Dendritic cells with TGF-β1 and IL-2 differentiate naive CD4+ T Cells into alloantigen-specific and allograft protective foxp3+ regulatory T cells

Transplantation

Volumn 93, Issue 6, 2012, Pages 580-588

  Yang, Hua ^a   Cheng, Elaine Y ^a   Sharma, Vijay K ^a   Lagman, Mila ^a   Chang, Christina ^a   Song, Ping ^a   Ding, Ruchuang ^a   Muthukumar, Thangamani ^a   Suthanthiran, Manikkam ^a  

^a WEILL CORNELL MEDICAL CENTER   (United States)

Author keywords

Dendritic cells; Foxp3; Islet cell transplantation; Regulatory T cells

Indexed keywords

ALLOANTIGEN; CD4 ANTIGEN; GLYCOPROTEIN P 15095; GRANZYME B; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR ALPHA; MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA1;

ALLOGRAFT; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN SPECIFICITY; ARTICLE; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL CLONE; CONTROLLED STUDY; DENDRITIC CELL; FOXP3+ REGULATORY T LYMPHOCYTE; GRAFT SURVIVAL; IMMUNE DEFICIENCY; IMMUNOCOMPETENCE; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE DIFFERENTIATION; MALE; MIXED LYMPHOCYTE REACTION; MOUSE; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; REGULATORY T LYMPHOCYTE; SURVIVAL TIME; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

ANIMALS; ANTIGENS, CD11; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CELL COMMUNICATION; CELL DIFFERENTIATION; CELLS, CULTURED; DENDRITIC CELLS; DIABETES MELLITUS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; FORKHEAD TRANSCRIPTION FACTORS; INTERLEUKIN-2; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; ISLETS OF LANGERHANS TRANSPLANTATION; ISOANTIGENS; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, INBRED CBA; RNA, MESSENGER; STREPTOZOCIN; T-LYMPHOCYTES, REGULATORY; TRANSFORMING GROWTH FACTOR BETA1; TRANSPLANTATION, HOMOLOGOUS;

EID: 84863346687     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e318244dd67     Document Type: Article

References (22)

1. Wing K, Sakaguchi S. Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 2010; 11: 7.
2. Kim JM, Rasmussen JP, Rudensky AY. Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice. Nat Immunol 2007; 8: 191.
3. Wood KJ, Sakaguchi S. Regulatory T cells in transplantation tolerance. Nat Rev Immunol 2003; 3: 199.
4. Yamazaki S, Patel M, Harper A, et al. Effective expansion of alloantigenspecific Foxp3CD25CD4+regulatory T cells by dendritic cells during the mixed leukocyte reaction. Proc Natl Acad Sci USA 2006; 103: 2758.
5. Luo X, Tarbell K, Yang H, et al. Dendritic cells with TGF-beta1 differentiate naïve CD4+CD25T cells into islet-protective Foxp3regulatory T cells. Proc Natl Acad Sci USA 2007; 104: 2821.
6. Zheng SG, Wang J, Wang P, et al. IL-2 is essential for TGF-beta to convert naive CD4+CD25cells to CD25Foxp3regulatory T cells and for expansion of these cells. J Immunol 2007; 178: 2018.
7. Chen W, Jin W, Hardegen N, et al. Conversion of peripheral CD4+CD25naive T cells to CD4+CD25regulatory T cells by TGF-beta induction of transcription factor Foxp3. J Exp Med 2003; 198: 1875.
8. Yamazaki S, Iyoda T, Tarbell K, et al. Direct expansion of functional CD25CD4+regulatory T cells by antigen-processing dendritic cells. J Exp Med 2003; 198: 235.
9. Muthukumar T, Dadhania D, Ding R, et al. MessengerRNAfor FOXP3 in the urine of renal-allograft recipients. N Engl J Med 2005; 353: 2342.
10. Zheng XX, Sánchez-Fueyo A, Sho M, et al. Favorably tipping the balance between cytopathic and regulatory T cells to create transplantation tolerance. Immunity 2003; 19: 503.
11. Raimondi G, Sumpter TL, Matta BM, et al. Mammalian target of rapamycin inhibition and alloantigen-specific regulatory T cells synergize to promote long-term graft survival in immunocompetent recipients. J Immunol 2010; 184: 624.
12. Xia G, He J, Zhang Z, et al. Targeting acute allograft rejection by immunotherapy with ex vivo-expanded naturalCD4+CD25regulatory T cells. Transplantation 2006; 82: 1749.
13. Xia G, He J, Leventhal J.R. Ex-vivo expanded natural CD4+CD25regulatory T cells synergize with host T-cell depletion to promote longterm survival of allografts. Am J Transplant 2008; 8: 298.
14. Gibly RF, Graham JG, Luo X, et al. Advancing islet transplantation: From engraftment to the immune response. Diabetologia 2011; 54: 2494.
15. Tarbell KV, Petit L, Zuo X, et al. Dendritic cell-expanded, islet-specific CD4+CD25CD62Lregulatory T cells restore normoglycemia in diabetic NOD mice. J Exp Med 2007; 204: 191.
16. Brennan TV, Tang Q, Liu FC, et al. Requirements for prolongation of allograft survival with regulatory T cell infusion in lymphosufficient hosts. J Surg Res 2011; 169: e69.
17. Zhou X, Bailey-Bucktrout S, Jeker LT, et al. Plasticity of CD4+Foxp3T cells. Curr Opin Immunol 2009; 21: 281.
18. Marie JC, Letterio JJ, Gavin M, et al. TGF-beta1 maintains suppressor function and Foxp3 expression in CD4+CD25regulatory T cells. J Exp Med 2005; 201: 1061.
19. Joffre O, Santolaria T, Calise D, et al. Prevention of acute and chronic allograft rejection with CD4+CD25Foxp3regulatory T lymphocytes. Nat Med 2008; 14: 88.
20. Tsang J, Tanriver Y, Jiang S, et al. Conferring indirect allospecificity on CD4+CD25Tregs by TCR gene transfer favors transplantation tolerance in mice. J Clin Invest 2008; 118: 3619.
21. Yang H, Ding R, Sharma V, et al. Hyperexpression of Foxp3 and IDO during acute rejection of islet allografts. Transplantation 2007; 83: 1643.
22. Yang H, Thomas D, Boffa D, et al. Enforced c-REL deficiency prolongs survival of islet allografts. Transplantation 2002; 74: 291.