Effect of metoprolol on sarcoplasmic reticulum Ca 2++ leak in a rabbit model of heart failure

Chinese Medical Journal

Volumn 125, Issue 5, 2012, Pages 815-822

  Zhang, Shi Jie ^a   Liu, Zhi Hua ^b   Zou, Cao ^b   Wang, Lei ^a  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

^b THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIVERSITY   (China)

Author keywords

blocker; Ca 2++ leak; Heart failure; Phosphorylation; Ryanodine receptor

Indexed keywords

CALCIUM; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CYCLIC AMP DEPENDENT PROTEIN KINASE; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 12.6; METOPROLOL; RYANODINE RECEPTOR 2; SARCOPLASMIC RETICULUM CALCIUM TRANSPORTING ADENOSINE TRIPHOSPHATASE; THAPSIGARGIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIASTOLIC BLOOD PRESSURE; ELECTRON MICROSCOPY; HEART FAILURE; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE MASS; HEART LEFT VENTRICLE WALL; HEART VENTRICLE SEPTUM; HEART VENTRICLE SIZE; HEMODYNAMIC PARAMETERS; IMMUNOPRECIPITATION; M MODE ECHOCARDIOGRAPHY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RABBIT; SARCOPLASMIC RETICULUM; SYSTOLIC BLOOD PRESSURE; WESTERN BLOTTING;

ANIMALS; CALCIUM; CALCIUM-CALMODULIN-DEPENDENT PROTEIN KINASE TYPE 2; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ECHOCARDIOGRAPHY; HEART FAILURE; HEMODYNAMICS; METOPROLOL; RATS; SARCOPLASMIC RETICULUM;

EID: 84863339154     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0366-6999.2012.05.016     Document Type: Article

References (42)

1. 2++ exchanger expression and function in an arrhythmogenic rabbit model of heart failure. Circ Res 1999; 85: 1009-1019.
2. Ward ML, Crossman DJ, Cannell MB. Mechanisms of reduced contractility in an animal model of hypertensive heart failure. Clin Exp Pharmacol Physiol 2011; 38: 711-716.
3. Shannon TR, Pogwizd SM, Bers DM. Elevated sarcoplasmic reticulum Ca leak in intact ventricular myocytes from rabbits in heart failure. Circ Res 2003; 93: 592-594.
4. Hobai IA, O'Rourke. Decreased sarcoplasmic reticulum calcium content is responsible for defective excitation-contraction coupling in canine heart failure. Circulation 2001; 103: 1577-1584.
5. Houmsse M, Franco V, Abraham WT. Epidemiology of sudden cardiac death in patients with heart failure. Heart Fail Clin 2011; 7:147-155.
6. Pogwizd SM. Nonreentrant mechanisms underlying spontaneous ventricular arrhythmias in a model of nonischemic heart failure in rabbits. Circulation 1995; 92: 1034-1048.
7. 2++ leak via RyR2 in heart failure progression. Hypertension 2010; 55: 849-851.
8. Lehnart SE, Terrenoire C, Reiken S, Wehrens XH, Song LS, Tillman EJ, et al. Stabilization of cardiac ryanodine receptor prevents intracellular calcium leak and arrhythmias. Proc Natl Acad Sci 2006; 103: 7906-7910.
9. Marx SO, Reiken S, Hisamatsu Y, Jayaraman T, Burkhoff D, Rosemblit N, et al. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts. Cell 2000; 101: 365-376.
10. 2++/calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res 2004; 94: e61-e70.
11. Ni L, Zhou C, Duan Q, Lv J, Fu X, Xia Y, et al. β-AR Blockers Suppresses ER Stress in Cardiac Hypertrophy and Heart Failure. PLoS One 2011; 6: e27294.
12. Waller DG, Waller JR. Beta blockers for heart failure with reduced ejection fraction. BMJ 2011; 343:d5603.
13. Doi M, Yano M, Kobayashi S, Kohno M, Tokuhisa T, Okuda S, et al. Propranolol prevents the development of heart failure by restoring FKBP12.6-mediated stabilization of ryanodine receptor. Circulation 2002; 105: 1374-1379.
14. Shan J, Betzenhauser MJ, Kushnir A, Reiken S, Meli AC, Wronska A, et al. Role of chronic ryanodine receptor phosphorylation in heart failure and β-adrenergic receptor blockade in mice. J Clin Invest 2010; 120: 4375-4387.
15. Reiken S, Wehrens XH, Vest JA, Barbone A, Klotz S, Mancini D, et al. β-Blockers Restore Calcium Release Channel Function and Improve Cardiac Muscle Performance in Human Heart Failure. Circulation 2003; 107: 2459-2466.
16. Guo T, Cornea RL, Huke S, Camors E, Yang Y, Picht E, et al. Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and the effects on Ca sparks. Circ Res 2010; 106: 1743-1752.
17. Li Y, Kranias EG, Mignery GA, Bers DM. Protein kinase A phosphorylation of the ryanodine receptor does not affect Ca sparks in permeabilized mouse ventricular myocytes. Circ Res 2002; 90: 309-316.
18. 2++-release channel (ryanodine receptor) does not dissociate 12.6-kDa FK506-binding protein (FKBP12.6). Circ Res 2004; 94: 487-495.
19. Kranias EG, Schwartz A, Jungmann RA. Characterization of cyclic 3':5'-amp-dependent protein kinase in sarcoplasmic reticulum and cytosol of canine myocardium. Biochim Biophys Acta 1982; 709: 28-37.
20. Goueli BS, Hsiao K, Tereba A, Goueli SA. A novel and simple method to assay the activity of individual protein kinases in a crude tissue extract. Anal Biochem 1995; 225: 10-17.
21. 2++/Calmodulin-dependent protein kinase II phosphorylation regulates the cardiac ryanodine receptor. Circ Res 2004; 94: 61-70.
22. Rodriguez P, Bhogal MS, Colyer J. Stoichiometric phosphorylation of cardiac ryanodine receptor on serine-2809 by calmodulin-dependent kinase II and protein kinase A. J Biol Chem 2003; 278: 38593-38600.
23. Huke S, Bers DM. Ryanodine receptor phosphorylation at Serine 2030, 2808 and 2814 in rat cardiomyocytes. Biochem Biophys Res Commun 2008; 376: 80-85.
24. Jones PP, Meng X, Xiao B, Cai S, Bolstad J, Wagenknecht T, et al. Localization of PKA phosphorylation site, Ser (2030), in the three-dimensional structure of cardiac ryanodine receptor. Biochem J 2008; 410: 261-270.
25. Kitzman DW, Little WC, Brubaker PH, Anderson RT, Hundley WG, Marburger CT, et al. Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure. JAMA 2002; 288: 2144-2150.
26. Konstam MA. "Systolic and diastolic dysfunction" in heart failure? Time for a new paradigm. J Card Fail 2003; 9: 1-3.
27. van Heerebeek L, Borbely A, Niessen HW, Bronzwaer JG, van der Velden J, Stienen GJ, et al. Myocardial structure and function differ in systolic and diastolic heart failure. Circulation 2006; 113: 1966-1973.
28. Kawai M, Konishi M. Measurement of sarcoplasmic reticulum calcium content in skinned mammalian cardiac muscle. Cell Calcium 1994; 16: 123-136.
29. 2++ leak in chronic heart failure. Circ Res 2008; 103: 1466-1472.
30. 2++ leak in failing hearts. Cardiovasc Res 2009; 81: 536-545.
31. 2++ exchanger. J Physiol Pharmacol 2008; 59: 287-300.
32. 2++ leak in heart failure: mere observation or functional relevance? Cardiovasc Res 2008; 77: 302-314.
33. 2++ release in heart failure. Cardiovasc Res 2010; 87: 609-617.
34. 2++ leak through ryanodine receptor in heart failure. Circulation 2000; 102: 2131-2136.
35. 2++ leak in heart failure. Circ Res 2005; 97: 1314-1322.
36. Curran J, Hinton MJ, Rios E, Bers DM, Shannon TR. Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ Res 2007; 100: 391-398.
37. Xiao B, Jiang MT, Zhao M, Yang D, Sutherland C, Lai FA. Characterization of a novel PKA phosphorylation site, serine-2030, reveals no PKA hyperphosphorylation of the cardiac Ryanodine receptor in canine heart failure. Circ Res 2005; 96: 847-855.
38. 2++ leak from the sarcoplasmic reticulum and increases contractility. Circ Res 2001; 88: 188-194.
39. 2++]i differ in mouse and rabbit ventricular myocytes. J Pharmacol Exp Ther 2003; 304: 334-341.
40. Wehrens XH, Lehnart SE, Huang F, Vest JA, Reiken SR, Mohler PJ, et al. FKBP12.6 deficiency and defective calcium release channel (ryanodine receptor) function linked to exercise-induced sudden cardiac death. Cell 2003; 113: 829-840.
41. Blayney LM, Jones JL, Griffiths J, Lai FA. A mechanism of ryanodine receptor modulation by FKBP12/12.6, protein kinase A, and K201. Cardiovasc Res 2010; 85: 68-78.
42. Xiao J, Tian X, Jones PP, Bolstad J, Kong H, Wang R, et al. Removal of FKBP12.6 does not alter the conductance and activation of the cardiac ryanodine receptor or the susceptibility to stress-induced ventricular arrhythmias. J Biol Chem 2007; 282: 34828-34838.