메뉴 건너뛰기




Volumn 86, Issue 12, 2008, Pages 2685-2695

N-acetylcysteine prevents β-amyloid toxicity by a stimulatory effect on p35/cyclin-dependent kinase 5 activity in cultured cortical neurons

Author keywords

Amyloid peptide; Apoptosis; Bcl 2; Cdk5; N acetylcysteine; Neuroprotection

Indexed keywords

[1 [(1 FORMYL 2 PHENYLETHYL)CARBAMOYL] 2 METHYLPROPYL]CARBAMIC ACID BENZYL ESTER; ACETYLCYSTEINE; AMYLOID BETA PROTEIN[25-35]; BUTYROLACTONE; CALPEPTIN; CYCLIN DEPENDENT KINASE 5; PROTEIN BCL 2; PROTEIN P25; PROTEIN P35; ROSCOVITINE; SMALL INTERFERING RNA;

EID: 57049099718     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.21710     Document Type: Article
Times cited : (20)

References (40)
  • 2
    • 0031018336 scopus 로고    scopus 로고
    • Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality
    • Chae T, Kwon YT, Bronson R, Dikkes P, Li E, Tsai LH. 1997. Mice lacking p35, a neuronal specific activator of Cdk5, display cortical lamination defects, seizures, and adult lethality. Neuron 18:29-42.
    • (1997) Neuron , vol.18 , pp. 29-42
    • Chae, T.1    Kwon, Y.T.2    Bronson, R.3    Dikkes, P.4    Li, E.5    Tsai, L.H.6
  • 3
    • 2342634487 scopus 로고    scopus 로고
    • Cdk5: Mediator of neuronal death and survival
    • Cheung ZH, Ip NY. 2004. Cdk5: mediator of neuronal death and survival. Neurosci Lett 361:47-51.
    • (2004) Neurosci Lett , vol.361 , pp. 47-51
    • Cheung, Z.H.1    Ip, N.Y.2
  • 4
    • 4444262625 scopus 로고    scopus 로고
    • Cdk5 deregulation in the pathogenesis of Alzheimer's disease
    • Cruz JC, Tsai LH. 2004. Cdk5 deregulation in the pathogenesis of Alzheimer's disease. Trends Mol Med 10:452-458.
    • (2004) Trends Mol Med , vol.10 , pp. 452-458
    • Cruz, J.C.1    Tsai, L.H.2
  • 5
    • 0345405447 scopus 로고    scopus 로고
    • Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles
    • Cruz JC, Tseng H, Goldman JA, Shih H, Tsai LH. 2003. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 40:471-483.
    • (2003) Neuron , vol.40 , pp. 471-483
    • Cruz, J.C.1    Tseng, H.2    Goldman, J.A.3    Shih, H.4    Tsai, L.H.5
  • 6
    • 0030808462 scopus 로고    scopus 로고
    • Aggregated amyloid-β protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction
    • Estus S, Tucker HM, van Rooyen C, Wright S, Brigham EF, Wogulis M, Rydel RE. 1997. Aggregated amyloid-β protein induces cortical neuronal apoptosis and concomitant "apoptotic" pattern of gene induction. J Neurosci 17:7736-7745.
    • (1997) J Neurosci , vol.17 , pp. 7736-7745
    • Estus, S.1    Tucker, H.M.2    van Rooyen, C.3    Wright, S.4    Brigham, E.F.5    Wogulis, M.6    Rydel, R.E.7
  • 7
    • 28744449248 scopus 로고    scopus 로고
    • Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory
    • Fischer A, Sananbenesi F, Pang PT, Lu B, Tsai LH. 2005. Opposing roles of transient and prolonged expression of p25 in synaptic plasticity and hippocampus-dependent memory. Neuron 48:825-838.
    • (2005) Neuron , vol.48 , pp. 825-838
    • Fischer, A.1    Sananbenesi, F.2    Pang, P.T.3    Lu, B.4    Tsai, L.H.5
  • 8
    • 0037144442 scopus 로고    scopus 로고
    • Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage
    • Ghahremani MH, Keramaris E, Shree T, Xia Z, Davis RJ, Flavell R, Slack RS, Park DS. 2002. Interaction of the c-Jun/JNK pathway and cyclin-dependent kinases in death of embryonic cortical neurons evoked by DNA damage. J Biol Chem 277:35586-35596.
    • (2002) J Biol Chem , vol.277 , pp. 35586-35596
    • Ghahremani, M.H.1    Keramaris, E.2    Shree, T.3    Xia, Z.4    Davis, R.J.5    Flavell, R.6    Slack, R.S.7    Park, D.S.8
  • 9
    • 0037431130 scopus 로고    scopus 로고
    • Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis
    • Gong X, Tang X, Wiedmann M, Wang X, Peng J, Zheng D, Blair LA, Marshall J, Mao Z. 2003. Cdk5-mediated inhibition of the protective effects of transcription factor MEF2 in neurotoxicity-induced apoptosis. Neuron 38:33-46.
    • (2003) Neuron , vol.38 , pp. 33-46
    • Gong, X.1    Tang, X.2    Wiedmann, M.3    Wang, X.4    Peng, J.5    Zheng, D.6    Blair, L.A.7    Marshall, J.8    Mao, Z.9
  • 10
    • 0035021950 scopus 로고    scopus 로고
    • ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1
    • Harada T, Morooka T, Ogawa S, Nishida E. 2001. ERK induces p35, a neuron-specific activator of Cdk5, through induction of Egr1. Nat Cell Biol 3:453-459.
    • (2001) Nat Cell Biol , vol.3 , pp. 453-459
    • Harada, T.1    Morooka, T.2    Ogawa, S.3    Nishida, E.4
  • 11
    • 2342562573 scopus 로고    scopus 로고
    • Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke
    • Khan M, Sekhon B, Jatana M, Giri S, Gilg AG, Sekhon C, Singh I, Singh AK. 2004. Administration of N-acetylcysteine after focal cerebral ischemia protects brain and reduces inflammation in a rat model of experimental stroke. J Neurosci Res 76:519-527.
    • (2004) J Neurosci Res , vol.76 , pp. 519-527
    • Khan, M.1    Sekhon, B.2    Jatana, M.3    Giri, S.4    Gilg, A.G.5    Sekhon, C.6    Singh, I.7    Singh, A.K.8
  • 12
    • 25644456097 scopus 로고    scopus 로고
    • Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease
    • Kitazawa M, Oddo S, Yamasaki TR, Green KN, LaFerla FM. 2005. Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease. J Neurosci 25:8843-8853.
    • (2005) J Neurosci , vol.25 , pp. 8843-8853
    • Kitazawa, M.1    Oddo, S.2    Yamasaki, T.R.3    Green, K.N.4    LaFerla, F.M.5
  • 13
    • 0034595834 scopus 로고    scopus 로고
    • Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25
    • Kusakawa G, Saito T, Onuki R, Ishiguro K, Kishimoto T, Hisanaga S. 2000. Calpain-dependent proteolytic cleavage of the p35 cyclin-dependent kinase 5 activator to p25. J Biol Chem 275:17166-17172.
    • (2000) J Biol Chem , vol.275 , pp. 17166-17172
    • Kusakawa, G.1    Saito, T.2    Onuki, R.3    Ishiguro, K.4    Kishimoto, T.5    Hisanaga, S.6
  • 15
    • 0036469286 scopus 로고    scopus 로고
    • Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3
    • Li BS, Zhang L, Takahashi S, Ma W, Jaffe H, Kulkarni AB, Pant HC. 2002. Cyclin-dependent kinase 5 prevents neuronal apoptosis by negative regulation of c-Jun N-terminal kinase 3. EMBO J 21:324-333.
    • (2002) EMBO J , vol.21 , pp. 324-333
    • Li, B.S.1    Zhang, L.2    Takahashi, S.3    Ma, W.4    Jaffe, H.5    Kulkarni, A.B.6    Pant, H.C.7
  • 16
    • 0042817922 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-5 is involved in neuregulindependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival
    • Li BS, Ma W, Jaffe H, Zheng Y, Takahashi S, Zhang L, Kulkarni AB, Pant HC. 2003a. Cyclin-dependent kinase-5 is involved in neuregulindependent activation of phosphatidylinositol 3-kinase and Akt activity mediating neuronal survival. J Biol Chem 278:35702-35709.
    • (2003) J Biol Chem , vol.278 , pp. 35702-35709
    • Li, B.S.1    Ma, W.2    Jaffe, H.3    Zheng, Y.4    Takahashi, S.5    Zhang, L.6    Kulkarni, A.B.7    Pant, H.C.8
  • 17
    • 0037269505 scopus 로고    scopus 로고
    • Stabilization of the cyclin-dependent kinase 5 activator, p35, by paclitaxel decreases β-amyloid toxicity in cortical neurons
    • Li G, Faibushevich A, Turunen BJ, Yoon SO, Georg G, Michaelis ML, Dobrowsky RT. 2003b. Stabilization of the cyclin-dependent kinase 5 activator, p35, by paclitaxel decreases β-amyloid toxicity in cortical neurons. J Neurochem 84:347-362.
    • (2003) J Neurochem , vol.84 , pp. 347-362
    • Li, G.1    Faibushevich, A.2    Turunen, B.J.3    Yoon, S.O.4    Georg, G.5    Michaelis, M.L.6    Dobrowsky, R.T.7
  • 19
    • 0029880475 scopus 로고    scopus 로고
    • Demonstration of cyclin-dependent kinase inhibitory serine/threonine kinase in bovine thymus
    • Matsuura I, Wang JH. 1996. Demonstration of cyclin-dependent kinase inhibitory serine/threonine kinase in bovine thymus. J Biol Chem 271:5443-5450.
    • (1996) J Biol Chem , vol.271 , pp. 5443-5450
    • Matsuura, I.1    Wang, J.H.2
  • 20
    • 0021061819 scopus 로고
    • Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assay
    • Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assay. J Immunol Methods 65:55-63.
    • (1983) J Immunol Methods , vol.65 , pp. 55-63
    • Mosmann, T.1
  • 21
    • 0037459081 scopus 로고    scopus 로고
    • Mitochondria: Releasing power for life and unleashing the machineries of death
    • Newmeyer DD, Ferguson-Miller S. 2003. Mitochondria: releasing power for life and unleashing the machineries of death. Cell 112:481-490.
    • (2003) Cell , vol.112 , pp. 481-490
    • Newmeyer, D.D.1    Ferguson-Miller, S.2
  • 22
    • 17744368458 scopus 로고    scopus 로고
    • Deregulation of Cdk5 in a mouse model of ALS: Toxicity alleviated by perikaryal neurofilament inclusions
    • Nguyen MD, Lariviere RC, Julien JP. 2001. Deregulation of Cdk5 in a mouse model of ALS: toxicity alleviated by perikaryal neurofilament inclusions. Neuron 30:135-147.
    • (2001) Neuron , vol.30 , pp. 135-147
    • Nguyen, M.D.1    Lariviere, R.C.2    Julien, J.P.3
  • 23
    • 0029966469 scopus 로고    scopus 로고
    • The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation
    • Nikolic M, Dudek H, Kwon YT, Ramos YF, Tsai LH. 1996. The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. Genes Dev 10:816-825.
    • (1996) Genes Dev , vol.10 , pp. 816-825
    • Nikolic, M.1    Dudek, H.2    Kwon, Y.T.3    Ramos, Y.F.4    Tsai, L.H.5
  • 28
    • 0032844418 scopus 로고    scopus 로고
    • inhibition of thrombin-induced neuronal cell death by recombinant thrombomodulin and E5510, a synthetic thrombin receptor signaling inhibitor
    • Sarker KP, Abeyama K, Nishi J, Nakata M, Tokioka T, Nakajima T. 1999. inhibition of thrombin-induced neuronal cell death by recombinant thrombomodulin and E5510, a synthetic thrombin receptor signaling inhibitor. Thromb Haemost 82:1071-1077.
    • (1999) Thromb Haemost , vol.82 , pp. 1071-1077
    • Sarker, K.P.1    Abeyama, K.2    Nishi, J.3    Nakata, M.4    Tokioka, T.5    Nakajima, T.6
  • 29
    • 0001181116 scopus 로고    scopus 로고
    • Alzheimer's disease: Molecular understanding predicts amyloid-based therapeutics
    • Selkoe DJ, Schenk D. 2003. Alzheimer's disease: molecular understanding predicts amyloid-based therapeutics. Annu Rev Pharmacol Toxicol 43:545-584.
    • (2003) Annu Rev Pharmacol Toxicol , vol.43 , pp. 545-584
    • Selkoe, D.J.1    Schenk, D.2
  • 30
    • 1642269125 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-5 in neurodegeneration
    • Shelton SB, Johnson GVW. 2004. Cyclin-dependent kinase-5 in neurodegeneration. J Neurochem 88:1313-1326.
    • (2004) J Neurochem , vol.88 , pp. 1313-1326
    • Shelton, S.B.1    Johnson, G.V.W.2
  • 32
    • 0028912996 scopus 로고
    • Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: Protection by the antioxidant N-acetylcysteine and the gene bcl-2 and crmA
    • Talley AK, Dewhurst S, Perry SW, Dollard SC, Gummuluru S, Fine SM. 1995. Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the gene bcl-2 and crmA. Mol Cell Biol 15:2359-2366.
    • (1995) Mol Cell Biol , vol.15 , pp. 2359-2366
    • Talley, A.K.1    Dewhurst, S.2    Perry, S.W.3    Dollard, S.C.4    Gummuluru, S.5    Fine, S.M.6
  • 33
    • 0027978170 scopus 로고
    • p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5
    • Tsai LH, Delalle I, Caviness VS Jr, Chae T, Harlow E. 1994. p35 is a neural-specific regulatory subunit of cyclin-dependent kinase 5. Nature 371:419-423.
    • (1994) Nature , vol.371 , pp. 419-423
    • Tsai, L.H.1    Delalle, I.2    Caviness Jr, V.S.3    Chae, T.4    Harlow, E.5
  • 34
    • 0141542665 scopus 로고    scopus 로고
    • Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors
    • Wang J, Liu S, Fu Y, Wang JH, Lu Y. 2003. Cdk5 activation induces hippocampal CA1 cell death by directly phosphorylating NMDA receptors. Nat Neurosci 6:1039-1047.
    • (2003) Nat Neurosci , vol.6 , pp. 1039-1047
    • Wang, J.1    Liu, S.2    Fu, Y.3    Wang, J.H.4    Lu, Y.5
  • 35
    • 33745192268 scopus 로고    scopus 로고
    • Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2
    • Wang CX, Song JH, Song DK, Yong VW, Shuaib A and Hao C. 2006. Cyclin-dependent kinase-5 prevents neuronal apoptosis through ERK-mediated upregulation of Bcl-2. Cell Death Differ 13:1203-1212.
    • (2006) Cell Death Differ , vol.13 , pp. 1203-1212
    • Wang, C.X.1    Song, J.H.2    Song, D.K.3    Yong, V.W.4    Shuaib, A.5    Hao, C.6
  • 36
    • 0029800074 scopus 로고    scopus 로고
    • Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ ERK-dependent mechanism
    • Xia Z, Dudek H, Miranti CK, Greenberg ME. 1996. Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ ERK-dependent mechanism. J Neurosci 16:5425-5436.
    • (1996) J Neurosci , vol.16 , pp. 5425-5436
    • Xia, Z.1    Dudek, H.2    Miranti, C.K.3    Greenberg, M.E.4
  • 37
    • 0344878874 scopus 로고    scopus 로고
    • Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway
    • Yan CYI, Greene LA. 1998. Prevention of PC12 cell death by N-acetylcysteine requires activation of the Ras pathway. J Neurosci 18:4042-4049.
    • (1998) J Neurosci , vol.18 , pp. 4042-4049
    • Yan, C.Y.I.1    Greene, L.A.2
  • 38
    • 13944275183 scopus 로고    scopus 로고
    • β-Amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w
    • Yao M, Nguyen TVV, Pike CJ. 2005. β-Amyloid-induced neuronal apoptosis involves c-Jun N-terminal kinase-dependent downregulation of Bcl-w. J Neurosci 25:1149-1158.
    • (2005) J Neurosci , vol.25 , pp. 1149-1158
    • Yao, M.1    Nguyen, T.V.V.2    Pike, C.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.