Functional and structural characterization of a thermostable acetyl esterase from Thermotoga maritima

Proteins: Structure, Function and Bioinformatics

Volumn 80, Issue 6, 2012, Pages 1545-1559

  Levisson, Mark ^a   Han, Gye Won ^b,c   Deller, Marc C ^b,c   Xu, Qingping ^b,d   Biely, Peter ^e   Hendriks, Sjon ^a   Ten Eyck, Lynn F ^f,g   Flensburg, Claus ^h   Roversi, Pietro ^h   Miller, Mitchell D ^b,d   McMullan, Daniel ⁱ   von Delft, Frank ^b,c   Kreusch, Andreas ⁱ   Deacon, Ashley M ^b,d   van der Oost, John ^a   Lesley, Scott A ^b,c,i   Elsliger, Marc André ^b,c   Kengen, Servé W M ^a   Wilson, Ian A ^b,c  

^a WAGENINGEN UNIVERSITY   (Netherlands)

^b Joint Center for Structural Genomics   (United States)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d SLAC NATIONAL ACCELERATOR LABORATORY   (United States)

^e INSTITUTE OF CHEMISTRY   (Slovakia)

^f UNIVERSITY OF CALIFORNIA   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

^h GLOBAL PHASING LTD   (United Kingdom)

ⁱ GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

hydrolase; Acetyl esterase; Crystal structure; Inhibitor; Serine rotation; Thermotoga maritima

Indexed keywords

4 NITROPHENYL BETA DEXTRO XYLOPYRANOSIDE MONOACETATE DERIVATIVE; ACETYL ESTERASE; BENZYLSULFONYL FLUORIDE; CEPHALOSPORIN C; ESTERASE; PARAOXON; SELENOMETHIONINE; SERINE; TM 0077; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG; XYLAN; XYLAN 1,4 BETA XYLOSIDASE;

ARTICLE; CATALYSIS; COVALENT BOND; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME ANALYSIS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; THERMOSTABILITY; THERMOTOGA MARITIMA;

ACETYLESTERASE; CATALYTIC DOMAIN; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; ENZYME STABILITY; HOT TEMPERATURE; HYDROGEN-ION CONCENTRATION; MODELS, MOLECULAR; PROTEIN CONFORMATION; REPRODUCIBILITY OF RESULTS; SERINE; THERMOTOGA MARITIMA;

THERMOTOGA MARITIMA;

EID: 84863405359     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24041     Document Type: Article

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