Synthesis, X-ray analysis, and biological evaluation of a new class of stereopure lactam-based HIV-1 protease inhibitors

Journal of Medicinal Chemistry

Volumn 55, Issue 6, 2012, Pages 2724-2736

  Wu, Xiongyu ^a   Öhrngren, Per ^a   Joshi, Advait A ^a   Trejos, Alejandro ^a   Persson, Magnus ^a   Arvela, Riina K ^a   Wallberg, Hans ^b   Vrang, Lotta ^b   Rosenquist, Åsa ^b   Samuelsson, Bertil B ^b   Unge, Johan ^c   Larhed, Mats ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b MEDIVIR AB   (Sweden)

^c LUND UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; ASPARTIC ACID; GAMMA LACTAM DERIVATIVE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; NONHUMAN; PROCESS OPTIMIZATION; X RAY ANALYSIS;

CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; CRYSTALLOGRAPHY, X-RAY; HIV PROTEASE; HIV PROTEASE INHIBITORS; HIV-1; HUMANS; LACTAMS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84863342365     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm201620t     Document Type: Article

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