PPARβ agonists trigger neuronal differentiation in the human neuroblastoma cell line SH-SY5Y

Journal of Cellular Physiology

Volumn 211, Issue 3, 2007, Pages 837-847

  Di Loreto, S ^b   D'Angelo, B ^a   D'Amico, M A ^a   Benedetti, E ^a   Cristiano, L ^a   Cinque, B ^c   Cifone, M G ^c   Ceru M P ^a   Festuccia, C ^c   Cimini, A ^a  

^a UNIVERSITY OF L'AQUILA   (Italy)

^b CNR   (Italy)

^c UNIVERSITY OF L'AQUILA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; OLEIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; GW0742; SMALL INTERFERING RNA; THIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; CELL MIGRATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; NERVE CELL DIFFERENTIATION; NERVE CELL GROWTH; NEUROBLASTOMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; CELL DIFFERENTIATION; CELL DIVISION; CELL MOTION; DRUG EFFECT; DRUG POTENTIATION; GENE EXPRESSION; GENETICS; METABOLISM; NEURITE; NEUROBLASTOMA; PATHOLOGY; PERIPHERAL NERVE TUMOR; PHYSIOLOGY; TUMOR CELL LINE;

BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL ADHESION; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE, TUMOR; CELL MOVEMENT; GENE EXPRESSION; HUMANS; NEURITES; NEUROBLASTOMA; OLEIC ACID; PERIPHERAL NERVOUS SYSTEM NEOPLASMS; PPAR-BETA; RECEPTOR, TRKB; RNA, SMALL INTERFERING; THIAZOLES;

EID: 34247588060     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.20996     Document Type: Article

References (26)

1. Barbacid M. 1994. The Trk family of neurotrophin receptors. J Neurobiol 25:1386-1403.
2. Biedler JL, Helson L, Spengler BA. 1973. Morphology and growth, tumorigenicity, and cytogenetics of human neuroblastoma cells in continuous culture. Cancer Res 33:2643-2652.
3. Binder DK, Scharfman HE. 2004. Brain-derived neurotrophicfactor. Growth Factors 22:123-131.
4. Cimini A, Benedetti E, Cristiano L, Sebastiani P, D'Amico MA, D'Angelo B, Di Loreto S. 2005a. Expression of peroxisome proliferator-activated receptors (PPARs) and retinoic acid receptors (RXRs) in rat cortical neurons. Neuroscience 130:325-337.
5. Cimini A, Cristiano L, Colafarina S, Benedetti E, Di Loreto S, Festuccia C, Amicarelli F, Canuto RA, Ceru MP. 2005b. PPARgamma-dependent effects of conjugated linoleic acid on the human glioblastoma cell line (ADF). Int J Cancer 117:923-933.
6. Escher P, Wahli W. 2000. Peroxisome proliferator-activated receptors: Insight into multiple cellular functions. Mutat Res 448:121-138.
7. Fagerstrom S, Pahlman S, Gestblom C, Nanberg E. 1996. Protein kinase C-epsilon is implicated in neurite outgrowth in differentiating human neuroblastoma cells. Cell Growth Differ 7:775-785.
8. Granneman J, Skoff R, Yang X. 1998. Member of the peroxisome proliferator-activated receptor family of transcription factors is differentially expressed by oligodendrocytes. J Neurosci Res 51:563-573.
9. Hutton LA, deVellis J, Perez-Polo JR. 1992. Expression of p75NGFR TrkA, and TrkB mRNA in rat C6 glioma and type 1 astrocyte cultures. J Neurosci Res 32:375-383.
10. Jaboin J, Kim CJ, Kaplan DR, Thiele CJ. 2002. Brain-derived neurotrophic factor activation of TrkB protects neuroblastoma cells from chemotherapy-induced apoptosis via phosphatidylinositol 3′-kinase pathway. Cancer Res 62:6756-6763.
11. Kalb R. 2005. The protean actions of neurotrophins and their receptors on the life and death of neurons. Trends Neurosci 28:5-11.
12. Li Z, Jaboin J, Dennis PA, Thiele CJ. 2005. Genetic and pharmacologi identification of Akt as a mediator of brain-derived neurotrophic factor/TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death. Cancer Res 65:2070-2075.
13. Liu Y, Encinas M, Comella JX, Aldea M, Gallego C. 2004. Basic helix-loop-helix proteins bind to TrkB and p21(Cip1) promoters linking differentiation and cell cycle arrest in neuroblastoma cells. Mol Cell Biol 24:2662-2672.
14. Michalik L, Desvergne B, Tan NS, Basu-Modak S, Escher P, Rieusset J, Peters JM, Kaya G, Gonzalez FJ, Zakany J, Metzger D, Chambon P, Duboule D, Wahli W. 2001. Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. J Cell Biol 154:799-814.
15. Michalik L, Desvergne B, Wahli W. 2004. Peroxisome-proliferator-activated receptors and cancers: Complex stories. Nat Rev Cancer 4:61-70.
16. Nanda SA, Mack KJ. 2000. Seizures and sensory stimulation result in different patterns of brain derived neurotrophic factor protein expression in the barrel cortex and hippocampus. Brain Res Mol Brain Res 78:1-14.
17. Noujaim D, van Golen CM, van Golen KL, Grauman A, Feldman EL 2002. N-Myc and Bcl-2 coexpression induces MMP-2 secretion and activation in human neuroblastoma cells. Oncogene 21:4549-4557.
18. Oliver WR Jr, Shenk JL, Snaith MR, Russell CS, Plunket KD, Bodkin NL, Lewis MC, Winegar DA, Sznaidman ML, Lambert MH, Xu HE, Sternbach DD, Kliewer SA, Hansen BC, Willson TM. 2001. A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc Natl Acad Sci USA 98:5306-11.
19. Pahlman S, Odelstad L, Larsson E, Grotte G, Nilsson K. 1981. Phenotypic changes of human neuroblastoma cells in culture induced by 12-O-tetradecanoyl- phorbol-13-acetate. Int J Cancer 28:583-589.
20. Pahlman S, Meyerson G, Lindgren E, Schalling M, Johansson I. 1991. Insulin-like growth factor 1 shifts from promoting cell division to potentiating maturation during neuronal differentiation. Proc Natl Acad Sci USA 88:9994-9998.
21. Parrow V, Nanberg E, Heikkila J, Hammerling U, Pahlman S. 1992. Protein kinase C remains functionally active during TPA induced neuronal differentiation of SH-SY5Y human neuroblastoma cells. J Cell Physiol 152:536-544.
22. Saluja I, Granneman JG, Skoff RP. 2001. PPAR delta agonists stimulate oligodendrocyte differentiation in tissue culture. Glia 33:191-204.
23. Sidell N. 1982. Retinoic acid-induced growth inhibition and morphologic differentiation of human neuroblastoma cells in vitro. J Natl Cancer Inst 68:589-596.
24. Smith PK, Krohn RI, Hermanson GT, Mallia AK, Gartner FH, Provenzano MD, Fujimoto EK, Goeke NM, Olson BJ, Klenk DC. 1985. Measurement of protein using bicinchoninic acid. Anal Biochem 150:76-85.
25. Tabernero A, Lavado EM, Granda B, Velasco A, Medina JM. 2001. Neuronal differentiation is triggered by oleic acid synthesized and released by astrocytes. J Neurochem 79:606-616.
26. Zhang X, Zhao M, Huang AY, Fei Z, Zhang W, Wang XL. 2005. The effect of cyclin D expression on cell proliferation in human gliomas. Clin Neurosci 12:166-168.