatment. J Biol Regul Homeost Agents 8: 108-112
6. Bonniaud P, Margetts PJ, Kolb M, Schroeder JA, Kapoun AM, Damm D, Murphy A, Chakravarty S, Dugar S, Higgins L, Protter AA, Gauldie J. 2005 Progressive Transforming Growth Factor {beta}1-induced Lung Fibrosis is Blocked by an orally Active ALK5 Kinase Inhibitor. Am J Respir Crit Care Med 171: 889-898 (Pubitemid 40562720)
7. Chang LY, Stockstill BL, Menache MG, Mercer RR, Crapo JD. 1995 Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part VIII: Morphometric analysis of structural alterations in alveolar regions. Res Rep Health Eff Inst, 3-39; discussion 99
8. Chuang-Tsai S, Sisson TH, Hattori N, Tsai CG, Subbotina NM, Hanson KE, Simon RH. 2003 Reduction in fibrotic tissue formation in mice genetically deficient in plasminogen activator inhibitor-1 Am J Pathol 163: 445-452 (Pubitemid 36909408)
9. Churg A, Zhou S, Preobrazhenska O, Tai H, Wang R, Wright JL. 2009 Expression of Profibrotic Mediators in Small Airways versus Parenchyma after Cigarette Smoke Exposure. Am J Respir Cell Mol Biol 40: 268-276
10. Coker RK, Laurent GJ, Shahzeidi S, Lympany PA, du Bois RM, Jeffery PK, McAnulty RJ. 1997 Transforming growth factors-beta 1, -beta 2, and -beta 3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis. Am J Pathol 150: 981-991
11. Davidson JM. 1990 Biochemistry and turnover of lung interstitium. Eur Respir J 3: 1048-1063
12. Dormans JA, van Bree L, Boere AJ, Marra M, Rombout PJ. 1999 Interspecies differences in time course of pulmonary toxicity following repeated exposure to ozone. Inhal Toxicol 11: 309-329 (Pubitemid 29201371)
13. Eitzman DT, McCoy RD, Zheng X, Fay WP, Shen T, Ginsburg D, Simon RH. 1996 Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J Clin Invest 97: 232-237 (Pubitemid 26021713)
14. Fahy RJ, Lichtenberger F, McKeegan CB, Nuovo GJ, Marsh CB, Wewers MD. 2003 The acute respiratory distress syndrome: a role for transforming growth factor-beta 1 Am J Respir Cell Mol Biol 28: 499-503 (Pubitemid 36399372)
15. Fanucchi MV, Buckpitt AR, Murphy ME, Plopper CG. 1997 Naphthalene cytotoxicity of differentiating Clara cells in neonatal mice. Toxicol Appl Pharmacol 144: 96-104 (Pubitemid 27208342)
16. Gunther A, Mosavi P, Heinemann S, Ruppert C, Muth H, Markart P, Grimminger F, Walmrath D, Temmesfeld-Wollbruck B, Seeger W. 2000a. Alveolar fibrin formation caused by enhanced procoagulant and depressed fibrinolytic capacities in severe pneumonia. Comparison with the acute respiratory distress syndrome. Am J Respir Crit Care Med 161: 454-462 (Pubitemid 30129452)
17. Gunther A, Mosavi P, Ruppert C, Heinemann S, Temmesfeld B, Velcovsky HG, Morr H, Grimminger F, Walmrath D, Seeger W. 2000b. Enhanced tissue factor pathway activity and fibrin turnover in the alveolar compartment of patients with interstitial lung disease. Thromb Haemost 83: 853-860 (Pubitemid 30411683)
18. Hattori N, Degen JL, Sisson TH, Liu H, Moore BB, Pandrangi RG, Simon RH, Drew AF. 2000 Bleomycin-induced pulmonary fibrosis in fibrinogen-null mice. J Clin Invest 106: 1341-1350
19. Higashiyama H, Yoshimoto D, Kaise T, Matsubara S, Fujiwara M, Kikkawa H, Asano S, Kinoshita M. 2007 Inhibition of activin receptor-like kinase 5 attenuates bleomycin-induced pulmonary fibrosis. Exp Mol Pathol 83: 39-46 (Pubitemid 46842964)
20. Idell S, James KK, Levin EG, Schwartz BS, Manchanda N, Maunder RJ, Martin TR, McLarty J, Fair DS. 1989 Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest 84:695-705 (Pubitemid 19197006)
21. Kim JH, Song HY, Park JH, Yoon HJ, Park HG, Kim DK. 2010 IN-1233, an ALK-5 inhibitor: prevention of granulation tissue formation after bare metallic stent placement in a rat urethral model. Radiology 255: 75-82
22. Kolb M, Bonniaud P, Galt T, Sime PJ, Kelly MM, Margetts PJ, Gauldie J. 2002 Differences in the fibrogenic response after transfer of active transforming growth factor-beta1 gene to lungs of "fibrosis-prone" and "fibrosis-resistant" mouse strains. Am J Respir Cell Mol Biol 27: 141-150 (Pubitemid 34780793)
23. Lang DS, Jorres RA, Mucke M, Siegfried W, Magnussen H, 1998 Interactions between human bronchoepithelial cells and lung fibroblasts after ozone exposure in vitro. Toxicol Lett 96-97: 13-24 (Pubitemid 28430292)
24. Last JA, Gelzleichter TR, Harkema J, Hawk S. 1994 Consequences of prolonged inhalation of ozone on Fischer-344/N rats: collaborative studies. Part I: Content and cross-linking of lung collagen. Res Rep Health Eff Inst 1-29; discussion 31-40
25. Last JA, Hesterberg TW, Reiser KM, Cross CE, Amis TC, Gunn C, Steffey EP, Grandy J, Henrickson R. 1981 Ozone-induced alterations in collagen metabolism of monkey lungs: use of biopsy-obtained lung tissue. Toxicol Appl Pharmacol 60: 579-585 (Pubitemid 12194296)
26. Last JA, Reiser KM, Tyler WS, Rucker RB. 1984 Long-term consequences of exposure to ozone. I. Lung collagen content. Toxicol Appl Pharmacol 72: 111-118 (Pubitemid 14175571)
27. Laurent GJ. 1987 Dynamic state of collagen: pathways of collagen degradation in vivo and their possible role in regulation of collagen mass. Am J Physiol 252: C1-9
28. Lee CG, Cho SJ, Kang MJ, Chapoval SP, Lee PJ, Noble PW, Yehualaeshet T, Lu B, Flavell RA, Milbrandt J, Homer RJ, Elias JA. 2004 Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. J Exp Med 200: 377-389 (Pubitemid 39031256)
29. Leonarduzzi G, Scavazza A, Biasi F, Chiarpotto E, Camandola S, Vogel S, Dargel R, Poli G. 1997 The lipid peroxidation end product 4-hydroxy-2,3-nonenal up-regulates transforming growth factor beta1 expression in the macrophage lineage: a link between oxidative injury and fibrosclerosis. Faseb J 11: 851-857 (Pubitemid 27371894)
30. Liu RM. 2008 Oxidative stress, plasminogen activator inhibitor 1, and lung fibrosis. Antioxid Redox Signal 10: 303-319
31. Liu RM, Choi J, Wu JH, Gaston Pravia KA, Lewis KM, Brand JD, Mochel NS, Krzywanski DM, Lambeth JD, Hagood JS, Forman HJ, Thannickal VJ, Postlethwait EM. 2010 Oxidative modification of nuclear mitogenactivated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts. J Biol Chem 285:16239-16247
32. Long L, Crosby A, Yang X, Southwood M, Upton PD, Kim D-K, Morrell NW. 2009 Altered Bone Morphogenetic Protein and Transforming Growth Factor-{beta} Signaling in Rat Models of Pulmonary Hypertension: Potential for Activin Receptor-Like Kinase-5 Inhibition in Prevention and Progression of Disease. Circulation 119: 566-576
33. Parks WC, Roby JD. 1994 Consequences of prolonged inhalation of ozone on F344/N rats: collaborative studies. Part IV: Effects on expression of extracellular matrix genes. Res Rep Health Eff Inst 3-20; discussion 21-29
34. Pickrell JA, Hahn FF, Rebar AH, Horoda RA, Henderson RF. 1987 Changes in collagen metabolism and proteinolysis after repeated inhalation exposure to ozone. Exp Mol Pathol 46: 159-167 (Pubitemid 17048727)
35. Reiser KM, Tyler WS, Hennessy SM, Dominguez JJ, Last JA. 1987 Longterm consequences of exposure to ozone. II. Structural alterations in lung collagen of monkeys. Toxicol Appl Pharmacol 89: 314-322 (Pubitemid 17101950)
36. Rube CE, Uthe D, Schmid KW, Richter KD, Wessel J, Schuck A, Willich N, Rube C. 2000 Dose-dependent induction of transforming growth factor beta (TGF-beta) in the lung tissue of fibrosis-prone mice after thoracic irradiation. Int J Radiat Oncol Biol Phys 47: 1033-1042 (Pubitemid 30345604)
37. Saito K, Ishizaka N, Aizawa T, Sata M, Iso-o N, Noiri E, Mori I, Ohno M, Nagai R. 2005 Iron chelation and a free radical scavenger suppress angiotensin II-induced upregulation of TGF-beta1 in the heart. Am J Physiol Heart Circ Physiol 288: H1836-1843 (Pubitemid 40418011)
38. Shima M, Adachi M. 1991 [Changes of procoagulant and fibrinolytic activities in the alveoli of rats exposed to ozone]. Nippon Eiseigaku Zasshi 46: 724-733
39. Shvedova AA, Kisin ER, Murray AR, Kommineni C, Castranova V, Fadeel B, Kagan VE. 2008 Increased accumulation of neutrophils and decreased fibrosis in the lung of NADPH oxidase-deficient C57BL/6 mice exposed to carbon nanotubes. Toxicol Appl Pharmacol 231: 235-240
40. Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J. 1997 denovectormediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest 100: 768-776 (Pubitemid 27371693)
41. Stockstill BL, Chang LY, Menache MG, Mellick PW, Mercer RR, Crapo JD. 1995 Bronchiolarized metaplasia and interstitial fibrosis in rat lungs chronically exposed to high ambient levels of ozone. Toxicol Appl Pharmacol 134: 251-263
42. Sullivan DE, Ferris M, Pociask D, Brody AR. 2008 The latent form of TGFbeta(1) is induced by TNFalpha through an ERK specific pathway and is activated by asbestos-derived reactive oxygen species in vitro and in vivo. J Immunotoxicol 5: 145-149 (Pubitemid 351882416)
43. Sun JD, Pickrell JA, Harkema JR, McLaughlin SI, Hahn FF, Henderson RF. 1988 Effects of buthionine sulfoximine on the development of ozone-induced pulmonary fibrosis. Exp Mol Pathol 49:254-266
44. Tzortzaki EG, Antoniou KM, Zervo, MI, Lambiri I, Koutsopoulos A, Tzanakis N, Plataki M, Maltezakis G, Bouros D, Siafakas NM. 2007 Effects of antifibrotic agents on TGF-[beta]1, CTGF and IFN-[gamma] expression in patients with idiopathic pulmonary fibrosis. Respiratory Medicine 101: 1821-1829 (Pubitemid 46930700)
45. Valacchi G, Bocci V. 1999 Studies on the biological effects of ozone: 10 Release of factors from ozonated human platelets. Mediators Inflamm 8: 205-209 (Pubitemid 30019330)
46. Van Bree L, Dormans JA, Boere AJ, Rombout PJ. 2001 Time study on development and repair of lung injury following ozone exposure in rats. Inhal Toxicol 13: 703-718
47. Vayalil PK, Iles KE, Choi J, Yi A-K, Postlethwait EM, Liu R-M. 2007 Glutathione suppresses TGF-beta-induced PAI-1 expression by inhibiting p38 and JNK MAPK and the binding of AP-1, SP-1, and Smad to the PAI-1 promoter. Am J Physiol Lung Cell Mol Physiol 293:L1281-1292 (Pubitemid 350159412)
48. Vayalil PK, Olman M, Murphy-Ullrich JE, Postlethwait EM, Liu RM. 2005 Glutathione restores collagen degradation in TGF-betatreated fibroblasts by blocking plasminogen activator inhibitor-1 expression and activating plasminogen. Am J Physiol Lung Cell Mol Physiol 289: L937-945 (Pubitemid 41681328)
49. Vicencio AG, Lee CG, Cho SJ, Eickelberg O, Chuu Y, Haddad GG, Elias JA. 2004 Conditional overexpression of bioactive transforming growth factor-beta1 in neonatal mouse lung: a new model for bronchopulmonary dysplasia? Am J Respir Cell Mol Biol 31: 650-656 (Pubitemid 39587495)
50. Williams AO, Flanders KC, Saffiotti U. 1993 Immunohistochemical localization of transforming growth factor-beta 1 in rats with experimental silicosis, alveolar type II hyperplasia, and lung cancer. Am J Pathol 142: 1831-1840 (Pubitemid 24057077)
51. Yamaguchi Y, Mann DM, Ruoslahti E. 1990 Negative regulation of transforming growth factor-beta by the proteoglycan decorin. Nature 346: 281-284
52. Zhao W, Zhao T, Chen Y, Ahokas RA, Sun Y. 2008 Oxidative stress mediates cardiac fibrosis by enhancing transforming growth factor-beta1 in hypertensive rats. Mol Cell Biochem 317: 43-50