Propranolol prevents the development of heart failure by restoring FKBP12.6-mediated stabilization of ryanodine receptor

Circulation

Volumn 105, Issue 11, 2002, Pages 1374-1379

  Doi, Masahiro ^a   Yano, Masafumi ^a   Kobayashi, Shigeki ^a   Kohno, Masateru ^a   Tokuhisa, Takahiro ^a   Okuda, Shinichi ^a   Suetsugu, Masae ^a   Hisamatsu, Yuhji ^a   Ohkusa, Tomoko ^a   Kohno, Michihiro ^a   Matsuzaki, Masunori ^a  

^a YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

blocker; Calcium; Heart failure; Sarcoplasmic reticulum

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM; PROPRANOLOL; RYANODINE RECEPTOR; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BETA ADRENERGIC RECEPTOR BLOCKING; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; DOSE RESPONSE; DRUG MECHANISM; HEART FAILURE; HEART FUNCTION; HEMODYNAMICS; NONHUMAN; PRIORITY JOURNAL; SARCOPLASMIC RETICULUM;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; CALCIUM; CARDIAC PACING, ARTIFICIAL; DIASTOLE; DISEASE MODELS, ANIMAL; DOGS; HEART FAILURE, CONGESTIVE; HEART VENTRICLES; HEMODYNAMIC PROCESSES; MYOCARDIUM; PHOSPHORYLATION; PROPRANOLOL; PROTEIN BINDING; PROTEIN CONFORMATION; RYANODINE RECEPTOR CALCIUM RELEASE CHANNEL; SARCOPLASMIC RETICULUM; SYSTOLE; TACROLIMUS; TACROLIMUS BINDING PROTEINS; VENTRICULAR REMODELING;

EID: 0037133555     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc1102.105270     Document Type: Article

References (29)

1. Compensatory downregulation of myocardial Ca channel in SR from dogs with heart failure
2. 2+-ATPase in failing and nonfailing human hearts
3. Intracellular calcium-release channels: Regulators of cell life and death
4. Alterations of calcium-regulatory proteins in heart failure
5. Cardiac intracellular calcium release channels: Role in heart failure
6. 2+ leak through ryanodine receptor in heart failure
7. 2+ release from cardiac sarcoplasmic reticulum in tachycardia-induced heart failure
8. 2+ release in heart failure
9. Coupled gating between cardiac calcium release channels (ryanodine receptors)
10. 2+ release channels (ryanodine receptors)
11. PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): Defective regulation in failing hearts
12. Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure
13. The Cardiac Insufficiency Bisoprolol Study II (CIBIS-II). A randomised trial
14. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)
15. Effects of chronic β-adrenergic blockade on the left ventricular and cardiocyte abnormalities of chronic canine mitral regurgitation
16. 2+ leak from the sarcoplasmic reticulum and increases contractility
17. Characterization of cyclic 3′:5′-AMP-dependent protein kinase in sarcoplasmic reticulum and cytosol of canine myocardium
18. 2+ release from sareoplasmic reticulum
19. 2+ release from sarcoplasmic reticulum
20. The calcium release channel of sareoplasmic reticulum is modulated by FK-506-binding protein: Dissociation and reconstitution of FKBP-12 to the calcium release channel of skeletal muscle sarcoplasmic reticulum
21. The paradox of β-adrenergic blockade for the management of congestive heart failure
22. Patients with end-stage congestive heart failure treated with β-adrenergic receptor antagonists have improved ventricular myocyte calcium regulatory protein abundance
23. Cellular and molecular remodeling in a heart failure model treated with the β-blocker carteolol
24. β-adrenergic receptor blockers restore cardiac calcium release channel (ryanodine receptor) structure and function in heart failure
25. Intracellular calcium handling in isolated ventricular myocytes from patients with terminal heart failure
26. Impairment of the myocardial ultrastructure and changes of the cytoskeleton in dilated cardiomyopathy
27. Decreased catecholamine sensitivity and β-adrenergic-receptor density in failing human hearts
28. Comparative hemodynamic, LV functional, and antiadrenergic effects of chronic treatment with metoprolol vs carvedilol in the failing heart
29. FKBP binding characteristics of cardiac microsomes from diverse vertebrates