58-kDa microspherule protein (MSP58) is novel brahma-related gene 1 (BRG1)-associated protein that modulates p53/p21 senescence pathway

Journal of Biological Chemistry

Volumn 287, Issue 27, 2012, Pages 22533-22548

  Hsu, Che Chia ^a   Lee, Yi Chao ^b   Yeh, Shiu Hwa ^c   Chen, Chang Han ^d   Wu, Chih Ching ^e   Wang, Tsui Ying ^f   Chen, Yu Nong ^f   Hung, Liang Yi ^a   Liu, Yao Wen ^g   Chen, Han Ku ^h   Hsiao, Yi Ting ^c   Wang, Wei Sheng ^d   Tsou, Jen Hui ^a   Tsou, Yi Huan ^f   Wu, Mei Hsiang ^a   Chang, Wen Chang ^a,f,i   Lin, Ding Yen ^a,f  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^d CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^e CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^f NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^g KUO GENERAL HOSPITAL   (Taiwan)

^h FOOYIN UNIVERSITY HOSPITAL   (Taiwan)

ⁱ TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ANEUPLOIDY; CELLULAR MORPHOLOGY; CELLULAR PROLIFERATIONS; CELLULAR SENESCENCE; CONTEXT DEPENDENT; DNA DAMAGE RESPONSE; DOWN-REGULATION; ECTOPIC EXPRESSIONS; EXPRESSION LEVELS; FIBROSARCOMA CELLS; GALACTOSIDASES; HT-1080; MAMMARY EPITHELIAL CELLS; MOUSE EMBRYONIC FIBROBLASTS; NORMAL TISSUE; PROTEIN LEVEL; REPLICATIVE SENESCENCE; SIGNALING PATHWAYS; STRESS-INDUCED; SWI/SNF; TERNARY COMPLEX;

CELL CULTURE; CELL DEATH; CELL PROLIFERATION; FIBROBLASTS; GENES; TUMORS;

PROTEINS;

BETA GALACTOSIDASE; BRG1 PROTEIN; DNA; MICROSPHERULE PROTEIN 58; ONCOPROTEIN; PROTEIN P21; PROTEIN P53; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANEUPLOIDY; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL AGING; CELL PROLIFERATION; CELL SPECIFICITY; CELL STRAIN 3T3; CELL STRESS; CELL STRUCTURE; COMPLEX FORMATION; CONTROLLED STUDY; DNA REPAIR; EMBRYO; ENZYME ACTIVITY; FIBROBLAST; FIBROSARCOMA; GENE SILENCING; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INDUCTION; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR GENE;

ANIMALS; APOPTOSIS; CELL AGING; CELL DIVISION; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; DNA DAMAGE; DNA HELICASES; FIBROSARCOMA; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE KNOCKDOWN TECHNIQUES; HUMANS; MAMMARY GLANDS, HUMAN; MICE; NIH 3T3 CELLS; NUCLEAR PROTEINS; ONCOGENE PROTEIN P21(RAS); RNA-BINDING PROTEINS; SIGNAL TRANSDUCTION; STRESS, PHYSIOLOGICAL; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84863308674     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.335331     Document Type: Article

References (58)

1. Hayflick, L., and Moorhead, P. S. (1961) The serial cultivation of human diploid cell strains. Exp. Cell Res. 25, 585-621
2. Blackburn, E. H. (2000) Telomere states and cell fates. Nature 408, 53-56
3. Kim Sh, S. H., Kaminker, P., and Campisi, J. (2002) Telomeres, aging and cancer: in search of a happy ending. Oncogene 21, 503-511 (Pubitemid 34146250)
4. Stewart, S. A., and Weinberg, R. A. (2000) Telomerase and human tumorigenesis. Semin. Cancer Biol. 10, 399-406 (Pubitemid 32181910)
5. Chen, Q. M. (2000) Replicative senescence and oxidant-induced premature senescence. Beyond the control of cell cycle checkpoints. Ann. N.Y. Acad. Sci. 908, 111-125
6. Ben-Porath, I., and Weinberg, R. A. (2005) The signals and pathways activating cellular senescence. Int. J. Biochem. Cell Biol. 37, 961-976 (Pubitemid 40311739)
7. Serrano, M., and Blasco, M. A. (2001) Putting the stress on senescence. Curr. Opin. Cell Biol. 13, 748-753 (Pubitemid 33042736)
8. Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., and Lowe, S. W. (1997) Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602 (Pubitemid 27152402)
9. Sitte, N., Merker, K., Von Zglinicki, T., Grune, T., and Davies, K. J. (2000) Protein oxidation and degradation during cellular senescence of human BJ fibroblasts: part I-effects of proliferative senescence. FASEB J. 14, 2495-2502
10. Campisi, J. (2000) Cancer, aging and cellular senescence. In Vivo 14, 183-188
11. Dimri, G. P., Lee, X., Basile, G., Acosta, M., Scott, G., Roskelley, C., Medrano, E. E., Linskens, M., Rubelj, I., and Pereira-Smith, O. (1995) A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. U.S.A. 92, 9363-9367
12. Shay, J. W., Pereira-Smith, O. M., and Wright, W. E. (1991) A role for both RB and p53 in the regulation of human cellular senescence. Exp. Cell Res. 196, 33-39 (Pubitemid 121006368)
13. Hunter, T. (1993) Braking the cycle. Cell 75, 839-841
14. Harper, J. W., Adami, G. R., Wei, N., Keyomarsi, K., and Elledge, S. J. (1993) The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. Cell 75, 805-816 (Pubitemid 23346377)
15. Narita, M., Nunez, S., Heard, E., Lin, A. W., Hearn, S. A., Spector, D. L., Hannon, G. J., and Lowe, S. W. (2003) Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113, 703-716 (Pubitemid 36724935)
16. Adams, P. D. (2007) Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging. Gene 397, 84-93
17. Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A. H., Schlegelberger, B., Stein, H., Dörken, B., Jenuwein, T., and Schmitt, C. A. (2005) Oncogene-induced senescence as an initial barrier in lymphoma development. Nature 436, 660-665 (Pubitemid 41117262)
18. Chen, Z., Trotman, L. C., Shaffer, D., Lin, H. K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., Cordon-Cardo, C., and Pandolfi, P. P. (2005) Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436, 725-730 (Pubitemid 41117277)
19. Ivanova, A. V., Ivanov, S. V., and Lerman, M. L. (2005) Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins. Cell. Mol. Life Sci. 62, 471-484 (Pubitemid 40379237)
20. Lin, D. Y., and Shih, H. M. (2002) Essential role of the 58-kDa microspherule protein in the modulation of Daxx-dependent transcriptional repression as revealed by nucleolar sequestration. J. Biol. Chem. 277, 25446-25456
21. Ren, Y., Busch, R. K., Perlaky, L., and Busch, H. (1998) The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with nucleolar protein p120. Eur. J. Biochem. 253, 734-742 (Pubitemid 28223542)
22. Shimono, K., Shimono, Y., Shimokata, K., Ishiguro, N., and Takahashi, M. (2005) Microspherule protein 1, Mi-2β, and RET finger protein associate in the nucleolus and up-regulate ribosomal gene transcription. J. Biol. Chem. 280, 39436-39447 (Pubitemid 41713901)
23. Wu, J. L., Lin, Y. S., Yang, C. C., Lin, Y. J., Wu, S. F., Lin, Y. T., and Huang, C. F. (2009) MCRS2 represses the transactivation activities of Nrf1. BMC Cell Biol. 10, 9
24. Andersen, D. S., Raja, S. J., Colombani, J., Shaw, R. L., Langton, P. F., Akhtar, A., and Tapon, N. (2010) Drosophila MCRS2 associates with RNA polymerase II complexes to regulate transcription. Mol. Cell. Biol. 30, 4744-4755
25. Hirohashi, Y., Wang, Q., Liu, Q., Du, X., Zhang, H., Sato, N., and Greene, M. I. (2006) p78/MCRS1 forms a complex with centrosomal protein Nde1 and is essential for cell viability. Oncogene 25, 4937-4946 (Pubitemid 44201184)
26. Du, X., Wang, Q., Hirohashi, Y., and Greene, M. I. (2006) DIPA, which can localize to the centrosome, associates with p78/MCRS1/MSP58 and acts as a repressor of gene transcription. Exp. Mol. Pathol. 81, 184-190 (Pubitemid 44665866)
27. Bader, A. G., Schneider, M. L., Bister, K., and Hartl, M. (2001) TOJ3, a target of the v-Jun transcription factor, encodes a protein with transforming activity related to human microspherule protein 1 (MCRS1). Oncogene 20, 7524-7535 (Pubitemid 33086912)
28. Okumura, K., Zhao, M., Depinho, R. A., Furnari, F. B., and Cavenee, W. K. (2005) Cellular transformation by the MSP58 oncogene is inhibited by its physical interaction with the PTEN tumor suppressor. Proc. Natl. Acad. Sci. U.S.A. 102, 2703-2706 (Pubitemid 40299856)
29. Shi, H., Chen, S., Jin, H., Xu, C., Dong, G., Zhao, Q., Wang, W., Zhang, H., Lin, W., Zhang, J., Davidovic, L., Yao, L., and Fan, D. (2009) Downregulation of MSP58 inhibits growth of human colorectal cancer cells via regulation of the cyclin D1-cyclin-dependent kinase 4-p21 pathway. Cancer Sci. 100, 1585-1590
30. Lin, W., Zhang, J., Zhang, J., Liu, X., Fei, Z., Li, X., Davidovic, L., Tang, Z., Shen, L., Deng, Y., Yang, A., Han, H., Zhang, X., and Yao, L. (2009) RNAimediated inhibition of MSP58 decreases tumour growth, migration and invasion in a human glioma cell line. J. Cell. Mol. Med. 13, 4608-4622
31. Song, H., Li, Y., Chen, G., Xing, Z., Zhao, J., Yokoyama, K. K., Li, T., and Zhao, M. (2004) Human MCRS2, a cell-cycle-dependent protein, associates with LPTS/PinX1 and reduces the telomere length. Biochem. Biophys. Res. Commun. 316, 1116-1123 (Pubitemid 38369068)
32. Lam, E. W., and Watson, R. J. (1993) An E2F-binding site mediates cellcycle regulated repression of mouse B-myb transcription. EMBO J. 12, 2705-2713 (Pubitemid 23218320)
33. Wu, R. C., and Schönthal, A. H. (1997) Activation of p53-p21waf1 pathway in response to disruption of cell-matrix interactions. J. Biol. Chem. 272, 29091-29098
34. McCabe, N., Turner, N. C., Lord, C. J., Kluzek, K., Bialkowska, A., Swift, S., Giavara, S., O'Connor, M. J., Tutt, A. N., Zdzienicka, M. Z., Smith, G. C., and Ashworth, A. (2006) Deficiency in the repair of DNA damage by homologous recombination and sensitivity to poly(ADP-ribose) polymerase inhibition. Cancer Res. 66, 8109-8115 (Pubitemid 44299177)
35. Shats, I., Milyavsky, M., Tang, X., Stambolsky, P., Erez, N., Brosh, R., Kogan, I., Braunstein, I., Tzukerman, M., Ginsberg, D., and Rotter, V. (2004) p53-dependent down-regulation of telomerase is mediated by p21waf1. J. Biol. Chem. 279, 50976-50985 (Pubitemid 40017838)
36. Zhang, J., Ohta, T., Maruyama, A., Hosoya, T., Nishikawa, K., Maher, J. M., Shibahara, S., Itoh, K., and Yamamoto, M. (2006) BRG1 interacts with Nrf2 to selectively mediate HO-1 induction in response to oxidative stress. Mol. Cell. Biol. 26, 7942-7952 (Pubitemid 44630994)
37. Lin, D. Y., Fang, H. I., Ma, A. H., Huang, Y. S., Pu, Y. S., Jenster, G., Kung, H. J., and Shih, H. M. (2004) Negative modulation of androgen receptor transcriptional activity by Daxx. Mol. Cell. Biol. 24, 10529-10541 (Pubitemid 39603115)
38. Dignam, J. D., Lebovitz, R. M., and Roeder, R. G. (1983) Accurate transcription initiation byRNApolymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475-1489
39. Chen, C. H., Lu, P. J., Chen, Y. C., Fu, S. L., Wu, K. J., Tsou, A. P., Lee, Y. C., Lin, T. C., Hsu, S. L., Lin, W. J., Huang, C. Y., and Chou, C. K. (2007) FLJ10540-elicited cell transformation is through the activation of PI3-kinase/AKT pathway. Oncogene 26, 4272-4283
40. Kadam, S., and Emerson, B. M. (2003) Transcriptional specificity of human SWI/SNF BRG1 and BRM chromatin remodeling complexes. Mol. Cell 11, 377-389 (Pubitemid 36293832)
41. Kang, H., Cui, K., and Zhao, K. (2004) BRG1 controls the activity of the retinoblastoma protein via regulation of p21CIP1/WAF1/SDI. Mol. Cell. Biol. 24, 1188-1199 (Pubitemid 38112181)
42. Sharma, S. V., and Settleman, J. (2010) Exploiting the balance between life and death: targeted cancer therapy and "oncogenic shock". Biochem. Pharmacol. 80, 666-673
43. Courtois-Cox, S., Jones, S. L., and Cichowski, K. (2008) Many roads lead to oncogene-induced senescence. Oncogene 27, 2801-2809 (Pubitemid 351620451)
44. Halazonetis, T. D., Gorgoulis, V. G., and Bartek, J. (2008) An oncogeneinduced DNA damage model for cancer development. Science 319, 1352-1355 (Pubitemid 351354863)
45. Prieur, A., and Peeper, D. S. (2008) Cellular senescence in vivo: a barrier to tumorigenesis. Curr. Opin. Cell Biol. 20, 150-155
46. Bartkova, J., Horejsí, Z., Koed, K., Krämer, A., Tort, F., Zieger, K., Guldberg, P., Sehested, M., Nesland, J. M., Lukas, C., ∅rntoft, T., Lukas, J., and Bartek, J. (2005) DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434, 864-870 (Pubitemid 40558993)
47. Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L. V., Kolettas, E., Niforou, K., Zoumpourlis, V. C., Takaoka, M., Nakagawa, H., Tort, F., Fugger, K., Johansson, F., Sehested, M., Andersen, C. L., Dyrskjot, L., Ørntoft, T., Lukas, J., Kittas, C., Helleday, T., Halazonetis, T. D., Bartek, J., and Gorgoulis, V. G. (2006) Oncogene-induced senescence is part of the tumorigenesis barrier imposed byDNAdamage check-points. Nature 444, 633-637 (Pubitemid 44864442)
48. Di Micco, R., Fumagalli, M., Cicalese, A., Piccinin, S., Gasparini, P., Luise, C., Schurra, C., Garre', M., Nuciforo, P. G., Bensimon, A., Maestro, R., Pelicci, P. G., and d'Adda di Fagagna, F. (2006) Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444, 638-642
49. Mallette, F. A., Gaumont-Leclerc, M. F., and Ferbeyre, G. (2007) TheDNA damage signaling pathway is a critical mediator of oncogene-induced senescence. Genes Dev. 21, 43-48 (Pubitemid 46089705)
50. Raja, S. J., Charapitsa, I., Conrad, T., Vaquerizas, J. M., Gebhardt, P., Holz, H., Kadlec, J., Fraterman, S., Luscombe, N. M., and Akhtar, A. (2010) The nonspecific lethal complex is a transcriptional regulator in Drosophila. Mol. Cell 38, 827-841
51. Chen, L., Cai, Y., Jin, J., Florens, L., Swanson, S. K., Washburn, M. P., Conaway, J. W., and Conaway, R. C. (2011) Subunit organization of the human INO80 chromatin remodeling complex: an evolutionarily conserved core complex catalyzes ATP-dependent nucleosome remodeling. J. Biol. Chem. 286, 11283-11289
52. Cai, Y., Jin, J., Swanson, S. K., Cole, M. D., Choi, S. H., Florens, L., Washburn, M. P., Conaway, J. W., and Conaway, R. C. (2010) Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. J. Biol. Chem. 285, 4268-4272
53. Dunaief, J. L., Strober, B. E., Guha, S., Khavari, P. A., Alin, K., Luban, J., Begemann, M., Crabtree, G. R., and Goff, S. P. (1994) The retinoblastoma protein and BRG1 form a complex and cooperate to induce cell cycle arrest. Cell 79, 119-130 (Pubitemid 24309518)
54. Lee, D., Kim, J. W., Seo, T., Hwang, S. G., Choi, E. J., and Choe, J. (2002) SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription. J. Biol. Chem. 277, 22330-22337 (Pubitemid 34967200)
55. Xu, Y., Zhang, J., and Chen, X. (2007) The activity of p53 is differentially regulated by Brm- and Brg1-containing SWI/SNF chromatin remodeling complexes. J. Biol. Chem. 282, 37429-37435
56. Hendricks, K. B., Shanahan, F., and Lees, E. (2004) Role for BRG1 in cell cycle control and tumor suppression. Mol. Cell. Biol. 24, 362-376 (Pubitemid 38010061)
57. Zhang, H. S., Gavin, M., Dahiya, A., Postigo, A. A., Ma, D., Luo, R. X., Harbour, J. W., and Dean, D. C. (2000) Exit fromG1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. Cell 101, 79-89
58. Chung, C. H., Bernard, P. S., and Perou, C. M. (2002) Molecular portraits and the family tree of cancer. Nat. Genet. 32, (suppl.) 533-540 (Pubitemid 35435158)